Výsledky vyhľadávania - "Erickson, Caroline"

Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors Autor Wang, Eric, Mi, Xiaoli, Thompson, Meghan C, Montoya, Skye, Notti, Ryan Q, Afaghani, Jumana, Durham, Benjamin H, Penson, Alex, Witkowski, Matthew T, Lu, Sydney X, Bourcier, Jessie, Hogg, Simon J, Erickson, Caroline, Cui, Dan, Cho, Hana, Singer, Michael, Totiger, Tulasigeri M, Chaudhry, Sana, Geyer, Mark, Alencar, Alvaro, Linley, Adam J, Palomba, M. Lia, Coombs, Catherine C, Park, Jae H, Zelenetz, Andrew, Roeker, Lindsey, Rosendahl, Mary, Tsai, Donald E, Ebata, Kevin, Brandhuber, Barbara, Hyman, David M, Aifantis, Iannis, Mato, Anthony, Taylor, Justin, Abdel-Wahab, Omar

“…In nine patients with chronic lymphocytic leukemia that responded to the noncovalent BTK inhibitor pirtobrutinib and then developed resistance, analysis…”
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Pharmacologic modulation of RNA splicing enhances anti-tumor immunity Autor Lu, Sydney X, De Neef, Emma, Thomas, James D, Sabio, Erich, Rousseau, Benoit, Gigoux, Mathieu, Knorr, David A, Greenbaum, Benjamin, Elhanati, Yuval, Hogg, Simon J, Chow, Andrew, Ghosh, Arnab, Xie, Abigail, Zamarin, Dmitriy, Cui, Daniel, Erickson, Caroline, Singer, Michael, Cho, Hana, Wang, Eric, Lu, Bin, Durham, Benjamin H, Shah, Harshal, Chowell, Diego, Gabel, Austin M, Shen, Yudao, Liu, Jing, Jin, Jian, Rhodes, Matthew C, Taylor, Richard E, Molina, Henrik, Wolchok, Jedd D, Merghoub, Taha, Diaz, Jr, Luis A, Abdel-Wahab, Omar, Bradley, Robert K

“…Although mutations in DNA are the best-studied source of neoantigens that determine response to immune checkpoint blockade, alterations in RNA splicing within…”
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Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms Autor Durham, Benjamin H, Lopez Rodrigo, Estibaliz, Picarsic, Jennifer, Abramson, David, Rotemberg, Veronica, De Munck, Steven, Pannecoucke, Erwin, Lu, Sydney X, Pastore, Alessandro, Yoshimi, Akihide, Mandelker, Diana, Ceyhan-Birsoy, Ozge, Ulaner, Gary A, Walsh, Michael, Yabe, Mariko, Petrova-Drus, Kseniya, Arcila, Maria E, Ladanyi, Marc, Solit, David B, Berger, Michael F, Hyman, David M, Lacouture, Mario E, Erickson, Caroline, Saganty, Ruth, Ki, Michelle, Dunkel, Ira J, Santa-María López, Vicente, Mora, Jaume, Haroche, Julien, Emile, Jean-Francois, Decaux, Olivier, Geissmann, Frederic, Savvides, Savvas N, Drilon, Alexander, Diamond, Eli L, Abdel-Wahab, Omar

“…Histiocytoses are clonal hematopoietic disorders frequently driven by mutations mapping to the BRAF and MEK1 and MEK2 kinases. Currently, however, the…”
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Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia Autor Wang, Eric, Pineda, Jose Mario Bello, Kim, Won Jun, Chen, Sisi, Bourcier, Jessie, Stahl, Maximilian, Hogg, Simon J, Bewersdorf, Jan Phillipp, Han, Cuijuan, Singer, Michael E, Cui, Daniel, Erickson, Caroline E, Tittley, Steven M, Penson, Alexander V, Knorr, Katherine, Stanley, Robert F, Rahman, Jahan, Krishnamoorthy, Gnana, Fagin, James A, Creger, Emily, McMillan, Elizabeth, Mak, Chi-Ching, Jarvis, Matthew, Bossard, Carine, Beaupre, Darrin M, Bradley, Robert K, Abdel-Wahab, Omar

“…Therapy resistance is a major challenge in the treatment of cancer. Here, we performed CRISPR-Cas9 screens across a broad range of therapies used in acute…”
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Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition Autor Inoue, Daichi, Polaski, Jacob T., Taylor, Justin, Castel, Pau, Chen, Sisi, Kobayashi, Susumu, Hogg, Simon J., Hayashi, Yasutaka, Pineda, Jose Mario Bello, El Marabti, Ettaib, Erickson, Caroline, Knorr, Katherine, Fukumoto, Miki, Yamazaki, Hiromi, Tanaka, Atsushi, Fukui, Chie, Lu, Sydney X., Durham, Benjamin H., Liu, Bo, Wang, Eric, Mehta, Sanjoy, Zakheim, Daniel, Garippa, Ralph, Penson, Alex, Chew, Guo-Liang, McCormick, Frank, Bradley, Robert K., Abdel-Wahab, Omar

