Suchergebnisse - "Fitzgerald, Katherine A"

DNA sensing by the cGAS-STING pathway in health and disease von Motwani, Mona, Pesiridis, Scott, Fitzgerald, Katherine A

“… The detection of pathogens through nucleic acid sensors is a defining principle of innate immunity. RNA-sensing and DNA-sensing receptors sample subcellular …”
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Inflammasome Complexes: Emerging Mechanisms and Effector Functions von Rathinam, Vijay A K, Fitzgerald, Katherine A

“… Canonical activation of the inflammasome is critical to promote caspase-1-dependent maturation of the proinflammatory cytokines IL-1β and IL-18, as well as to …”
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Immunobiology of Long Noncoding RNAs von Atianand, Maninjay K, Caffrey, Daniel R, Fitzgerald, Katherine A

“… The discovery of long noncoding RNAs (lncRNA) has provided a new perspective on gene regulation in diverse biological contexts. lncRNAs are remarkably …”
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Long non-coding RNAs and control of gene expression in the immune system von Atianand, Maninjay K., Fitzgerald, Katherine A.

“… •The expression of lncRNAs in the immune system is cell type- and context-dependent.•Several lncRNAs identified to date regulate immune gene …”
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STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors von Woo, Seng-Ryong, Fuertes, Mercedes B, Corrales, Leticia, Spranger, Stefani, Furdyna, Michael J, Leung, Michael Y K, Duggan, Ryan, Wang, Ying, Barber, Glen N, Fitzgerald, Katherine A, Alegre, Maria-Luisa, Gajewski, Thomas F

“… Spontaneous T cell responses against tumors occur frequently and have prognostic value in patients. The mechanism of innate immune sensing of immunogenic …”
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Mechanisms of inflammasome activation: recent advances and novel insights von Vanaja, Sivapriya K., Rathinam, Vijay A.K., Fitzgerald, Katherine A.

“… •New inflammasomes and new microbial triggers of inflammasomes have been identified.•Cytosolic LPS is detected by caspase-11 resulting in its activation.•A …”
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Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes von Lu, Alvin, Magupalli, Venkat Giri, Ruan, Jianbin, Yin, Qian, Atianand, Maninjay K, Vos, Matthijn R, Schröder, Gunnar F, Fitzgerald, Katherine A, Wu, Hao, Egelman, Edward H

“… Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine maturation and cell death. AIM2 and NLRP3 are representative sensor …”
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Succination inactivates gasdermin D and blocks pyroptosis von Humphries, Fiachra, Shmuel-Galia, Liraz, Ketelut-Carneiro, Natalia, Li, Sheng, Wang, Bingwei, Nemmara, Venkatesh V, Wilson, Ruth, Jiang, Zhaozhao, Khalighinejad, Farnaz, Muneeruddin, Khaja, Shaffer, Scott A, Dutta, Ranjan, Ionete, Carolina, Pesiridis, Scott, Yang, Shuo, Thompson, Paul R, Fitzgerald, Katherine A

“… Activated macrophages undergo a metabolic switch to aerobic glycolysis, accumulating Krebs' cycle intermediates that alter transcription of immune response …”
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Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death von Orning, Pontus, Weng, Dan, Starheim, Kristian, Ratner, Dmitry, Best, Zachary, Lee, Bettina, Brooks, Alexandria, Xia, Shiyu, Wu, Hao, Kelliher, Michelle A, Berger, Scott B, Gough, Peter J, Bertin, John, Proulx, Megan M, Goguen, Jon D, Kayagaki, Nobuhiko, Fitzgerald, Katherine A, Lien, Egil

“… Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming fragment that controls pyroptosis in macrophages. GSDMD is processed via …”
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Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage von Bronner, Denise N, Abuaita, Basel H, Chen, Xiaoyun, Fitzgerald, Katherine A, Nuñez, Gabriel, He, Yongqun, Yin, Xiao-Ming, O'Riordan, Mary X D

“… Endoplasmic reticulum (ER) stress is observed in many human diseases, often associated with inflammation. ER stress can trigger inflammation through …”
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Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression von Elling, Roland, Chan, Jennie, Fitzgerald, Katherine A.

