Suchergebnisse - "Effern, Maike"

Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity von Li, Xian-Yang, Moesta, Achim K, Xiao, Christos, Nakamura, Kyohei, Casey, Mika, Zhang, Haiyan, Madore, Jason, Lepletier, Ailin, Aguilera, Amelia Roman, Sundarrajan, Ashmitha, Jacoberger-Foissac, Celia, Wong, Clifford, Dela Cruz, Tracy, Welch, Megan, Lerner, Alana G, Spatola, Bradley N, Soros, Vanessa B, Corbin, John, Anderson, Ana C, Effern, Maike, Hölzel, Michael, Robson, Simon C, Johnston, Rebecca L, Waddell, Nicola, Smith, Corey, Bald, Tobias, Geetha, Nishamol, Beers, Courtney, Teng, Michele W L, Smyth, Mark J

“… We explored the mechanism of action of CD39 antibodies that inhibit ectoenzyme CD39 conversion of extracellular ATP (eATP) to AMP and thus potentially augment …”
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Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma von Falletta, Paola, Sanchez-Del-Campo, Luis, Chauhan, Jagat, Effern, Maike, Kenyon, Amy, Kershaw, Christopher J, Siddaway, Robert, Lisle, Richard, Freter, Rasmus, Daniels, Matthew J, Lu, Xin, Tüting, Thomas, Middleton, Mark, Buffa, Francesca M, Willis, Anne E, Pavitt, Graham, Ronai, Ze'ev A, Sauka-Spengler, Tatjana, Hölzel, Michael, Goding, Colin R

“… The intratumor microenvironment generates phenotypically distinct but interconvertible malignant cell subpopulations that fuel metastatic spread and …”
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Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression von Layer, Julian P., Kronmüller, Marie T., Quast, Thomas, Boorn-Konijnenberg, Debby van den, Effern, Maike, Hinze, Daniel, Althoff, Kristina, Schramm, Alexander, Westermann, Frank, Peifer, Martin, Hartmann, Gunther, Tüting, Thomas, Kolanus, Waldemar, Fischer, Matthias, Schulte, Johannes, Hölzel, Michael

“… Immune checkpoint inhibitors have significantly improved the treatment of several cancers. T-cell infiltration and the number of neoantigens caused by …”
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From Tpex to Tex: a journey through CD8+ T cell responses in cancer immunotherapy von Messmer, Julia M., Effern, Maike, Hölzel, Michael

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Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma von Martins Nascentes Melo, Luiza, Herrera-Rios, Dayana, Hinze, Daniel, Löffek, Stefanie, Oezel, Irem, Turiello, Roberta, Klein, Juliane, Leonardelli, Sonia, Westedt, Isa-Vanessa, Al-Matary, Yahya, Egea-Rodriguez, Sara, Brenzel, Alexandra, Bau, Maja, Sucker, Antje, Hadaschik, Eva, Wirsdörfer, Florian, Hanenberg, Helmut, Uhlenbrock, Niklas, Rauh, Daniel, Poźniak, Joanna, Rambow, Florian, Marine, Jean-Christophe, Effern, Maike, Glodde, Nicole, Schadendorf, Dirk, Jablonska, Jadwiga, Hölzel, Michael, Helfrich, Iris

“… BackgroundImmune responses against tumors are subject to negative feedback regulation. Immune checkpoint inhibitors (ICIs) blocking Programmed cell death …”
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CRISPitope: A generic platform to model target antigens for adoptive T cell transfer therapy in mouse tumor models von Effern, Maike, Glodde, Nicole, Bawden, Emma, Liebing, Jana, Hinze, Daniel, Tüting, Thomas, Gebhardt, Thomas, Hölzel, Michael

“… This protocol details the procedure for CRISPR-assisted insertion of epitopes (CRISPitope), a flexible approach for generating tumor cells expressing model …”
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Not Sweet: Glucocorticoids from Intratumoral Myeloid Cells Disable T Cells von Effern, Maike, Hölzel, Michael

“… In this issue, Acharya et al. demonstrate that glucocorticoids produced by macrophages and monocytes in the tumor microenvironment induce a dysfunctional CD8 …”
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Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin von Park, Simone L., Buzzai, Anthony, Rautela, Jai, Hor, Jyh Liang, Hochheiser, Katharina, Effern, Maike, McBain, Nathan, Wagner, Teagan, Edwards, Jarem, McConville, Robyn, Wilmott, James S., Scolyer, Richard A., Tüting, Thomas, Palendira, Umaimainthan, Gyorki, David, Mueller, Scott N., Huntington, Nicholas D., Bedoui, Sammy, Hölzel, Michael, Mackay, Laura K., Waithman, Jason, Gebhardt, Thomas

