Suchergebnisse - "Florquin, Sandrine"

TREM-1 and its potential ligands in non-infectious diseases: from biology to clinical perspectives von Tammaro, Alessandra, Derive, Marc, Gibot, Sebastien, Leemans, Jaklien C., Florquin, Sandrine, Dessing, Mark C.

“… Triggering receptor expressed on myeloid cells-1 (TREM-1) is expressed on the majority of innate immune cells and to a lesser extent on parenchymal cells. Upon …”
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Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration von Tammaro, Alessandra, Kers, Jesper, Scantlebery, Angelique M. L., Florquin, Sandrine

“… Renal ischemia reperfusion injury (IRI), a common event after renal transplantation, causes acute kidney injury (AKI), increases the risk of delayed graft …”
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Deep Learning-Based Histopathologic Assessment of Kidney Tissue von Hermsen, Meyke, de Bel, Thomas, den Boer, Marjolijn, Steenbergen, Eric J, Kers, Jesper, Florquin, Sandrine, Roelofs, Joris J T H, Stegall, Mark D, Alexander, Mariam P, Smith, Byron H, Smeets, Bart, Hilbrands, Luuk B, van der Laak, Jeroen A W M

“… The development of deep neural networks is facilitating more advanced digital analysis of histopathologic images. We trained a convolutional neural network for …”
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NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity von Stokman, Geurt, Kors, Lotte, Bakker, Pieter J, Rampanelli, Elena, Claessen, Nike, Teske, Gwendoline J D, Butter, Loes, van Andel, Harmen, van den Bergh Weerman, Marius A, Larsen, Per W B, Dessing, Mark C, Zuurbier, Coert J, Girardin, Stephen E, Florquin, Sandrine, Leemans, Jaklien C

“… Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and chronic kidney disease. NLRX1 is a receptor of the innate immune system …”
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Pattern recognition receptors and the inflammasome in kidney disease von Leemans, Jaklien C., Kors, Lotte, Anders, Hans-Joachim, Florquin, Sandrine

“… Key Points Toll-like receptors (TLRs), nucleotide-binding oligomerization domain receptors (NLRs) and the NACHT, LRR and PYD domains-containing protein 3 …”
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Depletion of Gut Microbiota Protects against Renal Ischemia-Reperfusion Injury von Emal, Diba, Rampanelli, Elena, Stroo, Ingrid, Butter, Loes M, Teske, Gwendoline J, Claessen, Nike, Stokman, Geurt, Florquin, Sandrine, Leemans, Jaklien C, Dessing, Mark C

“… An accumulating body of evidence shows that gut microbiota fulfill an important role in health and disease by modulating local and systemic immunity. The …”
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Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome von Iyer, Shankar S, Pulskens, Wilco P, Sadler, Jeffrey J, Butter, Loes M, Teske, Gwendoline J, Ulland, Tyler K, Eisenbarth, Stephanie C, Florquin, Sandrine, Flavell, Richard A, Leemans, Jaklien C, Sutterwala, Fayyaz S

“… Dying cells are capable of activating the innate immune system and inducing a sterile inflammatory response. Here, we show that necrotic cells are sensed by …”
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Efficacy of FP‐025: A novel matrix metalloproteinase‐12 (MMP‐12) inhibitor in murine allergic asthma von Ravanetti, Lara, Dekker, Tamara, Guo, Lihui, Dijkhuis, Annemiek, Dierdorp, Barbara S., Diamant, Zuzana, Florquin, Sandrine, Lutter, René

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Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia von de Porto, Alexander P., Liu, Zhe, de Beer, Regina, Florquin, Sandrine, de Boer, Onno J., Hendriks, Rudi W., van der Poll, Tom, de Vos, Alex F.

“… Background Streptococcus pneumoniae is a major causative agent in community-acquired pneumonia and sepsis. Overwhelming lung inflammation during pneumococcal …”
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Protease‐activated receptor‐1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy von Waasdorp, Maaike, de Rooij, Dennis M., Florquin, Sandrine, Duitman, JanWillem, Spek, C. Arnold

“… End‐stage renal disease, the final stage of all chronic kidney disorders, is associated with renal fibrosis and inevitably leads to renal failure and death …”
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Platelets induce epithelial to mesenchymal transition in renal proximal tubular epithelial cells through TGF-β signaling pathway von Rustiasari, Ukhti Jamil, Uil, Melissa, Zhang, Xiaomeng, Claessen, Nike, Butter, Loes, Florquin, Sandrine, Tammaro, Alessandra, Roelofs, Joris J.T.H.

