Výsledky vyhľadávania - "Flume, Patrick A."

Amikacin Liposome Inhalation Suspension for Treatment-Refractory Lung Disease Caused by Mycobacterium avium Complex (CONVERT). A Prospective, Open-Label, Randomized Study Autor Griffith, David E., Eagle, Gina, Thomson, Rachel, Aksamit, Timothy R., Hasegawa, Naoki, Morimoto, Kozo, Addrizzo-Harris, Doreen J., O’Donnell, Anne E., Marras, Theodore K., Flume, Patrick A., Loebinger, Michael R., Morgan, Lucy, Codecasa, Luigi R., Hill, Adam T., Ruoss, Stephen J., Yim, Jae-Joon, Ringshausen, Felix C., Field, Stephen K., Philley, Julie V., Wallace, Richard J., van Ingen, Jakko, Coulter, Chris, Nezamis, James, Winthrop, Kevin L.

“…Improved therapeutic options are needed for patients with treatment-refractory nontuberculous mycobacterial lung disease caused by complex (MAC). To evaluate…”
Získať plný text

Randomized Trial of Liposomal Amikacin for Inhalation in Nontuberculous Mycobacterial Lung Disease Autor Olivier, Kenneth N., Griffith, David E., Eagle, Gina, McGinnis, John P., Micioni, Liza, Liu, Keith, Daley, Charles L., Winthrop, Kevin L., Ruoss, Stephen, Addrizzo-Harris, Doreen J., Flume, Patrick A., Dorgan, Daniel, Salathe, Matthias, Brown-Elliott, Barbara A., Gupta, Renu, Wallace, Richard J.

“…Lengthy, multidrug, toxic, and low-efficacy regimens limit management of pulmonary nontuberculous mycobacterial disease. In this phase II study, we…”
Získať plný text

Ivacaftor in subjects with cystic fibrosis who are homozygous for the F508del-CFTR mutation Autor Flume, Patrick A, Liou, Theodore G, Borowitz, Drucy S, Li, Haihong, Yen, Karl, Ordoñez, Claudia L, Geller, David E

“…Ivacaftor (VX-770) is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that was approved in the United States for the treatment of…”
Zistit podrobnosti o prístupe

Efficacy and safety of ivacaftor in patients with cystic fibrosis who have an Arg117His-CFTR mutation: a double-blind, randomised controlled trial Autor Moss, Richard B, Flume, Patrick A, Elborn, J Stuart, Cooke, Jon, Rowe, Steven M, McColley, Susanna A, Rubenstein, Ronald C, Higgins, Mark

“…Ivacaftor has been previously assessed in patients with cystic fibrosis with Gly551Asp-CFTR or other gating mutations. We assessed ivacaftor in patients with…”
Zistit podrobnosti o prístupe

Alterations of lipid metabolism provide serologic biomarkers for the detection of asymptomatic versus symptomatic COVID-19 patients Autor Janneh, Alhaji H., Kassir, Mohamed Faisal, Dwyer, Connor J., Chakraborty, Paramita, Pierce, Jason S., Flume, Patrick A., Li, Hong, Nadig, Satish N., Mehrotra, Shikhar, Ogretmen, Besim

“…COVID-19 pandemic exerts a health care emergency around the world. The illness severity is heterogeneous. It is mostly unknown why some individuals who are…”
Získať plný text

Amikacin Liposome Inhalation Suspension for Mycobacterium avium Complex Lung Disease: A 12-Month Open-Label Extension Clinical Trial Autor Winthrop, Kevin L, Flume, Patrick A, Thomson, Rachel, Mange, Kevin C, Yuen, Dayton W, Ciesielska, Monika, Morimoto, Kozo, Ruoss, Stephen J, Codecasa, Luigi R, Yim, Jae-Joon, Marras, Theodore K, van Ingen, Jakko, Wallace, Richard J, Brown-Elliott, Barbara A, Coulter, Chris, Griffith, David E

“…Rationale: Patients with refractory Mycobacterium avium complex (MAC) lung disease have limited treatment options. In the CONVERT study, amikacin liposome…”
Zistit podrobnosti o prístupe

State of progress in treating cystic fibrosis respiratory disease Autor Flume, Patrick A, Van Devanter, Donald R

“…Since the discovery of the gene associated with cystic fibrosis (CF), there has been tremendous progress in the care of patients with this disease. New…”
Získať plný text

Safety, efficacy and convenience of tobramycin inhalation powder in cystic fibrosis patients: The EAGER trial Autor Konstan, Michael W., Flume, Patrick A., Kappler, Matthias, Chiron, Raphaël, Higgins, Mark, Brockhaus, Florian, Zhang, Jie, Angyalosi, Gerhild, He, Ellie, Geller, David E.

