Výsledky vyhľadávania - "Function and Dysfunction of the Nervous System"

Ravulizumab in Aquaporin‐4–Positive Neuromyelitis Optica Spectrum Disorder Autor Pittock, Sean J., Barnett, Michael, Bennett, Jeffrey L., Berthele, Achim, Sèze, Jérôme, Levy, Michael, Nakashima, Ichiro, Oreja‐Guevara, Celia, Palace, Jacqueline, Paul, Friedemann, Pozzilli, Carlo, Yountz, Marcus, Allen, Kerstin, Mashhoon, Yasmin, Kim, Ho Jin

“…Objective CHAMPION‐NMOSD (NCT04201262) is a phase 3, open‐label, externally controlled interventional study evaluating the efficacy and safety of the terminal…”
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MOG encephalomyelitis: international recommendations on diagnosis and antibody testing Autor Jarius, S., Paul, F., Aktas, O., Asgari, N., Dale, R. C., de Seze, J., Franciotta, D., Fujihara, K., Jacob, A., Kim, H. J., Kleiter, I., Kümpfel, T., Levy, M., Palace, J., Ruprecht, K., Saiz, A., Trebst, C., Weinshenker, B. G., Wildemann, B.

“…Over the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte…”
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Human Cerebrospinal Fluid Monoclonal LGI1 Autoantibodies Increase Neuronal Excitability Autor Kornau, Hans‐Christian, Kreye, Jakob, Stumpf, Alexander, Fukata, Yuko, Parthier, Daniel, Sammons, Rosanna P., Imbrosci, Barbara, Kurpjuweit, Sarah, Kowski, Alexander B., Fukata, Masaki, Prüss, Harald, Schmitz, Dietmar

“…Objective Leucine‐rich glioma‐inactivated 1 (LGI1) encephalitis is the second most common antibody‐mediated encephalopathy, but insight into the intrathecal…”
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Serum neurofilament light chain levels at attack predict post-attack disability worsening and are mitigated by inebilizumab: analysis of four potential biomarkers in neuromyelitis optica spectrum disorder Autor Aktas, Orhan, Hartung, Hans-Peter, Smith, Michael A, Rees, William A, Fujihara, Kazuo, Paul, Friedemann, Marignier, Romain, Bennett, Jeffrey L, Kim, Ho Jin, Weinshenker, Brian G, Pittock, Sean J, Wingerchuk, Dean M, Cutter, Gary, She, Dewei, Gunsior, Michele, Cimbora, Daniel, Katz, Eliezer, Cree, Bruce A

“…ObjectiveTo investigate relationships between serum neurofilament light chain (sNfL), ubiquitin C-terminal hydrolase L1 (sUCHL1), tau (sTau) and glial…”
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Nervous System Regionalization Entails Axial Allocation before Neural Differentiation Autor Metzis, Vicki, Steinhauser, Sebastian, Pakanavicius, Edvinas, Gouti, Mina, Stamataki, Despina, Ivanovitch, Kenzo, Watson, Thomas, Rayon, Teresa, Mousavy Gharavy, S Neda, Lovell-Badge, Robin, Luscombe, Nicholas M, Briscoe, James

“…Neural induction in vertebrates generates a CNS that extends the rostral-caudal length of the body. The prevailing view is that neural cells are initially…”
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Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells Autor Lahmann, Ines, Bröhl, Dominique, Zyrianova, Tatiana, Isomura, Akihiro, Czajkowski, Maciej T, Kapoor, Varun, Griger, Joscha, Ruffault, Pierre-Louis, Mademtzoglou, Despoina, Zammit, Peter S, Wunderlich, Thomas, Spuler, Simone, Kühn, Ralf, Preibisch, Stephan, Wolf, Jana, Kageyama, Ryoichiro, Birchmeier, Carmen

“…The balance between proliferation and differentiation of muscle stem cells is tightly controlled, ensuring the maintenance of a cellular pool needed for muscle…”
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Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures Autor Kreye, Jakob, Wright, Sukhvir K, van Casteren, Adriana, Stöffler, Laura, Machule, Marie-Luise, Reincke, S Momsen, Nikolaus, Marc, van Hoof, Scott, Sanchez-Sendin, Elisa, Homeyer, Marie A, Cordero Gómez, César, Kornau, Hans-Christian, Schmitz, Dietmar, Kaindl, Angela M, Boehm-Sturm, Philipp, Mueller, Susanne, Wilson, Max A, Upadhya, Manoj A, Dhangar, Divya R, Greenhill, Stuart, Woodhall, Gavin, Turko, Paul, Vida, Imre, Garner, Craig C, Wickel, Jonathan, Geis, Christian, Fukata, Yuko, Fukata, Masaki, Prüss, Harald

