Výsledky vyhľadávania - "Ferrucci, Luigi"

The genetics of human ageing Autor Melzer, David, Pilling, Luke C, Ferrucci, Luigi

“…The past two centuries have witnessed an unprecedented rise in human life expectancy. Sustaining longer lives with reduced periods of disability will require…”
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Human T cell immunosenescence and inflammation in aging Autor Bektas, Arsun, Schurman, Shepherd H., Sen, Ranjan, Ferrucci, Luigi

“…Review of the origin of the mild proinflammatory state that characterizes many older individuals, with a focus on changes in T cell function over time. The…”
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Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases Autor Kalyani, Rita Rastogi, Corriere, Mark, Ferrucci, Luigi

“…The term sarcopenia refers to the loss of muscle mass that occurs with ageing. On the basis of study results showing that muscle mass is only moderately…”
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Assessment of Gene Set Enrichment Analysis using curated RNA-seq-based benchmarks Autor Candia, Julián, Ferrucci, Luigi

“…Pathway enrichment analysis is a ubiquitous computational biology method to interpret a list of genes (typically derived from the association of large-scale…”
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Age-Related Changes in Glucose Metabolism, Hyperglycemia, and Cardiovascular Risk Autor Chia, Chee W, Egan, Josephine M, Ferrucci, Luigi

“…Aging and diabetes mellitus are 2 well-known risk factors for cardiovascular disease (CVD). During the past 50 years, there has been an dramatic increase in…”
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A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study Autor Liu, Zuyun, Kuo, Pei-Lun, Horvath, Steve, Crimmins, Eileen, Ferrucci, Luigi, Levine, Morgan

“…A person's rate of aging has important implications for his/her risk of death and disease; thus, quantifying aging using observable characteristics has…”
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A mitochondrial root to accelerated ageing and frailty Autor Ferrucci, Luigi, Zampino, Marta

“…A discovery metabolomic study was performed in a large cohort of adults to identify circulating biomarkers of frailty. The study found that carnitine and…”
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A proteomic atlas of senescence-associated secretomes for aging biomarker development Autor Basisty, Nathan, Kale, Abhijit, Jeon, Ok Hee, Kuehnemann, Chisaka, Payne, Therese, Rao, Chirag, Holtz, Anja, Shah, Samah, Sharma, Vagisha, Ferrucci, Luigi, Campisi, Judith, Schilling, Birgit

“…The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions,…”
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Connecting aging biology and inflammation in the omics era Autor Walker, Keenan A., Basisty, Nathan, Wilson, David M., Ferrucci, Luigi

“…Aging is characterized by the accumulation of damage to macromolecules and cell architecture that triggers a proinflammatory state in blood and solid tissues,…”
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Assessment of variability in the plasma 7k SomaScan proteomics assay Autor Candia, Julián, Daya, Gulzar N., Tanaka, Toshiko, Ferrucci, Luigi, Walker, Keenan A.

“…SomaScan is a high-throughput, aptamer-based proteomics assay designed for the simultaneous measurement of thousands of proteins with a broad range of…”
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Measuring biological aging in humans: A quest Autor Ferrucci, Luigi, Gonzalez‐Freire, Marta, Fabbri, Elisa, Simonsick, Eleanor, Tanaka, Toshiko, Moore, Zenobia, Salimi, Shabnam, Sierra, Felipe, Cabo, Rafael

“…The global population of individuals over the age of 65 is growing at an unprecedented rate and is expected to reach 1.6 billion by 2050. Most older…”
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Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria Autor Ubaida-Mohien, Ceereena, Lyashkov, Alexey, Gonzalez-Freire, Marta, Tharakan, Ravi, Shardell, Michelle, Moaddel, Ruin, Semba, Richard D, Chia, Chee W, Gorospe, Myriam, Sen, Ranjan, Ferrucci, Luigi

“…A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty in older persons, but the molecular mechanisms of such decline…”
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Frailty assessment in the cardiovascular care of older adults Autor Afilalo, Jonathan, Alexander, Karen P, Mack, Michael J, Maurer, Mathew S, Green, Philip, Allen, Larry A, Popma, Jeffrey J, Ferrucci, Luigi, Forman, Daniel E

“…Due to the aging and increasingly complex nature of our patients, frailty has become a high-priority theme in cardiovascular medicine. Despite the recognition…”
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Acetyl-cholinesterase-inhibitors slow cognitive decline and decrease overall mortality in older patients with dementia Autor Zuin, Marco, Cherubini, Antonio, Volpato, Stefano, Ferrucci, Luigi, Zuliani, Giovanni