“… Background Management of chronic kidney disease (CKD) remains a major challenge due limited therapeutic options to reverse fibrosis, which is a critical …”
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Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice von Waasdorp, Maaike, Duitman, JanWillem, Florquin, Sandrine, Spek, C. Arnold

“… Endogenously administered activated protein C ameliorates diabetic nephropathy (DN) in a protease-activated receptor-1 (PAR-1)-dependent manner, suggesting …”
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Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist von Wösten-van Asperen, Roelie M, Lutter, René, Specht, Patricia A, Moll, Gert N, van Woensel, Job B, van der Loos, Chris M, van Goor, Harry, Kamilic, Jelena, Florquin, Sandrine, Bos, Albert P

“… Acute respiratory distress syndrome (ARDS) is a devastating clinical syndrome. Angiotensin‐converting enzyme (ACE) and its effector peptide angiotensin (Ang) …”
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Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation von Bakker, Pieter J., Butter, Loes M., Kors, Lotte, Teske, Gwendoline J.D., Aten, Jan, Sutterwala, Fayyaz S., Florquin, Sandrine, Leemans, Jaklien C.

“… Metabolic syndrome (MetSyn) is a major health concern and associates with the development of kidney disease. The mechanisms linking MetSyn to renal disease …”
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The Sirt1 Activator SRT1720 Mitigates Human Monocyte Activation and Improves Outcome During Gram-Negative Pneumosepsis in Mice von Blot, Mathieu, Léopold, Valentine, de Beer, Regina, Florquin, Sandrine, Butler, Joe M., van’t Veer, Cornelis, de Vos, Alex F., van der Poll, Tom

“… Community-acquired pneumonia (CAP) is a leading cause of death, with mortality linked to an unbalanced host response. Sirtuin (Sirt)1, a histone deacetylase, …”
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CD44 is required for the pathogenesis of experimental crescentic glomerulonephritis and collapsing focal segmental glomerulosclerosis von Eymael, Jennifer, Sharma, Shagun, Loeven, Markus A, Wetzels, Jack F, Mooren, Fieke, Florquin, Sandrine, Deegens, Jeroen K, Willemsen, Brigith K, Sharma, Vikram, van Kuppevelt, Toin H, Bakker, Marinka A, Ostendorf, Tammo, Moeller, Marcus J, Dijkman, Henry B, Smeets, Bart, van der Vlag, Johan

“… A key feature of glomerular diseases such as crescentic glomerulonephritis and focal segmental glomerulosclerosis is the activation, migration and …”
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The dysregulation of metabolic pathways and induction of the pentose phosphate pathway in renal ischaemia–reperfusion injury von Scantlebery, Angelique ML, Tammaro, Alessandra, Mills, James D, Rampanelli, Elena, Kors, Lotte, Teske, Gwendoline J, Butter, Loes M, Liebisch, Gerhard, Schmitz, Gerd, Florquin, Sandrine, Leemans, Jaklien C, Roelofs, Joris JTH

“… Lipid accumulation is associated with various forms of acute renal injury; however, the causative factors and pathways underpinning this lipid accumulation …”
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Calcineurin inhibitor Tacrolimus impairs host immune response against urinary tract infection von Emal, Diba, Rampanelli, Elena, Claessen, Nike, Bemelman, Frederike J., Leemans, Jaklien C., Florquin, Sandrine, Dessing, Mark C.

“… Calcineurin inhibitor Tacrolimus, is a potent immunosuppressive drug widely used in order to prevent acute graft rejection. Urinary tract infection (UTI) is …”
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Transformer-based multiclass segmentation pipeline for basic kidney histology von He, Junling, Valkema, Pieter A., Long, Jingmin, Li, Jia, Florquin, Sandrine, Naesens, Maarten, Koshy, Priyanka, Nguyen, Tri Q., Meziyerh, Soufian, de Vries, Aiko P. J., De Boer, Onno J., Verbeek, Fons J., Xiong, Zhan, Kers, Jesper

“… Current applications of deep learning in renal pathology focused on anatomical structures with morphology, yet little research has focused on the performance …”
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A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion von Bakker, Pieter J, Butter, Loes M, Claessen, Nike, Teske, Gwendoline J D, Sutterwala, Fayyaz S, Florquin, Sandrine, Leemans, Jaklien C

“… Ischemia/reperfusion injury is a major cause of acute kidney injury. Improving renal repair would represent a therapeutic strategy to prevent renal …”
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