Suchergebnisse - "Fraser, Claire M"

Establishing What Constitutes a Healthy Human Gut Microbiome: State of the Science, Regulatory Considerations, and Future Directions von McBurney, Michael I, Davis, Cindy, Fraser, Claire M, Schneeman, Barbara O, Huttenhower, Curtis, Verbeke, Kristin, Walter, Jens, Latulippe, Marie E

“… ABSTRACT On December 17, 2018, the North American branch of the International Life Sciences Institute (ILSI North America) convened a workshop “Can We Begin to …”
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Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications von Bäckhed, Fredrik, Fraser, Claire M, Ringel, Yehuda, Sanders, Mary Ellen, Sartor, R Balfour, Sherman, Philip M, Versalovic, James, Young, Vincent, Finlay, B Brett

“… Indigenous microbiota are an essential component in the modern concept of human health, but the composition and functional characteristics of a healthy …”
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Integrated Metagenomics/Metaproteomics Reveals Human Host-Microbiota Signatures of Crohn's Disease von Erickson, Alison R., Cantarel, Brandi L., Lamendella, Regina, Darzi, Youssef, Mongodin, Emmanuel F., Pan, Chongle, Shah, Manesh, Halfvarson, Jonas, Tysk, Curt, Henrissat, Bernard, Raes, Jeroen, Verberkmoes, Nathan C., Fraser, Claire M., Hettich, Robert L., Jansson, Janet K.

“… Crohn's disease (CD) is an inflammatory bowel disease of complex etiology, although dysbiosis of the gut microbiota has been implicated in chronic …”
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Gut Microbiota in Multiple Sclerosis: Possible Influence of Immunomodulators von Cantarel, Brandi L., Waubant, Emmanuelle, Chehoud, Christel, Kuczynski, Justin, DeSantis, Todd Z., Warrington, Janet, Venkatesan, Arun, Fraser, Claire M., Mowry, Ellen M.

“… Objectives Differences in gut bacteria have been described in several autoimmune disorders. In this exploratory pilot study, we compared gut bacteria in …”
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An integrated genomic and transcriptomic survey of mucormycosis-causing fungi von Chibucos, Marcus C., Soliman, Sameh, Gebremariam, Teclegiorgis, Lee, Hongkyu, Daugherty, Sean, Orvis, Joshua, Shetty, Amol C., Crabtree, Jonathan, Hazen, Tracy H., Etienne, Kizee A., Kumari, Priti, O’Connor, Timothy D., Rasko, David A., Filler, Scott G., Fraser, Claire M., Lockhart, Shawn R., Skory, Christopher D., Ibrahim, Ashraf S., Bruno, Vincent M.

“… Mucormycosis is a life-threatening infection caused by Mucorales fungi. Here we sequence 30 fungal genomes, and perform transcriptomics with three …”
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Culture-Independent Evaluation of the Appendix and Rectum Microbiomes in Children with and without Appendicitis von Jackson, Hope T., Mongodin, Emmanuel F., Davenport, Katherine P., Fraser, Claire M., Sandler, Anthony D., Zeichner, Steven L.

“… The function of the appendix is largely unknown, but its microbiota likely contributes to function. Alterations in microbiota may contribute to appendicitis, …”
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Functional Dynamics of the Gut Microbiome in Elderly People during Probiotic Consumption von Eloe-Fadrosh, Emiley A., Brady, Arthur, Crabtree, Jonathan, Drabek, Elliott F., Ma, Bing, Mahurkar, Anup, Ravel, Jacques, Haverkamp, Miriam, Fiorino, Anne-Maria, Botelho, Christine, Andreyeva, Irina, Hibberd, Patricia L., Fraser, Claire M.