“…Autoantibodies targeting the GABAA receptor (GABAAR) hallmark an autoimmune encephalitis presenting with frequent seizures and psychomotor abnormalities. Their…”
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Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells Autor Zhang, Yao, Lahmann, Ines, Baum, Katharina, Shimojo, Hiromi, Mourikis, Philippos, Wolf, Jana, Kageyama, Ryoichiro, Birchmeier, Carmen

“…Cell-cell interactions mediated by Notch are critical for the maintenance of skeletal muscle stem cells. However, dynamics, cellular source and identity of…”
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Cephalopod-omics: Emerging Fields and Technologies in Cephalopod Biology Autor Baden, Tom, Briseño, John, Coffing, Gabrielle, Cohen-Bodénès, Sophie, Courtney, Amy, Dickerson, Dominick, Dölen, Gül, Fiorito, Graziano, Gestal, Camino, Gustafson, Taryn, Heath-Heckman, Elizabeth, Hua, Qiaz, Imperadore, Pamela, Kimbara, Ryosuke, Król, Mirela, Lajbner, Zdeněk, Lichilín, Nicolás, Macchi, Filippo, McCoy, Matthew J, Nishiguchi, Michele K, Nyholm, Spencer V, Otjacques, Eve, Pérez-Ferrer, Pedro Antonio, Ponte, Giovanna, Pungor, Judit R, Rogers, Thea F, Rosenthal, Joshua J C, Rouressol, Lisa, Rubas, Noelle, Sanchez, Gustavo, Santos, Catarina Pereira, Schultz, Darrin T, Seuntjens, Eve, Songco-Casey, Jeremea O, Stewart, Ian Erik, Styfhals, Ruth, Tuanapaya, Surangkana, Vijayan, Nidhi, Weissenbacher, Anton, Zifcakova, Lucia, Schulz, Grace, Weertman, Willem, Simakov, Oleg, Albertin, Caroline B

“…Synopsis Few animal groups can claim the level of wonder that cephalopods instill in the minds of researchers and the general public. Much of cephalopod…”
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Minocycline rescues decrease in neurogenesis, increase in microglia cytokines and deficits in sensorimotor gating in an animal model of schizophrenia Autor Mattei, Daniele, Djodari-Irani, Anaïs, Hadar, Ravit, Pelz, Andreas, de Cossío, Lourdes Fernandez, Goetz, Thomas, Matyash, Marina, Kettenmann, Helmut, Winter, Christine, Wolf, Susanne A.

“…Adult neurogenesis in the hippocampus is impaired in schizophrenic patients and in an animal model of schizophrenia. Amongst a plethora of regulators, the…”
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Interleukin-6 Receptor Blockade in Treatment-Refractory MOG-IgG–Associated Disease and Neuromyelitis Optica Spectrum Disorders Autor Ringelstein, Marius, Ayzenberg, Ilya, Lindenblatt, Gero, Fischer, Katinka, Gahlen, Anna, Novi, Giovanni, Hayward-Könnecke, Helen, Schippling, Sven, Rommer, Paulus S., Kornek, Barbara, Zrzavy, Tobias, Biotti, Damien, Ciron, Jonathan, Audoin, Bertrand, Berthele, Achim, Giglhuber, Katrin, Zephir, Helene, Kümpfel, Tania, Berger, Robert, Röther, Joachim, Häußler, Vivien, Stellmann, Jan-Patrick, Whittam, Daniel, Jacob, Anu, Kraemer, Markus, Gueguen, Antoine, Deschamps, Romain, Bayas, Antonios, Hümmert, Martin W., Trebst, Corinna, Haarmann, Axel, Jarius, Sven, Wildemann, Brigitte, Grothe, Matthias, Siebert, Nadja, Ruprecht, Klemens, Paul, Friedemann, Collongues, Nicolas, Marignier, Romain, Levy, Michael, Karenfort, Michael, Deppe, Michael, Albrecht, Philipp, Hellwig, Kerstin, Gold, Ralf, Hartung, Hans-Peter, Meuth, Sven G., Kleiter, Ingo, Aktas, Orhan

