Suchergebnisse - "Elhanati, Yuval"

Inferring processes underlying B-cell repertoire diversity von Elhanati, Yuval, Sethna, Zachary, Marcou, Quentin, Callan, Jr, Curtis G, Mora, Thierry, Walczak, Aleksandra M

“… We quantify the VDJ recombination and somatic hypermutation processes in human B cells using probabilistic inference methods on high-throughput DNA sequence …”
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Quantifying selection in immune receptor repertoires von Elhanati, Yuval, Murugan, Anand, Callan, Jr, Curtis G, Mora, Thierry, Walczak, Aleksandra M

“… The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell …”
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Population variability in the generation and selection of T-cell repertoires von Sethna, Zachary, Isacchini, Giulio, Dupic, Thomas, Mora, Thierry, Walczak, Aleksandra M., Elhanati, Yuval

“… The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ …”
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Genetic and environmental determinants of human TCR repertoire diversity von Krishna, Chirag, Chowell, Diego, Gönen, Mithat, Elhanati, Yuval, Chan, Timothy A.

“… T cell discrimination of self and non-self is the foundation of the adaptive immune response, and is orchestrated by the interaction between T cell receptors …”
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repgenHMM: a dynamic programming tool to infer the rules of immune receptor generation from sequence data von Elhanati, Yuval, Marcou, Quentin, Mora, Thierry, Walczak, Aleksandra M.

“… Motivation: The diversity of the immune repertoire is initially generated by random rearrangements of the receptor gene during early T and B cell development …”
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Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires von Pogorelyy, Mikhail V., Elhanati, Yuval, Marcou, Quentin, Sycheva, Anastasiia L., Komech, Ekaterina A., Nazarov, Vadim I., Britanova, Olga V., Chudakov, Dmitriy M., Mamedov, Ilgar Z., Lebedev, Yury B., Mora, Thierry, Walczak, Aleksandra M.

“… The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent …”
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DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age von Urbanus, Jos, Cosgrove, Jason, Beltman, Joost B., Elhanati, Yuval, Moral, Rafael A., Conrad, Cecile, van Heijst, Jeroen W., Tubeuf, Emilie, Velds, Arno, Kok, Lianne, Merle, Candice, Magnusson, Jens P., Guyonnet, Léa, Frisén, Jonas, Fre, Silvia, Walczak, Aleksandra M., Mora, Thierry, Jacobs, Heinz, Schumacher, Ton N., Perié, Leïla

“… Ageing is associated with changes in the cellular composition of the immune system. During ageing, hematopoietic stem and progenitor cells (HSPCs) that produce …”
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Metabolic Variability in Micro-Populations von Elhanati, Yuval, Brenner, Naama

“… Biological cells in a population are variable in practically every property. Much is known about how variability of single cells is reflected in the …”
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Preoperative immune checkpoint inhibition and cryoablation in early-stage breast cancer von Comen, Elizabeth, Budhu, Sadna, Elhanati, Yuval, Page, David, Rasalan-Ho, Teresa, Ritter, Erika, Wong, Phillip, Plitas, George, Patil, Sujata, Brogi, Edi, Jochelson, Maxine, Bryce, Yolanda, Solomon, Stephen B., Norton, Larry, Merghoub, Taha, McArthur, Heather L.

“… Local cryoablation can engender systemic immune activation/anticancer responses in tumors otherwise resistant to immune checkpoint blockade (ICB). We evaluated …”
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Evidence for Shaping of Light Chain Repertoire by Structural Selection von Toledano, Adar, Elhanati, Yuval, Benichou, Jennifer I. C., Walczak, Aleksandra M., Mora, Thierry, Louzoun, Yoram

“… The naïve immunoglobulin (IG) repertoire in the blood differs from the direct output of the rearrangement process. These differences stem from selection that …”
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High-throughput interrogation of immune responses using the Human Immune Profiling Pipeline von Wang, Guanning, Lyudovyk, Olga, Kim, Justin Y., Lin, Ya-Hui, Elhanati, Yuval, Mathew, Divij, Wherry, E. John, Herati, Ramin S., Greenplate, Allison R., Greenbaum, Benjamin, Vardhana, Santosha A., Huang, Alexander C.

“… The current abundance of immunotherapy clinical trials presents an opportunity to learn about the underlying mechanisms and pharmacodynamic effects of novel …”
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OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs von Sethna, Zachary, Elhanati, Yuval, Callan, Curtis G, Walczak, Aleksandra M, Mora, Thierry

“… High-throughput sequencing of large immune repertoires has enabled the development of methods to predict the probability of generation by V(D)J recombination …”
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Predicting the spectrum of TCR repertoire sharing with a data‐driven model of recombination von Elhanati, Yuval, Sethna, Zachary, Callan, Curtis G., Mora, Thierry, Walczak, Aleksandra M.

“… Summary Despite the extreme diversity of T‐cell repertoires, many identical T‐cell receptor (TCR) sequences are found in a large number of individual mice and …”
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Neoantigen quality predicts immunoediting in survivors of pancreatic cancer von Łuksza, Marta, Sethna, Zachary M., Rojas, Luis A., Lihm, Jayon, Bravi, Barbara, Elhanati, Yuval, Soares, Kevin, Amisaki, Masataka, Dobrin, Anton, Hoyos, David, Guasp, Pablo, Zebboudj, Abderezak, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Odgerel, Zagaa, Leung, Joanne, Kappagantula, Rajya, Makohon-Moore, Alvin, Johns, Amber, Gill, Anthony, Gigoux, Mathieu, Wolchok, Jedd, Merghoub, Taha, Sadelain, Michel, Patterson, Erin, Monasson, Remi, Mora, Thierry, Walczak, Aleksandra M., Cocco, Simona, Iacobuzio-Donahue, Christine, Greenbaum, Benjamin D., Balachandran, Vinod P.

