Výsledky vyhledávání - "Frontiers in cellular neuroscience"

Overview of General and Discriminating Markers of Differential Microglia Phenotypes Autor Jurga, Agnieszka M., Paleczna, Martyna, Kuter, Katarzyna Z.

“…Inflammatory processes and microglia activation accompanies most of the pathophysiological diseases in the central nervous system. It is proven that glial…”
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Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain Autor Miranda, Magdalena, Morici, Juan Facundo, Zanoni, María Belén, Bekinschtein, Pedro

“…Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes related to learning and memory. The expression of BDNF is highly…”
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Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction Autor Takata, Fuyuko, Nakagawa, Shinsuke, Matsumoto, Junichi, Dohgu, Shinya

“…Neuroinflammation is involved in the onset or progression of various neurodegenerative diseases. Initiation of neuroinflammation is triggered by endogenous…”
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Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets Autor Ng, Si Yun, Lee, Alan Yiu Wah

“…Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality amongst civilians and military personnel globally. Despite advances…”
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Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response Autor Bachiller, Sara, Jiménez-Ferrer, Itzia, Paulus, Agnes, Yang, Yiyi, Swanberg, Maria, Deierborg, Tomas, Boza-Serrano, Antonio

“…Microglia represent a specialized population of macrophages-like cells in the central nervous system (CNS) considered immune sentinels that are capable of…”
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Genetic Causes and Modifiers of Autism Spectrum Disorder Autor Rylaarsdam, Lauren, Guemez-Gamboa, Alicia

“…Autism Spectrum Disorder (ASD) is one of the most prevalent neurodevelopmental disorders, affecting an estimated 1 in 59 children. ASD is highly genetically…”
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Ischemia-Triggered Glutamate Excitotoxicity From the Perspective of Glial Cells Autor Belov Kirdajova, Denisa, Kriska, Jan, Tureckova, Jana, Anderova, Miroslava

“…A plethora of neurological disorders shares a final common deadly pathway known as excitotoxicity. Among these disorders, ischemic injury is a prominent cause…”
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Neurologic Alterations Due to Respiratory Virus Infections Autor Bohmwald, Karen, Gálvez, Nicolás M. S., Ríos, Mariana, Kalergis, Alexis M.

“…Central Nervous System (CNS) infections are one of the most critical problems in public health, as frequently patients exhibit neurologic sequelae. Usually,…”
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The Role of BDNF on Neural Plasticity in Depression Autor Yang, Tao, Nie, Zheng, Shu, Haifeng, Kuang, Yongqin, Chen, Xin, Cheng, Jingmin, Yu, Sixun, Liu, Huiying

“…Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes…”
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The Success and Failure of the Schwann Cell Response to Nerve Injury Autor Jessen, Kristjan R., Mirsky, Rhona

“…The remarkable plasticity of Schwann cells allows them to adopt the Remak (non-myelin) and myelin phenotypes, which are specialized to meet the needs of small…”
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Pericytes and Neurovascular Function in the Healthy and Diseased Brain Autor Brown, Lachlan S., Foster, Catherine G., Courtney, Jo-Maree, King, Natalie E., Howells, David W., Sutherland, Brad A.

“…Pericytes are multi-functional cells embedded within the walls of capillaries throughout the body, including the brain. Pericytes were first identified in the…”
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Bidirectional Microglia–Neuron Communication in Health and Disease Autor Szepesi, Zsuzsanna, Manouchehrian, Oscar, Bachiller, Sara, Deierborg, Tomas

“…Microglia are ramified cells that exhibit highly motile processes, which continuously survey the brain parenchyma and react to any insult to the CNS…”
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Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases Autor Armada-Moreira, Adam, Gomes, Joana I., Pina, Carolina Campos, Savchak, Oksana K., Gonçalves-Ribeiro, Joana, Rei, Nádia, Pinto, Sara, Morais, Tatiana P., Martins, Robertta Silva, Ribeiro, Filipa F., Sebastião, Ana M., Crunelli, Vincenzo, Vaz, Sandra H.

“…Excitotoxicity is a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged…”
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Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions Autor Fogaça, Manoela V., Duman, Ronald S.

“…Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical and functional alterations in limbic structures, notably the…”
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Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia/Macrophage Polarization via TLR4/NF-κB Signaling Pathway Autor Ye, Yingze, Jin, Tong, Zhang, Xu, Zeng, Zhi, Ye, Baixin, Wang, Jinchen, Zhong, Yi, Xiong, Xiaoxing, Gu, Lijuan

“…Ischemic stroke is a devastating disease with long-term disability. However, the pathogenesis is unclear and treatments are limited. Meisoindigo, a…”
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A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases Autor Saha, Sarmistha, Buttari, Brigitta, Profumo, Elisabetta, Tucci, Paolo, Saso, Luciano

“…Neuroinflammation plays a pivotal role in Alzheimer's disease (AD) and Parkinson's disease (PD), the leading causes of dementia. These neurological disorders…”
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Effect of Chronic Oxidative Stress on Neuroinflammatory Response Mediated by CD4+T Cells in Neurodegenerative Diseases Autor Solleiro-Villavicencio, Helena, Rivas-Arancibia, Selva

“…In a state of oxidative stress, there is an increase of reactive species, which induce an altered intracellular signaling, leading to dysregulation of the…”
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An Inflammation-Centric View of Neurological Disease: Beyond the Neuron Autor Skaper, Stephen D., Facci, Laura, Zusso, Morena, Giusti, Pietro

“…Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and…”
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Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders Autor Kelly, John R., Kennedy, Paul J., Cryan, John F., Dinan, Timothy G., Clarke, Gerard, Hyland, Niall P.

“…The emerging links between our gut microbiome and the central nervous system (CNS) are regarded as a paradigm shift in neuroscience with possible implications…”
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Modulation of the Hypothalamic-Pituitary-Adrenal Axis by Early Life Stress Exposure Autor van Bodegom, Miranda, Homberg, Judith R., Henckens, Marloes J. A. G.

“…Exposure to stress during critical periods in development can have severe long-term consequences, increasing overall risk on psychopathology. One of the key…”
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