Suchergebnisse - "Forsyth, Nicholas R."

Telomerase Regulation: A Role for Epigenetics von Dogan, Fatma, Forsyth, Nicholas R.

“… Telomerase was first described by Greider and Blackburn in 1984, a discovery ultimately recognized by the Nobel Prize committee in 2009. The three decades …”
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Stem cell-based therapy for human diseases von Hoang, Duc M., Pham, Phuong T., Bach, Trung Q., Ngo, Anh T. L., Nguyen, Quyen T., Phan, Trang T. K., Nguyen, Giang H., Le, Phuong T. T., Hoang, Van T., Forsyth, Nicholas R., Heke, Michael, Nguyen, Liem Thanh

“… Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based …”
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Hypoxia-Modified Cancer Cell Metabolism von Al Tameemi, Wafaa, Dale, Tina P., Al-Jumaily, Rakad M. Kh, Forsyth, Nicholas R.

“… While oxygen is critical to the continued existence of complex organisms, extreme levels of oxygen within a system, known as hypoxia (low levels of oxygen) and …”
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Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors von Chen, Ruoli, Lai, U Hin, Zhu, Lingling, Singh, Ayesha, Ahmed, Muhammad, Forsyth, Nicholas R.

“… Hypoxia inducible factor (HIF) is the master oxygen sensor within cells and is central to the regulation of cell responses to varying oxygen levels. HIF …”
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TERT Promoter Methylation Is Oxygen-Sensitive and Regulates Telomerase Activity von Dogan, Fatma, Forsyth, Nicholas R.

“… Telomere repeats protect linear chromosomes from degradation, and telomerase has a prominent role in their maintenance. Telomerase has telomere-independent …”
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Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination von Gomes, Nuno M. V., Ryder, Oliver A., Houck, Marlys L., Charter, Suellen J., Walker, William, Forsyth, Nicholas R., Austad, Steven N., Venditti, Chris, Pagel, Mark, Shay, Jerry W., Wright, Woodring E.

“… Summary Progressive telomere shortening from cell division (replicative aging) provides a barrier for human tumor progression. This program is not conserved in …”
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Tendon tissue engineering: An overview of biologics to promote tendon healing and repair von Citro, Vera, Clerici, Marta, Boccaccini, Aldo R., Della Porta, Giovanna, Maffulli, Nicola, Forsyth, Nicholas R.

“… Tendons are dense connective tissues with a hierarchical polarized structure that respond to and adapt to the transmission of muscle contraction forces to the …”
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Mesenchymal stem cells promote alveolar epithelial cell wound repair in vitro through distinct migratory and paracrine mechanisms von Akram, Khondoker M, Samad, Sohel, Spiteri, Monica A, Forsyth, Nicholas R

“… Background Mesenchymal stem cells (MSC) are in clinical trials for widespread indications including musculoskeletal, neurological, cardiac and haematological …”
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Physoxia alters human mesenchymal stem cell secretome von Merkhan, Marwan M, Shephard, Matthew T, Forsyth, Nicholas R

“… The human mesenchymal stem cell (hMSC) secretome has pleiotropic effects which underpin their therapeutic potential. hMSC serum-free conditioned media (SFCM) …”
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Chorionic and amniotic membrane-derived stem cells have distinct, and gestational diabetes mellitus independent, proliferative, differentiation, and immunomodulatory capacities von Chen, Liyun, Merkhan, Marwan M., Forsyth, Nicholas R., Wu, Pensee

“… Placental membrane-derived mesenchymal stem cells (MSCs), with the advantages of being non-invasive and having fewer ethical issues, are a promising source for …”
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Tenogenic Differentiation of Human Embryonic Stem Cells von Dale, Tina P., Mazher, Shazia, Webb, William R., Zhou, Jing, Maffulli, Nicola, Chen, Guo-Qiang, El Haj, Alicia J., Forsyth, Nicholas R.

