Výsledky vyhľadávania - "Franceschi, Claudio"

Gut microbiota changes in the extreme decades of human life: a focus on centenarians Autor Santoro, Aurelia, Ostan, Rita, Candela, Marco, Biagi, Elena, Brigidi, Patrizia, Capri, Miriam, Franceschi, Claudio

“…The gut microbiota (GM) is a complex, evolutionarily molded ecological system, which contributes to a variety of physiological functions. The GM is highly…”
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Perilipin 2 and Age-Related Metabolic Diseases: A New Perspective Autor Conte, Maria, Franceschi, Claudio, Sandri, Marco, Salvioli, Stefano

“…Perilipin 2 (Plin2), a protein associated with the metabolism of intracellular lipid droplets (LDs), has long been considered only for its role in lipid…”
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Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine Autor Ostan, Rita, Monti, Daniela, Gueresi, Paola, Bussolotto, Mauro, Franceschi, Claudio, Baggio, Giovannella

“…Data showing a remarkable gender difference in life expectancy and mortality, including survival to extreme age, are reviewed starting from clinical and…”
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Aging and Imaging Assessment of Body Composition: From Fat to Facts Autor Ponti, Federico, Santoro, Aurelia, Mercatelli, Daniele, Gasperini, Chiara, Conte, Maria, Martucci, Morena, Sangiorgi, Luca, Franceschi, Claudio, Bazzocchi, Alberto

“…The aging process is characterized by the chronic inflammatory status called "inflammaging", which shares major molecular and cellular features with the…”
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Chronic inflammation in the etiology of disease across the life span Autor Furman, David, Campisi, Judith, Verdin, Eric, Carrera-Bastos, Pedro, Targ, Sasha, Franceschi, Claudio, Ferrucci, Luigi, Gilroy, Derek W, Fasano, Alessio, Miller, Gary W, Miller, Andrew H, Mantovani, Alberto, Weyand, Cornelia M, Barzilai, Nir, Goronzy, Jorg J, Rando, Thomas A, Effros, Rita B, Lucia, Alejandro, Kleinstreuer, Nicole, Slavich, George M

“…Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain…”
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Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? Autor Fulop, Tamas, Larbi, Anis, Dupuis, Gilles, Le Page, Aurélie, Frost, Eric H., Cohen, Alan A., Witkowski, Jacek M., Franceschi, Claudio

“…The immune system is the most important protective physiological system of the organism. It has many connections with other systems and is, in fact, often…”
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Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity Autor Franceschi, Claudio, Salvioli, Stefano, Garagnani, Paolo, de Eguileor, Magda, Monti, Daniela, Capri, Miriam

“…Owing to its memory and plasticity, the immune system (IS) is capable of recording all the immunological experiences and stimuli it was exposed to. The…”
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Reconfiguration of DNA methylation in aging Autor Zampieri, Michele, Ciccarone, Fabio, Calabrese, Roberta, Franceschi, Claudio, Bürkle, Alexander, Caiafa, Paola

“…•Methylated cytosines have a non-random distribution throughout the genome.•DNA methylation patterns are dynamic states balanced by methylation and…”
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Mitochondria, immunosenescence and inflammaging: a role for mitokines? Autor Conte, Maria, Martucci, Morena, Chiariello, Antonio, Franceschi, Claudio, Salvioli, Stefano

“…A global reshaping of the immune responses occurs with ageing, indicated as immunosenescence, where mitochondria and mitochondrial metabolism play an important…”
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Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence Autor Tezze, Caterina, Romanello, Vanina, Desbats, Maria Andrea, Fadini, Gian Paolo, Albiero, Mattia, Favaro, Giulia, Ciciliot, Stefano, Soriano, Maria Eugenia, Morbidoni, Valeria, Cerqua, Cristina, Loefler, Stefan, Kern, Helmut, Franceschi, Claudio, Salvioli, Stefano, Conte, Maria, Blaauw, Bert, Zampieri, Sandra, Salviati, Leonardo, Scorrano, Luca, Sandri, Marco

“…Mitochondrial dysfunction occurs during aging, but its impact on tissue senescence is unknown. Here, we find that sedentary but not active humans display an…”
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Accelerated epigenetic aging in Down syndrome Autor Horvath, Steve, Garagnani, Paolo, Bacalini, Maria Giulia, Pirazzini, Chiara, Salvioli, Stefano, Gentilini, Davide, Di Blasio, Anna Maria, Giuliani, Cristina, Tung, Spencer, Vinters, Harry V., Franceschi, Claudio

