Suchergebnisse - "Freimer, Nelson B"

Variance component model to account for sample structure in genome-wide association studies von Kang, Hyun Min, Sul, Jae Hoon, Service, Susan K, Zaitlen, Noah A, Kong, Sit-yee, Freimer, Nelson B, Sabatti, Chiara, Eskin, Eleazar

“… Eleazar Eskin and colleagues report a variance component model for correcting for sample structure in association studies. The EMMAX program is publicly …”
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Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci von Yin, Xianyong, Chan, Lap Sum, Bose, Debraj, Jackson, Anne U., VandeHaar, Peter, Locke, Adam E., Fuchsberger, Christian, Stringham, Heather M., Welch, Ryan, Yu, Ketian, Fernandes Silva, Lilian, Service, Susan K., Zhang, Daiwei, Hector, Emily C., Young, Erica, Ganel, Liron, Das, Indraniel, Abel, Haley, Erdos, Michael R., Bonnycastle, Lori L., Kuusisto, Johanna, Stitziel, Nathan O., Hall, Ira M., Wagner, Gregory R., Kang, Jian, Morrison, Jean, Burant, Charles F., Collins, Francis S., Ripatti, Samuli, Palotie, Aarno, Freimer, Nelson B., Mohlke, Karen L., Scott, Laura J., Wen, Xiaoquan, Fauman, Eric B., Laakso, Markku, Boehnke, Michael

“… Few studies have explored the impact of rare variants (minor allele frequency < 1%) on highly heritable plasma metabolites identified in metabolomic screens …”
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Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome von Huang, Alden Y, Yu, Dongmei, Davis, Lea K, Sul, Jae Hoon, Tsetsos, Fotis, Ramensky, Vasily, Zelaya, Ivette, Ramos, Eliana Marisa, Osiecki, Lisa, Chen, Jason A, McGrath, Lauren M, Illmann, Cornelia, Sandor, Paul, Barr, Cathy L, Grados, Marco, Singer, Harvey S, Nöthen, Markus M, Hebebrand, Johannes, King, Robert A, Dion, Yves, Rouleau, Guy, Budman, Cathy L, Depienne, Christel, Worbe, Yulia, Hartmann, Andreas, Müller-Vahl, Kirsten R, Stuhrmann, Manfred, Aschauer, Harald, Stamenkovic, Mara, Schloegelhofer, Monika, Konstantinidis, Anastasios, Lyon, Gholson J, McMahon, William M, Barta, Csaba, Tarnok, Zsanett, Nagy, Peter, Batterson, James R, Rizzo, Renata, Cath, Danielle C, Wolanczyk, Tomasz, Berlin, Cheston, Malaty, Irene A, Okun, Michael S, Woods, Douglas W, Rees, Elliott, Pato, Carlos N, Pato, Michele T, Knowles, James A, Posthuma, Danielle, Pauls, David L, Cox, Nancy J, Neale, Benjamin M, Freimer, Nelson B, Paschou, Peristera, Mathews, Carol A, Scharf, Jeremiah M, Coppola, Giovanni

“… Tourette syndrome (TS) is a model neuropsychiatric disorder thought to arise from abnormal development and/or maintenance of cortico-striato-thalamo-cortical …”
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Ancient hybridization and strong adaptation to viruses across African vervet monkey populations von Svardal, Hannes, Jasinska, Anna J, Apetrei, Cristian, Coppola, Giovanni, Huang, Yu, Schmitt, Christopher A, Jacquelin, Beatrice, Ramensky, Vasily, Müller-Trutwin, Michaela, Antonio, Martin, Weinstock, George, Grobler, J Paul, Dewar, Ken, Wilson, Richard K, Turner, Trudy R, Warren, Wesley C, Freimer, Nelson B, Nordborg, Magnus