“… Tendon healing is complex to manage because of the limited regeneration capacity of tendon tissue; stem cell-based tissue engineering approaches may provide …”
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Syndecan-3 regulates MSC adhesion, ERK and AKT signalling in vitro and its deletion enhances MSC efficacy in a model of inflammatory arthritis in vivo von Jones, Fiona K., Stefan, Andrei, Kay, Alasdair G., Hyland, Mairead, Morgan, Rebecca, Forsyth, Nicholas R., Pisconti, Addolorata, Kehoe, Oksana

“… Rheumatoid arthritis (RA) is a debilitating and painful inflammatory autoimmune disease characterised by the accumulation of leukocytes in the synovium, …”
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Tendon and Cytokine Marker Expression by Human Bone Marrow Mesenchymal Stem Cells in a Hyaluronate/Poly-Lactic-Co-Glycolic Acid (PLGA)/Fibrin Three-Dimensional (3D) Scaffold von Ciardulli, Maria C., Marino, Luigi, Lovecchio, Joseph, Giordano, Emanuele, Forsyth, Nicholas R., Selleri, Carmine, Maffulli, Nicola, Porta, Giovanna Della

“… We developed a (three-dimensional) 3D scaffold, we named HY-FIB, incorporating a force-transmission band of braided hyaluronate embedded in a cell localizing …”
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Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells von Fadayomi, Idowu E., Johnson-Ajinwo, Okiemute R., Pires, Elisabete, McCullagh, James, Claridge, Tim D.W., Forsyth, Nicholas R., Li, Wen-Wu

“… Objectives: The toxicity of chemotherapeutic anticancer drugs is a serious issue in clinics. Drug discovery from edible and medicinal plants represents a …”
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Human tendon stem/progenitor cell-derived extracellular vesicle production promoted by dynamic culture von Clerici, Marta, Ciardulli, Maria Camilla, Lamparelli, Erwin Pavel, Lovecchio, Joseph, Giordano, Emanuele, Dale, Tina P., Forsyth, Nicholas R., Maffulli, Nicola, Della Porta, Giovanna

“… Tendon injuries significantly impact quality of life, prompting the exploration of innovative solutions beyond conventional surgery. Extracellular Vesicles …”
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Tenogenic Cues Are Biochemically and Environmentally Distinct for Tendon Stem Cells and Mesenchymal/Stromal Stem Cells von Citro, Vera, Clerici, Marta, Porta, Giovanna Della, Maffulli, Nicola, Boccaccini, Aldo R., Dale, Tina P., Forsyth, Nicholas R.

“… Tendon tissue engineering draws on regenerative medicine principles, offering innovative solutions to address the challenges posed by tendon injuries and …”
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A phosphate glass reinforced composite acrylamide gradient scaffold for osteochondral interface regeneration von Younus, Zaid M., Ahmed, Ifty, Roach, Paul, Forsyth, Nicholas R.

“… •Combining two acrylamide hydrogels, poly n-isopropyl acrylamide (pNIPAM) and poly n‑tert‑butyl acrylamide (pNTBAM), created multi-regional scaffold featuring …”
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Genetically engineered distal airway stem cell transplantation protects mice from pulmonary infection von Zhou, Yue‐qing, Shi, Yun, Yang, Ling, Sun, Yu‐fen, Han, Yu‐fei, Zhao, Zi‐xian, Wang, Yu‐jia, Liu, Ying, Ma, Yu, Zhang, Ting, Ren, Tao, Dale, Tina P, Forsyth, Nicholas R, Jin, Fa‐guang, Qu, Jie‐ming, Zuo, Wei, Xu, Jin‐fu

“… Severe pulmonary infection is a major threat to human health accompanied by substantial medical costs, prolonged inpatient requirements, and high mortality …”
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Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes von Chen, Liyun, Wang, Chung-Teng, Forsyth, Nicholas R., Wu, Pensee

“… Background Gestational diabetes (GDM) is a common complication of pregnancy. The impact of pregnancy complications on placental function suggests that …”
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Amnion-Derived Teno-Inductive Secretomes: A Novel Approach to Foster Tendon Differentiation and Regeneration in an Ovine Model von Citeroni, Maria Rita, Mauro, Annunziata, Ciardulli, Maria Camilla, Di Mattia, Miriam, El Khatib, Mohammad, Russo, Valentina, Turriani, Maura, Santer, Michael, Della Porta, Giovanna, Maffulli, Nicola, Forsyth, Nicholas R., Barboni, Barbara

“… Regenerative medicine has greatly progressed, but tendon regeneration mechanisms and robust in vitro tendon differentiation protocols remain to be elucidated …”
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