Výsledky vyhľadávania - "Esmon, Charles T"

Basic mechanisms and pathogenesis of venous thrombosis Autor Esmon, Charles T.

“…In 1856 Virchow proposed a triad of causes for venous thrombosis, postulating that stasis, changes in the vessel wall or changes in the blood could lead to…”
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Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice Autor McDonald, Braedon, Davis, Rachelle P, Kim, Seok-Joo, Tse, Mandy, Esmon, Charles T, Kolaczkowska, Elzbieta, Jenne, Craig N

“…Neutrophil extracellular traps (NETs; webs of DNA coated in antimicrobial proteins) are released into the vasculature during sepsis where they contribute to…”
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Targeting factor Xa and thrombin: impact on coagulation and beyond Autor Esmon, Charles T

“…Great advances have been made in recent years in understanding the haemostatic system and the molecular and cellular basis of thrombus formation. Although…”
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Protein C anticoagulant system—anti-inflammatory effects Autor Esmon, Charles T.

“…Activated protein C (APC) plays active roles in preventing progression of a number of disease processes. These include thrombosis due to its direct…”
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The interactions between inflammation and coagulation Autor Esmon, Charles T.

“…Summary Inflammation initiates clotting, decreases the activity of natural anticoagulant mechanisms and impairs the fibrinolytic system. Inflammatory cytokines…”
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Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury Autor Xu, Jun, Zhang, Xiaomei, Monestier, Marc, Esmon, Naomi L, Esmon, Charles T

“…We previously reported that extracellular histones are major mediators of death in sepsis. Infusion of extracellular histones leads to increased cytokine…”
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Endothelial cell protein C receptor: a multiliganded and multifunctional receptor Autor Mohan Rao, L Vijaya, Esmon, Charles T, Pendurthi, Usha R

“…Endothelial cell protein C receptor (EPCR) was first identified and isolated as a cellular receptor for protein C on endothelial cells. EPCR plays a crucial…”
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Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4 Autor Semeraro, Fabrizio, Ammollo, Concetta T, Morrissey, James H, Dale, George L, Friese, Paul, Esmon, Naomi L, Esmon, Charles T

“…The release of histones from dying cells is associated with microvascular thrombosis and, because histones activate platelets, this could represent a possible…”
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Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition Autor Nazir, Sumra, Gadi, Ihsan, Al-Dabet, Moh'd Mohanad, Elwakiel, Ahmed, Kohli, Shrey, Ghosh, Sanchita, Manoharan, Jayakumar, Ranjan, Satish, Bock, Fabian, Braun-Dullaeus, Ruediger C, Esmon, Charles T, Huber, Tobias B, Camerer, Eric, Dockendorff, Chris, Griffin, John H, Isermann, Berend, Shahzad, Khurrum

“…Cytoprotection by activated protein C (aPC) after ischemia-reperfusion injury (IRI) is associated with apoptosis inhibition. However, IRI is hallmarked by…”
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Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll‐like receptor 9 in mice Autor Huang, Hai, Evankovich, John, Yan, Wei, Nace, Gary, Zhang, Lemeng, Ross, Mark, Liao, Xinghua, Billiar, Timothy, Xu, Jun, Esmon, Charles T., Tsung, Allan

“…Sterile inflammatory insults are known to activate innate immunity and propagate organ damage through the recognition of extracellular damage‐associated…”
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Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients Autor Cohen, Mitchell Jay, Call, Mariah, Nelson, Mary, Calfee, Carolyn S, Esmon, Charles T, Brohi, Karim, Pittet, Jean Francois

“…Recent studies have identified an acute traumatic coagulopathy that is present on admission to the hospital and is independent of iatrogenic causes. We have…”
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Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury Autor Huang, Hai, Chen, Hui-Wei, Evankovich, John, Yan, Wei, Rosborough, Brian R, Nace, Gary W, Ding, Qing, Loughran, Patricia, Beer-Stolz, Donna, Billiar, Timothy R, Esmon, Charles T, Tsung, Allan

