Výsledky vyhledávání - "Enhancer Elements"

SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism Autor Oishi, Yumiko, Spann, Nathanael J, Link, Verena M, Muse, Evan D, Strid, Tobias, Edillor, Chantle, Kolar, Matthew J, Matsuzaka, Takashi, Hayakawa, Sumio, Tao, Jenhan, Kaikkonen, Minna U, Carlin, Aaron F, Lam, Michael T, Manabe, Ichiro, Shimano, Hitoshi, Saghatelian, Alan, Glass, Christopher K

“…Macrophages play pivotal roles in both the induction and resolution phases of inflammatory processes. Macrophages have been shown to synthesize…”
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YY1 Is a Structural Regulator of Enhancer-Promoter Loops Autor Weintraub, Abraham S, Li, Charles H, Zamudio, Alicia V, Sigova, Alla A, Hannett, Nancy M, Day, Daniel S, Abraham, Brian J, Cohen, Malkiel A, Nabet, Behnam, Buckley, Dennis L, Guo, Yang Eric, Hnisz, Denes, Jaenisch, Rudolf, Bradner, James E, Gray, Nathanael S, Young, Richard A

“…There is considerable evidence that chromosome structure plays important roles in gene control, but we have limited understanding of the proteins that…”
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Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants Autor Parker, Stephen C J, Stitzel, Michael L, Taylor, D Leland, Orozco, Jose Miguel, Erdos, Michael R, Akiyama, Jennifer A, van Bueren, Kelly Lammerts, Chines, Peter S, Narisu, Narisu, Black, Brian L, Visel, Axel, Pennacchio, Len A, Collins, Francis S

“…Chromatin-based functional genomic analyses and genomewide association studies (GWASs) together implicate enhancers as critical elements influencing gene…”
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Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution Autor Long, Hannah K, Prescott, Sara L, Wysocka, Joanna

“…A class of cis-regulatory elements, called enhancers, play a central role in orchestrating spatiotemporally precise gene-expression programs during…”
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Global view of enhancer-promoter interactome in human cells Autor He, Bing, Chen, Changya, Teng, Li, Tan, Kai

“…Enhancer mapping has been greatly facilitated by various genomic marks associated with it. However, little is available in our toolbox to link enhancers with…”
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Master transcription factors and mediator establish super-enhancers at key cell identity genes Autor Whyte, Warren A, Orlando, David A, Hnisz, Denes, Abraham, Brian J, Lin, Charles Y, Kagey, Michael H, Rahl, Peter B, Lee, Tong Ihn, Young, Richard A

“…Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent…”
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Functional Enhancers Shape Extrachromosomal Oncogene Amplifications Autor Morton, Andrew R, Dogan-Artun, Nergiz, Faber, Zachary J, MacLeod, Graham, Bartels, Cynthia F, Piazza, Megan S, Allan, Kevin C, Mack, Stephen C, Wang, Xiuxing, Gimple, Ryan C, Wu, Qiulian, Rubin, Brian P, Shetty, Shashirekha, Angers, Stephane, Dirks, Peter B, Sallari, Richard C, Lupien, Mathieu, Rich, Jeremy N, Scacheri, Peter C

“…Non-coding regions amplified beyond oncogene borders have largely been ignored. Using a computational approach, we find signatures of significant…”
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Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers Autor Hnisz, Denes, Schuijers, Jurian, Lin, Charles Y, Weintraub, Abraham S, Abraham, Brian J, Lee, Tong Ihn, Bradner, James E, Young, Richard A

“…Super-enhancers and stretch enhancers (SEs) drive expression of genes that play prominent roles in normal and disease cells, but the functional importance of…”
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Systematic mapping of functional enhancer-promoter connections with CRISPR interference Autor Fulco, Charles P, Munschauer, Mathias, Anyoha, Rockwell, Munson, Glen, Grossman, Sharon R, Perez, Elizabeth M, Kane, Michael, Cleary, Brian, Lander, Eric S, Engreitz, Jesse M

“…Gene expression in mammals is regulated by noncoding elements that can affect physiology and disease, yet the functions and target genes of most noncoding…”
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Histone H3K27ac separates active from poised enhancers and predicts developmental state Autor Creyghton, Menno P, Cheng, Albert W, Welstead, G Grant, Kooistra, Tristan, Carey, Bryce W, Steine, Eveline J, Hanna, Jacob, Lodato, Michael A, Frampton, Garrett M, Sharp, Phillip A, Boyer, Laurie A, Young, Richard A, Jaenisch, Rudolf

“…Developmental programs are controlled by transcription factors and chromatin regulators, which maintain specific gene expression programs through epigenetic…”
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Single-cell epigenomics reveals mechanisms of human cortical development Autor Ziffra, Ryan S., Kim, Chang N., Ross, Jayden M., Wilfert, Amy, Turner, Tychele N., Haeussler, Maximilian, Casella, Alex M., Przytycki, Pawel F., Keough, Kathleen C., Shin, David, Bogdanoff, Derek, Kreimer, Anat, Pollard, Katherine S., Ament, Seth A., Eichler, Evan E., Ahituv, Nadav, Nowakowski, Tomasz J.