“…To evaluate the long-term safety and efficacy of tocilizumab (TCZ), a humanized anti-interleukin-6 receptor antibody in myelin oligodendrocyte…”
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Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional Programs Autor Kutejova, Eva, Sasai, Noriaki, Shah, Ankita, Gouti, Mina, Briscoe, James

“…In the vertebrate neural tube, a morphogen-induced transcriptional network produces multiple molecularly distinct progenitor domains, each generating different…”
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Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve Autor Kleineidam, Luca, Wolfsgruber, Steffen, Weyrauch, Anne-Sophie, Zulka, Linn E., Forstmeier, Simon, Roeske, Sandra, van den Bussche, Hendrik, Kaduszkiewicz, Hanna, Wiese, Birgitt, Weyerer, Siegfried, Werle, Jochen, Fuchs, Angela, Pentzek, Michael, Brettschneider, Christian, König, Hans-Helmut, Weeg, Dagmar, Bickel, Horst, Luppa, Melanie, Rodriguez, Francisca S., Freiesleben, Silka Dawn, Erdogan, Selin, Unterfeld, Chantal, Peters, Oliver, Spruth, Eike J., Altenstein, Slawek, Lohse, Andrea, Priller, Josef, Fliessbach, Klaus, Kobeleva, Xenia, Schneider, Anja, Bartels, Claudia, Schott, Björn H., Wiltfang, Jens, Maier, Franziska, Glanz, Wenzel, Incesoy, Enise I., Butryn, Michaela, Düzel, Emrah, Buerger, Katharina, Janowitz, Daniel, Ewers, Michael, Rauchmann, Boris-Stephan, Perneczky, Robert, Kilimann, Ingo, Görß, Doreen, Teipel, Stefan, Laske, Christoph, Munk, Matthias H. J., Spottke, Annika, Roy, Nina, Brosseron, Frederic, Heneka, Michael T., Ramirez, Alfredo, Yakupov, Renat, Scherer, Martin, Maier, Wolfgang, Jessen, Frank, Riedel-Heller, Steffi G., Wagner, Michael

“…Several lifestyle factors promote protection against Alzheimer's disease (AD) throughout a person's lifespan. Although such protective effects have been…”
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Update on biomarkers in neuromyelitis optica Autor Melamed, Esther, Levy, Michael, Waters, Patrick J., Sato, Douglas Kazutoshi, Bennett, Jeffrey L., John, Gareth R., Hooper, Douglas C., Saiz, Albert, Bar-Or, Amit, Kim, Ho Jin, Pandit, Lakha, Leite, Maria Isabel, Asgari, Nasrin, Kissani, Najib, Hintzen, Rogier, Marignier, Romain, Jarius, Sven, Marcelletti, John, Smith, Terry J., Yeaman, Michael R., Han, May H., Aktas, Orhan, Apiwattanakul, Metha, Banwell, Brenda, Bichuetti, Denis, Broadley, Simon, Cabre, Philippe, Chitnis, Tanuja, De Seze, Jerome, Fujihara, Kazuo, Greenberg, Benjamin, Hellwig, Kerstin, Iorio, Raffaele, Klawiter, Eric, Kleiter, Ingo, Lana-Peixoto, Marco, Nakashima, OʼConnor, Kevin, Palace, Jacqueline, Paul, Friedman, Prayoonwiwat, Naraporn, Ruprecht, Klemens, Stuve, Olaf, Tedder, Thomas, Tenembaum, Silvia, Garrahan, Juan P., Aires, Buenos, van Herle, Katja, van Pelt, Danielle, Villoslada, Pablo, Waubant, Emmanuelle, Weinshenker, Brian, Wingerchuk, Dean, Würfel, Jens, Zamvil, Scott

“…Neuromyelitis optica (NMO) (and NMO spectrum disorder) is an autoimmune inflammatory disease of the CNS primarily affecting spinal cord and optic nerves…”
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Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity Autor Miyazaki, Yuri, Otsuka, Takeshi, Yamagata, Yoko, Endo, Toshihiro, Sanbo, Makoto, Sano, Hiromi, Kobayashi, Kenta, Inahashi, Hiroki, Kornau, Hans-Christian, Schmitz, Dietmar, Prüss, Harald, Meijer, Dies, Hirabayashi, Masumi, Fukata, Yuko, Fukata, Masaki