“… Cancer immunoediting 1 is a hallmark of cancer 2 that predicts that lymphocytes kill more immunogenic cancer cells to cause less immunogenic clones to dominate …”
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RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer von Sethna, Zachary, Guasp, Pablo, Reiche, Charlotte, Milighetti, Martina, Ceglia, Nicholas, Patterson, Erin, Lihm, Jayon, Payne, George, Lyudovyk, Olga, Rojas, Luis A., Pang, Nan, Ohmoto, Akihiro, Amisaki, Masataka, Zebboudj, Abderezak, Odgerel, Zagaa, Bruno, Emmanuel M., Zhang, Siqi Linsey, Cheng, Charlotte, Elhanati, Yuval, Derhovanessian, Evelyna, Manning, Luisa, Müller, Felicitas, Rhee, Ina, Yadav, Mahesh, Merghoub, Taha, Wolchok, Jedd D., Basturk, Olca, Gönen, Mithat, Epstein, Andrew S., Momtaz, Parisa, Park, Wungki, Sugarman, Ryan, Varghese, Anna M., Won, Elizabeth, Desai, Avni, Wei, Alice C., D’Angelica, Michael I., Kingham, T. Peter, Soares, Kevin C., Jarnagin, William R., Drebin, Jeffrey, O’Reilly, Eileen M., Mellman, Ira, Sahin, Ugur, Türeci, Özlem, Greenbaum, Benjamin D., Balachandran, Vinod P.

“… A fundamental challenge for cancer vaccines is to generate long-lived functional T cells that are specific for tumour antigens. Here we find that mRNA–lipoplex …”
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Pharmacologic modulation of RNA splicing enhances anti-tumor immunity von Lu, Sydney X, De Neef, Emma, Thomas, James D, Sabio, Erich, Rousseau, Benoit, Gigoux, Mathieu, Knorr, David A, Greenbaum, Benjamin, Elhanati, Yuval, Hogg, Simon J, Chow, Andrew, Ghosh, Arnab, Xie, Abigail, Zamarin, Dmitriy, Cui, Daniel, Erickson, Caroline, Singer, Michael, Cho, Hana, Wang, Eric, Lu, Bin, Durham, Benjamin H, Shah, Harshal, Chowell, Diego, Gabel, Austin M, Shen, Yudao, Liu, Jing, Jin, Jian, Rhodes, Matthew C, Taylor, Richard E, Molina, Henrik, Wolchok, Jedd D, Merghoub, Taha, Diaz, Jr, Luis A, Abdel-Wahab, Omar, Bradley, Robert K

“… Although mutations in DNA are the best-studied source of neoantigens that determine response to immune checkpoint blockade, alterations in RNA splicing within …”
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Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses von Lyudovyk, Olga, Kim, Justin Y, Qualls, David, Hwee, Madeline A, Lin, Ya-Hui, Boutemine, Sawsan R, Elhanati, Yuval, Solovyov, Alexander, Douglas, Melanie, Chen, Eunise, Babady, N Esther, Ramanathan, Lakshmi, Vedantam, Pallavi, Bandlamudi, Chaitanya, Gouma, Sigrid, Wong, Philip, Hensley, Scott E, Greenbaum, Benjamin, Huang, Alexander C, Vardhana, Santosha A

“… How immune dysregulation affects recovery from COVID-19 infection in patients with cancer remains unclear. We analyzed cellular and humoral immune responses in …”
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Population variability in the generation and thymic selection of T-cell repertoires von Sethna, Zachary, Isacchini, Giulio, Dupic, Thomas, Mora, Thierry, Walczak, Aleksandra, Elhanati, Yuval

“… The diversity of T-cell receptor (TCR) repertoires is achieved by a combination of two intrinsically stochastic steps: random receptor generation by VDJ …”
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A Prospective, Phase 1 Trial of Nivolumab, Ipilimumab, and Radiotherapy in Patients with Advanced Melanoma von Postow, Michael A, Knox, Susan J, Goldman, Debra A, Elhanati, Yuval, Mavinkurve, Vikram, Wong, Phillip, Halpenny, Darragh, Reddy, Sunil K, Vado, Kenya, McCabe, Danielle, Ramirez, Kristen Aufiero, Macri, Mary, Schwarzenberger, Paul, Ricciardi, Toni, Ryan, Aileen, Venhaus, Ralph, Momtaz, Parisa, Shoushtari, Alexander N, Callahan, Margaret K, Chapman, Paul B, Wolchok, Jedd D, Subrahmanyam, Priyanka B, Maecker, Holden T, Panageas, Katherine S, Barker, Christopher A

“… Preclinical data suggest that radiotherapy (RT) is beneficial in combination with immune checkpoint blockade. Clinical trials have explored RT with …”
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Langerhans dendritic cell vaccine bearing mRNA-encoded tumor antigens induces antimyeloma immunity after autotransplant von Chung, David J., Sharma, Sneh, Rangesa, Madhumitha, DeWolf, Susan, Elhanati, Yuval, Perica, Karlo, Young, James W.

“… Posttransplant vaccination targeting residual disease is an immunotherapeutic strategy to improve antigen-specific immune responses and prolong disease-free …”
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