Suchergebnisse - "Francisco, Loise M"

PD-1 pathway in tolerance and autoimmunity von Francisco, Loise M, Sage, Peter T, Sharpe, Arlene H

“… Regulatory T cells (Tregs) and the PD-1: PD-ligand (PD-L) pathway are both critical to terminating immune responses. Elimination of either can result in the …”
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Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1 von Hirahara, Kiyoshi, Ghoreschi, Kamran, Yang, Xiang-Ping, Takahashi, Hayato, Laurence, Arian, Vahedi, Golnaz, Sciumè, Giuseppe, Hall, Aisling O'Hara, Dupont, Christopher D, Francisco, Loise M, Chen, Qian, Tanaka, Masao, Kanno, Yuka, Sun, Hong-Wei, Sharpe, Arlene H, Hunter, Christopher A, O'Shea, John J

“… Interleukin-27 (IL-27) is a key immunosuppressive cytokine that counters T helper 17 (Th17) cell-mediated pathology. To identify mechanisms by which IL-27 …”
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The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection von Pauken, Kristen E., Godec, Jernej, Odorizzi, Pamela M., Brown, Keturah E., Yates, Kathleen B., Ngiow, Shin Foong, Burke, Kelly P., Maleri, Seth, Grande, Shannon M., Francisco, Loise M., Ali, Mohammed-Alkhatim, Imam, Sabrina, Freeman, Gordon J., Haining, W. Nicholas, Wherry, E. John, Sharpe, Arlene H.

“… The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the role of this pathway during acute infection remains less clear. Here, …”
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Physiologic control of IDO competence in splenic dendritic cells von Baban, Babak, Chandler, Phillip R, Johnson, 3rd, Burles A, Huang, Lei, Li, Minghui, Sharpe, Marlon L, Francisco, Loise M, Sharpe, Arlene H, Blazar, Bruce R, Munn, David H, Mellor, Andrew L

“… Dendritic cells (DCs) competent to express the regulatory enzyme IDO in mice are a small but distinctive subset of DCs. Previously, we reported that a …”
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The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood von Sage, Peter T, Francisco, Loise M, Carman, Christopher V, Sharpe, Arlene H

“… Follicular regulatory T cells control humoral immune responses, but how these cells are in turn controlled has been unclear. Sharpe and colleagues demonstrate …”
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PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance von Tan, Catherine L, Kuchroo, Juhi R, Sage, Peter T, Liang, Dan, Francisco, Loise M, Buck, Jessica, Thaker, Youg Raj, Zhang, Qianxia, McArdel, Shannon L, Juneja, Vikram R, Lee, Sun Jung, Lovitch, Scott B, Lian, Christine, Murphy, George F, Blazar, Bruce R, Vignali, Dario A A, Freeman, Gordon J, Sharpe, Arlene H

“… Inhibitory signals through the PD-1 pathway regulate T cell activation, T cell tolerance, and T cell exhaustion. Studies of PD-1 function have focused …”
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RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance von Xiao, Yanping, Yu, Sanhong, Zhu, Baogong, Bedoret, Denis, Bu, Xia, Francisco, Loise M, Hua, Ping, Duke-Cohan, Jonathan S, Umetsu, Dale T, Sharpe, Arlene H, DeKruyff, Rosemarie H, Freeman, Gordon J

“… We report that programmed death ligand 2 (PD-L2), a known ligand of PD-1, also binds to repulsive guidance molecule b (RGMb), which was originally identified …”
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PD-L1 regulates the development, maintenance, and function of induced regulatory T cells von Francisco, Loise M, Salinas, Victor H, Brown, Keturah E, Vanguri, Vijay K, Freeman, Gordon J, Kuchroo, Vijay K, Sharpe, Arlene H

“… Both the programmed death (PD) 1-PD-ligand (PD-L) pathway and regulatory T (T reg) cells are instrumental to the maintenance of peripheral tolerance. We …”
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PD-1 and its ligands in T-cell immunity von Keir, Mary E, Francisco, Loise M, Sharpe, Arlene H

