Suchergebnisse - "Fiedler, Jan"

Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression von Gupta, Shashi Kumar, Garg, Ankita, Bär, Christian, Chatterjee, Shambhabi, Foinquinos, Ariana, Milting, Hendrik, Streckfuß-Bömeke, Katrin, Fiedler, Jan, Thum, Thomas

“… RBPs (RNA-binding proteins) have been described to be expressed and regulated in various organs including the heart. Little is known about the role of RBPs in …”
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Preclinical development of a miR-132 inhibitor for heart failure treatment von Foinquinos, Ariana, Batkai, Sandor, Genschel, Celina, Viereck, Janika, Rump, Steffen, Gyöngyösi, Mariann, Traxler, Denise, Riesenhuber, Martin, Spannbauer, Andreas, Lukovic, Dominika, Weber, Natalie, Zlabinger, Katrin, Hašimbegović, Ena, Winkler, Johannes, Fiedler, Jan, Dangwal, Seema, Fischer, Martin, de la Roche, Jeanne, Wojciechowski, Daniel, Kraft, Theresia, Garamvölgyi, Rita, Neitzel, Sonja, Chatterjee, Shambhabi, Yin, Xiaoke, Bär, Christian, Mayr, Manuel, Xiao, Ke, Thum, Thomas

“… Despite proven efficacy of pharmacotherapies targeting primarily global neurohormonal dysregulation, heart failure (HF) is a growing pandemic with increasing …”
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Development of Long Noncoding RNA-Based Strategies to Modulate Tissue Vascularization von Fiedler, Jan, Breckwoldt, Kaja, Remmele, Christian W, Hartmann, Dorothee, Dittrich, Marcus, Pfanne, Angelika, Just, Annette, Xiao, Ke, Kunz, Meik, Müller, Tobias, Hansen, Arne, Geffers, Robert, Dandekar, Thomas, Eschenhagen, Thomas, Thum, Thomas

“… Long noncoding ribonucleic acids (lncRNAs) are a subclass of regulatory noncoding ribonucleic acids for which expression and function in human endothelial …”
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The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy von Ucar, Ahmet, Gupta, Shashi K., Fiedler, Jan, Erikci, Erdem, Kardasinski, Michal, Batkai, Sandor, Dangwal, Seema, Kumarswamy, Regalla, Bang, Claudia, Holzmann, Angelika, Remke, Janet, Caprio, Massimiliano, Jentzsch, Claudia, Engelhardt, Stefan, Geisendorf, Sabine, Glas, Carolina, Hofmann, Thomas G., Nessling, Michelle, Richter, Karsten, Schiffer, Mario, Carrier, Lucie, Napp, L. Christian, Bauersachs, Johann, Chowdhury, Kamal, Thum, Thomas

“… Pathological growth of cardiomyocytes (hypertrophy) is a major determinant for the development of heart failure, one of the leading medical causes of mortality …”
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Effect of asymmetric diffuser deflector on even distribution of steam leaving blade section of steam turbine: comparative computational study von Bobčík, Marek, Pospíšil, Jiří, Fiedler, Jan

“… This study presents a computational analysis comparing two designs of steam turbine diffuser deflectors: a conventional axisymmetric design and an innovative …”
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Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors von Gorinski, Nataliya, Bijata, Monika, Prasad, Sonal, Wirth, Alexander, Abdel Galil, Dalia, Zeug, Andre, Bazovkina, Daria, Kondaurova, Elena, Kulikova, Elizabeth, Ilchibaeva, Tatiana, Zareba-Koziol, Monika, Papaleo, Francesco, Scheggia, Diego, Kochlamazashvili, Gaga, Dityatev, Alexander, Smyth, Ian, Krzystyniak, Adam, Wlodarczyk, Jakub, Richter, Diethelm W., Strekalova, Tatyana, Sigrist, Stephan, Bang, Claudia, Hobuß, Lisa, Fiedler, Jan, Thum, Thomas, Naumenko, Vladimir S., Pandey, Ghanshyam, Ponimaskin, Evgeni

