Suchergebnisse - "Frontiers in genetics"

Review of Causal Discovery Methods Based on Graphical Models von Glymour, Clark, Zhang, Kun, Spirtes, Peter

“… A fundamental task in various disciplines of science, including biology, is to find underlying causal relations and make use of them. Causal relations can be …”
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Graph Neural Networks and Their Current Applications in Bioinformatics von Zhang, Xiao-Meng, Liang, Li, Liu, Lin, Tang, Ming-Jing

“… Graph neural networks (GNNs), as a branch of deep learning in non-Euclidean space, perform particularly well in various tasks that process graph structure …”
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Ethanol-Induced Behavioral Sensitization Alters the Synaptic Transcriptome and Exon Utilization in DBA/2J Mice von O’Brien, Megan A., Weston, Rory M., Sheth, Nihar U., Bradley, Steven, Bigbee, John, Pandey, Ashutosh, Williams, Robert W., Wolstenholme, Jennifer T., Miles, Michael F.

“… Alcoholism is a complex behavioral disorder characterized by loss of control in limiting intake, and progressive compulsion to seek and consume ethanol. Prior …”
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ggVennDiagram: An Intuitive, Easy-to-Use, and Highly Customizable R Package to Generate Venn Diagram von Gao, Chun-Hui, Yu, Guangchuang, Cai, Peng

“… Venn diagrams are widely used diagrams to show the set relationships in biomedical studies. In this study, we developed ggVennDiagram, an R package that could …”
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From GWAS to Function: Using Functional Genomics to Identify the Mechanisms Underlying Complex Diseases von Cano-Gamez, Eddie, Trynka, Gosia

“… Genome-wide association studies (GWAS) have successfully mapped thousands of loci associated with complex traits. These associations could reveal the molecular …”
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Single-Cell RNA-Seq Technologies and Related Computational Data Analysis von Chen, Geng, Ning, Baitang, Shi, Tieliu

“… Single-cell RNA sequencing (scRNA-seq) technologies allow the dissection of gene expression at single-cell resolution, which greatly revolutionizes …”
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Predicting Diabetes Mellitus With Machine Learning Techniques von Zou, Quan, Qu, Kaiyang, Luo, Yamei, Yin, Dehui, Ju, Ying, Tang, Hua

“… Diabetes mellitus is a chronic disease characterized by hyperglycemia. It may cause many complications. According to the growing morbidity in recent years, in …”
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The Potential for microRNA Therapeutics and Clinical Research von Hanna, Johora, Hossain, Gazi S., Kocerha, Jannet

“… As FDA-approved small RNA drugs start to enter clinical medicine, ongoing studies for the microRNA (miRNA) class of small RNAs expand its preclinical and …”
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Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways von Gureev, Artem P., Shaforostova, Ekaterina A., Popov, Vasily N.

“… Aging is a general degenerative process related to deterioration of cell functions in the entire organism. Mitochondria, which play a key role in energy …”
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Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives von Vaiserman, Alexander, Krasnienkov, Dmytro

“… Telomere shortening is a well-known hallmark of both cellular senescence and organismal aging. An accelerated rate of telomere attrition is also a common …”
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Chloroplot: An Online Program for the Versatile Plotting of Organelle Genomes von Zheng, Shuyu, Poczai, Peter, Hyvönen, Jaakko, Tang, Jing, Amiryousefi, Ali

“… Understanding the complexity of genomic structures and their unique architecture is linked with the power of visualization tools used to represent these …”
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Nanoparticle Delivery of CRISPR/Cas9 for Genome Editing von Duan, Li, Ouyang, Kan, Xu, Xiao, Xu, Limei, Wen, Caining, Zhou, Xiaoying, Qin, Zhuan, Xu, Zhiyi, Sun, Wei, Liang, Yujie

“… The emerging clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated system (Cas) gene-editing system represents a promising tool …”
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Use ggbreak to Effectively Utilize Plotting Space to Deal With Large Datasets and Outliers von Xu, Shuangbin, Chen, Meijun, Feng, Tingze, Zhan, Li, Zhou, Lang, Yu, Guangchuang

“… With the rapid increase of large-scale datasets, biomedical data visualization is facing challenges. The data may be large, have different orders of magnitude, …”
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DNA Methylation Cancer Biomarkers: Translation to the Clinic von Locke, Warwick J., Guanzon, Dominic, Ma, Chenkai, Liew, Yi Jin, Duesing, Konsta R., Fung, Kim Y.C., Ross, Jason P.

“… Carcinogenesis is accompanied by widespread DNA methylation changes within the cell. These changes are characterized by a globally hypomethylated genome with …”
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State of the Field in Multi-Omics Research: From Computational Needs to Data Mining and Sharing von Krassowski, Michal, Das, Vivek, Sahu, Sangram K., Misra, Biswapriya B.

“… Multi-omics, variously called integrated omics, pan-omics, and trans-omics, aims to combine two or more omics data sets to aid in data analysis, visualization …”
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LDlinkR: An R Package for Rapidly Calculating Linkage Disequilibrium Statistics in Diverse Populations von Myers, Timothy A., Chanock, Stephen J., Machiela, Mitchell J.

“… Genomic research involving human genetics and evolutionary biology relies heavily on linkage disequilibrium (LD) to investigate population-specific genetic …”
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pathfindR: An R Package for Comprehensive Identification of Enriched Pathways in Omics Data Through Active Subnetworks von Ulgen, Ege, Ozisik, Ozan, Sezerman, Osman Ugur

“… Pathway analysis is often the first choice for studying the mechanisms underlying a phenotype. However, conventional methods for pathway analysis do not take …”
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Circulating MicroRNAs in Cancer: Potential and Challenge von Cui, Mengying, Wang, Hongdan, Yao, Xiaoxiao, Zhang, Dan, Xie, Yingjun, Cui, Ranji, Zhang, Xuewen

“… MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be secreted into the circulation and exist in remarkably stable forms. Like …”
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Long-Read Sequencing Emerging in Medical Genetics von Mantere, Tuomo, Kersten, Simone, Hoischen, Alexander

“… The wide implementation of next-generation sequencing (NGS) technologies has revolutionized the field of medical genetics. However, the short read lengths of …”
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Incomplete Penetrance and Variable Expressivity: From Clinical Studies to Population Cohorts von Kingdom, Rebecca, Wright, Caroline F.

“… The same genetic variant found in different individuals can cause a range of diverse phenotypes, from no discernible clinical phenotype to severe disease, even …”
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