Search Results - "Ferré, Pascal"

Dihydroceramides: their emerging physiological roles and functions in cancer and metabolic diseases by Lachkar, Floriane, Ferré, Pascal, Foufelle, Fabienne, Papaioannou, Alexandra

“…Dihydroceramides (DhCers) are a type of sphingolipids that for a long time were regarded as biologically inactive. They are metabolic intermediates of the de…”
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The biology of peroxisome proliferator-activated receptors: Relationship with lipid metabolism and insulin sensitivity by FERRE, Pascal

“…Peroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to the superfamily of nuclear receptors. Three isoforms (alpha, delta,…”
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Roles of Ceramides in Non-Alcoholic Fatty Liver Disease by Hajduch, Eric, Lachkar, Floriane, Ferré, Pascal, Foufelle, Fabienne

“…Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging from simple steatosis to steatohepatitis, fibrosis, and cirrhosis…”
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New insights into ER stress-induced insulin resistance by Flamment, Mélissa, Hajduch, Eric, Ferré, Pascal, Foufelle, Fabienne

“…Insulin resistance is a major characteristic of obesity and type 2 diabetes (T2DM). During the last decade, endoplasmic reticulum (ER) stress has emerged as a…”
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Functions of AMP-activated protein kinase in adipose tissue by Daval, Marie, Foufelle, Fabienne, Ferré, Pascal

“…AMP-activated protein kinase (AMPK) is involved in cellular energy homeostasis. Its functions have been extensively studied in muscles and liver. AMPK…”
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GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice by Kammoun, Hélène L., Chabanon, Hervé, Hainault, Isabelle, Luquet, Serge, Magnan, Christophe, Koike, Tatsuro, Ferré, Pascal, Foufelle, Fabienne

“…Hepatic steatosis is present in insulin-resistant obese rodents and is concomitant with active lipogenesis. Hepatic lipogenesis depends on the insulin-induced…”
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Steatosis and NASH in type 2 diabetes by Hu, Mengyue, Phan, Franck, Bourron, Olivier, Ferré, Pascal, Foufelle, Fabienne

“…Non Alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the world, encompassing various conditions ranging from simple…”
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Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver by Dentin, Renaud, Tomas-Cobos, Lidia, Foufelle, Fabienne, Leopold, Jane, Girard, Jean, Postic, Catherine, Ferré, Pascal

“…In liver, the glucose-responsive transcription factor ChREBP plays a critical role in converting excess carbohydrates into triglycerides through de novo…”
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Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes by Szpigel, Anaïs, Hainault, Isabelle, Carlier, Aurélie, Venteclef, Nicolas, Batto, Anne-Françoise, Hajduch, Eric, Bernard, Catherine, Ktorza, Alain, Gautier, Jean-François, Ferré, Pascal, Bourron, Olivier, Foufelle, Fabienne

“…Aims/hypothesis Obesity and type 2 diabetes are concomitant with low-grade inflammation affecting insulin sensitivity and insulin secretion. Recently, the…”
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Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE by Hage Hassan, Rima, Pacheco de Sousa, Ana Catarina, Mahfouz, Rana, Hainault, Isabelle, Blachnio-Zabielska, Agnieszka, Bourron, Olivier, Koskas, Fabien, Górski, Jan, Ferré, Pascal, Foufelle, Fabienne, Hajduch, Eric

“…In vivo, ectopic accumulation of fatty acids in muscles leads to alterations in insulin signaling at both the IRS1 and Akt steps. However, in vitro treatments…”
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Liver X receptor: from metabolism to cancer by Venteclef, Nicolas, Ferré, Pascal

“…Cholesterol plays an indispensable role in regulating the properties of cell membranes in mammalian cells. Accumulation of cholesterol and its intermediates,…”
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Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions by Bandet, Cécile L, Mahfouz, Rana, Véret, Julien, Sotiropoulos, Athanassia, Poirier, Maxime, Giussani, Paola, Campana, Mélanie, Philippe, Erwann, Blachnio-Zabielska, Agnieszka, Ballaire, Raphaëlle, Le Liepvre, Xavier, Bourron, Olivier, Berkeš, Dušan, Górski, Jan, Ferré, Pascal, Le Stunff, Hervé, Foufelle, Fabienne, Hajduch, Eric