“…We evaluated the effect of Acetyl-cholinesterase-inhibitors (AChEIs) on cognitive decline and overall survival in a large sample of older patients with late…”
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Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research Autor Fabbri, Elisa, Zoli, Marco, Gonzalez-Freire, Marta, Salive, Marcel E, Studenski, Stephanie A, Ferrucci, Luigi

“…Aging is characterized by rising susceptibility to development of multiple chronic diseases and, therefore, represents the major risk factor for…”
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Age-Related Change in Mobility: Perspectives From Life Course Epidemiology and Geroscience Autor Ferrucci, Luigi, Cooper, Rachel, Shardell, Michelle, Simonsick, Eleanor M, Schrack, Jennifer A, Kuh, Diana

“…Mobility is the most studied and most relevant physical ability affecting quality of life with strong prognostic value for disability and survival. Natural…”
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Chronic inflammation in the etiology of disease across the life span Autor Furman, David, Campisi, Judith, Verdin, Eric, Carrera-Bastos, Pedro, Targ, Sasha, Franceschi, Claudio, Ferrucci, Luigi, Gilroy, Derek W, Fasano, Alessio, Miller, Gary W, Miller, Andrew H, Mantovani, Alberto, Weyand, Cornelia M, Barzilai, Nir, Goronzy, Jorg J, Rando, Thomas A, Effros, Rita B, Lucia, Alejandro, Kleinstreuer, Nicole, Slavich, George M

“…Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain…”
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Biomarkers of aging for the identification and evaluation of longevity interventions Autor Moqri, Mahdi, Herzog, Chiara, Poganik, Jesse R, Justice, Jamie, Belsky, Daniel W, Higgins-Chen, Albert, Moskalev, Alexey, Fuellen, Georg, Cohen, Alan A, Bautmans, Ivan, Widschwendter, Martin, Ding, Jingzhong, Fleming, Alexander, Mannick, Joan, Han, Jing-Dong Jackie, Zhavoronkov, Alex, Barzilai, Nir, Kaeberlein, Matt, Cummings, Steven, Kennedy, Brian K, Ferrucci, Luigi, Horvath, Steve, Verdin, Eric, Maier, Andrea B, Snyder, Michael P, Sebastiano, Vittorio, Gladyshev, Vadim N

“…With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field…”
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Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts Autor Paluch, Amanda E, Bajpai, Shivangi, Bassett, David R, Carnethon, Mercedes R, Ekelund, Ulf, Evenson, Kelly R, Galuska, Deborah A, Jefferis, Barbara J, Kraus, William E, Lee, I-Min, Matthews, Charles E, Omura, John D, Patel, Alpa V, Pieper, Carl F, Rees-Punia, Erika, Dallmeier, Dhayana, Klenk, Jochen, Whincup, Peter H, Dooley, Erin E, Pettee Gabriel, Kelley, Palta, Priya, Pompeii, Lisa A, Chernofsky, Ariel, Larson, Martin G, Vasan, Ramachandran S, Spartano, Nicole, Ballin, Marcel, Nordström, Peter, Nordström, Anna, Anderssen, Sigmund A, Hansen, Bjørge H, Cochrane, Jennifer A, Dwyer, Terence, Wang, Jing, Ferrucci, Luigi, Liu, Fangyu, Schrack, Jennifer, Urbanek, Jacek, Saint-Maurice, Pedro F, Yamamoto, Naofumi, Yoshitake, Yutaka, Newton, Robert L, Yang, Shengping, Shiroma, Eric J, Fulton, Janet E

“…Although 10 000 steps per day is widely promoted to have health benefits, there is little evidence to support this recommendation. We aimed to determine the…”
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Skeletal muscle transcriptome in healthy aging Autor Tumasian, Robert A., Harish, Abhinav, Kundu, Gautam, Yang, Jen-Hao, Ubaida-Mohien, Ceereena, Gonzalez-Freire, Marta, Kaileh, Mary, Zukley, Linda M., Chia, Chee W., Lyashkov, Alexey, Wood, William H., Piao, Yulan, Coletta, Christopher, Ding, Jun, Gorospe, Myriam, Sen, Ranjan, De, Supriyo, Ferrucci, Luigi

“…Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve…”
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