Search Results - "Elliott, Paul"

Photophysics and photochemistry of 1,2,3-triazole-based complexes by Scattergood, Paul A., Sinopoli, Alessandro, Elliott, Paul I.P.

“…[Display omitted] •Triazole-based ‘click’ chemistry is a versatile tool in ligand design.•Triazole-based ligands enable access to rich coordination…”
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Reversible interactions with para-hydrogen enhance NMR sensitivity by polarization transfer by Adams, Ralph W, Aguilar, Juan A, Atkinson, Kevin D, Cowley, Michael J, Elliott, Paul I P, Duckett, Simon B, Green, Gary G R, Khazal, Iman G, López-Serrano, Joaquín, Williamson, David C

“…The sensitivity of both nuclear magnetic resonance spectroscopy and magnetic resonance imaging is very low because the detected signal strength depends on the…”
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An unexpected journey from highly tunable phosphorescence to novel photochemistry of 1,2,3-triazole-based complexes by Scattergood, Paul A, Elliott, Paul I P

“…The photophysical properties of transition metal complexes have long attracted interest in the literature with significant research activity during the past…”
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Persistent COVID-19 symptoms in a community study of 606,434 people in England by Whitaker, Matthew, Elliott, Joshua, Chadeau-Hyam, Marc, Riley, Steven, Darzi, Ara, Cooke, Graham, Ward, Helen, Elliott, Paul

“…Long COVID remains a broadly defined syndrome, with estimates of prevalence and duration varying widely. We use data from rounds 3–5 of the REACT-2 study ( n  …”
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OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis by Mevissen, Tycho E T, Hospenthal, Manuela K, Geurink, Paul P, Elliott, Paul R, Akutsu, Masato, Arnaudo, Nadia, Ekkebus, Reggy, Kulathu, Yogesh, Wauer, Tobias, El Oualid, Farid, Freund, Stefan M V, Ovaa, Huib, Komander, David

“…Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. Several OTU DUBs were reported to…”
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The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity by Damgaard, Rune Busk, Walker, Jennifer A, Marco-Casanova, Paola, Morgan, Neil V, Titheradge, Hannah L, Elliott, Paul R, McHale, Duncan, Maher, Eamonn R, McKenzie, Andrew N J, Komander, David

“…Methionine-1 (M1)-linked ubiquitin chains regulate the activity of NF-κB, immune homeostasis, and responses to infection. The importance of negative regulators…”
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Triazole-based osmium() complexes displaying red/near-IR luminescence: antimicrobial activity and super-resolution imaging by Smitten, Kirsty L, Scattergood, Paul A, Kiker, Charlotte, Thomas, Jim A, Elliott, Paul I. P

“…Cellular uptake, luminescence imaging and antimicrobial activity against clinically relevant methicillin-resistant S. aureus (MRSA) bacteria are reported. The…”
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Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease by Elliott, Joshua, Bodinier, Barbara, Bond, Tom A, Chadeau-Hyam, Marc, Evangelou, Evangelos, Moons, Karel G M, Dehghan, Abbas, Muller, David C, Elliott, Paul, Tzoulaki, Ioanna

“…The incremental value of polygenic risk scores in addition to well-established risk prediction models for coronary artery disease (CAD) is uncertain. To…”
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SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling by Elliott, Paul R, Leske, Derek, Hrdinka, Matous, Bagola, Katrin, Fiil, Berthe K, McLaughlin, Stephen H, Wagstaff, Jane, Volkmar, Norbert, Christianson, John C, Kessler, Benedikt M, Freund, Stefan M V, Komander, David, Gyrd-Hansen, Mads

“…The linear ubiquitin chain assembly complex (LUBAC) regulates immune signaling, and its function is regulated by the deubiquitinases OTULIN and CYLD, which…”
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Unravelling the Mechanism of Excited-State Interligand Energy Transfer and the Engineering of Dual Emission in [Ir(C ∧ N) 2 (N ∧ N)] + Complexes by Scattergood, Paul A, Ranieri, Anna M, Charalambou, Luke, Comia, Adrian, Ross, Daniel A W, Rice, Craig R, Hardman, Samantha J O, Heully, Jean-Louis, Dixon, Isabelle M, Massi, Massimiliano, Alary, Fabienne, Elliott, Paul I P