“…Cellular processes that drive sterile inflammatory injury after hepatic ischemia/reperfusion (I/R) injury are not completely understood. Activation of the…”
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PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells Autor Gur-Cohen, Shiri, Itkin, Tomer, Chakrabarty, Sagarika, Graf, Claudine, Kollet, Orit, Ludin, Aya, Golan, Karin, Kalinkovich, Alexander, Ledergor, Guy, Wong, Eitan, Niemeyer, Elisabeth, Porat, Ziv, Erez, Ayelet, Sagi, Irit, Esmon, Charles T, Ruf, Wolfram, Lapidot, Tsvee

“…Factors traditionally associated with coagulation and inflammation, such as thrombin, PAR1, aPC and EPCR, also independently control the nitric oxide…”
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EPCR deficiency or function-blocking antibody protects against joint bleeding-induced pathology in hemophilia mice Autor Magisetty, Jhansi, Pendurthi, Usha R, Esmon, Charles T, Rao, L Vijaya Mohan

“…We recently showed that clotting factor VIIa (FVIIa) binding to endothelial cell protein C receptor (EPCR) induces anti-inflammatory signaling and protects…”
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Thrombin spatial distribution determines protein C activation during hemostasis and thrombosis Autor Marar, Tanya T, Matzko, Chelsea N, Wu, Jie, Esmon, Charles T, Sinno, Talid, Brass, Lawrence F, Stalker, Timothy J, Tomaiuolo, Maurizio

“…Rebalancing the hemostatic system by targeting endogenous anticoagulant pathways, like the protein C (PC) system, is being tested as a means of improving…”
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Thrombomodulin Mutations in Atypical Hemolytic–Uremic Syndrome Autor Delvaeye, Mieke, Noris, Marina, De Vriese, Astrid, Esmon, Charles T, Esmon, Naomi L, Ferrell, Gary, Del-Favero, Jurgen, Plaisance, Stephane, Claes, Bart, Lambrechts, Diether, Zoja, Carla, Remuzzi, Giuseppe, Conway, Edward M

“…Atypical hemolytic–uremic syndrome, a complex of microangiopathic hemolytic anemia, thrombocytopenia, and renal failure, is not associated with shigella toxin…”
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Activated protein C has a regulatory role in factor VIII function Autor Wilhelm, Amelia R, Parsons, Nicole A, Samelson-Jones, Benjamin J, Davidson, Robert J, Esmon, Charles T, Camire, Rodney M, George, Lindsey A

“…Mechanisms thought to regulate activated factor VIII (FVIIIa) cofactor function include A2-domain dissociation and activated protein C (APC) cleavage. Unlike…”
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Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice Autor Lopez-Ramirez, Miguel Alejandro, Pham, Angela, Girard, Romuald, Wyseure, Tine, Hale, Preston, Yamashita, Atsuki, Koskimäki, Janne, Polster, Sean, Saadat, Laleh, Romero, Ignacio A, Esmon, Charles T, Lagarrigue, Frederic, Awad, Issam A, Mosnier, Laurent O, Ginsberg, Mark H

“…Cerebral cavernous malformations (CCMs) are common brain vascular dysplasias that are prone to acute and chronic hemorrhage with significant clinical sequelae…”
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The Role of Extracellular Histones in Influenza Virus Pathogenesis Autor Ashar, Harshini K, Mueller, Nathan C, Rudd, Jennifer M, Snider, Timothy A, Achanta, Mallika, Prasanthi, Maram, Pulavendran, Sivasami, Thomas, Paul G, Ramachandran, Akhilesh, Malayer, Jerry R, Ritchey, Jerry W, Rajasekhar, Rachakatla, Chow, Vincent T K, Esmon, Charles T, Teluguakula, Narasaraju

“…Although exaggerated host immune responses have been implicated in influenza-induced lung pathogenesis, the etiologic factors that contribute to these events…”
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Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1 Autor Kondreddy, Vijay, Wang, Jue, Keshava, Shiva, Esmon, Charles T, Rao, L Vijaya Mohan, Pendurthi, Usha R

“…Recent studies show that endothelial cell protein C receptor (EPCR) interacts with diverse ligands, in addition to its known ligands protein C and activated…”
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