Search Results - "Fowell, D J"

Peptides derived from murine insulin are diabetogenic in both rats and mice, but the disease-inducing epitopes are different: evidence against a common environmental cross-reactivity in the pathogenicity of type 1 diabetes by Heath, V L, Hutchings, P, Fowell, D J, Cooke, A, Mason, D W

“…Peptides derived from murine insulin are diabetogenic in both rats and mice, but the disease-inducing epitopes are different: evidence against a common…”
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Susceptibility to infectious diseases: Leishmania as a paradigm by Locksley, R M, Pingel, S, Lacy, D, Wakil, A E, Bix, M, Fowell, D J

“…The diverse response of individuals within populations to infectious pathogens remains poorly understood, although genetic determinants undoubtedly contribute…”
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Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro by Ramírez, F, Fowell, D J, Puklavec, M, Simmonds, S, Mason, D

“…Purified rat CD4+ T cells were activated in vitro in the presence or absence of the glucocorticoid dexamethasone. They were then expanded in IL-2 and…”
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Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells by Fowell, D J, Shinkai, K, Liao, X C, Beebe, A M, Coffman, R L, Littman, D R, Locksley, R M

“…Naive Itk-deficient CD4+ T cells were unable to establish stable IL-4 production, even when primed in Th2-inducing conditions. In contrast, IFNgamma production…”
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Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40) by Pippig, S D, Peña-Rossi, C, Long, J, Godfrey, W R, Fowell, D J, Reiner, S L, Birkeland, M L, Locksley, R M, Barclay, A N, Killeen, N

“…CD134 (OX40) is a member of the TNF receptor family that is expressed on activated T lymphocytes. T cells from mice that lack expression of CD134 made strong…”
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Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells by Gurunathan, S, Stobie, L, Prussin, C, Sacks, D L, Glaichenhaus, N, Iwasaki, A, Fowell, D J, Locksley, R M, Chang, J T, Wu, C Y, Seder, R A

“…Protective immunity against Leishmania major generated by DNA encoding the LACK (Leishmania homologue of receptor for activated C kinase) Ag has been shown to…”
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Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses by Brown, D R, Fowell, D J, Corry, D B, Wynn, T A, Moskowitz, N H, Cheever, A W, Locksley, R M, Reiner, S L

“…A number of investigations have established the critical role of interleukin 4 (IL-4) in mediating the development of T helper (Th)2 effector cells in vitro…”
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The Role of the Thymus in the Control of Autoimmunity by Heath, Victoria L., Saoudi, Abdelhadi, Seddon, Benedict P., Moore, Nel C., Fowell, Deborah J., Mason, Don W.

“…Self tolerance among T cells is believed to be maintained by two principal mechanisms: clonal deletion for self antigens expressed in the thymus and T cell…”
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Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development by Wakil, A E, Wang, Z E, Ryan, J C, Fowell, D J, Locksley, R M

“…Interferon gamma (IFN-gamma) has been implicated in T helper type 1 (Th1) cell development through its ability to optimize interleukin 12 (IL-12) production…”
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Impaired Th2 subset development in the absence of CD4 by Fowell, D J, Magram, J, Turck, C W, Killeen, N, Locksley, R M

“…Prior studies in CD4-deficient mice established the capacity of T helper (Th) lineage cells to mature into Th1 cells. Unexpectedly, challenge of these mice…”
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Altered immune responses in interleukin 10 transgenic mice by Hagenbaugh, A, Sharma, S, Dubinett, S M, Wei, S H, Aranda, R, Cheroutre, H, Fowell, D J, Binder, S, Tsao, B, Locksley, R M, Moore, K W, Kronenberg, M

“…Interleukin (IL)-10 is a pleiotropic cytokine which inhibits a broad array of immune parameters including T helper cell type 1 (Th1) cytokine production,…”
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Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases by Fowell, Deborah J., Locksley, Richard M.

“…Leishmania major infection of inbred mice leads to a major dichotomous response—death or survival—that depends on the strain of mice. This finding has…”
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Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope by Pingel, S, Launois, P, Fowell, D J, Turck, C W, Southwood, S, Sette, A, Glaichenhaus, N, Louis, J A, Locksley, R M

“…Experimental leishmaniasis offers a well characterized model of T helper type 1 cell (Th1)-mediated control of infection by an intracellular organism…”
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Control of Leishmania major by a monoclonal alpha beta T cell repertoire by Reiner, S L, Fowell, D J, Moskowitz, N H, Swier, K, Brown, D R, Brown, C R, Turck, C W, Scott, P A, Killeen, N, Locksley, R M

“…Little is known regarding the diversity of the host T cell response that is required to maintain immunologic control of microbial pathogens. Leishmania major…”
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Interleukin-12 in murine leishmaniasis — match, flame or fuel? by Fowell, D.J., Wakil, A.E., Locksley, R.M.

“…The murine model of Leishmania major infection has proven particularly robust in delineating the role of CD4 super(+) subset maturation in vivo. Effector CD4…”
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Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model by Fowell, D J, Bix, M, Shinkai, K, Lacy, D, Locksley, R M

“…The murine Leishmania major model has proven fertile ground for the elucidation of CD4+ T cell effector subset differentiation in vivo. The availability of a…”
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The development of effector T cell subsets in murine Leishmania major infection by Locksley, R M, Wakil, A E, Corry, D B, Pingel, S, Bix, M, Fowell, D J

“…Leishmania major infection has proven an exceptional model for CD4+ subset development in inbred mice. Most strains contain infection coincident with the…”
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Early kinetic window of target T cell susceptibility to CD25+ regulatory T cell activity by Sojka, Dorothy K, Hughson, Angela, Sukiennicki, Teresa L, Fowell, Deborah J

“…Peripheral tolerance is maintained in part by thymically derived CD25+CD4+ T cells (regulatory T cells (Tregs)). Their mechanism of action has not been well…”
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Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells by Morales-Tirado, Vanessa, Johannson, Sara, Hanson, Elaine, Howell, Alan, Zhang, Jinyi, Siminovitch, Katherine A, Fowell, Deborah J

“…The mechanism of cytokine secretion is not well understood, but cytokines appear to be synthesized and released in a polarized fashion toward an Ag-specific…”
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Development of CD4+ effector T cells and susceptibility to infectious diseases by Locksley, R M, Fowell, D J, Shinkai, K, Wakil, A E, Lacy, D, Bix, M

“…The mechanisms by which naive helper T cells differentiate into potent cytokine-expressing effectors remain critical to understanding both successful and…”
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