Suchergebnisse - "Günther, Ulrich L"

Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells von Favaro, Elena, Bensaad, Karim, Chong, Mei G, Tennant, Daniel A, Ferguson, David J P, Snell, Cameron, Steers, Graham, Turley, Helen, Li, Ji-Liang, Günther, Ulrich L, Buffa, Francesca M, McIntyre, Alan, Harris, Adrian L

“… Metabolic reprogramming of cancer cells provides energy and multiple intermediates critical for cell growth. Hypoxia in tumors represents a hostile environment …”
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Early Stage Diagnosis of Oral Cancer Using 1H NMR–Based Metabolomics von Tiziani, Stefano, Lopes, Victor, Günther, Ulrich L.

“… Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is …”
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MetaboLab - advanced NMR data processing and analysis for metabolomics von Ludwig, Christian, Günther, Ulrich L

“… Background Despite wide-spread use of Nuclear Magnetic Resonance (NMR) in metabolomics for the analysis of biological samples there is a lack of graphically …”
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TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression von Baptista, Inês, Karakitsou, Effrosyni, Cazier, Jean-Baptiste, Günther, Ulrich L., Marin, Silvia, Cascante, Marta

“… Increased expression of transketolase (TKT) and its isoform transketolase-like-1 (TKTL1) has been related to the malignant leukemia phenotype through promoting …”
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Fast NMR-Based Assessment of Cancer-Associated Protein Glycosylations from Serum Samples von Rudolph, Lorena, Krellmann, Renia, Castven, Darko, Jegodzinski, Lina, Deriš, Helena, Štambuk, Jerko, Mölbitz, Jarne, Dechent, Luna, Sperling, Kai, Lindloge, Melissa, Friedrich, Nele, Schmelter, Franziska, Föh, Bandik, Trbojević-Akmačić, Irena, Sina, Christian, Nauck, Matthias, Petersmann, Astrid, Marquardt, Jens U, Günther, Ulrich L, Mallagaray, Alvaro

“… Nuclear magnetic resonance (NMR) spectra of blood serum and plasma show signals arising from metabolites, lipoproteins, and -acetyl methyl groups of -glycans …”
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Digital biomarkers for interstitial glucose prediction in healthy individuals using wearables and machine learning von Huang, Xinyu, Schmelter, Franziska, Seitzer, Christian, Martensen, Lars, Otzen, Hans, Piet, Artur, Witt, Oliver, Schröder, Torsten, Günther, Ulrich L., Marshall, Lisa, Grzegorzek, Marcin, Sina, Christian

“… A personalized low-glycemic diet, maintaining stable blood glucose levels, aids in weight reduction and managing (pre-)diabetes and migraines in individuals …”
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Improved classification accuracy in 1- and 2-dimensional NMR metabolomics data using the variance stabilising generalised logarithm transformation von Parsons, Helen M, Ludwig, Christian, Günther, Ulrich L, Viant, Mark R

“… Classifying nuclear magnetic resonance (NMR) spectra is a crucial step in many metabolomics experiments. Since several multivariate classification techniques …”
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A framework for tracer-based metabolism in mammalian cells by NMR von Saborano, Raquel, Eraslan, Zuhal, Roberts, Jennie, Khanim, Farhat L., Lalor, Patricia F., Reed, Michelle A. C., Günther, Ulrich L.

“… Metabolism changes extensively during the normal proliferation and differentiation of mammalian cells, and in cancer and inflammatory diseases. Since changes …”
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The glutamate/aspartate transporter EAAT1 is crucial for T-cell acute lymphoblastic leukemia proliferation and survival von Stanulović, Vesna S., Al Omair, Shorog, Reed, Michelle A.C., Roberts, Jennie, Potluri, Sandeep, Fulton-Ward, Taylor, Gudgeon, Nancy, Bishop, Emma L., Roels, Juliette, Perry, Tracey A., Sarkar, Sovan, Pratt, Guy, Taghon, Tom, Dimeloe, Sarah, Günther, Ulrich L., Ludwig, Christian, Hoogenkamp, Maarten

“… T-cell acute lymphoblastic leukemia (T-ALL) is a cancer of the immune system. Approximately 20% of paediatric and 50% of adult T-ALL patients have refractory …”
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Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells von Vilaplana-Lopera, Nuria, Cuminetti, Vincent, Almaghrabi, Ruba, Papatzikas, Grigorios, Rout, Ashok Kumar, Jeeves, Mark, González, Elena, Alyahyawi, Yara, Cunningham, Alan, Erdem, Ayşegül, Schnütgen, Frank, Raghavan, Manoj, Potluri, Sandeep, Cazier, Jean-Baptiste, Schuringa, Jan Jacob, Reed, Michelle AC, Arranz, Lorena, Günther, Ulrich L, Garcia, Paloma

“… Acute myeloid leukaemia (AML) cells interact and modulate components of their surrounding microenvironment into their own benefit. Stromal cells have been …”
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Metabolic and Lipidomic Markers Differentiate COVID-19 From Non-Hospitalized and Other Intensive Care Patients von Schmelter, Franziska, Föh, Bandik, Mallagaray, Alvaro, Rahmöller, Johann, Ehlers, Marc, Lehrian, Selina, von Kopylow, Vera, Künsting, Inga, Lixenfeld, Anne Sophie, Martin, Emily, Ragab, Mohab, Meyer-Saraei, Roza, Kreutzmann, Fabian, Eitel, Ingo, Taube, Stefan, Käding, Nadja, Jantzen, Eckard, Graf, Tobias, Sina, Christian, Günther, Ulrich L.