“…Most eukaryotes harbor two distinct pre-mRNA splicing machineries: the major spliceosome, which removes >99% of introns, and the minor spliceosome, which…”
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Depression predicts long-term cognitive impairment in survivors of critical illness Autor Nordness, Mina Faye, Bipin Patel, Mayur, Erickson, Caroline R, Kiehl, Amy, Jackson, James C, Raman, Rameela, Pandharipande, Pratik P, Ely, E Wesley, Wilson, Jo Ellen

“…Intensive care unit (ICU) survivorship is associated with long-term cognitive impairment (LTCI). Our work has found post-ICU depression in up to 30% and…”
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Moving the needle on time to resuscitation: An EAST prospective multicenter study of vascular access in hypotensive injured patients using trauma video review Autor Dumas, Ryan P, Vella, Michael A, Maiga, Amelia W, Erickson, Caroline R, Dennis, Brad M, da Luz, Luis T, Pannell, Dylan, Quigley, Emily, Velopulos, Catherine G, Hendzlik, Peter, Marinica, Alexander, Bruce, Nolan, Margolick, Joseph, Butler, Dale F, Estroff, Jordan, Zebley, James A, Alexander, Ashley, Mitchell, Sarah, Grossman Verner, Heather M, Truitt, Michael, Berry, Stepheny, Middlekauff, Jennifer, Luce, Siobhan, Leshikar, David, Krowsoski, Leandra, Bukur, Marko, Polite, Nathan M, McMann, Ashley H, Staszak, Ryan, Armen, Scott B, Horrigan, Tiffany, Moore, Forrest O, Bjordahl, Paul, Guido, Jenny, Mathew, Sarah, Diaz, Bernardo F, Mooney, Jennifer, Hebeler, Katherine, Holena, Daniel N

“…Vascular access in hypotensive trauma patients is challenging. Little evidence exists on the time required and success rates of vascular access types. We…”
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Systematic Evaluation of AML-Associated Antigens Identifies Novel Anti-U5 snRNP200 Therapeutic Antibodies for the Treatment of AML Autor Katherine Knorr, Caroline Erickson, Eric Wang, Jahan Rahman, Xiaoli Mi, Sydney Lu, Nina Fox, Alex Penson, Simon Hogg, Robert Stanley, Daichi Inoue, David Knorr, Jeffrey Ravetch, Omar Abdel-Wahab

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COVID-19 update: the first 6 months of the pandemic Autor Novelli, Giuseppe, Biancolella, Michela, Mehrian-Shai, Ruty, Erickson, Caroline, Godri Pollitt, Krystal J., Vasiliou, Vasilis, Watt, Jessica, Reichardt, Juergen K. V.

“…The COVID-19 pandemic is sweeping the world and will feature prominently in all our lives for months and most likely for years to come. We review here the…”
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Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation Autor Chen, Sisi, Vedula, Rahul S, Cuevas-Navarro, Antonio, Lu, Bin, Hogg, Simon J, Wang, Eric, Benbarche, Salima, Knorr, Katherine, Kim, Won Jun, Stanley, Robert F, Cho, Hana, Erickson, Caroline, Singer, Michael, Cui, Dan, Tittley, Steven, Durham, Benjamin H, Pavletich, Tatiana S, Fiala, Elise, Walsh, Michael F, Inoue, Daichi, Monette, Sebastien, Taylor, Justin, Rosen, Neal, McCormick, Frank, Lindsley, R Coleman, Castel, Pau, Abdel-Wahab, Omar

“…Recently, screens for mediators of resistance to FLT3 and ABL kinase inhibitors in leukemia resulted in the discovery of LZTR1 as an adapter of a Cullin-3 RING…”
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Impaired RAS Proteolysis Drives Clonal Hematopoietic Transformation Autor Benjamin H. Durham, Pau Castel, Caroline Erickson, Frank McCormick, Michael E Singer, Neal Rosen, Hana Cho, Eric Wang, Daniel Cui, R. Coleman Lindsley, Salima Benbarche, Xiaoli Mi, Omar Abdel-Wahab, Rahul S. Vedula, Simon J. Hogg, Sebastien Monette, Won Jun Kim, Antonio Cuevas Navarro, Sisi Chen, Katherine Knorr, Daichi Inoue