“… Analysis of whole-genome sequencing data from 163 vervet monkeys from Africa and the Caribbean shows high diversity among taxa and identifies signatures of …”
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ForestQC: Quality control on genetic variants from next-generation sequencing data using random forest von Li, Jiajin, Jew, Brandon, Zhan, Lingyu, Hwang, Sungoo, Coppola, Giovanni, Freimer, Nelson B., Sul, Jae Hoon

“… Next-generation sequencing technology (NGS) enables the discovery of nearly all genetic variants present in a genome. A subset of these variants, however, may …”
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Genome-wide association analysis of metabolic traits in a birth cohort from a founder population von Sabatti, Chiara, Service, Susan K, Hartikainen, Anna-Liisa, Pouta, Anneli, Ripatti, Samuli, Brodsky, Jae, Jones, Chris G, Zaitlen, Noah A, Varilo, Teppo, Kaakinen, Marika, Sovio, Ulla, Ruokonen, Aimo, Laitinen, Jaana, Jakkula, Eveliina, Coin, Lachlan, Hoggart, Clive, Collins, Andrew, Turunen, Hannu, Gabriel, Stacey, Elliot, Paul, McCarthy, Mark I, Daly, Mark J, Järvelin, Marjo-Riitta, Freimer, Nelson B, Peltonen, Leena

“… Nelson Freimer and colleagues report the first genome-wide association study of a longitudinal birth cohort (the Northern Finland Birth Cohort 1966). The …”
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Evidence of selection in the uncoupling protein 1 gene region suggests local adaptation to solar irradiance in savannah monkeys ( Chlorocebus spp.) von Gagnon, Christian M, Svardal, Hannes, Jasinska, Anna J, Danzy Cramer, Jennifer, Freimer, Nelson B, Paul Grobler, J, Turner, Trudy R, Schmitt, Christopher A

“… In the last 300 thousand years, the genus expanded from equatorial Africa into the southernmost latitudes of the continent, where colder climate was a probable …”
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Replicating genotype–phenotype associations von Chanock, Stephen J., Manolio, Teri, Boehnke, Michael, Boerwinkle, Eric, Hunter, David J., Thomas, Gilles, Hirschhorn, Joel N., Abecasis, Goncalo, Altshuler, David, Bailey-Wilson, Joan E., Brooks, Lisa D., Cardon, Lon R., Daly, Mark, Donnelly, Peter, Fraumeni, Joseph F., Freimer, Nelson B., Gerhard, Daniela S., Gunter, Chris, Guttmacher, Alan E., Guyer, Mark S., Harris, Emily L., Hoh, Josephine, Hoover, Robert, Kong, C. Augustine, Merikangas, Kathleen R., Morton, Cynthia C., Palmer, Lyle J., Phimister, Elizabeth G., Rice, John P., Roberts, Jerry, Rotimi, Charles, Tucker, Margaret A., Vogan, Kyle J., Wacholder, Sholom, Wijsman, Ellen M., Winn, Deborah M., Collins, Francis S.

“… What constitutes replication of a genotype–phenotype association, and how best can it be achieved? Gene association pitfalls Reviews of the many genetic …”
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5-HTTLPR genotype and anxiety-related personality traits: A meta-analysis and new data von Munafò, Marcus R., Freimer, Nelson B., Ng, Whitney, Ophoff, Roel, Veijola, Juha, Miettunen, Jouko, Järvelin, Marjo-Riitta, Taanila, Anja, Flint, Jonathan

“… We investigated the strength of evidence for association of the 5‐HTTLPR polymorphism and the personality trait of Harm Avoidance. We used new primary data …”
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ACE2 and TMPRSS2 variation in savanna monkeys (Chlorocebus spp.): Potential risk for zoonotic/anthroponotic transmission of SARS-CoV-2 and a potential model for functional studies von Schmitt, Christopher A., Bergey, Christina M., Jasinska, Anna J., Ramensky, Vasily, Burt, Felicity, Svardal, Hannes, Jorgensen, Matthew J., Freimer, Nelson B., Grobler, J. Paul, Turner, Trudy R.