“… The immune system can suppress tumour development both by eliminating malignant cells and by preventing the outgrowth and spread of cancer cells that resist …”
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CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8 + T Cells von Braun, Matthias, Aguilera, Amelia Roman, Sundarrajan, Ashmitha, Corvino, Dillon, Stannard, Kimberley, Krumeich, Sophie, Das, Indrajit, Lima, Luize G, Meza Guzman, Lizeth G, Li, Kunlun, Li, Rui, Salim, Nazhifah, Jorge, Maria Villancanas, Ham, Sunyoung, Kelly, Gabrielle, Vari, Frank, Lepletier, Ailin, Raghavendra, Ashwini, Pearson, Sally, Madore, Jason, Jacquelin, Sebastien, Effern, Maike, Quine, Brodie, Koufariotis, Lambros T, Casey, Mika, Nakamura, Kyohei, Seo, Eun Y, Hölzel, Michael, Geyer, Matthias, Kristiansen, Glen, Taheri, Touraj, Ahern, Elizabeth, Hughes, Brett G M, Wilmott, James S, Long, Georgina V, Scolyer, Richard A, Batstone, Martin D, Landsberg, Jennifer, Dietrich, Dimo, Pop, Oltin T, Flatz, Lukas, Dougall, William C, Veillette, André, Nicholson, Sandra E, Möller, Andreas, Johnston, Robert J, Martinet, Ludovic, Smyth, Mark J, Bald, Tobias

“… The activating receptor CD226 is expressed on lymphocytes, monocytes, and platelets and promotes anti-tumor immunity in pre-clinical models. Here, we examined …”
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The experimental power of FR900359 to study Gq-regulated biological processes von Schrage, Ramona, Schmitz, Anna-Lena, Gaffal, Evelyn, Annala, Suvi, Kehraus, Stefan, Wenzel, Daniela, Büllesbach, Katrin M., Bald, Tobias, Inoue, Asuka, Shinjo, Yuji, Galandrin, Ségolène, Shridhar, Naveen, Hesse, Michael, Grundmann, Manuel, Merten, Nicole, Charpentier, Thomas H., Martz, Matthew, Butcher, Adrian J., Slodczyk, Tanja, Armando, Sylvain, Effern, Maike, Namkung, Yoon, Jenkins, Laura, Horn, Velten, Stößel, Anne, Dargatz, Harald, Tietze, Daniel, Imhof, Diana, Galés, Céline, Drewke, Christel, Müller, Christa E., Hölzel, Michael, Milligan, Graeme, Tobin, Andrew B., Gomeza, Jesús, Dohlman, Henrik G., Sondek, John, Harden, T. Kendall, Bouvier, Michel, Laporte, Stéphane A., Aoki, Junken, Fleischmann, Bernd K., Mohr, Klaus, König, Gabriele M., Tüting, Thomas, Kostenis, Evi

“… Despite the discovery of heterotrimeric αβγ G proteins ∼25 years ago, their selective perturbation by cell-permeable inhibitors remains a fundamental …”
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T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels von Messmer, Julia M, Thommek, Calvin, Piechutta, Manuel, Venkataramani, Varun, Wehner, Rebekka, Westphal, Dana, Schubert, Marc, Mayer, Chanté D, Effern, Maike, Berghoff, Anna S, Hinze, Daniel, Helfrich, Iris, Schadendorf, Dirk, Wick, Wolfgang, Hölzel, Michael, Karreman, Matthia A, Winkler, Frank

“… To improve immunotherapy for brain tumors, it is important to determine the principal intracranial site of T cell recruitment from the bloodstream and their …”
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RNase T2 restricts TLR13-mediated autoinflammation in vivo von Gomez-Diaz, Carlos, Greulich, Wilhelm, Wefers, Benedikt, Wang, Meiyue, Bolsega, Silvia, Effern, Maike, Varga, Daniel P, Han, Zhe, Chen, Minyi, Bérouti, Marleen, Leonardi, Natascia, Schillinger, Ulrike, Holzmann, Bernhard, Liesz, Arthur, Roers, Axel, Hölzel, Michael, Basic, Marijana, Wurst, Wolfgang, Hornung, Veit

“… RNA-sensing TLRs are strategically positioned in the endolysosome to detect incoming nonself RNA. RNase T2 plays a critical role in processing long, structured …”
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Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma von Effern, Maike, Glodde, Nicole, Braun, Matthias, Liebing, Jana, Boll, Helena N, Yong, Michelle, Bawden, Emma, Hinze, Daniel, van den Boorn-Konijnenberg, Debby, Daoud, Mila, Aymans, Pia, Landsberg, Jennifer, Smyth, Mark J, Flatz, Lukas, Tüting, Thomas, Bald, Tobias, Gebhardt, Thomas, Hölzel, Michael

“… Tumor immune escape limits durable responses to T cell therapy. Here, we examined how regulation and function of gene products that provide the target epitopes …”
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Author Correction: Tissue-resident memory CD8.sup.+ T cells promote melanoma-immune equilibrium in skin von Park, Simone L, Buzzai, Anthony, Rautela, Jai, Hor, Jyh Liang, Hochheiser, Katharina, Effern, Maike, McBain, Nathan