“… The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR …”
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New Spectroelectrochemical Insights into Manganese and Rhenium Bipyridine Complexes as Catalysts for the Electrochemical Reduction of Carbon Dioxide von Barbero, Alice, Rotundo, Laura, Reviglio, Chiara, Gobetto, Roberto, Sokolova, Romana, Fiedler, Jan, Nervi, Carlo

“… This study aimed to demonstrate the behavior of different complexes using IR spectroelectrochemistry (SEC), a technique that combines IR spectroscopy with …”
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Introduction of a guideline for measurements of greenhouse gas fluxes from soils using non‐steady‐state chambers von Maier, Martin, Weber, Tobias K. D., Fiedler, Jan, Fuß, Roland, Glatzel, Stephan, Huth, Vytas, Jordan, Sabine, Jurasinski, Gerald, Kutzbach, Lars, Schäfer, Klaus, Weymann, Daniel, Hagemann, Ulrike

“… Soils represent a major global source and sink of greenhouse gases (GHGs). Many studies of GHG fluxes between soil, plant and atmosphere rely on chamber …”
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MicroRNA-24 antagonism prevents renal ischemia reperfusion injury von Lorenzen, Johan M, Kaucsar, Tamas, Schauerte, Celina, Schmitt, Roland, Rong, Song, Hübner, Anika, Scherf, Kristian, Fiedler, Jan, Martino, Filippo, Kumarswamy, Regalla, Kölling, Malte, Sörensen, Inga, Hinz, Hebke, Heineke, Joerg, van Rooij, Eva, Haller, Hermann, Thum, Thomas

“… Ischemia-reperfusion (I/R) injury of the kidney is a major cause of AKI. MicroRNAs (miRs) are powerful regulators of various diseases. We investigated the role …”
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MicroRNA-24 regulates vascularity after myocardial infarction von Fiedler, Jan, Jazbutyte, Virginija, Kirchmaier, Bettina C, Gupta, Shashi K, Lorenzen, Johan, Hartmann, Dorothee, Galuppo, Paolo, Kneitz, Susanne, Pena, John T G, Sohn-Lee, Cherin, Loyer, Xavier, Soutschek, Juergen, Brand, Thomas, Tuschl, Thomas, Heineke, Joerg, Martin, Ulrich, Schulte-Merker, Stefan, Ertl, Georg, Engelhardt, Stefan, Bauersachs, Johann, Thum, Thomas

“… Myocardial infarction leads to cardiac remodeling and development of heart failure. Insufficient myocardial capillary density after myocardial infarction has …”
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Non-coding RNAs in vascular disease - from basic science to clinical applications: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology von Fiedler, Jan, Baker, Andrew H, Dimmeler, Stefanie, Heymans, Stephane, Mayr, Manuel, Thum, Thomas

“… Non-coding RNAs are increasingly recognized not only as regulators of various biological functions but also as targets for a new generation of RNA therapeutics …”
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Hypoxia-Induced MicroRNA-212/132 Alter Blood-Brain Barrier Integrity Through Inhibition of Tight Junction-Associated Proteins in Human and Mouse Brain Microvascular Endothelial Cells von Burek, Malgorzata, König, Anna, Lang, Mareike, Fiedler, Jan, Oerter, Sabrina, Roewer, Norbert, Bohnert, Michael, Thal, Serge C., Blecharz-Lang, Kinga G., Woitzik, Johannes, Thum, Thomas, Förster, Carola Y.