“…During mammalian development, differences in chromatin state coincide with cellular differentiation and reflect changes in the gene regulatory landscape 1 . In…”
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Architectural and Functional Commonalities between Enhancers and Promoters Autor Kim, Tae-Kyung, Shiekhattar, Ramin

“…With the explosion of genome-wide studies of regulated transcription, it has become clear that traditional definitions of enhancers and promoters need to be…”
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Comprehensive In Vivo Interrogation Reveals Phenotypic Impact of Human Enhancer Variants Autor Kvon, Evgeny Z, Zhu, Yiwen, Kelman, Guy, Novak, Catherine S, Plajzer-Frick, Ingrid, Kato, Momoe, Garvin, Tyler H, Pham, Quan, Harrington, Anne N, Hunter, Riana D, Godoy, Janeth, Meky, Eman M, Akiyama, Jennifer A, Afzal, Veena, Tran, Stella, Escande, Fabienne, Gilbert-Dussardier, Brigitte, Jean-Marçais, Nolwenn, Hudaiberdiev, Sanjarbek, Ovcharenko, Ivan, Dobbs, Matthew B, Gurnett, Christina A, Manouvrier-Hanu, Sylvie, Petit, Florence, Visel, Axel, Dickel, Diane E, Pennacchio, Len A

“…Establishing causal links between non-coding variants and human phenotypes is an increasing challenge. Here, we introduce a high-throughput mouse reporter…”
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Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation Autor Dorighi, Kristel M, Swigut, Tomek, Henriques, Telmo, Bhanu, Natarajan V, Scruggs, Benjamin S, Nady, Nataliya, Still, 2nd, Christopher D, Garcia, Benjamin A, Adelman, Karen, Wysocka, Joanna

“…Monomethylation of histone H3 at lysine 4 (H3K4me1) and acetylation of histone H3 at lysine 27 (H3K27ac) are correlated with transcriptionally engaged enhancer…”
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Neuronal enhancers are hotspots for DNA single-strand break repair Autor Wu, Wei, Kargbo-Hill, Sarah E., Nathan, William J., Paiano, Jacob, Callen, Elsa, Wang, Dongpeng, Shinoda, Kenta, van Wietmarschen, Niek, Colón-Mercado, Jennifer M., Zong, Dali, De Pace, Raffaella, Shih, Han-Yu, Coon, Steve, Parsadanian, Maia, Pavani, Raphael, Hanzlikova, Hana, Park, Solji, Jung, Seol Kyoung, McHugh, Peter J., Canela, Andres, Chen, Chongyi, Casellas, Rafael, Caldecott, Keith W., Ward, Michael E., Nussenzweig, André

“…Defects in DNA repair frequently lead to neurodevelopmental and neurodegenerative diseases, underscoring the particular importance of DNA repair in long-lived…”
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Functional annotation of native enhancers with a Cas9–histone demethylase fusion Autor Kearns, Nicola A, Pham, Hannah, Tabak, Barbara, Genga, Ryan M, Silverstein, Noah J, Garber, Manuel, Maehr, René

“…Targeting a histone demethylase to specific enhancers with Cas9 allows modification of epigenetic marks at the enhancers. Understanding of mammalian enhancers…”
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Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage Autor Wamstad, Joseph A, Alexander, Jeffrey M, Truty, Rebecca M, Shrikumar, Avanti, Li, Fugen, Eilertson, Kirsten E, Ding, Huiming, Wylie, John N, Pico, Alexander R, Capra, John A, Erwin, Genevieve, Kattman, Steven J, Keller, Gordon M, Srivastava, Deepak, Levine, Stuart S, Pollard, Katherine S, Holloway, Alisha K, Boyer, Laurie A, Bruneau, Benoit G

“…Heart development is exquisitely sensitive to the precise temporal regulation of thousands of genes that govern developmental decisions during differentiation…”
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BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis Autor Canver, Matthew C., Smith, Elenoe C., Sher, Falak, Pinello, Luca, Sanjana, Neville E., Shalem, Ophir, Chen, Diane D., Schupp, Patrick G., Vinjamur, Divya S., Garcia, Sara P., Luc, Sidinh, Kurita, Ryo, Nakamura, Yukio, Fujiwara, Yuko, Maeda, Takahiro, Yuan, Guo-Cheng, Zhang, Feng, Orkin, Stuart H., Bauer, Daniel E.

“…Enhancers, critical determinants of cellular identity, are commonly recognized by correlative chromatin marks and gain-of-function potential, although only…”
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PANTHER version 16: a revised family classification, tree-based classification tool, enhancer regions and extensive API Autor Mi, Huaiyu, Ebert, Dustin, Muruganujan, Anushya, Mills, Caitlin, Albou, Laurent-Philippe, Mushayamaha, Tremayne, Thomas, Paul D

“…Abstract PANTHER (Protein Analysis Through Evolutionary Relationships, http://www.pantherdb.org) is a resource for the evolutionary and functional…”
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Enhancer cooperativity can compensate for loss of activity over large genomic distances Autor Thomas, Henry F, Feng, Songjie, Haslhofer, Felix, Huber, Marie, García Gallardo, María, Loubiere, Vincent, Vanina, Daria, Pitasi, Mattia, Stark, Alexander, Buecker, Christa

“…Enhancers are short DNA sequences that activate their target promoter from a distance; however, increasing the genomic distance between the enhancer and the…”
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