“… The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has devastated health infrastructure around the world. Both ACE2 (an entry receptor) and TMPRSS2 …”
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Diversity matters: opportunities in the study of the genetics of psychotic disorders in low- and middle-income countries in Latin America von Fonseca, Lais, Sena, Brena F., Crossley, Nicolas, Lopez-Jaramillo, Carlos, Koenen, Karestan, Freimer, Nelson B., Bressan, Rodrigo A., Belangero, Sintia I., Santoro, Marcos L., Gadelha, Ary

“… Lack of diversity regarding genetic and environmental backgrounds weakens the generalization and clinical applicability of research findings on psychotic …”
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Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder von Pagani, Lucia, St Clair, Patricia A, Teshiba, Terri M, Service, Susan K, Fears, Scott C, Araya, Carmen, Araya, Xinia, Bejarano, Julio, Ramirez, Margarita, Castrillón, Gabriel, Gomez-Makhinson, Juliana, Lopez, Maria C, Montoya, Gabriel, Montoya, Claudia P, Aldana, Ileana, Navarro, Linda, Freimer, Daniel G, Safaie, Brian, Keung, Lap-Woon, Greenspan, Kiefer, Chou, Katty, Escobar, Javier I, Ospina-Duque, Jorge, Kremeyer, Barbara, Ruiz-Linares, Andres, Cantor, Rita M, Lopez-Jaramillo, Carlos, Macaya, Gabriel, Molina, Julio, Reus, Victor I, Sabatti, Chiara, Bearden, Carrie E, Takahashi, Joseph S, Freimer, Nelson B

“… Abnormalities in sleep and circadian rhythms are central features of bipolar disorder (BP), often persisting between episodes. We report here, to our …”
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Decomposing decision components in the stop-signal task: a model-based approach to individual differences in inhibitory control von White, Corey N, Congdon, Eliza, Mumford, Jeanette A, Karlsgodt, Katherine H, Sabb, Fred W, Freimer, Nelson B, London, Edythe D, Cannon, Tyrone D, Bilder, Robert M, Poldrack, Russell A

“… The stop-signal task, in which participants must inhibit prepotent responses, has been used to identify neural systems that vary with individual differences in …”
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Geographic Patterns of Genome Admixture in Latin American Mestizos von Wang, Sijia, Ray, Nicolas, Rojas, Winston, Parra, Maria V., Bedoya, Gabriel, Gallo, Carla, Poletti, Giovanni, Mazzotti, Guido, Hill, Kim, Hurtado, Ana M., Camrena, Beatriz, Nicolini, Humberto, Klitz, William, Barrantes, Ramiro, Molina, Julio A., Freimer, Nelson B., Bortolini, Maria Cátira, Salzano, Francisco M., Petzl-Erler, Maria L., Tsuneto, Luiza T., Dipierri, José E., Alfaro, Emma L., Bailliet, Graciela, Bianchi, Nestor O., Llop, Elena, Rothhammer, Francisco, Excoffier, Laurent, Ruiz-Linares, Andrés

“… The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture …”
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Polygenic Hyperlipidemias and Coronary Artery Disease Risk von Ripatti, Pietari, Rämö, Joel T, Mars, Nina J, Fu, Yu, Lin, Jake, Söderlund, Sanni, Benner, Christian, Surakka, Ida, Kiiskinen, Tuomo, Havulinna, Aki S, Palta, Priit, Freimer, Nelson B, Widén, Elisabeth, Salomaa, Veikko, Tukiainen, Taru, Pirinen, Matti, Palotie, Aarno, Taskinen, Marja-Riitta, Ripatti, Samuli