“…Summary Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of…”
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GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness Autor Conte, Maria, Martucci, Morena, Mosconi, Giovanni, Chiariello, Antonio, Cappuccilli, Maria, Totti, Valentina, Santoro, Aurelia, Franceschi, Claudio, Salvioli, Stefano

“…Growth differentiation factor 15 (GDF15) is a stress molecule produced in response to mitochondrial, metabolic and inflammatory stress with a number of…”
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Microbiomes other than the gut: inflammaging and age-related diseases Autor Santoro, Aurelia, Zhao, Jiangchao, Wu, Lu, Carru, Ciriaco, Biagi, Elena, Franceschi, Claudio

“…During the course of evolution, bacteria have developed an intimate relationship with humans colonizing specific body sites at the interface with the body…”
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The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates Autor Franceschi, Claudio, Garagnani, Paolo, Morsiani, Cristina, Conte, Maria, Santoro, Aurelia, Grignolio, Andrea, Monti, Daniela, Capri, Miriam, Salvioli, Stefano

“…Geroscience, the new interdisciplinary field that aims to understand the relationship between aging and chronic age-related diseases (ARDs) and geriatric…”
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Suggestions from Geroscience for the Genetics of Age-Related Diseases Autor Franceschi, Claudio, Garagnani, Paolo

“…[...]the authors were able to validate risk loci buried in well studied datasets. The revolution in hygiene awareness, a major contributor to the unprecedented…”
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A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging? Autor Bektas, Arsun, Schurman, Shepherd H., Franceschi, Claudio, Ferrucci, Luigi

“…A central clinical question as the world deals with the COVID-19 pandemic is what the long-term sequelae for the millions of individuals will be who recover…”
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Elevated gut microbiome abundance of Christensenellaceae, Porphyromonadaceae and Rikenellaceae is associated with reduced visceral adipose tissue and healthier metabolic profile in Italian elderly Autor Tavella, Teresa, Rampelli, Simone, Guidarelli, Giulia, Bazzocchi, Alberto, Gasperini, Chiara, Pujos-Guillot, Estelle, Comte, Blandine, Barone, Monica, Biagi, Elena, Candela, Marco, Nicoletti, Claudio, Kadi, Fawzi, Battista, Giuseppe, Salvioli, Stefano, O'Toole, Paul W., Franceschi, Claudio, Brigidi, Patrizia, Turroni, Silvia, Santoro, Aurelia

“…Aging is accompanied by physiological changes affecting body composition and functionality, including accumulation of fat mass at the expense of muscle mass,…”
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Plasma proteomics identify biomarkers predicting Parkinson’s disease up to 7 years before symptom onset Autor Hällqvist, Jenny, Bartl, Michael, Dakna, Mohammed, Schade, Sebastian, Garagnani, Paolo, Bacalini, Maria-Giulia, Pirazzini, Chiara, Bhatia, Kailash, Schreglmann, Sebastian, Xylaki, Mary, Weber, Sandrina, Ernst, Marielle, Muntean, Maria-Lucia, Sixel-Döring, Friederike, Franceschi, Claudio, Doykov, Ivan, Śpiewak, Justyna, Vinette, Héloїse, Trenkwalder, Claudia, Heywood, Wendy E., Mills, Kevin, Mollenhauer, Brit

“…Parkinson’s disease is increasingly prevalent. It progresses from the pre-motor stage (characterised by non-motor symptoms like REM sleep behaviour disorder),…”
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Distinct biological ages of organs and systems identified from a multi-omics study Autor Nie, Chao, Li, Yan, Li, Rui, Yan, Yizhen, Zhang, Detao, Li, Tao, Li, Zhiming, Sun, Yuzhe, Zhen, Hefu, Ding, Jiahong, Wan, Ziyun, Gong, Jianping, Shi, Yanfang, Huang, Zhibo, Wu, Yiran, Cai, Kaiye, Zong, Yang, Wang, Zhen, Wang, Rong, Jian, Min, Jin, Xin, Wang, Jian, Yang, Huanming, Han, Jing-Dong J., Zhang, Xiuqing, Franceschi, Claudio, Kennedy, Brian K., Xu, Xun

“…Biological age (BA) has been proposed to evaluate the aging status instead of chronological age (CA). Our study shows evidence that there might be multiple…”
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The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity Autor Abondio, Paolo, Sazzini, Marco, Garagnani, Paolo, Boattini, Alessio, Monti, Daniela, Franceschi, Claudio, Luiselli, Donata, Giuliani, Cristina

“…Human longevity is a complex phenotype resulting from the combinations of context-dependent gene-environment interactions that require analysis as a dynamic…”
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