Suchergebnisse - "Ganesh, Santhi K."

Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association von Hayes, Sharonne N, Kim, Esther S H, Saw, Jacqueline, Adlam, David, Arslanian-Engoren, Cynthia, Economy, Katherine E, Ganesh, Santhi K, Gulati, Rajiv, Lindsay, Mark E, Mieres, Jennifer H, Naderi, Sahar, Shah, Svati, Thaler, David E, Tweet, Marysia S, Wood, Malissa J

“… Spontaneous coronary artery dissection (SCAD) has emerged as an important cause of acute coronary syndrome, myocardial infarction, and sudden death, …”
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Peripartum dapagliflozin improves late-life maternal cardiovascular outcomes in a murine model of superimposed preeclampsia von Hesson, Ashley M., Sangtani, Ajleeta, Bergin, Ingrid L., Langen, Elizabeth, Hunker, Kristina, Kumar, Nitin, Ganesh, Santhi K.

“… Hypertensive disorders of pregnancy are important risk factors for later-life cardiovascular diseases. SGLT2 (sodium-glucose cotransporter-2) inhibition …”
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PHACTR1 Is a Genetic Susceptibility Locus for Fibromuscular Dysplasia Supporting Its Complex Genetic Pattern of Inheritance von Kiando, Soto Romuald, Tucker, Nathan R., Castro-Vega, Luis-Jaime, Katz, Alexander, D’Escamard, Valentina, Tréard, Cyrielle, Fraher, Daniel, Albuisson, Juliette, Kadian-Dodov, Daniella, Ye, Zi, Austin, Erin, Yang, Min-Lee, Hunker, Kristina, Barlassina, Cristina, Cusi, Daniele, Galan, Pilar, Empana, Jean-Philippe, Jouven, Xavier, Gimenez-Roqueplo, Anne-Paule, Bruneval, Patrick, Hyun Kim, Esther Soo, Olin, Jeffrey W., Gornik, Heather L., Azizi, Michel, Plouin, Pierre-François, Ellinor, Patrick T., Kullo, Iftikhar J., Milan, David J., Ganesh, Santhi K., Boutouyrie, Pierre, Kovacic, Jason C., Jeunemaitre, Xavier, Bouatia-Naji, Nabila

“… Fibromuscular dysplasia (FMD) is a nonatherosclerotic vascular disease leading to stenosis, dissection and aneurysm affecting mainly the renal and …”
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SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism von Kumar, Nitin, Zuo, Yu, Yalavarthi, Srilakshmi, Hunker, Kristina L., Knight, Jason S., Kanthi, Yogendra, Obi, Andrea T., Ganesh, Santhi K.

“… Men are disproportionately affected by the coronavirus disease-2019 (COVID-19), and face higher odds of severe illness and death compared to women. The …”
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Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressure von Lee, Dongwon, Han, Seong Kyu, Yaacov, Or, Berk-Rauch, Hanna, Mathiyalagan, Prabhu, Ganesh, Santhi K., Chakravarti, Aravinda

“… Genome-wide association studies (GWASs) have identified numerous variants associated with polygenic traits and diseases. However, with few exceptions, a …”
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Oxidative Stress in Kidney Injury and Hypertension von Arendshorst, Willaim J., Vendrov, Aleksandr E., Kumar, Nitin, Ganesh, Santhi K., Madamanchi, Nageswara R.

“… Hypertension (HTN) is a major contributor to kidney damage, leading to conditions such as nephrosclerosis and hypertensive nephropathy, significant causes of …”
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IFN-γ and TNF-α synergism may provide a link between psoriasis and inflammatory atherogenesis von Mehta, Nehal N., Teague, Heather L., Swindell, William R., Baumer, Yvonne, Ward, Nicole L., Xing, Xianying, Baugous, Brooke, Johnston, Andrew, Joshi, Aditya A., Silverman, Joanna, Barnes, Drew H., Wolterink, Liza, Nair, Rajan P., Stuart, Philip E., Playford, Martin, Voorhees, John J., Sarkar, Mrinal K., Elder, James T., Gallagher, Katherine, Ganesh, Santhi K., Gudjonsson, Johann E.