“… Coronavirus disease 2019 (COVID-19) is a viral infection affecting multiple organ systems of great significance for metabolic processes. Thus, there is …”
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Metabolomic Evidence for a Field Effect in Histologically Normal and Metaplastic Tissues in Patients with Esophageal Adenocarcinoma von Reed, Michelle A.C., Singhal, Rishi, Ludwig, Christian, Carrigan, John B., Ward, Douglas G., Taniere, Phillipe, Alderson, Derek, Günther, Ulrich L.

“… Patients with Barrett's esophagus (BO) are at increased risk of developing esophageal adenocarcinoma (EAC). Most Barrett's patients, however, do not develop …”
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Food Fingerprinting: LC-ESI-IM-QTOF-Based Identification of Blumeatin as a New Marker Metabolite for the Detection of Origanum majorana Admixtures to O. onites/vulgare von Creydt, Marina, Flügge, Friedemann, Dammann, Robin, Schütze, Burkhard, Günther, Ulrich L., Fischer, Markus

“… Oregano (Origanum vulgare and O. onites) is one of the most frequently counterfeited herbs in the world and is diluted with the leaves of a wide variety of …”
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Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis von Shepherd, Emma L., Saborano, Raquel, Northall, Ellie, Matsuda, Kae, Ogino, Hitomi, Yashiro, Hiroaki, Pickens, Jason, Feaver, Ryan E., Cole, Banumathi K., Hoang, Stephen A., Lawson, Mark J., Olson, Matthew, Figler, Robert A., Reardon, John E., Nishigaki, Nobuhiro, Wamhoff, Brian R., Günther, Ulrich L., Hirschfield, Gideon, Erion, Derek M., Lalor, Patricia F.

“… Increasing evidence highlights dietary fructose as a major driver of non-alcoholic fatty liver disease (NAFLD) pathogenesis, the majority of which is cleared …”
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Modulation of structure and dynamics by disulfide bond formation in unfolded states von Silvers, Robert, Sziegat, Friederike, Tachibana, Hideki, Segawa, Shin-ichi, Whittaker, Sara, Günther, Ulrich L, Gabel, Frank, Huang, Jie-rong, Blackledge, Martin, Wirmer-Bartoschek, Julia, Schwalbe, Harald

“… During oxidative folding, the formation of disulfide bonds has profound effects on guiding the protein folding pathway. Until now, comparatively little is …”
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Regulation of the Mitochondrion-Fatty Acid Axis for the Metabolic Reprogramming of Chlamydia trachomatis during Treatment with β-Lactam Antimicrobials von Shima, Kensuke, Kaufhold, Inga, Eder, Thomas, Käding, Nadja, Schmidt, Nis, Ogunsulire, Iretiolu M., Deenen, René, Köhrer, Karl, Friedrich, Dirk, Isay, Sophie E., Grebien, Florian, Klinger, Matthias, Richer, Barbara C., Günther, Ulrich L., Deepe, George S., Rattei, Thomas, Rupp, Jan

“… The mitochondrion generates most of the ATP in eukaryotic cells, and its activity is used for controlling the intracellular growth of Chlamydia trachomatis  …”
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Targeting Asparagine and Serine Metabolism in Germinal Centre-Derived B Cells Non-Hodgkin Lymphomas (B-NHL) von Eraslan, Zuhal, Papatzikas, Grigorios, Cazier, Jean-Baptiste, Khanim, Farhat L., Günther, Ulrich L.

“… BL and DLBCL are subtypes of B-cell lymphomas that arise from germinal centre B lymphocytes. Differentiation between BL and DLBCL is critical and can be …”
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Metabolomic Profiling of Drug Responses in Acute Myeloid Leukaemia Cell Lines von Tiziani, Stefano, Lodi, Alessia, Khanim, Farhat L., Viant, Mark R., Bunce, Christopher M., Günther, Ulrich L.

“… Combined bezafibrate (BEZ) and medroxyprogesterone acetate (MPA) exert unexpected antileukaemic activities against acute myeloid leukaemia (AML) and these …”
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Proton NMR-Based Metabolite Analyses of Archived Serial Paired Serum and Urine Samples from Myeloma Patients at Different Stages of Disease Activity Identifies Acetylcarnitine as a Novel Marker of Active Disease von Lodi, Alessia, Tiziani, Stefano, Khanim, Farhat L., Günther, Ulrich L., Viant, Mark R., Morgan, Gareth J., Bunce, Christopher M., Drayson, Mark T.

“… Biomarker identification is becoming increasingly important for the development of personalized or stratified therapies. Metabolomics yields biomarkers …”
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Hypoxia-Like Signatures Induced by BCR-ABL Potentially Alter the Glutamine Uptake for Maintaining Oxidative Phosphorylation von Sontakke, Pallavi, Koczula, Katarzyna M., Jaques, Jennifer, Wierenga, Albertus T. J., Brouwers-Vos, Annet Z., Pruis, Maurien, Günther, Ulrich L., Vellenga, Edo, Schuringa, Jan Jacob

“… The Warburg effect is probably the most prominent metabolic feature of cancer cells, although little is known about the underlying mechanisms and consequences …”
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