Suchergebnisse - "EBioMedicine"

Gut microbiota and its metabolites in depression: from pathogenesis to treatment von Liu, Lanxiang, Wang, Haiyang, Chen, Xueyi, Zhang, Yangdong, Zhang, Hanping, Xie, Peng

“… Major depressive disorder is one of the most disabling mental disorders worldwide. Increasing preclinical and clinical studies have highlighted that …”
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Microplastics detected in cirrhotic liver tissue von Horvatits, Thomas, Tamminga, Matthias, Liu, Beibei, Sebode, Marcial, Carambia, Antonella, Fischer, Lutz, Püschel, Klaus, Huber, Samuel, Fischer, Elke Kerstin

“… The contamination of ecosystem compartments by microplastics (MPs) is an ubiquitous problem. MPs have been observed in mice tissues, and recently in human …”
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Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients von Liu, Jing, Li, Sumeng, Liu, Jia, Liang, Boyun, Wang, Xiaobei, Wang, Hua, Li, Wei, Tong, Qiaoxia, Yi, Jianhua, Zhao, Lei, Xiong, Lijuan, Guo, Chunxia, Tian, Jin, Luo, Jinzhuo, Yao, Jinghong, Pang, Ran, Shen, Hui, Peng, Cheng, Liu, Ting, Zhang, Qian, Wu, Jun, Xu, Ling, Lu, Sihong, Wang, Baoju, Weng, Zhihong, Han, Chunrong, Zhu, Huabing, Zhou, Ruxia, Zhou, Helong, Chen, Xiliu, Ye, Pian, Zhu, Bin, Wang, Lu, Zhou, Wenqing, He, Shengsong, He, Yongwen, Jie, Shenghua, Wei, Ping, Zhang, Jianao, Lu, Yinping, Wang, Weixian, Zhang, Li, Li, Ling, Zhou, Fengqin, Wang, Jun, Dittmer, Ulf, Lu, Mengji, Hu, Yu, Yang, Dongliang, Zheng, Xin

“… The dynamic changes of lymphocyte subsets and cytokines profiles of patients with novel coronavirus disease (COVID-19) and their correlation with the disease …”
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Attention is not all you need: the complicated case of ethically using large language models in healthcare and medicine von Harrer, Stefan

“… Large Language Models (LLMs) are a key component of generative artificial intelligence (AI) applications for creating new content including text, imagery, …”
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Role of gut microbiota in type 2 diabetes pathophysiology von Gurung, Manoj, Li, Zhipeng, You, Hannah, Rodrigues, Richard, Jump, Donald B, Morgun, Andrey, Shulzhenko, Natalia

“… A substantial body of literature has provided evidence for the role of gut microbiota in metabolic diseases including type 2 diabetes. However, reports vary …”
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Short chain fatty acids and its producing organisms: An overlooked therapy for IBD? von Deleu, Sara, Machiels, Kathleen, Raes, Jeroen, Verbeke, Kristin, Vermeire, Séverine

“… The gut microbiome and the intestinal immune system are driving contributors to inflammatory bowel diseases (IBD). Both have an important signalling factor in …”
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Benchmarking large language models’ performances for myopia care: a comparative analysis of ChatGPT-3.5, ChatGPT-4.0, and Google Bard von Lim, Zhi Wei, Pushpanathan, Krithi, Yew, Samantha Min Er, Lai, Yien, Sun, Chen-Hsin, Lam, Janice Sing Harn, Chen, David Ziyou, Goh, Jocelyn Hui Lin, Tan, Marcus Chun Jin, Sheng, Bin, Cheng, Ching-Yu, Koh, Victor Teck Chang, Tham, Yih-Chung

“… Large language models (LLMs) are garnering wide interest due to their human-like and contextually relevant responses. However, LLMs’ accuracy across specific …”
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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease von Hickson, LaTonya J., Langhi Prata, Larissa G.P., Bobart, Shane A., Evans, Tamara K., Giorgadze, Nino, Hashmi, Shahrukh K., Herrmann, Sandra M., Jensen, Michael D., Jia, Qingyi, Jordan, Kyra L., Kellogg, Todd A., Khosla, Sundeep, Koerber, Daniel M., Lagnado, Anthony B., Lawson, Donna K., LeBrasseur, Nathan K., Lerman, Lilach O., McDonald, Kathleen M., McKenzie, Travis J., Passos, João F., Pignolo, Robert J., Pirtskhalava, Tamar, Saadiq, Ishran M., Schaefer, Kalli K., Textor, Stephen C., Victorelli, Stella G., Volkman, Tammie L., Xue, Ailing, Wentworth, Mark A., Wissler Gerdes, Erin O., Zhu, Yi, Tchkonia, Tamara, Kirkland, James L.

“… Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with …”
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The potential impacts of micro-and-nano plastics on various organ systems in humans von Ali, Nurshad, Katsouli, Jenny, Marczylo, Emma L., Gant, Timothy W., Wright, Stephanie, Bernardino de la Serna, Jorge

“… Humans are exposed to micro-and-nano plastics (MNPs) through various routes, but the adverse health effects of MNPs on different organ systems are not yet …”
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CAR-NK cells: A promising cellular immunotherapy for cancer von Xie, Guozhu, Dong, Han, Liang, Yong, Ham, James Dongjoo, Rizwan, Romee, Chen, Jianzhu

“… Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can kill target cells through similar cytotoxic mechanisms. With the …”
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Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression von Miao, Yu, Chen, Yiwei, Xue, Feng, Liu, Kexin, Zhu, Bin, Gao, Junjie, Yin, Junhui, Zhang, Changqing, Li, Guangyi

“… Osteoarthritis (OA) is the most common joint disease and is the leading cause of chronic disability among older people. Chondrocyte death and extracellular …”
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Therapeutic targeting of “undruggable” MYC von Llombart, Victor, Mansour, Marc R

“… c-MYC controls global gene expression and regulates cell proliferation, cell differentiation, cell cycle, metabolism and apoptosis. According to some …”
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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study von Justice, Jamie N., Nambiar, Anoop M., Tchkonia, Tamar, LeBrasseur, Nathan K., Pascual, Rodolfo, Hashmi, Shahrukh K., Prata, Larissa, Masternak, Michal M., Kritchevsky, Stephen B., Musi, Nicolas, Kirkland, James L.

“… Cellular senescence is a key mechanism that drives age-related diseases, but has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis …”
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Lactate in the tumour microenvironment: From immune modulation to therapy von Wang, Zi-Hao, Peng, Wen-Bei, Zhang, Pei, Yang, Xiang-Ping, Zhou, Qiong

“… Disordered metabolic states, which are characterised by hypoxia and elevated levels of metabolites, particularly lactate, contribute to the immunosuppression …”
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The complex genetic architecture of Alzheimer's disease: novel insights and future directions von Andrews, Shea J., Renton, Alan E., Fulton-Howard, Brian, Podlesny-Drabiniok, Anna, Marcora, Edoardo, Goate, Alison M.

“… Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder and the most common form of dementia. AD is highly heritable, with heritability …”
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Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies von Larsson, Susanna C., Burgess, Stephen

“… The causal association between cigarette smoking and several diseases remains equivocal. The purpose of this study was to appraise the causal role of smoking …”
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Vascular occlusion by neutrophil extracellular traps in COVID-19 von Leppkes, Moritz, Knopf, Jasmin, Naschberger, Elisabeth, Lindemann, Aylin, Singh, Jeeshan, Herrmann, Irmgard, Stürzl, Michael, Staats, Léonie, Mahajan, Aparna, Schauer, Christine, Kremer, Anita N., Völkl, Simon, Amann, Kerstin, Evert, Katja, Falkeis, Christina, Wehrfritz, Andreas, Rieker, Ralf J., Hartmann, Arndt, Kremer, Andreas E., Neurath, Markus F., Muñoz, Luis E., Schett, Georg, Herrmann, Martin

“… Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that …”
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Fisetin is a senotherapeutic that extends health and lifespan von Yousefzadeh, Matthew J., Zhu, Yi, McGowan, Sara J., Angelini, Luise, Fuhrmann-Stroissnigg, Heike, Xu, Ming, Ling, Yuan Yuan, Melos, Kendra I., Pirtskhalava, Tamar, Inman, Christina L., McGuckian, Collin, Wade, Erin A., Kato, Jonathon I., Grassi, Diego, Wentworth, Mark, Burd, Christin E., Arriaga, Edgar A., Ladiges, Warren L., Tchkonia, Tamara, Kirkland, James L., Robbins, Paul D., Niedernhofer, Laura J.

“… Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a …”
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Improving CAR-T immunotherapy: Overcoming the challenges of T cell exhaustion von Gumber, Diana, Wang, Leo D.

“… Chimeric antigen receptor (CAR) T cell therapy has emerged as a cancer treatment with enormous potential, demonstrating impressive antitumor activity in the …”
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Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment von Nagpal, Ravinder, Neth, Bryan J., Wang, Shaohua, Craft, Suzanne, Yadav, Hariom

“… Alzheimer's disease (AD) prevalence is increasing, but its etiology remains elusive. Gut microbes can contribute to AD pathology and may help identifying novel …”
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