“… Chronic inflammation is a critical component of atherogenesis, however, reliable human translational models aimed at characterizing these mechanisms are …”
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Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve von Yang, Bo, Zhou, Wei, Jiao, Jiao, Nielsen, Jonas B., Mathis, Michael R., Heydarpour, Mahyar, Lettre, Guillaume, Folkersen, Lasse, Prakash, Siddharth, Schurmann, Claudia, Fritsche, Lars, Farnum, Gregory A., Lin, Maoxuan, Othman, Mohammad, Hornsby, Whitney, Driscoll, Anisa, Levasseur, Alexandra, Thomas, Marc, Farhat, Linda, Dubé, Marie-Pierre, Isselbacher, Eric M., Franco-Cereceda, Anders, Guo, Dong-chuan, Bottinger, Erwin P., Deeb, G. Michael, Booher, Anna, Kheterpal, Sachin, Chen, Y. Eugene, Kang, Hyun Min, Kitzman, Jacob, Cordell, Heather J., Keavney, Bernard D., Goodship, Judith A., Ganesh, Santhi K., Abecasis, Gonçalo, Eagle, Kim A., Boyle, Alan P., Loos, Ruth J. F., Eriksson, Per, Tardif, Jean-Claude, Brummett, Chad M., Milewicz, Dianna M., Body, Simon C., Willer, Cristen J.

“… Bicuspid aortic valve (BAV) is a heritable congenital heart defect and an important risk factor for valvulopathy and aortopathy. Here we report a genome-wide …”
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Histologic and morphologic character of pediatric renal artery occlusive disease von Coleman, Dawn M, Heider, Amer, Gordon, David, Ganesh, Santhi K, Eliason, Jonathan L, Stanley, James C

“… The pathologic nature of pediatric renal artery occlusive lesions causing renovascular hypertension has been the subject of numerous anecdotal reports. This …”
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Histologic and morphologic character of pediatric abdominal aortic developmental coarctation and hypoplasia von Heider, Amer, Gordon, David, Coleman, Dawn M, Eliason, Jonathan L, Ganesh, Santhi K, Stanley, James C

“… Abdominal aortic coarctation and hypoplasia are uncommon diseases, recognized most often in pediatric-aged individuals. Comprehensive studies regarding the …”
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Surgical management of pediatric renin-mediated hypertension secondary to renal artery occlusive disease and abdominal aortic coarctation von Coleman, Dawn M, Eliason, Jonathan L, Beaulieu, Robert, Jackson, Tatum, Karmakar, Monita, Kershaw, David B, Modi, Zubin J, Ganesh, Santhi K, Khaja, Minhaj S, Williams, David, Stanley, James C

“… Renovascular hypertension (RVH) associated with renal artery and abdominal aortic narrowings is the third most common cause of pediatric hypertension …”
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Placental transcriptome analysis of hypertensive pregnancies identifies distinct gene expression profiles of preeclampsia superimposed on chronic hypertension von Hesson, Ashley M., Langen, Elizabeth S., Plazyo, Olesya, Gudjonsson, Johann E., Ganesh, Santhi K.

“… Background The pathogenesis of preeclampsia superimposed on chronic hypertension (SI) is poorly understood relative to preeclampsia (PreE) occurring in …”
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Loss-of-Function Mutations in YY1AP1 Lead to Grange Syndrome and a Fibromuscular Dysplasia-Like Vascular Disease von Guo, Dong-Chuan, Duan, Xue-Yan, Regalado, Ellen S, Mellor-Crummey, Lauren, Kwartler, Callie S, Kim, Dong, Lieberman, Kenneth, de Vries, Bert B A, Pfundt, Rolph, Schinzel, Albert, Kotzot, Dieter, Shen, Xuetong, Yang, Min-Lee, Bamshad, Michael J, Nickerson, Deborah A, Gornik, Heather L, Ganesh, Santhi K, Braverman, Alan C, Grange, Dorothy K, Milewicz, Dianna M

“… Fibromuscular dysplasia (FMD) is a heterogeneous group of non-atherosclerotic and non-inflammatory arterial diseases that primarily involves the renal and …”
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Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project von Auer, Paul L, Johnsen, Jill M, Johnson, Andrew D, Logsdon, Benjamin A, Lange, Leslie A, Nalls, Michael A, Zhang, Guosheng, Franceschini, Nora, Fox, Keolu, Lange, Ethan M, Rich, Stephen S, O'Donnell, Christopher J, Jackson, Rebecca D, Wallace, Robert B, Chen, Zhao, Graubert, Timothy A, Wilson, James G, Tang, Hua, Lettre, Guillaume, Reiner, Alex P, Ganesh, Santhi K, Li, Yun

“… Researchers have successfully applied exome sequencing to discover causal variants in selected individuals with familial, highly penetrant disorders. We …”
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Pediatric nonaortic arterial aneurysms von Davis, Frank M, Eliason, Jonathan L, Ganesh, Santhi K, Blatt, Neal B, Stanley, James C, Coleman, Dawn M

