Suchergebnisse - "Experimental eye research"

Biological functions of tear film von Pflugfelder, Stephen C., Stern, Michael E.

“… Tears have a vital function to protect and lubricate the ocular surface. Tear production, distribution and clearance is tightly regulated by the lacrimal …”
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3D bioprinting of a corneal stroma equivalent von Isaacson, Abigail, Swioklo, Stephen, Connon, Che J.

“… Corneal transplantation constitutes one of the leading treatments for severe cases of loss of corneal function. Due to its limitations, a concerted effort has …”
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Corneal wound healing von Wilson, Steven E.

“… The corneal wound healing response is typically initiated by injuries to the epithelium and/or endothelium that may also involve the stroma. However, it can …”
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Consensus recommendations for trabecular meshwork cell isolation, characterization and culture von Keller, Kate E., Bhattacharya, Sanjoy K., Borrás, Theresa, Brunner, Thomas M., Chansangpetch, Sunee, Clark, Abbott F., Dismuke, W. Michael, Du, Yiqin, Elliott, Michael H., Ethier, C. Ross, Faralli, Jennifer A., Freddo, Thomas F., Fuchshofer, Rudolf, Giovingo, Michael, Gong, Haiyan, Gonzalez, Pedro, Huang, Alex, Johnstone, Murray A., Kaufman, Paul L., Kelley, Mary J., Knepper, Paul A., Kopczynski, Casey C., Kuchtey, John G., Kuchtey, Rachel W., Kuehn, Markus H., Lieberman, Raquel L., Lin, Shan C., Liton, Paloma, Liu, Yutao, Lütjen-Drecoll, Elke, Mao, Weiming, Masis-Solano, Marisse, McDonnell, Fiona, McDowell, Colleen M., Overby, Darryl R., Pattabiraman, Padmanabhan P., Raghunathan, Vijay K., Rao, P. Vasanth, Rhee, Douglas J., Chowdhury, Uttio Roy, Russell, Paul, Samples, John R., Schwartz, Donald, Stubbs, Evan B., Tamm, Ernst R., Tan, James C., Toris, Carol B., Torrejon, Karen Y., Vranka, Janice A., Wirtz, Mary K., Yorio, Thomas, Zhang, Jie, Zode, Gulab S., Fautsch, Michael P., Peters, Donna M., Acott, Ted S., Stamer, W. Daniel

“… Cultured trabecular meshwork (TM) cells are a valuable model system to study the cellular mechanisms involved in the regulation of conventional outflow …”
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Corneal neovascularization von Nicholas, Matthew P., Mysore, Naveen

“… The optical clarity of the cornea is essential for maintaining good visual acuity. Corneal neovascularization, which is a major cause of vision loss worldwide, …”
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Composition, structure and function of the corneal stroma von Espana, Edgar M., Birk, David E.

“… No other tissue in the body depends more on the composition and organization of the extracellular matrix (ECM) for normal structure and function than the …”
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Candidate pathways for retina to scleral signaling in refractive eye growth von Brown, Dillon M., Mazade, Reece, Clarkson-Townsend, Danielle, Hogan, Kelleigh, Datta Roy, Pooja M., Pardue, Machelle T.

“… The global prevalence of myopia, or nearsightedness, has increased at an alarming rate over the last few decades. An eye is myopic if incoming light focuses …”
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Myofibroblasts von Hinz, Boris

“… Myofibroblasts are activated in response to tissue injury with the primary task to repair lost or damaged extracellular matrix. Enhanced collagen secretion and …”
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Oxidative stress induces ferroptotic cell death in retinal pigment epithelial cells von Totsuka, Kiyohito, Ueta, Takashi, Uchida, Takatoshi, Roggia, Murilo F., Nakagawa, Suguru, Vavvas, Demetrios G., Honjo, Megumi, Aihara, Makoto

“… The dysfunction and cell death of retinal pigment epithelial (RPE) cells are hallmarks of late-stage dry (atrophic) age-related macular degeneration (AMD), for …”
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Inflammatory basis for dry eye disease flares von Perez, Victor L., Stern, Michael E., Pflugfelder, Stephen C.

“… Most patients with chronic dry eye disease (DED) have episodic flares, which can be triggered by a variety of activities and environmental stresses. These …”
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Retinal remodeling in human retinitis pigmentosa von Jones, B.W., Pfeiffer, R.L., Ferrell, W.D., Watt, C.B., Marmor, M., Marc, R.E.

“… Retinitis Pigmentosa (RP) in the human is a progressive, currently irreversible neural degenerative disease usually caused by gene defects that disrupt the …”
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Corneal myofibroblasts and fibrosis von Wilson, Steven E.

“… Myofibroblasts are alpha-smooth muscle actin (SMA)+ cells that have a critical role in the corneal stromal response to infections, injuries, and surgeries, and …”
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The renin-angiotensin-aldosterone system and its therapeutic targets von Mirabito Colafella, Katrina M., Bovée, Dominique M., Danser, A.H. Jan

“… The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the regulation of blood pressure and body fluid homeostasis and is a mainstay for the …”
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The many faces of the trabecular meshwork cell von Stamer, W. Daniel, Clark, Abbot F.

“… With the combined purpose of facilitating useful vision over a lifetime, a number of ocular cells have evolved specialized features not found elsewhere in the …”
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TGF beta −1, −2 and −3 in the modulation of fibrosis in the cornea and other organs von Wilson, Steven E.

“… The TGF beta-1, -2 and -3 isoforms are transcribed from different genes but bind to the same receptors and signal through the same canonical and non-canonical …”
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Co-expression modules construction by WGCNA and identify potential prognostic markers of uveal melanoma von Wan, Qi, Tang, Jing, Han, Yu, Wang, Dan

“… Uveal melanoma is an aggressive cancer which has a high percentage recurrence and with a worse prognosis. Identify the potential prognostic markers of uveal …”
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Neuroinflammation in glaucoma: A new opportunity von Williams, Pete A., Marsh-Armstrong, Nick, Howell, Gareth R., Bosco, Alejandra, Danias, John, Simon, John, Di Polo, Adriana, Kuehn, Markus H., Przedborski, Serge, Raff, Martin, Trounce, Ian

“… Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the precise roles are not known. Understanding these complex processes, which …”
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Extracellular matrix in the trabecular meshwork: Intraocular pressure regulation and dysregulation in glaucoma von Vranka, Janice A., Kelley, Mary J., Acott, Ted S., Keller, Kate E.

“… The trabecular meshwork (TM) is located in the anterior segment of the eye and is responsible for regulating the outflow of aqueous humor. Increased resistance …”
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The role of fungi in fungal keratitis von Mills, Bethany, Radhakrishnan, Naveen, Karthikeyan Rajapandian, Siva Ganesa, Rameshkumar, Gunasekaran, Lalitha, Prajna, Prajna, N. Venkatesh

“… Fungal keratitis (FK) accounts for approximately half of the microbial keratitis encountered in low middle income countries (LMICs) and predominantly affect …”
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Narrow-band, long-wavelength lighting promotes hyperopia and retards vision-induced myopia in infant rhesus monkeys von Hung, Li-Fang, Arumugam, Baskar, She, Zhihui, Ostrin, Lisa, Smith, Earl L.

“… The purpose of this investigation was to determine the effects of narrow band, long-wavelength lighting on normal refractive development and the phenomena of …”
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