Search Results - "Effros, Rita B"

T cell replicative senescence in human aging by Chou, Jennifer P, Effros, Rita B

“…The decline of the immune system appears to be an intractable consequence of aging, leading to increased susceptibility to infections, reduced effectiveness of…”
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Chronic inflammation in the etiology of disease across the life span by Furman, David, Campisi, Judith, Verdin, Eric, Carrera-Bastos, Pedro, Targ, Sasha, Franceschi, Claudio, Ferrucci, Luigi, Gilroy, Derek W, Fasano, Alessio, Miller, Gary W, Miller, Andrew H, Mantovani, Alberto, Weyand, Cornelia M, Barzilai, Nir, Goronzy, Jorg J, Rando, Thomas A, Effros, Rita B, Lucia, Alejandro, Kleinstreuer, Nicole, Slavich, George M

“…Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain…”
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Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein by Watson, Melanie B., Richter, Franziska, Lee, Soo Kyung, Gabby, Lauryn, Wu, Jennifer, Masliah, Eliezer, Effros, Rita B., Chesselet, Marie-Françoise

“…Parkinson's disease (PD) is characterized by widespread alpha-synuclein pathology and neuronal loss, primarily of the nigrostriatal dopaminergic neurons…”
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Vaccination in the elderly: an immunological perspective by Chen, Wilbur H., Kozlovsky, Bernard F., Effros, Rita B., Grubeck-Loebenstein, Beatrix, Edelman, Robert, Sztein, Marcelo B.

“…Successful vaccination of the elderly against important infectious pathogens that cause high morbidity and mortality represents a growing public health…”
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Distinct aging profiles of CD8+ T cells in blood versus gastrointestinal mucosal compartments by Dock, Jeffrey, Ramirez, Christina M., Hultin, Lance, Hausner, Mary Ann, Hultin, Patricia, Elliott, Julie, Yang, Otto O., Anton, Peter A., Jamieson, Beth D., Effros, Rita B.

“…A hallmark of human immunosenescence is the accumulation of late-differentiated memory CD8+ T cells with features of replicative senescence, such as inability…”
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Prostaglandin E2 Promotes Features of Replicative Senescence in Chronically Activated Human CD8+ T Cells by Chou, Jennifer P., Ramirez, Christina M., Ryba, Danielle M., Koduri, Megha P., Effros, Rita B.

“…Prostaglandin E2 (PGE2), a pleiotropic immunomodulatory molecule, and its free radical catalyzed isoform, iso-PGE2, are frequently elevated in the context of…”
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Accelerated Aging in HIV/AIDS: Novel Biomarkers of Senescent Human CD8+ T Cells by Chou, Jennifer P., Ramirez, Christina M., Wu, Jennifer E., Effros, Rita B.

“…Clinical evaluation of immune reconstitution and health status during HIV-1 infection and anti-retroviral therapy (ART) is largely based on CD4+ T cell counts…”
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Challenges for vaccination in the elderly by Aspinall, Richard, Del Giudice, Giuseppe, Effros, Rita B, Grubeck-Loebenstein, Beatrix, Sambhara, Suryaprakash

“…The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the…”
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The silent war of CMV in aging and HIV infection by Effros, Rita B.

“…•Importance of to human health.•Replicative senescence within the human immune system.•Senescent T cells accumulate with age.•Cytomegalovirus is a major driver…”
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The Dual Impact of HIV-1 Infection and Aging on Naïve CD4+ T-Cells: Additive and Distinct Patterns of Impairment by Rickabaugh, Tammy M., Kilpatrick, Ryan D., Hultin, Lance E., Hultin, Patricia M., Hausner, Mary Ann, Sugar, Catherine A., Althoff, Keri N., Margolick, Joseph B., Rinaldo, Charles R., Detels, Roger, Phair, John, Effros, Rita B., Jamieson, Beth D.

“…HIV-1-infected adults over the age of 50 years progress to AIDS more rapidly than adults in their twenties or thirties. In addition, HIV-1-infected individuals…”
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Telomere/telomerase dynamics within the human immune system: Effect of chronic infection and stress by Effros, Rita B.

“…Aging of the immune system is a major factor responsible for the increased severity of infections, reduced responses to vaccines, and higher cancer incidence…”
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Roy Walford and the immunologic theory of aging by Effros, Rita B

“…Roy Walford died on April 27, 2004, at the age of 79. His contributions to gerontological research in such diverse areas as caloric restriction, genetics of…”
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Immunosenescence: what does it mean to health outcomes in older adults? by McElhaney, Janet E, Effros, Rita B

“…The most profound consequences of immune senescence with respect to human health are the increased susceptibility to infectious diseases and decreased vaccine…”
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Role of T lymphocyte replicative senescence in vaccine efficacy by Effros, Rita B.

“…Immunological changes associated with aging play a major role in both the blunted responses to infections as well as to vaccines intended to prevent many of…”
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Functional Assessment of Pharmacological Telomerase Activators in Human T Cells by Molgora, Brenda, Bateman, Riley, Sweeney, Greg, Finger, Danielle, Dimler, Taylor, Effros, Rita, Valenzuela, Hector

“…Telomeres are structures at the ends of chromosomes that shorten during cell division and eventually signal an irreversible state of growth arrest known as…”
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HIV and aging: state of knowledge and areas of critical need for research. A report to the NIH Office of AIDS Research by the HIV and Aging Working Group by High, Kevin P, Brennan-Ing, Mark, Clifford, David B, Cohen, Mardge H, Currier, Judith, Deeks, Steven G, Deren, Sherry, Effros, Rita B, Gebo, Kelly, Goronzy, Jörg J, Justice, Amy C, Landay, Alan, Levin, Jules, Miotti, Paolo G, Munk, Robert J, Nass, Heidi, Rinaldo, Jr, Charles R, Shlipak, Michael G, Tracy, Russell, Valcour, Victor, Vance, David E, Walston, Jeremy D, Volberding, Paul

“…HIV risk behaviors, susceptibility to HIV acquisition, progression of disease after infection, and response to antiretroviral therapy all vary by age. In those…”
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Insomnia and Telomere Length in Older Adults by Carroll, Judith E, Esquivel, Stephanie, Goldberg, Alyssa, Seeman, Teresa E, Effros, Rita B, Dock, Jeffrey, Olmstead, Richard, Breen, Elizabeth C, Irwin, Michael R

“…Insomnia, particularly in later life, may raise the risk for chronic diseases of aging and mortality through its effect on cellular aging. The current study…”
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Kleemeier Award Lecture 2008--the canary in the coal mine: telomeres and human healthspan by Effros, Rita B

“…Telomeres, the repeated series of DNA sequences that cap the ends of linear chromosomes, become shorter during cell division and oxidative stress. Shortened…”
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Differential impairment of lytic and cytokine functions in senescent human immunodeficiency virus type 1-specific cytotoxic T lymphocytes by Dagarag, Mirabelle, Ng, Hwee, Lubong, Rachel, Effros, Rita B, Yang, Otto O

“…Telomere length is abnormally short in the CD8(+) T-cell compartment of human immunodeficiency virus type 1 (HIV-1)-infected persons, likely because of chronic…”
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Reduced telomerase activity in human T lymphocytes exposed to cortisol by Choi, Jenny, Fauce, Steven R., Effros, Rita B.

“…Accelerated telomere shortening in lymphocytes has been associated with a variety of human pathologies, including HIV disease, Down syndrome, and…”
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