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ZRSR2 Mutation Induced Minor Intron Retention Drives MDS and Diverse Cancer Predisposition Via Aberrant Splicing of LZTR1 Autor Daniel Zakheim, Ralph Garippa, Hiromi Yamazaki, Jose Mario Bello Pineda, Ettaib El Marabti, Guo-Liang Chew, Pau Castel, Daichi Inoue, Frank McCormick, Jacob T. Polaski, Bo Liu, Sydney X. Lu, Chie Fukui, Robert K. Bradley, Justin Taylor, Simon J. Hogg, Omar Abdel-Wahab, Miki Fukumoto, Yasutaka Hayashi, Caroline Erickson, Sanjoy Mehta, Benjamin H. Durham, Sisi Chen, Susumu Kobayashi, Alexander V Penson

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Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia Autor Knorr, Katherine, Rahman, Jahan, Erickson, Caroline, Wang, Eric, Monetti, Mara, Li, Zhuoning, Ortiz-Pacheco, Juliana, Jones, Andrew, Lu, Sydney X., Stanley, Robert F., Baez, Maria, Fox, Nina, Castro, Cynthia, Marino, Alessandra E., Jiang, Caroline, Penson, Alex, Hogg, Simon J., Mi, Xiaoli, Nakajima, Hideaki, Kunimoto, Hiroyoshi, Nishimura, Koutarou, Inoue, Daichi, Greenbaum, Benjamin, Knorr, David, Ravetch, Jeffrey, Abdel-Wahab, Omar

“…Despite recent advances in the treatment of acute myeloid leukemia (AML), there has been limited success in targeting surface antigens in AML, in part due to…”
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Addressing Colorectal Cancer Disparities in Unhoused Populations: A Call for Equitable Access and Compassionate Care Autor Decker, Hannah, Erickson, Caroline, Wick, Elizabeth

“…Housing is essential for health. Unhoused individuals have markedly worse health status than the general population culminating in higher rates of premature…”
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Assessing impacts of Landuse and Landcover changes on hydrology for the upper San Pedro watershed Autor Nie, Wenming, Yuan, Yongping, Kepner, William, Nash, Maliha S., Jackson, Michael, Erickson, Caroline

“…► Urban expansion is the strongest contributor for runoff/water yield increase. ► Mesquite invasion into grassland also contributed to runoff change…”
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Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology Autor Xu, Ranjie, Boreland, Andrew J., Li, Xiaoxi, Erickson, Caroline, Jin, Mengmeng, Atkins, Colm, Pang, Zhiping P., Daniels, Brian P., Jiang, Peng

“…Microglia play critical roles in brain development, homeostasis, and disease. Microglia in animal models cannot accurately model human microglia due to notable…”
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Redox Changes in the Livers of Mice Exposed to Environmentally Relevant Doses of 1,4-Dioxane in Drinking Water Autor Erickson, Caroline

“…1,4-dioxane (DX) is designated as a probable human carcinogen (Group 2B) based on demonstrated liver carcinogenicity in animal models. DX was a widely-used…”
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Medical Certification for Utility Shut-Off Protection and Health-Related Social Needs Autor Rosenberg, Julia, Rosenthal, Alice, Castillo, Suzanne, Edwards, Emily, Erickson, Caroline, Nogelo, Patricia, Fenick, Ada M

“…Children in families facing energy insecurity have greater odds of poor health and developmental problems. In this study of families who requested and received…”
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Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells Autor North, Khrystyna, Benbarche, Salima, Liu, Bo, Pangallo, Joseph, Chen, Sisi, Stahl, Maximilian, Bewersdorf, Jan Philipp, Stanley, Robert F., Erickson, Caroline, Cho, Hana, Pineda, Jose Mario Bello, Thomas, James D., Polaski, Jacob T., Belleville, Andrea E., Gabel, Austin M., Udy, Dylan B., Humbert, Olivier, Kiem, Hans-Peter, Abdel-Wahab, Omar, Bradley, Robert K.

“…Many cancers carry recurrent, change-of-function mutations affecting RNA splicing factors. Here, we describe a method to harness this abnormal splicing…”
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Mutant SF3B1 promotes AKT- and NF-κB–driven mammary tumorigenesis Autor Liu, Bo, Liu, Zhaoqi, Chen, Sisi, Ki, Michelle, Erickson, Caroline, Reis-Filho, Jorge S., Durham, Benjamin H., Chang, Qing, de Stanchina, Elisa, Sun, Yiwei, Rabadan, Raul, Abdel-Wahab, Omar, Chandarlapaty, Sarat

“…Mutations in the core RNA splicing factor SF3B1 are prevalent in leukemias and uveal melanoma, but hotspot SF3B1 mutations are also seen in epithelial…”
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