Výsledky vyhľadávania - "Fluconazole"

A randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjects Autor Rex, John H, Pappas, Peter G, Karchmer, Adolf W, Sobel, Jack, Edwards, John E, Hadley, Susan, Brass, Corstiaan, Vazquez, Jose A, Chapman, Stanley W, Horowitz, Harold W, Zervos, Marcus, McKinsey, David, Lee, Jeannette, Babinchak, Timothy, Bradsher, Robert W, Cleary, John D, Cohen, David M, Danziger, Larry, Goldman, Mitchell, Goodman, Jesse, Hilton, Eileen, Hyslop, Newton E, Kett, Daniel H, Lutz, Jon, Rubin, Robert H, Scheld, W Michael, Schuster, Mindy, Simmons, Bryan, Stein, David K, Washburn, Ronald G, Mautner, Linda, Chu, Teng-Chiao, Panzer, Helene, Rosenstein, Rebecca B, Booth, Jenia

“…A randomized, blinded, multicenter trial was conducted to compare fluconazole (800 mg per day) plus placebo with fluconazole plus amphotericin B…”
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Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open‐label, phase I study in healthy subjects Autor Tachibana, Masaya, Matsuki, Shunji, Maekawa, Yutaro, Kuroda, Kana, Shimizu, Takako, Tsutsumi, Junko, Ishizuka, Hitoshi

“… Itraconazole and fluconazole are antifungal medications often used as typical inhibitors of cytochrome P450 3A (CYP3A…”
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Effect of Fluconazole Coadministration and CYP2C9 Genetic Polymorphism on Siponimod Pharmacokinetics in Healthy Subjects Autor Gardin, Anne, Ufer, Mike, Legangneux, Eric, Rossato, Gianluca, Jin, Yi, Su, Zhenzhong, Pal, Parasar, Li, Wenkui, Shakeri-Nejad, Kasra

“…). Methods Study A was an open-label, single-dose study comprising periods 1 (14 days; day 1: siponimod 4 mg) and 2 (20 days; day 1: fluconazole 200 mg twice daily; days 2–19: fluconazole 200 mg once daily; day 3: siponimod 4 mg) in healthy subjects…”
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Multiple administrations of fluconazole increase plasma exposure to ruxolitinib in healthy adult subjects Autor Aslanis, Vassilios, Umehara, Kenichi, Huth, Felix, Ouatas, Taoufik, Bharathy, Savita, Butler, Andrew Avigdor, Zhou, Wen, Gadbaw, Brian

“…Purpose Ruxolitinib is metabolized by cytochrome P450 (CYP)3A4 and CYP2C9. Dual inhibitors of these enzymes (like fluconazole…”
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Pharmacokinetic interaction between SHR2554 and fluconazole: A single-center, open-label and one-sequence crossover phase I trial in healthy Chinese subjects Autor Dai, Yuyang, Hu, Minwan, Guo, Shaojie, Wu, Feng, Han, Ying, Ni, Siyang, Li, Shaorong, Zhu, Zhenyu, Yuan, Weilan, Zhao, Xiuli

“… 18 Chinese healthy subjects were orally administered SHR2554 100 mg on Day 1, fluconazole 400 mg on Day 4 and 200 mg QD from Days 5 to 6…”
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Effect of fluconazole on the pharmacokinetics of ainuovirine in healthy adult subjects

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Methoxyethyl Etomidate Hydrochloride (ET‐26): A Phase I Clinical Trial Assessing Drug–Drug Interactions in Healthy Subjects Autor Yang, Fan, Ye, Pan‐Pan, Lv, Wen‐Shuo, Li, Li‐Ze, Zhao, Bao‐Zhong, van denAnker, John, Yang, Xin‐Mei, Song, Lin‐Lin, Yang, Xiao‐Ran, Zheng, Yi, Ke, Bo‐Wen, Zhao, Wei

“…‐26 in 68 healthy subjects across three sequences, evaluating interactions with rifampin (CYP2C19/3A4 inducer), fluconazole…”
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Oteseconazole versus fluconazole for the treatment of severe vulvovaginal candidiasis: a multicenter, randomized, double-blinded, phase 3 trial Autor Wang, Xiaoqian, Chen, Lihong, Ruan, Hongjie, Xiong, Zhengai, Wang, Wenying, Qiu, Jin, Song, Weihua, Zhang, Chunlian, Xue, Fengxia, Qin, Tianhua, Zhang, Bei, An, Ruifang, Luo, Xiping, Wang, Wei, Zhang, Songling, Cai, Yunlang, Kang, Jiali, Deng, Henan, Fan, Shangrong, Cui, Manhua, Wang, Shijin, Luo, Xiaowan, Su, Zhiying, Shu, Jing, Wang, Quanren, Wang, Fang, Bai, Jianling, Liao, Qinping

“… (600 mg on D1 and 450 mg on D2) or fluconazole (150 mg on D1 and D4) in a 1:1 ratio. The primary endpoint was the proportion of subjects achieving therapeutic cure…”
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A multicenter randomized trial evaluating posaconazole versus fluconazole for the treatment of oropharyngeal candidiasis in subjects with HIV/AIDS Autor Vazquez, Jose A, Skiest, Daniel J, Nieto, Leopoldo, Northland, Rebeca, Sanne, Ian, Gogate, Jagadish, Greaves, Wayne, Isaacs, Randi