“… Pediatric arterial aneurysms are extremely uncommon. Indications for intervention remain poorly defined and treatments vary. The impetus for this study was to …”
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Cross‐Ancestry Associations of Spontaneous Coronary Artery Dissection Genetic Risk With Coronary Atherosclerosis and Migraine Headache von Xu, Chang, Yang, Min‐Lee, Kho, Pik Fang, Clarke, Shoa L, Tcheandjieu, Catherine, Peyser, Patricia A., Fann, Cathy Shen‐Jang, Chen, Shih‐Pin, Saw, Jacqueline, Zhou, Xiang, Assimes, Themistocles L., Ganesh, Santhi K.

“… Research studies of spontaneous coronary artery dissection (SCAD) have been primarily focused on European-ancestry individuals, with limited recognition and …”
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A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model von Capell, Brian C, Olive, Michelle, Erdos, Michael R, Cao, Kan, Faddah, Dina A, Tavarez, Urraca L, Conneely, Karen N, Qu, Xuan, San, Hong, Ganesh, Santhi K, Chen, Xiaoyan, Avallone, Hedwig, Kolodgie, Frank D, Virmani, Renu, Nabel, Elizabeth G, Collins, Francis S

“… Hutchinson-Gilford progeria syndrome (HGPS) is the most dramatic form of human premature aging. Death occurs at a mean age of 13 years, usually from heart …”
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An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population von Sun, Pengfei, Zhou, Wei, Fu, Yi, Cheung, Chloe Y Y, Dong, Yujun, Yang, Min-Lee, Zhang, He, Jia, Jia, Huo, Yong, Willer, Cristen J, Chen, Y Eugene, Tang, Clara S, Tse, Hung-Fat, Lam, Karen S L, Gao, Wei, Xu, Ming, Yu, Haiyi, Sham, Pak Chung, Zhang, Yan, Ganesh, Santhi K

“… Genomic discovery efforts for hematological traits have been successfully conducted through genome-wide association study on samples of predominantly European …”
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Author Correction: Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases von Georges, Adrien, Yang, Min-Lee, Berrandou, Takiy-Eddine, Bakker, Mark K., Dikilitas, Ozan, Kiando, Soto Romuald, Ma, Lijiang, Satterfield, Benjamin A., Sengupta, Sebanti, Yu, Mengyao, Deleuze, Jean-François, Dupré, Delia, Hunker, Kristina L., Kyryachenko, Sergiy, Liu, Lu, Sayoud-Sadeg, Ines, Amar, Laurence, Brummett, Chad M., Coleman, Dawn M., d’Escamard, Valentina, de Leeuw, Peter, Fendrikova-Mahlay, Natalia, Kadian-Dodov, Daniella, Li, Jun Z., Lorthioir, Aurélien, Pappaccogli, Marco, Prejbisz, Aleksander, Smigielski, Witold, Stanley, James C., Zawistowski, Matthew, Zhou, Xiang, Zöllner, Sebastian, Amouyel, Philippe, De Buyzere, Marc L., Debette, Stéphanie, Dobrowolski, Piotr, Drygas, Wojciech, Gornik, Heather L., Olin, Jeffrey W., Piwonski, Jerzy, Rietzschel, Ernst R., Ruigrok, Ynte M., Vikkula, Miikka, Warchol Celinska, Ewa, Januszewicz, Andrzej, Kullo, Iftikhar J., Azizi, Michel, Jeunemaitre, Xavier, Persu, Alexandre, Kovacic, Jason C., Ganesh, Santhi K., Bouatia-Naji, Nabila

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Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1 von Ali, Ziad A., de Jesus Perez, Vinicio, Yuan, Ke, Orcholski, Mark, Pan, Stephen, Qi, Wei, Chopra, Gaurav, Adams, Christopher, Kojima, Yoko, Leeper, Nicholas J., Qu, Xiumei, Zaleta-Rivera, Kathia, Kato, Kimihiko, Yamada, Yoshiji, Oguri, Mitsutoshi, Kuchinsky, Allan, Hazen, Stanley L., Jukema, J. Wouter, Ganesh, Santhi K., Nabel, Elizabeth G., Channon, Keith, Leon, Martin B., Charest, Alain, Quertermous, Thomas, Ashley, Euan A.

“… Angioplasty and stenting is the primary treatment for flow-limiting atherosclerosis; however, this strategy is limited by pathological vascular remodeling …”
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