“… A mechanistic understanding of the purported health benefits conferred by consumption of probiotic bacteria has been limited by our knowledge of the resident …”
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Primordial origin and diversification of plasmids in Lyme disease agent bacteria von Casjens, Sherwood R., Di, Lia, Akther, Saymon, Mongodin, Emmanuel F., Luft, Benjamin J., Schutzer, Steven E., Fraser, Claire M., Qiu, Wei-Gang

“… Background With approximately one-third of their genomes consisting of linear and circular plasmids, the Lyme disease agent cluster of species has the most …”
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Genomic Confirmation of Borrelia garinii , United States von Rudenko, Natalie, Golovchenko, Maryna, Horak, Ales, Grubhoffer, Libor, Mongodin, Emmanuel F., Fraser, Claire M., Qiu, Weigang, Luft, Benjamin J., Morgan, Richard G., Casjens, Sherwood R., Schutzer, Steven E.

“… Lyme disease is a multisystem disorder primarily caused by Borrelia burgdorferi sensu lato. However, B. garinii, which has been identified on islands off the …”
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Refining the pathovar paradigm via phylogenomics of the attaching and effacing Escherichia coli von Hazen, Tracy H, Sahl, Jason W, Fraser, Claire M, Donnenberg, Michael S, Scheutz, Flemming, Rasko, David A

“… The attaching and effacing Escherichia coli (AEEC) are characterized by the presence of a type III secretion system encoded by the locus of enterocyte …”
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Analysis of the Gut Microbiota in the Old Order Amish and Its Relation to the Metabolic Syndrome von Zupancic, Margaret L., Cantarel, Brandi L., Liu, Zhenqiu, Drabek, Elliott F., Ryan, Kathleen A., Cirimotich, Shana, Jones, Cheron, Knight, Rob, Walters, William A., Knights, Daniel, Mongodin, Emmanuel F., Horenstein, Richard B., Mitchell, Braxton D., Steinle, Nanette, Snitker, Soren, Shuldiner, Alan R., Fraser, Claire M.

“… Obesity has been linked to the human gut microbiota; however, the contribution of gut bacterial species to the obese phenotype remains controversial because of …”
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Microbial transformation from normal oral microbiota to acute endodontic infections von Hsiao, William W L, Li, Kevin L, Liu, Zhenqiu, Jones, Cheron, Fraser-Liggett, Claire M, Fouad, Ashraf F

“… Background Endodontic infections are a leading cause of oro-facial pain and tooth loss in western countries, and may lead to severe life-threatening …”
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New signaling pathways govern the host response to C. albicans infection in various niches von Liu, Yaoping, Shetty, Amol C, Schwartz, Jennifer A, Bradford, L Latey, Xu, Wenjie, Phan, Qyunh T, Kumari, Priti, Mahurkar, Anup, Mitchell, Aaron P, Ravel, Jacques, Fraser, Claire M, Filler, Scott G, Bruno, Vincent M

“… Candida albicans, the major invasive fungal pathogen of humans, can cause both debilitating mucosal infections and fatal invasive infections. Understanding the …”
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Simultaneous Transcriptional Profiling of Bacteria and Their Host Cells von Humphrys, Michael S., Creasy, Todd, Sun, Yezhou, Shetty, Amol C., Chibucos, Marcus C., Drabek, Elliott F., Fraser, Claire M., Farooq, Umar, Sengamalay, Naomi, Ott, Sandy, Shou, Huizhong, Bavoil, Patrik M., Mahurkar, Anup, Myers, Garry S. A.

“… We developed an RNA-Seq-based method to simultaneously capture prokaryotic and eukaryotic expression profiles of cells infected with intracellular bacteria. As …”
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Impact of Oral Typhoid Vaccination on the Human Gut Microbiota and Correlations with S. Typhi-Specific Immunological Responses von Eloe-Fadrosh, Emiley A., McArthur, Monica A., Seekatz, Anna M., Drabek, Elliott F., Rasko, David A., Sztein, Marcelo B., Fraser, Claire M.