“… Panel j was inadvertently labelled as panel k in the caption to Fig. 4. Similarly, 'Fig. 4k' should have been 'Fig. 4j' in the sentence beginning …”
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Tissue-resident memory CD8.sup.+ T cells promote melanoma-immune equilibrium in skin von Park, Simone L, Buzzai, Anthony, Rautela, Jai, Hor, Jyh Liang, Hochheiser, Katharina, Effern, Maike, McBain, Nathan

“… The immune system can suppress tumour development both by eliminating malignant cells and by preventing the outgrowth and spread of cancer cells that resist …”
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CD4 + T cell immunity against cutaneous melanoma encompasses multifaceted MHC II-dependent responses von Bawden, Emma G, Wagner, Teagan, Schröder, Jan, Effern, Maike, Hinze, Daniel, Newland, Lewis, Attrill, Grace H, Lee, Ariane R, Engel, Sven, Freestone, David, de Lima Moreira, Marcela, Gressier, Elise, McBain, Nathan, Bachem, Annabell, Haque, Ashraful, Dong, Ruining, Ferguson, Angela L, Edwards, Jarem J, Ferguson, Peter M, Scolyer, Richard A, Wilmott, James S, Jewell, Christopher M, Brooks, Andrew G, Gyorki, David E, Palendira, Umaimainthan, Bedoui, Sammy, Waithman, Jason, Hochheiser, Katharina, Hölzel, Michael, Gebhardt, Thomas

“… Whereas CD4 T cells conventionally mediate antitumor immunity by providing help to CD8 T cells, recent clinical studies have implied an important role for …”
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Meeting Report: 47th Annual Meeting of the “Arbeitsgemeinschaft Dermatologische Forschung” von Stary, Georg, Fabri, Mario, Gebhardt, Christoffer, Eming, Rüdiger, Matthias, Julia, Vorobyev, Artem, Effern, Maike, Strobl, Johanna, Günther, Claudia, Zielinski, Christina, Dudziak, Diana, Géraud, Cyril, Raker, Verena, Butze, Monique, Zhao, Fang, Wang, Yuanyuan, Gerloff, Dennis, Bertschi, Nicole L., Gaffal, Evelyn, Buhl, Timo

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Altered Notch Signaling in Dowling-Degos Disease: Additional Mutations in POGLUT1 and Further Insights into Disease Pathogenesis von Ralser, Damian J, Takeuchi, Hideyuki, Fritz, Günter, Basmanav, F Buket, Effern, Maike, Sivalingam, Sugirthan, El-Shabrawi-Caelen, Laila, Degirmentepe, Ece N, Kocatürk, Emek, Singh, Manuraj, Booken, Nina, Spierings, Natalia M K, Schnabel, Viktor, Heineke, Andre, Knuever, Jana, Wolf, Sabrina, Wehner, Maria, Tronnier, Michael, Leverkus, Martin, Tantcheva-Poór, Iliana, Wenzel, Jörg, Oji, Vinzenz, Has, Cristina, Hölzel, Michael, Frank, Jorge, Haltiwanger, Robert S, Betz, Regina C

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Tissue-resident memory CD8^sup +^ T cells promote melanoma–immune equilibrium in skin von Park, Simone L, Buzzai, Anthony, Rautela, Jai, Hor, Jyh Liang, Hochheiser, Katharina, Effern, Maike, McBain, Nathan, Wagner, Teagan, Edwards, Jarem, McConville, Robyn, Wilmott, James S, Scolyer, Richard A, Tüting, Thomas, Palendria, Umaimainthan, Gyorki, David, Mueller, Scott N, Huntington, Nicholas D, Bedoui, Sammy, Hölzel, Michael, Mackay, Laura K, Waithman, Jason, Gebhardt, Thomas

“… The immune system can suppress tumour development both by eliminating malignant cells and by preventing the outgrowth and spread of cancer cells that resist …”
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Author Correction: Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin von Park, Simone L., Buzzai, Anthony, Rautela, Jai, Hor, Jyh Liang, Hochheiser, Katharina, Effern, Maike, McBain, Nathan, Wagner, Teagan, Edwards, Jarem, McConville, Robyn, Wilmott, James S., Scolyer, Richard A., Tüting, Thomas, Palendira, Umaimainthan, Gyorki, David, Mueller, Scott N., Huntington, Nicholas D., Bedoui, Sammy, Hölzel, Michael, Mackay, Laura K., Waithman, Jason, Gebhardt, Thomas

“… Panel j was inadvertently labelled as panel k in the caption to Fig. 4. Similarly, ‘Fig. 4k’ should have been ‘Fig. 4j’ in the sentence beginning …”
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