Search Results - "Enzyme"

Pharmacokinetics and Pharmacodynamics of Recombinant Human Angiotensin-Converting Enzyme 2 in Healthy Human Subjects by Haschke, Manuel, Schuster, Manfred, Poglitsch, Marko, Loibner, Hans, Salzberg, Marc, Bruggisser, Marcel, Penninger, Joseph, Krähenbühl, Stephan

“…Background and Objectives Angiotensin-converting enzyme 2 (ACE2) converts angiotensin II (Ang1-8…”
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Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM—Increased serum CIIM in subjects with severe radiographic osteoarthritis by Bay-Jensen, Anne-Christine, Liu, Qi, Byrjalsen, Inger, Li, Yi, Wang, Jianxia, Pedersen, Christian, Leeming, Diana J., Dam, Erik B., Zheng, Qinlong, Qvist, Per, Karsdal, Morten A.

“…In joint degenerative diseases, the collagens are degraded by matrix metalloproteinases and protein fragments are released to serum as potential biomarkers. A…”
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Pronounced between‐subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers by Jacobs, Bart A. W., Deenen, Maarten J., Pluim, Dick, Hasselt, J. G. Coen, Krähenbühl, Martin D., Geel, Robin M. J. M., Vries, Niels, Rosing, Hilde, Meulendijks, Didier, Burylo, Artur M., Cats, Annemieke, Beijnen, Jos H., Huitema, Alwin D. R., Schellens, Jan H. M.

“… between‐subject variability (BSV) and circadian rhythmicity in DPD and TS activity in human volunteers…”
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Corrigendum to “Distinctive domains and activity regulation of core fucosylation enzyme FUT8” [BBA General Subjects 1868 (2024)/130561] by Tomida, Seita, Nagae, Masamichi, Kizuka, Yasuhiko

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Co‐administration of rivaroxaban with drugs that share its elimination pathways: pharmacokinetic effects in healthy subjects by Mueck, Wolfgang, Kubitza, Dagmar, Becka, Michael

“…Aims The anticoagulant rivaroxaban is an oral, direct Factor Xa inhibitor for the management of thromboembolic disorders. Metabolism and excretion involve…”
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Insulin-degrading enzyme higher in subjects with metabolic syndrome by Sofer, Y., Nash, Y., Osher, E., Fursht, O., Goldsmith, G., Nahary, L., Shaklai, S., Tordjman, K. M., Serebro, M., Touati, E. B., Yacobi Bach, M., Marcus, Y., Tal, B., Sack, J., Shefer, G., Margaliot, M., Landis, N., Goldiner, I., Abu Ahmad, W., Stern, N., Benhar, I., Frenkel, D.

“… Insulin-degrading enzyme (IDE) is one of the mechanisms through which insulin blood levels are maintained…”
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Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421 by Lambert, Daniel W, Lambert, Louise A, Clarke, Nicola E, Hooper, Nigel M, Porter, Karen E, Turner, Anthony J

“…ACE2 (angiotensin converting enzyme 2) plays a critical role in the local tissue RAS…”
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A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome by Khan, Akram, Benthin, Cody, Zeno, Brian, Albertson, Timothy E., Boyd, John, Christie, Jason D., Hall, Richard, Poirier, Germain, Ronco, Juan J., Tidswell, Mark, Hardes, Kelly, Powley, William M., Wright, Tracey J., Siederer, Sarah K., Fairman, David A., Lipson, David A., Bayliffe, Andrew I., Lazaar, Aili L.

“…Background Renin-angiotensin system (RAS) signaling and angiotensin-converting enzyme 2 (ACE2…”
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Expression of clinically relevant drug‐metabolizing enzymes along the human intestine and their correlation to drug transporters and nuclear receptors: An intra‐subject analysis by Fritz, Anja, Busch, Diana, Lapczuk, Joanna, Ostrowski, Marek, Drozdzik, Marek, Oswald, Stefan

“… To estimate the impact of intestinal phase I and II metabolism on oral drug absorption, knowledge on the expression levels of the respective enzymes is an essential prerequisite…”
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Large Scale Mass Spectrometry-based Identifications of Enzyme-mediated Protein Methylation Are Subject to High False Discovery Rates by Hart-Smith, Gene, Yagoub, Daniel, Tay, Aidan P, Pickford, Russell, Wilkins, Marc R

“…All large scale LC-MS/MS post-translational methylation site discovery experiments require methylpeptide spectrum matches (methyl-PSMs) to be identified at…”
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Long-term efficacy and safety of vestronidase alfa enzyme replacement therapy in pediatric subjects < 5 years with mucopolysaccharidosis VII by Lau, Heather A., Viskochil, David, Tanpaiboon, Pranoot, Lopez, Antonio Gonzalez-Meneses, Martins, Esmeralda, Taylor, Julie, Malkus, Betsy, Zhang, Lin, Jurecka, Agnieszka, Marsden, Deborah

