Search Results - "Frontiers in immunology"

Tumor-Associated Macrophages in Tumor Immunity by Pan, Yueyun, Yu, Yinda, Wang, Xiaojian, Zhang, Ting

“…Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either of two…”
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IOBR: Multi-Omics Immuno-Oncology Biological Research to Decode Tumor Microenvironment and Signatures by Zeng, Dongqiang, Ye, Zilan, Shen, Rongfang, Yu, Guangchuang, Wu, Jiani, Xiong, Yi, Zhou, Rui, Qiu, Wenjun, Huang, Na, Sun, Li, Li, Xuejun, Bin, Jianping, Liao, Yulin, Shi, Min, Liao, Wangjun

“…Recent advances in next-generation sequencing (NGS) technologies have triggered the rapid accumulation of publicly available multi-omics datasets. The…”
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Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19) by Diao, Bo, Wang, Chenhui, Tan, Yingjun, Chen, Xiewan, Liu, Ying, Ning, Lifen, Chen, Li, Li, Min, Liu, Yueping, Wang, Gang, Yuan, Zilin, Feng, Zeqing, Zhang, Yi, Wu, Yuzhang, Chen, Yongwen

“…The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human…”
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Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity by Duan, Tianhao, Du, Yang, Xing, Changsheng, Wang, Helen Y., Wang, Rong-Fu

“…Innate immunity is the first defense system against invading pathogens. Toll-like receptors (TLRs) are well-defined pattern recognition receptors responsible…”
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The Genus Alistipes: Gut Bacteria With Emerging Implications to Inflammation, Cancer, and Mental Health by Parker, Bianca J., Wearsch, Pamela A., Veloo, Alida C. M., Rodriguez-Palacios, Alex

“…is a relatively new genus of bacteria isolated primarily from medical clinical samples, although at a low rate compared to other genus members of the phylum,…”
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The COVID-19 Cytokine Storm; What We Know So Far by Ragab, Dina, Salah Eldin, Haitham, Taeimah, Mohamed, Khattab, Rasha, Salem, Ramy

“…COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and…”
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Regulation of SIRT1 and Its Roles in Inflammation by Yang, Yunshu, Liu, Yang, Wang, Yunwei, Chao, Yongyi, Zhang, Jinxin, Jia, Yanhui, Tie, Jun, Hu, Dahai

“…The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD + -dependent deacetylase belonging to the sirtuin family, is a…”
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ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis by Zheng, Dongdong, Liu, Jia, Piao, Hulin, Zhu, Zhicheng, Wei, Ran, Liu, Kexiang

“…The endothelium is a single layer of epithelium covering the surface of the vascular system, and it represents a physical barrier between the blood and vessel…”
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Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation by Dhatchinamoorthy, Karthik, Colbert, Jeff D., Rock, Kenneth L.

“…Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's expressed genes and then transport and display this antigenic…”
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Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases by Parada Venegas, Daniela, De la Fuente, Marjorie K., Landskron, Glauben, González, María Julieta, Quera, Rodrigo, Dijkstra, Gerard, Harmsen, Hermie J. M., Faber, Klaas Nico, Hermoso, Marcela A.

“…Ulcerative colitis (UC) and Crohn's disease (CD), collectively known as Inflammatory Bowel Diseases (IBD), are caused by a complex interplay between genetic,…”
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Shaping Polarization Of Tumor-Associated Macrophages In Cancer Immunotherapy by Gao, Jing, Liang, Yuanzheng, Wang, Liang

“…Different stimuli can polarize macrophages into two basic types, M1 and M2. Tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) are…”
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Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body by Cristofori, Fernanda, Dargenio, Vanessa Nadia, Dargenio, Costantino, Miniello, Vito Leonardo, Barone, Michele, Francavilla, Ruggiero

“…Hosting millions of microorganisms, the digestive tract is the primary and most important part of bacterial colonization. On one side, in cases of…”
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Macrophage Polarization and Its Role in Liver Disease by Wang, Cheng, Ma, Cheng, Gong, Lihong, Guo, Yuqin, Fu, Ke, Zhang, Yafang, Zhou, Honglin, Li, Yunxia

“…Macrophages are important immune cells in innate immunity, and have remarkable heterogeneity and polarization. Under pathological conditions, in addition to…”
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Cancer immunotherapies: advances and bottlenecks by Rui, Rui, Zhou, Liqun, He, Shiming

“…Immunotherapy has ushered in a new era in cancer treatment, and cancer immunotherapy continues to be rejuvenated. The clinical goal of cancer immunotherapy is…”
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Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies by Tang, Yujun, Liu, Jiajia, Zhang, Dingyi, Xu, Zhenghao, Ji, Jinjun, Wen, Chengping

“…Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the pathogen that causes coronavirus disease 2019 (COVID-19). As of 25 May 2020, the outbreak…”
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The role of PD-1/PD-L1 and application of immune-checkpoint inhibitors in human cancers by Tang, Qing, Chen, Yun, Li, Xiaojuan, Long, Shunqin, Shi, Yao, Yu, Yaya, Wu, Wanyin, Han, Ling, Wang, Sumei

“…Programmed cell death protein-1 (PD-1) is a checkpoint receptor expressed on the surface of various immune cells. PD-L1, the natural receptor for PD-1, is…”
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Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies by Walcher, Lia, Kistenmacher, Ann-Kathrin, Suo, Huizhen, Kitte, Reni, Dluczek, Sarah, Strauß, Alexander, Blaudszun, André-René, Yevsa, Tetyana, Fricke, Stephan, Kossatz-Boehlert, Uta

“…The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest over the last decades. In particular, the analysis of biomarkers in…”
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The Metabolic Signature of Macrophage Responses by Viola, Antonella, Munari, Fabio, Sánchez-Rodríguez, Ricardo, Scolaro, Tommaso, Castegna, Alessandra

“…Macrophages are a heterogeneous population of immune cells playing several and diverse functions in homeostatic and immune responses. The broad spectrum of…”
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NF-κB: At the Borders of Autoimmunity and Inflammation by Barnabei, Laura, Laplantine, Emmanuel, Mbongo, William, Rieux-Laucat, Frédéric, Weil, Robert

“…The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory response. In…”
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Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages by Orecchioni, Marco, Ghosheh, Yanal, Pramod, Akula Bala, Ley, Klaus

“…Macrophages are found in tissues, body cavities, and mucosal surfaces. Most tissue macrophages are seeded in the early embryo before definitive hematopoiesis…”
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