Výsledky vyhľadávania - "Furmaniak, Jadwiga"

Evaluation of the RSR 3 screen ICA™ and 2 screen ICA™ as screening assays for type 1 diabetes in Sweden Autor Törn, Carina, Vaziri-Sani, Fariba, Ramelius, Anita, Elding Larsson, Helena, Ivarsson, Sten Anders, Amoroso, Marie, Furmaniak, Jadwiga, Powell, Michael, Smith, Bernard Rees

“…Aim The study aim was to evaluate the RSR 3 Screen ICA™ and 2 Screen ICA™ for detection of islet cell autoimmunity in healthy Swedish subjects and patients…”
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Characteristic phenotype of Chinese patients with adult-onset diabetes who are autoantibody positive by 3-Screen ICA™ ELISA Autor Wang, Zhida, Guo, Liang, Chen, Shu, Guan, Jun, Powell, Michael, Furmaniak, Jadwiga, Rees Smith, Bernard, Chen, Liming

“…Aims To assess the prevalence of diabetes-associated autoantibodies in Chinese patients recently diagnosed with adult-onset diabetes and to evaluate the…”
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The prevalence of diabetes and thyroid related autoantibodies in Sri Lankan children with type 1 diabetes and their unaffected siblings – The utility of a new screening assay Autor Atapattu, Navoda, Amoroso, Marie, Powell, Michael, de Silva, D. G. Harendra, de Silva, K. Shamya H., Furmaniak, Jadwiga, Rees Smith, Bernard, Premawardhana, Lakdasa D.

“…There is limited information about diabetes and thyroid related autoantibodies in children with type 1 diabetes (T1D) or their siblings in Sri Lanka. To assess…”
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Structure and activation of the TSH receptor transmembrane domain Autor Núñez Miguel, Ricardo, Sanders, Jane, Furmaniak, Jadwiga, Smith, Bernard Rees

“…Purpose The thyroid-stimulating hormone receptor (TSHR) is the target autoantigen for TSHR-stimulating autoantibodies in Graves’ disease. The TSHR is composed…”
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Thyrotrophin receptor antibody concentration and activity, several years after treatment for Graves’ disease Autor Nalla, Preethi, Young, Stuart, Sanders, Jane, Carter, Joanne, Adlan, Mohamed A., Kabelis, Katarzyna, Chen, Shu, Furmaniak, Jadwiga, Rees Smith, Bernard, Premawardhana, Lakdasa D. K. E.

“…Summary Objective TSH receptor antibodies (TRAb) are responsible for autoimmune hyperthyroid disease (Graves’ disease; GD) with TRAb levels tending to decrease…”
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Crystal structure of the TSH receptor (TSHR) bound to a blocking-type TSHR autoantibody Autor Sanders, Paul, Young, Stuart, Sanders, Jane, Kabelis, Katarzyna, Baker, Stuart, Sullivan, Andrew, Evans, Michele, Clark, Jill, Wilmot, Jane, Hu, Xiaoling, Roberts, Emma, Powell, Michael, Núñez Miguel, Ricardo, Furmaniak, Jadwiga, Rees Smith, Bernard

“…A complex of the TSH receptor extracellular domain (amino acids 22-260; TSHR260) bound to a blocking-type human monoclonal autoantibody (K1-70) was purified,…”
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Blocking type TSH receptor antibodies Autor Furmaniak, Jadwiga, Sanders, Jane, Rees Smith, Bernard

“…TSH receptor (TSHR) autoantibodies (TRAbs) play a key role in the pathogenesis of Graves’ disease. In the majority of patients, TRAbs stimulate thyroid hormone…”
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3 Screen ELISA for High-Throughput Detection of Beta Cell Autoantibodies in Capillary Blood Autor Ziegler, Anette-G, Haupt, Florian, Scholz, Marlon, Weininger, Katharina, Wittich, Susanne, Löbner, Stephanie, Matzke, Claudia, Gezginci, Cigdem, Riethausen, Stephanie, Beyerlein, Andreas, Zillmer, Stephanie, Amoroso, Marie, Coles, Rebecca, Powell, Michael, Furmaniak, Jadwiga, Smith, Bernard Rees, Winkler, Christiane, Bonifacio, Ezio, Achenbach, Peter

“…Testing for beta cell autoantibodies is used for wide-scale identification of early stages of type 1 diabetes. This requires suitable screening assays. We…”
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3 Screen islet cell autoantibody ELISA: A sensitive and specific ELISA for the combined measurement of autoantibodies to GAD65, to IA-2 and to ZnT8 Autor Amoroso, Marie, Achenbach, Peter, Powell, Michael, Coles, Rebecca, Chlebowska, Monika, Carr, Lorraine, Furmaniak, Jadwiga, Scholz, Marlon, Bonifacio, Ezio, Ziegler, Anette-G, Rees Smith, Bernard

“…3 Screen, a new ELISA for the combined measurement of autoantibodies to GAD65, to IA-2 and to ZnT8, has been developed and evaluated. In the assay serum…”
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Clinical Relevance of Serum Aquaporin-4 Antibody Levels in Neuromyelitis Optica Autor Isobe, Noriko, Yonekawa, Tomomi, Matsushita, Takuya, Masaki, Katsuhisa, Yoshimura, Satoshi, Fichna, Jakub, Chen, Shu, Furmaniak, Jadwiga, Smith, Bernard Rees, Kira, Jun-ichi