“…-glucuronidase, a lysosomal enzyme that hydrolyzes glycosaminoglycans (GAGs), including dermatan sulfate (DS…”
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Pancreatic enzyme replacement therapy in subjects with exocrine pancreatic insufficiency and diabetes mellitus: a real-life, case–control study by Alexandre-Heymann, Laure, Yaker, Fetta, Lassen, Pierre Bel, Dubois-Laforgue, Danièle, Larger, Etienne

“… Pancreatic enzyme replacement therapy (PERT) has short and long-term benefits in subjects with EPI, but its effects on diabetes control are uncertain…”
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Words of advice: teaching enzyme kinetics by Srinivasan, Bharath

“… It goes on to emphasize the necessity in taking an interdisciplinary approach in teaching this subject in order to gain a holistic appreciation of its various aspects…”
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The long-term safety and efficacy of vestronidase alfa, rhGUS enzyme replacement therapy, in subjects with mucopolysaccharidosis VII by Wang, Raymond Y., da Silva Franco, José Francisco, López-Valdez, Jaime, Martins, Esmeralda, Sutton, Vernon Reid, Whitley, Chester B., Zhang, Lin, Cimms, Tricia, Marsden, Deborah, Jurecka, Agnieszka, Harmatz, Paul

“…Vestronidase alfa (recombinant human beta-glucuronidase) is an enzyme replacement therapy (ERT…”
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Angiotensin‐converting enzyme gene polymorphism and digestive system cancer risk: A meta‐analysis based on 9656 subjects by Abdeahad, Hossein, Avan, Amir, Khazaei, Majid, Soleimanpour, Saman, Ferns, Gordon A., Fiuji, Hamid, Ryzhikov, Mikhail, Bahrami, Afsane, Hassanian, Seyed Mahdi

“…The angiotensin‐converting enzyme (ACE) is the major regulator of the renin‐angiotensin system, and it has been reported that genetic polymorphisms at this locus are associated with risk in numerous types of human cancers…”
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Impact of single nucleotide polymorphisms (SNPs) in antioxidant-enzyme genes on the concentrations of folate, homocysteine and glutathione in plasma from healthy subjects after folic acid supplementation – a randomized controlled crossover trial by Mansoor, Mohammad Azam, Stea, Tonje Holte, Slettan, Audun, Perera, Erandie, Maddumage, Ridmi, Kottahachchi, Darshana, Ali, Dhikra Saleem, Cabo, Rona, Blomhoff, Rune

“… Our aim was to investigate whether SNPs in antioxidant-enzyme genes impact the concentrations of folate in serum (s-folate…”
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Interferon-γ Secretion Enzyme-Linked Immunospot Assay Determined Among Human T Cell Lymphotropic Virus Type 1-Infected Subjects: A Potential Laboratory Marker for Early HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Diagnosis by Apoliano, Carlos Fernando, Assone, Tatiane, Maciel da Silva, Bosco Christiano, Andreetta Corral, Marcelo, de Oliveira, Augusto Cesar Penalva, Fonseca, Luiz Augusto Marcondes, Duarte, Alberto José da Silva, Tang, Yuyang, Casseb, Jorge

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Enzyme assay and clinical assessment in subjects with a Chinese hotspot late-onset Fabry mutation (IVS4 + 919G→A) by Lin, Hsiang-Yu, Huang, Cheng-Hung, Yu, Hsiao-Chi, Chong, Kah-Wai, Hsu, Ju-Hui, Lee, Pi-Chang, Cheng, Kang-Hsiang, Chiang, Chuan-Chi, Ho, Huey-Jane, Lin, Shuan-Pei, Chen, Shih-Jen, Lin, Po-Kang, Niu, Dau-Ming

“…%), including 14 of 21 men (67%) and 5 of 69 women (7%). Microalbuminuria, based on the urine albumin-to-creatinine ratio measured on at least two occasions, was present in 17 of 86 subjects (20%) (men: 5/20, 25%; women 12/66, 18…”
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MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects by Long, Justin M, Ray, Balmiki, Lahiri, Debomoy K

“…). The rate-limiting step in the production of Aβ from APP is mediated by the β-site APP-cleaving enzyme 1 (BACE1…”
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In vivo measurement of PDE10A enzyme occupancy by positron emission tomography (PET) following single oral dose administration of PF-02545920 in healthy male subjects by Delnomdedieu, Marielle, Forsberg, Anton, Ogden, Adam, Fazio, Patrik, Yu, Ching-Ray, Stenkrona, Per, Duvvuri, Sridhar, David, William, Al-Tawil, Nabil, Vitolo, Ottavio V., Amini, Nahid, Nag, Sangram, Halldin, Christer, Varrone, Andrea

“…Phosphodiesterase 10A (PDE10A) is an enzyme highly enriched in the striatal medium spiny neurons…”
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