Search Results - "Frontiers in molecular biosciences"

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance by Yao, Yihan, Zhou, Yunxiang, Liu, Lihong, Xu, Yanyan, Chen, Qiang, Wang, Yali, Wu, Shijie, Deng, Yongchuan, Zhang, Jianmin, Shao, Anwen

“…Nanotechnology has been extensively studied and exploited for cancer treatment as nanoparticles can play a significant role as a drug delivery system. Compared…”
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Is It Time to Start Transitioning From 2D to 3D Cell Culture? by Jensen, Caleb, Teng, Yong

“…Cell culture is an important and necessary process in drug discovery, cancer research, as well as stem cell study. Most cells are currently cultured using…”
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Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy by Henke, Erik, Nandigama, Rajender, Ergün, Süleyman

“…Solid tumors are complex organ-like structures that consist not only of tumor cells but also of vasculature, extracellular matrix (ECM), stromal, and immune…”
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Role of Copper on Mitochondrial Function and Metabolism by Ruiz, Lina M., Libedinsky, Allan, Elorza, Alvaro A.

“…Copper is essential for life processes like energy metabolism, reactive oxygen species detoxification, iron uptake, and signaling in eukaryotic organisms…”
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Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects by Scioli Montoto, Sebastián, Muraca, Giuliana, Ruiz, María Esperanza

“…In the golden age of pharmaceutical nanocarriers, we are witnessing a maturation stage of the original concepts and ideas. There is no doubt that…”
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Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization by Sanità, Gennaro, Carrese, Barbara, Lamberti, Annalisa

“…The use of nanoparticles (NP) in diagnosis and treatment of many human diseases, including cancer, is of increasing interest. However, cytotoxic effects of NPs…”
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Triple-Negative Breast Cancer: A Brief Review About Epidemiology, Risk Factors, Signaling Pathways, Treatment and Role of Artificial Intelligence by Almansour, Nahlah Makki

“…Triple-negative breast cancer (TNBC) is a kind of breast cancer that lacks estrogen, progesterone, and human epidermal growth factor receptor 2. This cancer is…”
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Triazoles and Their Derivatives: Chemistry, Synthesis, and Therapeutic Applications by Matin, Mohammed M., Matin, Priyanka, Rahman, Md. Rezaur, Ben Hadda, Taibi, Almalki, Faisal A., Mahmud, Shafi, Ghoneim, Mohammed M., Alruwaily, Maha, Alshehri, Sultan

“…Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Structurally, there are two types of…”
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The association between albumin levels and survival in patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis by Guven, Deniz Can, Sahin, Taha Koray, Erul, Enes, Rizzo, Alessandro, Ricci, Angela Dalia, Aksoy, Sercan, Yalcin, Suayib

“…Background: The albumin levels may potentially be used as a prognostic biomarker in patients with cancertreated with immune checkpoint inhibitors (ICIs) due to…”
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Immune Phenotyping Based on the Neutrophil-to-Lymphocyte Ratio and IgG Level Predicts Disease Severity and Outcome for Patients With COVID-19 by Zhang, Bicheng, Zhou, Xiaoyang, Zhu, Chengliang, Song, Yuxiao, Feng, Fan, Qiu, Yanru, Feng, Jia, Jia, Qingzhu, Song, Qibin, Zhu, Bo, Wang, Jun

“…A recently emerging respiratory disease named coronavirus disease 2019 (COVID-19) has quickly spread across the world. This disease is initiated by severe…”
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Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1 by Adams, Christopher J., Kopp, Megan C., Larburu, Natacha, Nowak, Piotr R., Ali, Maruf M. U.

“…The endoplasmic reticulum (ER) is an important site for protein folding and maturation in eukaryotes. The cellular requirement to synthesize proteins within…”
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Recent Developments and Applications of the MMPBSA Method by Wang, Changhao, Greene, D'Artagnan, Xiao, Li, Qi, Ruxi, Luo, Ray

“…The Molecular Mechanics Poisson-Boltzmann Surface Area (MMPBSA) approach has been widely applied as an efficient and reliable free energy simulation method to…”
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The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies by Zou, Ming-Li, Chen, Zhong-Hua, Teng, Ying-Ying, Liu, Si-Yu, Jia, Yuan, Zhang, Kai-Wen, Sun, Zi-Li, Wu, Jun-Jie, Yuan, Zheng-Dong, Feng, Yi, Li, Xia, Xu, Rui-Sheng, Yuan, Feng-Lai

“…Bone remodeling is a continuous process that maintains the homeostasis of the skeletal system, and it depends on the homeostasis between bone-forming…”
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Structural Biology in the Clouds: The WeNMR-EOSC Ecosystem by Honorato, Rodrigo V., Koukos, Panagiotis I., Jiménez-García, Brian, Tsaregorodtsev, Andrei, Verlato, Marco, Giachetti, Andrea, Rosato, Antonio, Bonvin, Alexandre M. J. J.

“…Structural biology aims at characterizing the structural and dynamic properties of biological macromolecules at atomic details. Gaining insight into three…”
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The Role of Iron Regulation in Immunometabolism and Immune-Related Disease by Cronin, Shane J. F., Woolf, Clifford J., Weiss, Guenter, Penninger, Josef M.

“…Immunometabolism explores how the intracellular metabolic pathways in immune cells can regulate their function under different micro-environmental and…”
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Circular RNAs: Biogenesis, Function and Role in Human Diseases by Greene, John, Baird, Anne-Marie, Brady, Lauren, Lim, Marvin, Gray, Steven G., McDermott, Raymond, Finn, Stephen P.

“…Circular RNAs (circRNAs) are currently classed as non-coding RNA (ncRNA) that, unlike linear RNAs, form covalently closed continuous loops and act as gene…”
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Oxidative Stress in Bacteria and the Central Dogma of Molecular Biology by Fasnacht, Michel, Polacek, Norbert

“…Ever since the “great oxidation event,” Earth’s cellular life forms had to cope with the danger of reactive oxygen species (ROS) affecting the integrity of…”
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The lipid composition of extracellular vesicles: applications in diagnostics and therapeutic delivery by Ghadami, Samaneh, Dellinger, Kristen

“…Extracellular vesicles (EVs), including exosomes, with nanoscale sizes, biological origins, various functions, and unique lipid and protein compositions have…”
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Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be by Mariano, Giuseppina, Farthing, Rebecca J., Lale-Farjat, Shamar L. M., Bergeron, Julien R. C.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread in humans in almost every country, causing the disease COVID-19. Since the…”
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Virus Detection: A Review of the Current and Emerging Molecular and Immunological Methods by Cassedy, A., Parle-McDermott, A., O’Kennedy, R.

“…Viruses are ubiquitous in the environment. While many impart no deleterious effects on their hosts, several are major pathogens. This risk of pathogenicity,…”
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