Výsledky vyhledávání - "Frontiers in oncology"

The role of BCL-2 family proteins in regulating apoptosis and cancer therapy Autor Qian, Shanna, Wei, Zhong, Yang, Wanting, Huang, Jinling, Yang, Yinfeng, Wang, Jinghui

“…Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the…”
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PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway? Autor Peng, Yan, Wang, Yuanyuan, Zhou, Cheng, Mei, Wuxuan, Zeng, Changchun

“…Cancer is a severe public health issue that is a leading cause of mortality globally. It is also an impediment to improving life expectancy worldwide…”
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Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches Autor Emran, Talha Bin, Shahriar, Asif, Mahmud, Aar Rafi, Rahman, Tanjilur, Abir, Mehedy Hasan, Siddiquee, Mohd. Faijanur - Rob, Ahmed, Hossain, Rahman, Nova, Nainu, Firzan, Wahyudin, Elly, Mitra, Saikat, Dhama, Kuldeep, Habiballah, Mahmoud M., Haque, Shafiul, Islam, Ariful, Hassan, Mohammad Mahmudul

“…Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective…”
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The role of IL-6/JAK2/STAT3 signaling pathway in cancers Autor Huang, Bei, Lang, Xiaoling, Li, Xihong

“…Interleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation. It can activate janus kinase 2 (JAK2)-signal transducer and activator of…”
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Role of Matrix Metalloproteinases in Angiogenesis and Cancer Autor Quintero-Fabián, Saray, Arreola, Rodrigo, Becerril-Villanueva, Enrique, Torres-Romero, Julio César, Arana-Argáez, Victor, Lara-Riegos, Julio, Ramírez-Camacho, Mario Alberto, Alvarez-Sánchez, María Elizbeth

“…During angiogenesis, new vessels emerge from existing endothelial lined vessels to promote the degradation of the vascular basement membrane and remodel the…”
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Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches Autor de la Cruz-López, Karen G., Castro-Muñoz, Leonardo Josué, Reyes-Hernández, Diego O., García-Carrancá, Alejandro, Manzo-Merino, Joaquín

“…Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain cell proliferation requirements. Otto Warburg showed that tumor cells…”
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Tumor-Associated Macrophages: Recent Insights and Therapies Autor Zhou, Jiawei, Tang, Ziwei, Gao, Siyang, Li, Chunyu, Feng, Yiting, Zhou, Xikun

“…Macrophages, which have functions of engulfing and digesting foreign substances, can clear away harmful matter, including cellular debris and tumor cells…”
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Evaluating the Polarization of Tumor-Associated Macrophages Into M1 and M2 Phenotypes in Human Cancer Tissue: Technicalities and Challenges in Routine Clinical Practice Autor Jayasingam, Sharmilla Devi, Citartan, Marimuthu, Thang, Thean Hock, Mat Zin, Anani Aila, Ang, Kai Cheen, Ch'ng, Ewe Seng

“…Tumor-associated macrophages (TAMs) as immune cells within the tumor microenvironment have gained much interests as basic science regarding their roles in…”
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CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future Autor Uddin, Fathema, Rudin, Charles M., Sen, Triparna

“…A series of recent discoveries harnessing the adaptive immune system of prokaryotes to perform targeted genome editing is having a transformative influence…”
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Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations Autor Seidel, Judith A., Otsuka, Atsushi, Kabashima, Kenji

“…Melanoma, a skin cancer associated with high mortality rates, is highly radio- and chemotherapy resistant but can also be very immunogenic. These circumstances…”
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Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy Autor Masucci, Maria Teresa, Minopoli, Michele, Carriero, Maria Vincenza

“…Tumor Associated Neutrophils (TANs) are engaged into the tumor microenvironment by cytokines and chemokines, can be distinguished according to their activation…”
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Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis Autor Zahra, Kulsoom, Dey, Tulika, Ashish, Mishra, Surendra Pratap, Pandey, Uma

“…Pyruvate kinase plays a pivotal role in regulating cell metabolism. The final and rate-limiting step of glycolysis is the conversion of Phosphoenolpyruvate…”
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Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold? Autor Wilson, Joseph D., Hammond, Ester M., Higgins, Geoff S., Petersson, Kristoffer

“…Radiotherapy is a cornerstone of both curative and palliative cancer care. However, radiotherapy is severely limited by radiation-induced toxicities. If these…”
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Artificial Convolutional Neural Network in Object Detection and Semantic Segmentation for Medical Imaging Analysis Autor Yang, Ruixin, Yu, Yingyan

“…In the era of digital medicine, a vast number of medical images are produced every day. There is a great demand for intelligent equipment for adjuvant…”
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Tumor-Associated Macrophages in Human Breast, Colorectal, Lung, Ovarian and Prostate Cancers Autor Larionova, Irina, Tuguzbaeva, Gulnara, Ponomaryova, Anastasia, Stakheyeva, Marina, Cherdyntseva, Nadezhda, Pavlov, Valentin, Choinzonov, Evgeniy, Kzhyshkowska, Julia

“…Tumor-associated macrophages (TAMs) are major innate immune cells that constitute up to 50% of the cell mass of human tumors. TAMs are highly heterogeneous…”
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Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma Autor Espíndola, Kaio Murilo Monteiro, Ferreira, Roseane Guimarães, Narvaez, Luis Eduardo Mosquera, Silva Rosario, Amanda Caroline Rocha, da Silva, Agnes Hanna Machado, Silva, Ana Gabrielle Bispo, Vieira, Ana Paula Oliveira, Monteiro, Marta Chagas

“…Caffeic acid (CA) is a phenolic compound synthesized by all plant species and is present in foods such as coffee, wine, tea, and popular medicines such as…”
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Melanoma, Melanin, and Melanogenesis: The Yin and Yang Relationship Autor Slominski, Radomir M., Sarna, Tadeusz, Płonka, Przemysław M., Raman, Chander, Brożyna, Anna A., Slominski, Andrzej T.

“…Melanin pigment plays a critical role in the protection against the harmful effects of ultraviolet radiation and other environmental stressors. It is produced…”
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Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis Autor Kartikasari, Apriliana E. R., Huertas, Cesar S., Mitchell, Arnan, Plebanski, Magdalena

“…Chronic inflammation generated by the tumor microenvironment is known to drive cancer initiation, proliferation, progression, metastasis, and therapeutic…”
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The Multidisciplinary Team (MDT) Approach and Quality of Care Autor Taberna, Miren, Gil Moncayo, Francisco, Jané-Salas, Enric, Antonio, Maite, Arribas, Lorena, Vilajosana, Esther, Peralvez Torres, Elisabet, Mesía, Ricard

“…The core function of a multidisciplinary team (MDT) is to bring together a group of healthcare professionals from different fields in order to determine…”
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Chronic Stress Promotes Cancer Development Autor Dai, Shirui, Mo, Yongzhen, Wang, Yumin, Xiang, Bo, Liao, Qianjin, Zhou, Ming, Li, Xiaoling, Li, Yong, Xiong, Wei, Li, Guiyuan, Guo, Can, Zeng, Zhaoyang

“…Stress is an inevitable part of life. Chronic stress on account of reasons like adversity, depression, anxiety, or loneliness/social isolation can endanger…”
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