“… The innate immune system represents the first line of defense during infection and is initiated by the detection of conserved microbial products by …”
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Molecular mechanisms involved in inflammasome activation von Bryant, Clare, Fitzgerald, Katherine A.

“… Germline-encoded pattern recognition receptors (PRRs) sense microbial or endogenous products released from damaged or dying cells and trigger innate immunity …”
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The cGAS-STING pathway for DNA sensing von Xiao, T Sam, Fitzgerald, Katherine A

“… The nucleotidyl transferase cGAS, its second-messenger product cGAMP, and the cGAMP sensor STING form the basic mechanism of DNA sensing in the cytoplasm of …”
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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria von Rathinam, Vijay A K, Vanaja, Sivapriya Kailasan, Waggoner, Lisa, Sokolovska, Anna, Becker, Christine, Stuart, Lynda M, Leong, John M, Fitzgerald, Katherine A

“… Systemic infections with Gram-negative bacteria are characterized by high mortality rates due to the "sepsis syndrome," a widespread and uncontrolled …”
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Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor von Jin, Tengchuan, Perry, Andrew, Jiang, Jiansheng, Smith, Patrick, Curry, James A, Unterholzner, Leonie, Jiang, Zhaozhao, Horvath, Gabor, Rathinam, Vijay A, Johnstone, Ricky W, Hornung, Veit, Latz, Eicke, Bowie, Andrew G, Fitzgerald, Katherine A, Xiao, T Sam

“… Recognition of DNA by the innate immune system is central to antiviral and antibacterial defenses, as well as an important contributor to autoimmune diseases …”
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Post-transcriptional regulation of gene expression in innate immunity von Carpenter, Susan, Ricci, Emiliano P., Mercier, Blandine C., Moore, Melissa J., Fitzgerald, Katherine A.

“… Key Points This Review summarizes post-transcriptional regulation in the innate immune response. We discuss the regulatory mechanisms that function at the …”
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NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING von Zhang, Lu, Mo, Jinyao, Swanson, Karen V, Wen, Haitao, Petrucelli, Alex, Gregory, Sean M, Zhang, Zhigang, Schneider, Monika, Jiang, Yan, Fitzgerald, Katherine A, Ouyang, Songying, Liu, Zhi-Jie, Damania, Blossom, Shu, Hong-Bing, Duncan, Joseph A, Ting, Jenny P-Y

“… Stimulator of interferon genes (STING, also named MITA, MYPS, or ERIS) is an intracellular DNA sensor that induces type I interferon through its interaction …”
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Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity von Barrat, Franck J, Elkon, Keith B, Fitzgerald, Katherine A

“… An important concept in immunology is the classification of immune responses as either innate or adaptive, based on whether the antigen receptors are encoded …”
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Recognition of cytosolic DNA by cGAS and other STING‐dependent sensors von Bhat, Numana, Fitzgerald, Katherine A.

“… The presence of DNA in the cytoplasm of mammalian cells is perceived as a danger signal, alerting the host to the presence of microbial infection. In response …”
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HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation von Magupalli, Venkat Giri, Negro, Roberto, Tian, Yuzi, Hauenstein, Arthur V, Di Caprio, Giuseppe, Skillern, Wesley, Deng, Qiufang, Orning, Pontus, Alam, Hasan B, Maliga, Zoltan, Sharif, Humayun, Hu, Jun Jacob, Evavold, Charles L, Kagan, Jonathan C, Schmidt, Florian I, Fitzgerald, Katherine A, Kirchhausen, Tom, Li, Yongqing, Wu, Hao

“… Inflammasomes are supramolecular complexes that play key roles in immune surveillance. This is accomplished by the activation of inflammatory caspases, which …”
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