“… (including fluconazole-resistant strains). This multicenter, randomized, evaluator-blinded study of subjects with HIV infection and oropharyngeal candidiasis compared efficacy of posaconazole with that of fluconazole…”
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Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial Autor Prates, Fernanda V de O, Dourado, Mayra E F, Silva, Silvana C, Schriefer, Albert, Guimarães, Luiz H, Brito, Maria das Graças O, Almeida, Juliana, Carvalho, Edgar M, Machado, Paulo R L

“…  A total of 53 subjects were included in the trial; 26 were treated with Sb , and 27 with fluconazole…”
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Brown locusts, Locustana pardalina, host fluconazole-resistant Candidozyma (Candida) auris, closely related to Clade III clinical strains Autor Ogundeji, Adepemi, Bello-Akinosho, Maryam, Swart, Vaughn, Featherston, Jonathan, Cason, Errol D, Bolsenbroek, Armand, Beneke, Carel, Musoke, Jolly, Baker, Tyla, Ismail, Arshad, Sebolai, Olihile, Albertyn, Jacobus, Pohl, Carolina

“…) auris is a subject of speculation, with hypotheses including avian species and marine environments…”
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An open label, single arm, pilot study to evaluate the safety, tolerability, and efficacy of daily fluconazole 150 mg in subjects suffering from Tinea cruris and Tinea corporis [version 1; peer review: awaiting peer review] Autor Saple, Dattatray Gopal, Save, Sushrut, Kumar, Devesh, Sood, Suneet

“…Background: Dermatophytes are the most common superficial fungal infections worldwide and are treated with prescribed regimens of terbinafine and itraconazole, or with weekly doses of fluconazole…”
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An open label, single arm, pilot study to evaluate the safety, tolerability, and efficacy of daily fluconazole 150 mg in subjects suffering from Tinea cruris and Tinea corporis [version 2; peer review: 1 approved with reservations, 1 not approved] Autor Saple, Dattatray Gopal, Save, Sushrut, Kumar, Devesh, Sood, Suneet

“…Background Dermatophytes are the most common superficial fungal infections worldwide and are treated with prescribed regimens of terbinafine and itraconazole, or with weekly doses of fluconazole…”
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Cytochrome P450 epoxygenase dependence of opioid analgesia: fluconazole does not interfere with remifentanil-mediated analgesia in human subjects Autor Oertel, B G, Vermehren, J, Huynh, T T, Doehring, A, Ferreiros, N, Zimmermann, M, Geisslinger, G, Lötsch, J

“… This suggestion was predicated on observations of highly attenuated morphine antinociception in rodents after intracerebroventricular injection of fluconazole or carrying a neuron-specific deletion…”
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Total bodyweight and sex both drive pharmacokinetic variability of fluconazole in obese adults Autor Chen, Lu, van Rhee, Koen P, Wasmann, Roeland E, Krekels, Elke H J, Wiezer, Marinus J, van Dongen, Eric P A, Verweij, Paul E, van der Linden, Paul D, Brüggemann, Roger J, Knibbe, Catherijne A J

“…Fluconazole is commonly used to treat or prevent fungal infections. It is typically used orally but in critical situations, IV administration is needed…”
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Serum 4β-hydroxycholesterol increases during fluconazole treatment Autor Lütjohann, Dieter, Stellaard, Frans, Kerksiek, Anja, Lötsch, Jörn, Oertel, Bruno G

“…-hydroxycholesterol, which is a validated marker for hepatic cytochrome P450 (CYP) 3A4 activity. We tested the effect of another antifungal triazole agent, fluconazole, on serum…”
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Lack of pharmacokinetic interaction between single oral doses of letermovir (MK-8228) and fluconazole in healthy subjects Autor Adedoyin, Adedayo, Fox-Bosetti, Sabrina, Fancourt, Craig, Liu, Fang, Menzel, Karsten, Zhao, Tian, Auger, Patrice, Mirzac, Angela, Tomek, Charles, Panebianco, Deborah, Macha, Sreeraj, McCrea, Jacqueline, Iwamoto, Marian

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Effects of the moderate CYP3A4 inhibitor, fluconazole, on the pharmacokinetics of fesoterodine in healthy subjects Autor Malhotra, Bimal, Dickins, Maurice, Alvey, Christine, Jumadilova, Zhanna, Li, Xiaoxi, Duczynski, Gregory, Gandelman, Kuan

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Available data suggest that fesoterodine dosage should not exceed 4…”
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Effects of fluconazole on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes Autor Cho, Chang-Keun, Kang, Pureum, Jang, Choon-Gon, Lee, Yun Jeong, Bae, Jung-Woo, Choi, Chang-Ik, Lee, Seok-Yong

“…This study aimed to investigate the effects of fluconazole, a moderate inhibitor of CYP2C9 and CYP3A4, on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes…”
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Effect of fluconazole on the pharmacokinetics of fuzuloparib: an open-label, crossover study in Chinese healthy male volunteers Autor Chen, Xue, Yang, Feng, Zhao, Jiao, Tang, Qi, Heng, Jianfu, Deng, Jun, Zhang, Jin, Chen, Yong, Li, Kunyan, Wang, Jing

“… We evaluated the pharmacokinetics and tolerability of fuzuloparib by fluconazole, which is a broad antifungal agent and a moderate inhibitor of CYP3A4…”
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