“…One main mechanism of insulin resistance (IR), a key feature of type 2 diabetes, is the accumulation of saturated fatty acids (FAs) in the muscles of obese…”
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Short Term Palmitate Supply Impairs Intestinal Insulin Signaling via Ceramide Production by Tran, Thi Thu Trang, Postal, Bárbara Graziela, Demignot, Sylvie, Ribeiro, Agnès, Osinski, Céline, Pais de Barros, Jean-Paul, Blachnio-Zabielska, Agnieszka, Leturque, Armelle, Rousset, Monique, Ferré, Pascal, Hajduch, Eric, Carrière, Véronique

“…The worldwide prevalence of metabolic diseases is increasing, and there are global recommendations to limit consumption of certain nutrients, especially…”
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Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat by Okamoto, Shiki, Sato, Tatsuya, Tateyama, Michihiro, Kageyama, Haruaki, Maejima, Yuko, Nakata, Masanori, Hirako, Satoshi, Matsuo, Takashi, Kyaw, Sanda, Shiuchi, Tetsuya, Toda, Chitoku, Sedbazar, Udval, Saito, Kumiko, Asgar, Nur Farehan, Zhang, Boyang, Yokota, Shigefumi, Kobayashi, Kenta, Foufelle, Fabienne, Ferré, Pascal, Nakazato, Masamitsu, Masuzaki, Hiroaki, Shioda, Seiji, Yada, Toshihiko, Kahn, Barbara B., Minokoshi, Yasuhiko

“…Food selection is essential for metabolic homeostasis and is influenced by nutritional state, food palatability, and social factors such as stress. However,…”
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The Acute Phase Protein Serum Amyloid A Induces Lipolysis and Inflammation in Human Adipocytes through Distinct Pathways by Faty, Aurélie, Ferré, Pascal, Commans, Stéphane

“…The acute phase response (APR) is characterized by alterations in lipid and glucose metabolism leading to an increased delivery of energy substrates. In…”
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New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c by Foufelle, Fabienne, Ferré, Pascal

“…The regulation of hepatic glucose metabolism has a key role in whole-body energy metabolism, since the liver is able to store (glycogen synthesis, lipogenesis)…”
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Characterising the Inhibitory Actions of Ceramide upon Insulin Signaling in Different Skeletal Muscle Cell Models: A Mechanistic Insight by Mahfouz, Rana, Khoury, Rhéa, Blachnio-Zabielska, Agnieszka, Turban, Sophie, Loiseau, Nicolas, Lipina, Christopher, Stretton, Clare, Bourron, Olivier, Ferré, Pascal, Foufelle, Fabienne, Hundal, Harinder S., Hajduch, Eric

“…Ceramides are known to promote insulin resistance in a number of metabolically important tissues including skeletal muscle, the predominant site of…”
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Ceramide analog C2-cer induces a loss in insulin sensitivity in muscle cells through the salvage/recycling pathway by Bandet, Cécile L., Tan-Chen, Sophie, Ali-Berrada, Sarah, Campana, Mélanie, Poirier, Maxime, Blachnio-Zabielska, Agnieszka, Pais-de-Barros, Jean-Paul, Rouch, Claude, Ferré, Pascal, Foufelle, Fabienne, Le Stunff, Hervé, Hajduch, Eric

“…Ceramides have been shown to play a major role in the onset of skeletal muscle insulin resistance and therefore in the prevalence of type 2 diabetes. However,…”
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SREBP transcription factors: master regulators of lipid homeostasis by Eberlé, Delphine, Hegarty, Bronwyn, Bossard, Pascale, Ferré, Pascal, Foufelle, Fabienne

“…Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid homeostasis by controlling the expression of a…”
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Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes by Daval, Marie, Diot-Dupuy, Francine, Bazin, Raymond, Hainault, Isabelle, Viollet, Benoît, Vaulont, Sophie, Hajduch, Eric, Ferré, Pascal, Foufelle, Fabienne

“…Despite its importance in terms of energy homeostasis, the role of AMP-activated protein kinase in adipose tissue remains controversial. Initial studies have…”
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