“…Neuromyelitis optica (NMO) is an inflammatory disease that selectively affects the optic nerves and spinal cord. The discovery of NMO-IgG targeting aquaporin-4…”
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A new assay for thyrotropin receptor autoantibodies Autor Smith, Bernard Rees, Bolton, Jane, Young, Stuart, Collyer, Alastair, Weeden, Alison, Bradbury, Janet, Weightman, David, Perros, Petros, Sanders, Jane, Furmaniak, Jadwiga

“…A new procedure for measuring patient serum thyrotropin receptor (TSHR) autoantibodies is described in which the autoantibodies inhibit binding of a human…”
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In vivo effects of a human thyroid-stimulating monoclonal autoantibody (M22) and a human thyroid-blocking autoantibody (K1-70) Autor Furmaniak, Jadwiga, Sanders, Jane, Young, Stuart, Kabelis, Katarzyna, Sanders, Paul, Evans, Michele, Clark, Jill, Wilmot, Jane, Rees Smith, Bernard

“…Purpose To study in vivo effects of the human monoclonal TSH receptor (TSHR) autoantibodies M22 (stimulating type) and K1-70 (blocking type) on thyroid hormone…”
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Thyrotropin Receptor Structure—In the Crystal New Horizons Shine Autor Furmaniak, Jadwiga, Sanders, Jane, Smith, Bernard Rees

“…The thyrotropin receptor (TSHR) expressed on the surface of the thyrocytes plays a key role in thyroid physiology and is also an important autoantibody target…”
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Estimation of serum TSH receptor autoantibody concentration and affinity Autor Nakatake, Nobuhiro, Sanders, Jane, Richards, Tonya, Burne, Peter, Barrett, Carol, Pra, Chiara Dal, Presotto, Fabio, Betterle, Corrado, Furmaniak, Jadwiga, Smith, Bernard Rees

“…We have used the human monoclonal TSH receptor (TSHR) autoantibody (M22) as a labeled ligand in competition with individual patient TSHR autoantibodies (TRAb)…”
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TSH receptor specific monoclonal autoantibody K1‐70TM targeting of the TSH receptor in subjects with Graves' disease and Graves' orbitopathy—Results from a phase I clinical trial Autor Furmaniak, Jadwiga, Sanders, Jane, Sanders, Paul, Li, Yang, Rees Smith, Bernard

“…Objectives In Graves' disease (GD), autoantibodies to the thyroid stimulating hormone receptor (TSHR) cause hyperthyroidism. The condition is often associated…”
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Analysis of the thyrotropin receptor-thyrotropin interaction by comparative modeling Autor Núñez Miguel, Ricardo, Sanders, Jane, Jeffreys, Jennifer, Depraetere, Hilde, Evans, Michele, Richards, Tonya, Blundell, Tom L, Rees Smith, Bernard, Furmaniak, Jadwiga

“…We have used the most advanced programs currently available to construct the first three-domain structure of the human thyrotropin receptor (TSHR) using…”
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Characterization of the thyrotropin binding pocket Autor Jeffreys, Jennifer, Depraetere, Hilde, Sanders, Jane, Oda, Yasuo, Evans, Michele, Kiddie, Angela, Richards, Tonya, Furmaniak, Jadwiga, Rees Smith, Bernard

“…A panel of monoclonal antibodies (mAbs) to the thyrotropin receptor (TSHR) was prepared using three different immunization strategies. The mAbs obtained (n =…”
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Sensitive non-isotopic assays for autoantibodies to IA-2 and to a combination of both IA-2 and GAD65 Autor Chen, Shu, Willis, Jinny, Maclean, Clare, Ananieva-Jordanova, Rossitza, Amoroso, Marie-Andrée, Brooking, Helen, Powell, Michael, Collins, Anne, Bennett, Stuart, Mitchell, Sarah, Burne, Peter, Furmaniak, Jadwiga, Smith, Bernard Rees

“…A sensitive ELISA for measurement of IA-2 autoantibodies has been developed and assessed. Also, a combination ELISA for detection of both GAD65 autoantibodies…”
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Implications of new monoclonal antibodies and the crystal structure of the TSH receptor for the treatment and management of thyroid diseases Autor Rees Smith, Bernard, Sanders, Jane, Furmaniak, Jadwiga

“…Autoantibodies to the thyroid-stimulating hormone receptor (TSHR) cause the hyperthyroidism of Graves ’ disease and contribute to Graves ’ eye signs. Human…”
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Cryo-electron microscopy structures of human thyroid peroxidase (TPO) in complex with TPO antibodies Autor Baker, Stuart, Miguel, Ricardo Núñez, Thomas, Daniel, Powell, Michael, Furmaniak, Jadwiga, Smith, Bernard Rees

“…Determination of the structure of the extracellular domain of human thyroid peroxidase (hTPO) by cryo-electron microscopy (cryo-EM) is described. TPO, purified…”
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