“… The past year has seen significant advances in our understanding of the critical roles of negative immunoregulatory signals delivered by the programmed death 1 …”
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The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment von Sharma, Madhav D, Shinde, Rahul, McGaha, Tracy L, Huang, Lei, Holmgaard, Rikke B, Wolchok, Jedd D, Mautino, Mario R, Celis, Esteban, Sharpe, Arlene H, Francisco, Loise M, Powell, Jonathan D, Yagita, Hideo, Mellor, Andrew L, Blazar, Bruce R, Munn, David H

“… The tumor microenvironment is profoundly immunosuppressive. We show that multiple tumor types create intratumoral immune suppression driven by a specialized …”
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B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function von Ruffner, Melanie A, Kim, Seon Hee, Bianco, Nicole R, Francisco, Loise M, Sharpe, Arlene H, Robbins, Paul D

“… Costimulatory molecules, such as B7-1/2 and PD-L1/2 play an important role in the function of APC. The regulation of the surface levels of costimulatory …”
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Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells von Chen, Ling, Sham, Caroline W, Chan, Ann M, Francisco, Loise M, Wu, Yin, Mareninov, Sergey, Sharpe, Arlene H, Freeman, Gordon J, Yang, Xian-Jie, Braun, Jonathan, Gordon, Lynn K

“… Mammalian programmed cell death (PD)-1 is a membrane-associated receptor regulating the balance between T-cell activation, tolerance, and immunopathology; …”
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Neuronal programmed cell death-1 ligand expression regulates retinal ganglion cell number in neonatal and adult mice von Sham, Caroline W, Chan, Ann M, Kwong, Jacky M K, Caprioli, Joseph, Nusinowitz, Steven, Chen, Bryan, Lee, Janice G, Gandhi, Nishant M, Francisco, Loise M, Sharpe, Arlene H, Chen, Ling, Braun, Jonathan, Gordon, Lynn K

“… During mouse retina maturation, the final number of retinal ganglion cells (RGCs) is determined by highly regulated programmed cell death. Previous studies …”
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The PTEN pathway in T regs is a critical driver of the suppressive tumor microenvironment von Sharma, Madhav D., Shinde, Rahul, McGaha, Tracy L., Huang, Lei, Holmgaard, Rikke B., Wolchok, Jedd D., Mautino, Mario R., Celis, Esteban, Sharpe, Arlene H., Francisco, Loise M., Powell, Jonathan D., Yagita, Hideo, Mellor, Andrew L., Blazar, Bruce R., Munn, David H.

“… Tumors depend on a specialized pathway of regulatory T cell activation to create their immunosuppressive microenvironment, which can be blocked by inhibiting …”
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PD-1 controls Lymph Node and Blood T Follicular Regulatory Cells von Sage, Peter T., Francisco, Loise M., Carman, Christopher V., Sharpe, Arlene H.

“… Newly defined CD4+CXCR5+FoxP3+ T Follicular Regulatory (TFR) cells inhibit CD4+CXCR5+FoxP3− T Follicular Helper (TFH)-mediated humoral immunity. Although PD-1 …”
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The PD-1 pathway in tolerance and autoimmunity: Terminating the Immune Response von FRANCISCO, Loise M, SAGE, Peter T, SHARPE, Arlene H

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Tumor-specific killer cells in paraneoplastic cerebellar degeneration von Albert, Matthew L., Darnell, Jennifer C., Bender, Armin, Francisco, Loise M., Bhardwaj, Nina, Darnell, Robert B.

“… Models for immune-mediated tumor regression in mice have defined an essential role for cytotoxic T lymphocytes (CTLs); however, naturally occurring tumor …”
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Characterization of human B7 -DC: A B7 costimulatory molecule functioning in bidirectional DC signaling von Francisco, Loise M

“… Priming of T cell responses involves the capture of antigen by immature dendritic cells (DCs) followed by a maturation process involving antigen processing, …”
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