“…Fundamental insights into the mechanism of triplet-excited-state interligand energy transfer dynamics and the origin of dual emission for phosphorescent…”
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Assembly and specific recognition of k29- and k33-linked polyubiquitin by Michel, Martin A, Elliott, Paul R, Swatek, Kirby N, Simicek, Michal, Pruneda, Jonathan N, Wagstaff, Jane L, Freund, Stefan M V, Komander, David

“…Protein ubiquitination regulates many cellular processes via attachment of structurally and functionally distinct ubiquitin (Ub) chains. Several atypical chain…”
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Molecular basis of MKLP2-dependent Aurora B transport from chromatin to the anaphase central spindle by Serena, Michela, Bastos, Ricardo Nunes, Elliott, Paul R, Barr, Francis A

“…The Aurora B chromosomal passenger complex (CPC) is a conserved regulator of mitosis. Its functions require localization first to the chromosome arms and then…”
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Synthesis and Photochromism of Novel Pyridyl-Substituted Naphthopyrans by de Azevedo, Orlando D. C. C., Elliott, Paul I. P., Gabbutt, Christopher D., Heron, B. Mark, Lord, Kyle J., Pullen, Christopher

“…Multitarget synthetic strategies to access novel photochromic 3H-naphtho[2,1-b]pyrans decorated with pyridyl units are described. The new pyridyl-substituted…”
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Spotlight collection on photoinduced redox chemistry by Elliott, Paul I P, Heinze, Katja, Teets, Thomas S

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TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure by Boyle, Keith B, Ellison, Cara J, Elliott, Paul R, Schuschnig, Martina, Grimes, Krista, Dionne, Marc S, Sasakawa, Chihiro, Munro, Sean, Martens, Sascha, Randow, Felix

“…Invasive bacteria enter the cytosol of host cells through initial uptake into bacteria‐containing vacuoles (BCVs) and subsequent rupture of the BCV membrane,…”
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Luminescent osmium(ii) bi-1,2,3-triazol-4-yl complexes: photophysical characterisation and application in light-emitting electrochemical cells by Ross, Daniel A W, Scattergood, Paul A, Babaei, Azin, Pertegás, Antonio, Bolink, Henk J, Elliott, Paul I P

“…The series of osmium(ii) complexes [Os(bpy)3-n(btz)n][PF6]2 (bpy = 2,2'-bipyridyl, btz = 1,1'-dibenzyl-4,4'-bi-1,2,3-triazolyl, n = 0, n = 1, n = 2, n = 3),…”
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Prediction and Rationalization of Different Photochemical Behaviors of mer - and fac -Isomers of [Ru(pyridyltriazole) 3 ] 2 by Scattergood, Paul A, Elliott, Paul I P

“…Facial and meridional isomerism of metal complexes is known to result in fundamental differences in photophysical properties. One may also envisage differences…”
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Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England by Whitaker, Matthew, Elliott, Joshua, Bodinier, Barbara, Barclay, Wendy, Ward, Helen, Cooke, Graham, Donnelly, Christl A., Chadeau-Hyam, Marc, Elliott, Paul

“…Infection with SARS-CoV-2 virus is associated with a wide range of symptoms. The REal-time Assessment of Community Transmission − 1 (REACT-1) study monitored…”
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Molecular basis for specificity of the Met1-linked polyubiquitin signal by Elliott, Paul R

“…The post-translational modification of proteins provides a rapid and versatile system for regulating all signalling pathways. Protein ubiquitination is one…”
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Molecular basis and regulation of OTULIN-LUBAC interaction by Elliott, Paul R, Nielsen, Sofie V, Marco-Casanova, Paola, Fiil, Berthe Katrine, Keusekotten, Kirstin, Mailand, Niels, Freund, Stefan M V, Gyrd-Hansen, Mads, Komander, David

“…The linear ubiquitin (Ub) chain assembly complex (LUBAC) generates Met1-linked "linear" Ub chains that regulate the activation of the nuclear factor κB (NFκB)…”
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