Search Results - "Dyczynski, Matheus"

Targeting autophagy in cancer by Onorati, Angelique V., Dyczynski, Matheus, Ojha, Rani, Amaravadi, Ravi K.

“…Autophagy is a conserved, self‐degradation system that is critical for maintaining cellular homeostasis during stress conditions. Dysregulated autophagy has…”
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The natural compound periplogenin suppresses the growth of prostate carcinoma cells by directly targeting ATP1A1 by Zhang, Xinquan, Pang, Tinglin, Zhang, Haifeng, Horn, Moritz, Michlits, Georg, Dyczynski, Matheus, Zhang, Liqun

“…Natural compounds constitute a major resource for the development of medicines for multiple diseases. While many natural compounds show strong biological…”
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Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection by Monteil, Vanessa, Dyczynski, Matheus, Lauschke, Volker M, Kwon, Hyesoo, Wirnsberger, Gerald, Youhanna, Sonia, Zhang, Haibo, Slutsky, Arthur S, Hurtado del Pozo, Carmen, Horn, Moritz, Montserrat, Nuria, Penninger, Josef M, Mirazimi, Ali

“…There is a critical need for safe and effective drugs for COVID‐19. Only remdesivir has received authorization for COVID‐19 and has been shown to improve…”
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Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib by Dyczynski, Matheus, Yu, Yasmin, Otrocka, Magdalena, Parpal, Santiago, Braga, Tiago, Henley, Aine Brigette, Zazzi, Henric, Lerner, Mikael, Wennerberg, Krister, Viklund, Jenny, Martinsson, Jessica, Grandér, Dan, De Milito, Angelo, Pokrovskaja Tamm, Katja

“…Resistance to chemotherapy is a challenging problem for treatment of cancer patients and autophagy has been shown to mediate development of resistance. In this…”
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Safe and Effective Treatment of Experimental Neuroblastoma and Glioblastoma Using Systemically Delivered Triple MicroRNA-Detargeted Oncolytic Semliki Forest Virus by Ramachandran, Mohanraj, Yu, Di, Dyczynski, Matheus, Baskaran, Sathishkumar, Zhang, Lei, Lulla, Aleksei, Lulla, Valeria, Saul, Sirle, Nelander, Sven, Dimberg, Anna, Merits, Andres, Leja-Jarblad, Justyna, Essand, Magnus

“…Glioblastoma multiforme and high-risk neuroblastoma are cancers with poor outcome. Immunotherapy in the form of neurotropic oncolytic viruses is a promising…”
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Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections by Monteil, Vanessa, Kwon, Hyesoo, John, Lijo, Salata, Cristiano, Jonsson, Gustav, Vorrink, Sabine U., Appelberg, Sofia, Youhanna, Sonia, Dyczynski, Matheus, Leopoldi, Alexandra, Leeb, Nicole, Volz, Jennifer, Hagelkruys, Astrid, Kellner, Max J., Devignot, Stéphanie, Michlits, Georg, Foong-Sobis, Michelle, Weber, Friedemann, Lauschke, Volker M., Horn, Moritz, Feldmann, Heinz, Elling, Ulrich, Penninger, Josef M., Mirazimi, Ali

“…Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors…”
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A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors by Taubenschmid‐Stowers, Jasmin, Orthofer, Michael, Laemmerer, Anna, Krauditsch, Christian, Rózsová, Marianna, Studer, Christian, Lötsch, Daniela, Gojo, Johannes, Gabler, Lisa, Dyczynski, Matheus, Efferth, Thomas, Hagelkruys, Astrid, Widhalm, Georg, Peyrl, Andreas, Spiegl‐Kreinecker, Sabine, Hoepfner, Dominic, Bian, Shan, Berger, Walter, Knoblich, Juergen A, Elling, Ulrich, Horn, Moritz, Penninger, Josef M

“…The natural compound Artemisinin is the most widely used antimalarial drug worldwide. Based on its cytotoxicity, it is also used for anticancer therapy…”
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Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment by Dyczynski, Matheus, Vesterlund, Mattias, Björklund, Ann-Charlotte, Zachariadis, Vasilios, Janssen, Jerry, Gallart-Ayala, Hector, Daskalaki, Evangelia, Wheelock, Craig E., Lehtiö, Janne, Grandér, Dan, Tamm, Katja Pokrovskaja, Nilsson, Roland

“…Glucocorticoids (GCs) are metabolic hormones with immunosuppressive effects that have proven effective drugs against childhood acute lymphoblastic leukemia…”
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Identification of novel small molecules that inhibit STAT3-dependent transcription and function by Kolosenko, Iryna, Yu, Yasmin, Busker, Sander, Dyczynski, Matheus, Liu, Jianping, Haraldsson, Martin, Palm Apergi, Caroline, Helleday, Thomas, Tamm, Katja Pokrovskaja, Page, Brent D. G., Grander, Dan

“…Activation of Signal Transducer and Activator of Transcription 3 (STAT3) has been linked to several processes that are critical for oncogenic transformation,…”
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Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells by Pellegrini, Paola, Dyczynski, Matheus, Sbrana, Francesca Vittoria, Karlgren, Maria, Buoncervello, Maria, Hägg-Olofsson, Maria, Ma, Ran, Hartman, Johan, Bajalica-Lagercrantz, Svetlana, Grander, Dan, Kharaziha, Pedram, De Milito, Angelo

“…Sustained autophagy contributes to the metabolic adaptation of cancer cells to hypoxic and acidic microenvironments. Since cells in such environments are…”
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Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells by Monteil, Vanessa M., Wright, Shane C., Dyczynski, Matheus, Kellner, Max J., Appelberg, Sofia, Platzer, Sebastian W., Ibrahim, Ahmed, Kwon, Hyesoo, Pittarokoilis, Ioannis, Mirandola, Mattia, Michlits, Georg, Devignot, Stephanie, Elder, Elizabeth, Abdurahman, Samir, Bereczky, Sándor, Bagci, Binnur, Youhanna, Sonia, Aastrup, Teodor, Lauschke, Volker M., Salata, Cristiano, Elaldi, Nazif, Weber, Friedemann, Monserrat, Nuria, Hawman, David W., Feldmann, Heinz, Horn, Moritz, Penninger, Josef M., Mirazimi, Ali

“…Climate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Crimean–Congo haemorrhagic fever virus…”
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