“…Neurodevelopmental disorders, such as intellectual disability (ID), epilepsy, and autism, involve altered synaptic transmission and plasticity. Functional…”
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Miyoshi myopathy and limb girdle muscular dystrophy R2 are the same disease Autor Moore, Ursula, Gordish, Heather, Diaz-Manera, Jordi, James, Meredith K., Mayhew, Anna G., Guglieri, Michela, Fernandez-Torron, Roberto, Rufibach, Laura E., Feng, Jia, Blamire, Andrew M., Carlier, Pierre G., Spuler, Simone, Day, John W., Jones, Kristi J., Bharucha-Goebel, Diana X., Salort-Campana, Emmanuelle, Pestronk, Alan, Walter, Maggie C., Paradas, Carmen, Stojkovic, Tanya, Mori-Yoshimura, Madoka, Bravver, Elena, Pegoraro, Elena, Lowes, Linda Pax, Mendell, Jerry R., Bushby, Kate, Straub, Volker

“…•Initial diagnosis does not predict subsequent pattern of muscle weakness in dysferlinopathy.•Pattern of weakness is an overlapping continuum that does not…”
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Cardiac and pulmonary findings in dysferlinopathy: A 3‐year, longitudinal study Autor Moore, Ursula, Fernandez‐Torron, Roberto, Jacobs, Marni, Gordish‐Dressman, Heather, Diaz‐Manera, Jordi, James, Meredith K., Mayhew, Anna G., Harris, Elizabeth, Guglieri, Michela, Rufibach, Laura E., Feng, Jia, Blamire, Andrew M., Carlier, Pierre G., Spuler, Simone, Day, John W., Jones, Kristi J., Bharucha‐Goebel, Diana X., Salort‐Campana, Emmanuelle, Pestronk, Alan, Walter, Maggie C., Paradas, Carmen, Stojkovic, Tanya, Mori‐Yoshimura, Madoka, Bravver, Elena, Pegoraro, Elena, Lowes, Linda Pax, Mendell, Jerry R., Bushby, Kate, Bourke, John, Straub, Volker

“…Introduction/Aims There is debate about whether and to what extent either respiratory or cardiac dysfunction occurs in patients with dysferlinopathy. This…”
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Attack adjudication in neuromyelitis optica spectrum disorder: Substantiation of criteria by magnetic resonance imaging and biomarkers in N-MOmentum Autor Weinshenker, Brian G, Wingerchuk, Dean M, Green, Ari J, Bennett, Jeffrey L, Kim, Ho Jin, Pittock, Sean J, Fujihara, Kazuo, Paul, Friedemann, Cutter, Gary, Marignier, Romain, Aktas, Orhan, Hartung, Hans-Peter, She, Dewei, Smith, Michael, Rees, William, Patterson, Kristina, Cimbora, Daniel, Katz, Eliezer, Cree, Bruce Ac

“…The N-MOmentum trial investigated safety and efficacy of inebilizumab in participants with neuromyelitis optica spectrum disorder (NMOSD). Evaluate the attack…”
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Sensitivity analysis of the primary endpoint from the N-MOmentum study of inebilizumab in NMOSD Autor Cree, Bruce Ac, Bennett, Jeffrey L, Kim, Ho Jin, Weinshenker, Brian G, Pittock, Sean J, Wingerchuk, Dean, Fujihara, Kazuo, Paul, Friedemann, Cutter, Gary R, Marignier, Romain, Green, Ari J, Aktas, Orhan, Hartung, Hans-Peter, Williams, Ian M, Drappa, Jorn, She, Dewei, Cimbora, Daniel, Rees, William, Ratchford, John N, Katz, Eliezer

“…In the N-MOmentum trial, the risk of an adjudicated neuromyelitis optica spectrum disorder (NMOSD) attack was significantly reduced with inebilizumab compared…”
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Placebo-controlled study in neuromyelitis optica-Ethical and design considerations Autor Cree, Bruce Ac, Bennett, Jeffrey L, Sheehan, Mark, Cohen, Jeffrey, Hartung, Hans-Peter, Aktas, Orhan, Kim, Ho Jin, Paul, Friedemann, Pittock, Sean, Weinshenker, Brian, Wingerchuk, Dean, Fujihara, Kazuo, Cutter, Gary, Patra, Kaushik, Flor, Armando, Barron, Gerard, Madani, Soraya, Ratchford, John N, Katz, Eliezer

“…To date, no treatment for neuromyelitis optica (NMO) has been granted regulatory approval, and no controlled clinical studies have been reported. To design a…”
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