Výsledky vyhledávání - "Endocrine System Diseases"

Endocrine toxicities of immune checkpoint inhibitors Autor Wright, Jordan J, Powers, Alvin C, Johnson, Douglas B

“…Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that target two key signalling pathways related to T cell activation and exhaustion, by binding…”
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The Klotho proteins in health and disease Autor Kuro-O, Makoto

“…The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine fibroblast growth factor (FGF) receptor complexes, as they are required for the…”
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COVID-19 and the endocrine system: exploring the unexplored Autor Pal, R., Banerjee, M.

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Long-Term Endocrine and Metabolic Consequences of Cancer Treatment: A Systematic Review Autor Gebauer, Judith, Higham, Claire, Langer, Thorsten, Denzer, Christian, Brabant, Georg

“…Abstract The number of patients surviving ≥5 years after initial cancer diagnosis has significantly increased during the last decades due to considerable…”
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Endoplasmic Reticulum (ER) Stress and Endocrine Disorders Autor Ariyasu, Daisuke, Yoshida, Hiderou, Hasegawa, Yukihiro

“…The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within…”
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Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease Autor Rickard, Brittany P., Rizvi, Imran, Fenton, Suzanne E.

“…Per- and poly-fluoroalkyl substances (PFAS) are widespread environmental contaminants frequently detected in drinking water supplies worldwide that have been…”
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The role of cellular senescence in ageing and endocrine disease Autor Khosla, Sundeep, Farr, Joshua N, Tchkonia, Tamara, Kirkland, James L

“…With the ageing of the global population, interest is growing in the 'geroscience hypothesis', which posits that manipulation of fundamental ageing mechanisms…”
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Immunotoxicity from checkpoint inhibitor therapy: clinical features and underlying mechanisms Autor Fessas, Petros, Possamai, Lucia A., Clark, James, Daniels, Ella, Gudd, Cathrin, Mullish, Benjamin H., Alexander, James L., Pinato, David J.

“…Summary Immune checkpoint inhibition with monoclonal antibodies is becoming increasingly commonplace in cancer medicine, having contributed to a widening of…”
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The role of regulated necrosis in endocrine diseases Autor Tonnus, Wulf, Belavgeni, Alexia, Beuschlein, Felix, Eisenhofer, Graeme, Fassnacht, Martin, Kroiss, Matthias, Krone, Nils P, Reincke, Martin, Bornstein, Stefan R, Linkermann, Andreas

“…The death of endocrine cells is involved in type 1 diabetes mellitus, autoimmunity, adrenopause and hypogonadotropism. Insights from research on basic cell…”
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Endocrine-related adverse events associated with immune checkpoint blockade and expert insights on their management Autor Sznol, Mario, Postow, Michael A., Davies, Marianne J., Pavlick, Anna C., Plimack, Elizabeth R., Shaheen, Montaser, Veloski, Colleen, Robert, Caroline

“…•High-grade immune-related endocrinopathies occur in ∼1–2% of patients.•Can affect thyroid, pituitary, adrenal, gonadal or islet cell…”
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Endocrine causes of nonalcoholic fatty liver disease Autor Marino, Laura, Jornayvaz, François R

“…Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the industrialized world. The prevalence of NAFLD is increasing,…”
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Interplay between endocrine disorders and liver dysfunction: Mechanisms of damage and therapeutic approaches Autor Vargas-Beltran, Andres M, Armendariz-Pineda, Samantha M, Martínez-Sánchez, Froylan D, Martinez-Perez, Carolina, Torre, Aldo, Cordova-Gallardo, Jacqueline

“…Endocrine disorders frequently lead to metabolic disturbances that significantly affect liver function. Understanding the complex interplay between hormonal…”
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Autoimmune endocrine diseases Autor Ruggeri, Rosaria M, Giuffrida, Giuseppe, Campennì, Alfredo

“…The endocrine system is interested by several autoimmune diseases, characterized by different impact and severity, according to the organs involved. Autoimmune…”
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Cancer immunotherapy — immune checkpoint blockade and associated endocrinopathies Autor Byun, David J., Wolchok, Jedd D., Rosenberg, Lynne M., Girotra, Monica

“…Key Points The emergence of cancer immunotherapy has revolutionized cancer treatment but is associated with serious immune-related adverse effects (IRAEs)…”
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Endocrine disorders in Prader-Willi syndrome: a model to understand and treat hypothalamic dysfunction Autor Tauber, Maithé, Hoybye, Charlotte

“…Prader-Willi syndrome is a rare genetic neurodevelopmental disorder resulting from the loss of expression of maternally imprinted genes located in the paternal…”
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Novel Role of the SIRT1 in Endocrine and Metabolic Diseases Autor Lu, Chenxi, Zhao, Huadong, Liu, Yanqing, Yang, Zhi, Yao, Hairong, Liu, Tong, Gou, Tiantian, Wang, Li, Zhang, Juan, Tian, Ye, Yang, Yang, Zhang, Huan

“…Silent information regulator 1 (SIRT1), a highly conserved NAD -dependent deacetylase, is a cellular regulator that has received extensive attention in recent…”
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Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice Guideline Autor Newman, Connie B, Blaha, Michael J, Boord, Jeffrey B, Cariou, Bertrand, Chait, Alan, Fein, Henry G, Ginsberg, Henry N, Goldberg, Ira J, Murad, M Hassan, Subramanian, Savitha, Tannock, Lisa R

“…Abstract Objective This guideline will provide the practicing endocrinologist with an approach to the assessment and treatment of dyslipidemia in patients with…”
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How I treat thalassemia Autor Rachmilewitz, Eliezer A, Giardina, Patricia J

“…The purpose of this article is to set forth our approach to diagnosing and managing the thalassemias, including β-thalassemia intermedia and β-thalassemia…”
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Autoimmune polyglandular diseases Autor Kahaly, George J., Frommer, Lara

“…Autoimmune polyglandular diseases (APD) are defined as the presence of two autoimmune –induced endocrine failures. With respect to the significant morbidity…”
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The endocrine manifestations of anorexia nervosa: mechanisms and management Autor Schorr, Melanie, Miller, Karen K.

“…Key Points Anorexia nervosa is associated with endocrine dysregulation, including dysfunction of the hypothalamic–pituitary axis and alterations in adipokines…”
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