“… The resident microbial consortia of the human gastrointestinal tract play an integral role in modulating immune responses both locally and systemically …”
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Metaproteomics reveals persistent and phylum-redundant metabolic functional stability in adult human gut microbiomes of Crohn’s remission patients despite temporal variations in microbial taxa, genomes, and proteomes von Blakeley-Ruiz, J. Alfredo, Erickson, Alison R., Cantarel, Brandi L., Xiong, Weili, Adams, Rachel, Jansson, Janet K., Fraser, Claire M., Hettich, Robert L.

“… Background The gut microbiome plays a fundamental role in the human host’s overall health by contributing key biological functions such as expanded metabolism …”
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Dynamics of the infant gut microbiota in the first 18 months of life: the impact of maternal HIV infection and breastfeeding von Grant-Beurmann, Silvia, Jumare, Jibreel, Ndembi, Nicaise, Matthew, Olayemi, Shutt, Ashley, Omoigberale, Augustine, Martin, Olivia A., Fraser, Claire M., Charurat, Man

“… Background Access to antiretroviral therapy (ART) during pregnancy and breastfeeding for mothers with HIV has resulted in fewer children acquiring HIV peri- …”
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Transcriptional Attenuation Controls Macrolide Inducible Efflux and Resistance in Streptococcus pneumoniae and in Other Gram-Positive Bacteria Containing mef/mel(msr(D)) Elements von Chancey, Scott T., Bai, Xianhe, Kumar, Nikhil, Drabek, Elliott F., Daugherty, Sean C., Colon, Thomas, Ott, Sandra, Sengamalay, Naomi, Sadzewicz, Lisa, Tallon, Luke J., Fraser, Claire M., Tettelin, Hervé, Stephens, David S.

“… Macrolide resistance, emerging in Streptococcus pneumoniae and other Gram-positive bacteria, is increasingly due to efflux pumps encoded by mef/mel(msr) …”
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Strains used in whole organism Plasmodium falciparum vaccine trials differ in genome structure, sequence, and immunogenic potential von Moser, Kara A., Drábek, Elliott F., Dwivedi, Ankit, Stucke, Emily M., Crabtree, Jonathan, Dara, Antoine, Shah, Zalak, Adams, Matthew, Li, Tao, Rodrigues, Priscila T., Koren, Sergey, Phillippy, Adam M., Munro, James B., Ouattara, Amed, Sparklin, Benjamin C., Dunning Hotopp, Julie C., Lyke, Kirsten E., Sadzewicz, Lisa, Tallon, Luke J., Spring, Michele D., Jongsakul, Krisada, Lon, Chanthap, Saunders, David L., Ferreira, Marcelo U., Nyunt, Myaing M., Laufer, Miriam K., Travassos, Mark A., Sauerwein, Robert W., Takala-Harrison, Shannon, Fraser, Claire M., Sim, B. Kim Lee, Hoffman, Stephen L., Plowe, Christopher V., Silva, Joana C.

“… Background Plasmodium falciparum (Pf) whole-organism sporozoite vaccines have been shown to provide significant protection against controlled human malaria …”
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High-level Relatedness among Mycobacterium abscessus subsp. massiliense Strains from Widely Separated Outbreaks von Tettelin, Hervé, Davidson, Rebecca M., Agrawal, Sonia, Aitken, Moira L., Shallom, Shamira, Hasan, Nabeeh A., Strong, Michael, Nogueira de Moura, Vinicius Calado, De Groote, Mary Ann, Duarte, Rafael S., Hine, Erin, Parankush, Sushma, Su, Qi, Daugherty, Sean C., Fraser, Claire M., Brown-Elliott, Barbara A., Wallace, Richard J., Holland, Steven M., Sampaio, Elizabeth P., Olivier, Kenneth N., Jackson, Mary, Zelazny, Adrian M.

“… Three recently sequenced strains isolated from patients during an outbreak of Mycobacterium abscessus subsp. massiliense infections at a cystic fibrosis center …”
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