“… Blood-brain barrier (BBB) integrity is one of the important elements of central nervous system (CNS) homeostasis. MicroRNAs (miRs) have been demonstrated to …”
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SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation von Schmidt, Kevin, Schmidt, Arne, Groß, Sonja, Just, Annette, Pfanne, Angelika, Fuchs, Maximilian, Jordan, Maria, Mohr, Elisa, Pich, Andreas, Fiedler, Jan, Thum, Thomas

“… Beneficial effects of sodium glucose co-transporter 2 inhibitors (SGLT2is) in cardiovascular diseases have been extensively reported leading to the inclusion …”
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Cardiovascular Importance of the MicroRNA-23/27/24 Family von BANG, CLAUDIA, FIEDLER, JAN, THUM, THOMAS

“… Please cite this paper as: Bang C, Fiedler J, Thum T. Cardiovascular importance of the microRNA‐23/27/24 family. Microcirculation19: 208–214, 2012. MicroRNAs …”
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Oxidation mechanism of flavanone taxifolin. Electrochemical and spectroelectrochemical investigation von Kocábová, Jana, Fiedler, Jan, Degano, Ilaria, Sokolová, Romana

“… •The oxidation mechanism of flavanone taxifolin was proposed.•The oxidation is specific and differs from oxidation of flavonol quercetin.•A benzofuranon common …”
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Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis von Lorenzen, Johan M, Schauerte, Celina, Hübner, Anika, Kölling, Malte, Martino, Filippo, Scherf, Kristian, Batkai, Sandor, Zimmer, Karina, Foinquinos, Ariana, Kaucsar, Tamas, Fiedler, Jan, Kumarswamy, Regalla, Bang, Claudia, Hartmann, Dorothee, Gupta, Shashi K, Kielstein, Jan, Jungmann, Andreas, Katus, Hugo A, Weidemann, Frank, Müller, Oliver J, Haller, Hermann, Thum, Thomas

“… Osteopontin (OPN) is a multifunctional cytokine critically involved in cardiac fibrosis. However, the underlying mechanisms are unresolved. Non-coding RNAs are …”
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Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis von Kenneweg, Franziska, Bang, Claudia, Xiao, Ke, Boulanger, Chantal M., Loyer, Xavier, Mazlan, Stephane, Schroen, Blanche, Hermans-Beijnsberger, Steffie, Foinquinos, Ariana, Hirt, Marc N., Eschenhagen, Thomas, Funcke, Sandra, Stojanovic, Stevan, Genschel, Celina, Schimmel, Katharina, Just, Annette, Pfanne, Angelika, Scherf, Kristian, Dehmel, Susann, Raemon-Buettner, Stella M., Fiedler, Jan, Thum, Thomas

“… Long non-coding RNAs (lncRNAs) have potential as novel therapeutic targets in cardiovascular diseases, but detailed information about the intercellular lncRNA …”
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Increase in mechanical load and pro-fibrotic stimulation leads to fibrotic and hypertrophic remodeling in porcine living myocardial slices von Bentele, Marco, Linke, Sophie, Neumüller, Susanne, Korte, Andrea, Gietz, Anika, Just, Annette, Stucki-Koch, Angelika, Pfanne, Angelika, Liu, Junqing, Zhao, Jiahao, Schwennen, Cornelia, Homann, Christian, Visscher, Christian, Pflaum, Michael, Wiegmann, Bettina, Bär, Christian, Weber, Natalie, Fiedler, Jan, Thum, Thomas

“… Heart failure (HF) is a growing global health concern, driven by factors such as increased mechanical load of the heart muscle tissue. This pathogenic …”
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Correlated Coordination and Redox Activity of a Hemilabile Noninnocent Ligand in Nickel Complexes von Paretzki, Alexa, Bubrin, Martina, Fiedler, Jan, Záliš, Stanislav, Kaim, Wolfgang

“… The compound [Ni(QM)2], QM=4,6‐di‐tert‐butyl‐N‐(2‐methylthiomethylphenyl)‐o‐iminobenzoquinone, is a singlet diradical species with approximately planar …”
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miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2 von Pfaff, Nils, Fiedler, Jan, Holzmann, Angelika, Schambach, Axel, Moritz, Thomas, Cantz, Tobias, Thum, Thomas

“… Induced pluripotent stem cells (iPSCs) can be generated by overexpression of Oct4, Sox2 and Klf4 in murine fibroblasts. By conducting a microRNA (miRNA) …”
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