“… Hyperlipidemia is a highly heritable risk factor for coronary artery disease (CAD). While monogenic familial hypercholesterolemia associates with severely …”
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Differences in presentation and progression between severe FIC1 and BSEP deficiencies von Pawlikowska, Ludmila, Strautnieks, Sandra, Jankowska, Irena, Czubkowski, Piotr, Emerick, Karan, Antoniou, Anthony, Wanty, Catherine, Fischler, Bjorn, Jacquemin, Emmanuel, Wali, Sami, Blanchard, Samra, Nielsen, Inge-Merete, Bourke, Billy, McQuaid, Shirley, Lacaille, Florence, Byrne, Jane A., van Eerde, Albertien M., Kolho, Kaija-Leena, Klomp, Leo, Houwen, Roderick, Bacchetti, Peter, Lobritto, Steven, Hupertz, Vera, McClean, Patricia, Mieli-Vergani, Giorgina, Shneider, Benjamin, Nemeth, Antal, Sokal, Etienne, Freimer, Nelson B., Knisely, A.S., Rosenthal, Philip, Whitington, Peter F., Pawlowska, Joanna, Thompson, Richard J., Bull, Laura N.

“… Progressive familial intrahepatic cholestasis (PFIC) with normal serum levels of gamma-glutamyltranspeptidase can result from mutations in ATP8B1 (encoding …”
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The Contribution of GWAS Loci in Familial Dyslipidemias von Ripatti, Pietari, Rämö, Joel T., Söderlund, Sanni, Surakka, Ida, Matikainen, Niina, Pirinen, Matti, Pajukanta, Päivi, Sarin, Antti-Pekka, Service, Susan K., Laurila, Pirkka-Pekka, Ehnholm, Christian, Salomaa, Veikko, Wilson, Richard K., Palotie, Aarno, Freimer, Nelson B., Taskinen, Marja-Riitta, Ripatti, Samuli

“… Familial combined hyperlipidemia (FCH) is a complex and common familial dyslipidemia characterized by elevated total cholesterol and/or triglyceride levels …”
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The enduring gap in educational attainment in schizophrenia according to the past 50 years of published research: a systematic review and meta-analysis von Crossley, Nicolás A, Alliende, Luz María, Czepielewski, Leticia S, Aceituno, David, Castañeda, Carmen Paz, Diaz, Camila, Iruretagoyena, Barbara, Mena, Carlos, Mena, Cristian, Ramirez-Mahaluf, Juan Pablo, Tepper, Angeles, Vasquez, Javiera, Fonseca, Lais, Machado, Viviane, Hernández, Camilo E, Vargas-Upegui, Cristian, Gomez-Cruz, Gladys, Kobayashi-Romero, Luis F, Moncada-Habib, Tomas, Arango, Celso, Barch, Deanna M, Carter, Cameron, Correll, Christoph U, Freimer, Nelson B, McGuire, Philip, Evans-Lacko, Sara, Undurraga, Eduardo, Bressan, Rodrigo, Gama, Clarissa S, Lopez-Jaramillo, Carlos, de la Fuente-Sandoval, Camilo, Gonzalez-Valderrama, Alfonso, Undurraga, Juan, Gadelha, Ary

“… Educational attainment is associated with wellbeing and health, but patients with schizophrenia achieve lower levels of education than people without. Several …”
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Advancing digital sensing in mental health research von Akre, Samir, Seok, Darsol, Douglas, Christopher, Aguilera, Adrian, Carini, Simona, Dunn, Jessilyn, Hotopf, Matthew, Mohr, David C., Bui, Alex A. T., Freimer, Nelson B.

“… Digital sensing tools, like smartphones and wearables, offer transformative potential for mental health research by enabling scalable, longitudinal data …”
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Recombination rates in admixed individuals identified by ancestry-based inference von Wegmann, Daniel, Kessner, Darren E, Veeramah, Krishna R, Mathias, Rasika A, Nicolae, Dan L, Yanek, Lisa R, Sun, Yan V, Torgerson, Dara G, Rafaels, Nicholas, Mosley, Thomas, Becker, Lewis C, Ruczinski, Ingo, Beaty, Terri H, Kardia, Sharon L R, Meyers, Deborah A, Barnes, Kathleen C, Becker, Diane M, Freimer, Nelson B, Novembre, John

“… John Novembre and colleagues present a new approach for constructing recombination maps based on ancestry switch points among individuals. They construct a …”
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