“…A light-porous-particle, dry-powder formulation of tobramycin was developed, using PulmoSphere® technology, to improve airway delivery efficiency,…”
Získať plný text

Early Life Growth Trajectories in Cystic Fibrosis are Associated with Pulmonary Function at Age 6 Years Autor Sanders, Don B., Fink, Aliza, Mayer-Hamblett, Nicole, Schechter, Michael S., Sawicki, Gregory S., Rosenfeld, Margaret, Flume, Patrick A., Morgan, Wayne J.

“…To determine whether severity of lung disease at age 6 years is associated with changes in nutritional status before age 6 within individual children with…”
Získať plný text

Time-to-positivity of Mycobacterium avium complex in broth culture associates with culture conversion Autor Mingora, Christina M., Garcia, Bryan A., Mange, Kevin C., Yuen, Dayton W., Ciesielska, Monika, van Ingen, Jakko, Flume, Patrick A., Dorman, Susan E.

“…Background Mycobacterial time to positivity (TTP) in liquid culture media has predictive value for longer term outcomes in pulmonary tuberculosis, but has not…”
Získať plný text

Is bronchiectasis really a disease? Autor Shteinberg, Michal, Flume, Patrick A., Chalmers, James D.

“…The definition of a disease requires that distinguishing signs and symptoms are present that are common, and that the constellation of signs and symptoms…”
Získať plný text

Integration of psychological care into a nontuberculous mycobacteria (NTM) program in the Southeastern United States: A retrospective cohort study Autor Christon, Lillian M., Bullington, Wendy, Sullivan, Lauren, Flume, Patrick A., Dorman, Susan, Alkabab, Yosra, Daigle, Brian, Taylor, Brandie, Mingora, Christina

“…Nontuberculous mycobacterial lung disease (NTM-LD) is a chronic infection of the lungs with a high symptom burden. NTM-LD treatment is typically long and…”
Získať plný text

US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis Autor Flume, Patrick A., MD

Získať plný text

Pulmonary exacerbations in insured patients with bronchiectasis over 2 years Autor Flume, Patrick A., Feliciano, Joseph, Lucci, Matthew, Wu, Jasmanda, Fucile, Sebastian, Hassan, Mariam, Chatterjee, Anjan

“…Patients with bronchiectasis experience persistent symptoms and frequent pulmonary exacerbations; this study investigated the frequency of exacerbations and…”
Získať plný text

Pharmacokinetics and safety of MP-376 (levofloxacin inhalation solution) in cystic fibrosis subjects Autor Geller, David E, Flume, Patrick A, Griffith, David C, Morgan, Elizabeth, White, Dan, Loutit, Jeffery S, Dudley, Michael N

“…The pharmacokinetics and tolerability of nebulized MP-376 (levofloxacin inhalation solution [Aeroquin]) were determined in cystic fibrosis (CF) subjects. Ten…”
Zistit podrobnosti o prístupe

Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity Autor Flume, Patrick A, Chalmers, James D, Olivier, Kenneth N

“…Bronchiectasis is characterised by pathological dilation of the airways. More specifically, the radiographic demonstration of airway enlargement is the common…”
Získať plný text

Trial Conduct, Baseline Characteristics, and Symptom Burden of Patients in the ARISE Study Autor Daley, Charles L., Chalmers, James D., Flume, Patrick A., Griffith, David E., Hasegawa, Naoki, Morimoto, Kozo, Winthrop, Kevin L., Sheu, Chau-Chyun, Avsar, Korkut, Andrisani, Dario, Codecasa, Luigi Ruffo, Yuen, Dayton W., Hassan, Mariam, Nevoret, Marie-Laure, Mange, Kevin

“…Introduction ARISE was a global clinical trial designed to generate evidence demonstrating the utility of the patient-reported outcome instruments Quality of…”
Získať plný text

Massive Hemoptysis in Cystic Fibrosis Autor Flume, Patrick A, Yankaskas, James R, Ebeling, Myla, Hulsey, Thomas, Clark, Leslie L

“…Massive hemoptysis is a complication commonly reported in patients with cystic fibrosis (CF). An understanding of the pathophysiology of this complication and…”
Získať plný text

Combined Aerobic Exercise and Virtual Reality-Based Upper Extremity Rehabilitation Intervention for Chronic Stroke: Feasibility and Preliminary Effects on Physical Function and Quality of Life Autor Ross, Ryan E., Hart, Emerson, Williams, Ewan R., Gregory, Chris M., Flume, Patrick A., Mingora, Christina M., Woodbury, Michelle L.

“…To (1) examine the feasibility of combining lower extremity aerobic exercise (AEx) with a virtual reality (VR) upper extremity (UE) rehabilitation intervention…”
Získať plný text

Preparing clinicians to be site investigators in multicenter clinical trials: A training program at an academic medical center Autor Loucks, Tammy L., Lee-Chavarria, Diana, Harvey, Jillian, Paranal, Rechelle, Denmark, Signe, Flume, Patrick A., Chimowitz, Marc, Turan, Tanya N.

“…Clinical trials are essential in the translation of biomedical discoveries to new clinical interventions and therapeutics. Successful multisite clinical trials…”
Získať plný text