Suchergebnisse - "Duarte, Alexandra"

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation von Rondinelli, Beatrice, Gogola, Ewa, Yücel, Hatice, Duarte, Alexandra A., van de Ven, Marieke, van der Sluijs, Roxanne, Konstantinopoulos, Panagiotis A., Jonkers, Jos, Ceccaldi, Raphaël, Rottenberg, Sven, D’Andrea, Alan D.

“… Rondinelli et al. show that EZH2-mediated H3K27me3 at stalled replication forks recruits MUS81 nuclease to facilitate fork degradation. Loss of EZH2 …”
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Replication fork stability confers chemoresistance in BRCA-deficient cells von Ray Chaudhuri, Arnab, Callen, Elsa, Ding, Xia, Gogola, Ewa, Duarte, Alexandra A., Lee, Ji-Eun, Wong, Nancy, Lafarga, Vanessa, Calvo, Jennifer A., Panzarino, Nicholas J., John, Sam, Day, Amanda, Crespo, Anna Vidal, Shen, Binghui, Starnes, Linda M., Ruiter, Julian R. de, Daniel, Jeremy A., Konstantinopoulos, Panagiotis A., Cortez, David, Cantor, Sharon B., Fernandez-Capetillo, Oscar, Ge, Kai, Jonkers, Jos, Rottenberg, Sven, Sharan, Shyam K., Nussenzweig, André

“… Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are …”
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Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality von Gogola, Ewa, Duarte, Alexandra A, de Ruiter, Julian R, Wiegant, Wouter W, Schmid, Jonas A, de Bruijn, Roebi, James, Dominic I, Guerrero Llobet, Sergi, Vis, Daniel J, Annunziato, Stefano, van den Broek, Bram, Barazas, Marco, Kersbergen, Ariena, van de Ven, Marieke, Tarsounas, Madalena, Ogilvie, Donald J, van Vugt, Marcel, Wessels, Lodewyk F A, Bartkova, Jirina, Gromova, Irina, Andújar-Sánchez, Miguel, Bartek, Jiri, Lopes, Massimo, van Attikum, Haico, Borst, Piet, Jonkers, Jos, Rottenberg, Sven

“… Inhibitors of poly(ADP-ribose) (PAR) polymerase (PARPi) have recently entered the clinic for the treatment of homologous recombination (HR)-deficient cancers …”
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BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance von Duarte, Alexandra A, Gogola, Ewa, Sachs, Norman, Barazas, Marco, Annunziato, Stefano, R de Ruiter, Julian, Velds, Arno, Blatter, Sohvi, Houthuijzen, Julia M, van de Ven, Marieke, Clevers, Hans, Borst, Piet, Jonkers, Jos, Rottenberg, Sven

“… Poly(ADP-ribose) polymerase inhibition (PARPi) is a promising new therapeutic approach for the treatment of cancers that show homologous recombination …”
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Connecting research, management, education and policy for the conservation of armadillos in the Orinoco Llanos of Colombia von Superina, Mariella, Cortés Duarte, Alexandra, Trujillo, Fernando

“… Successful conservation actions require strategies that combine research, policy formulation and enforcement, practical interventions and education. Here we …”
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Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors von Bhin, Jinhyuk, Paes Dias, Mariana, Gogola, Ewa, Rolfs, Frank, Piersma, Sander R., de Bruijn, Roebi, de Ruiter, Julian R., van den Broek, Bram, Duarte, Alexandra A., Sol, Wendy, van der Heijden, Ingrid, Andronikou, Christina, Kaiponen, Taina S., Bakker, Lara, Lieftink, Cor, Morris, Ben, Beijersbergen, Roderick L., van de Ven, Marieke, Jimenez, Connie R., Wessels, Lodewyk F.A., Rottenberg, Sven, Jonkers, Jos

“… BRCA1 and BRCA2 both function in DNA double-strand break repair by homologous recombination (HR). Due to their HR defect, BRCA1/2-deficient cancers are …”
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H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours von Dibitetto, Diego, Liptay, Martin, Vivalda, Francesca, Dogan, Hülya, Gogola, Ewa, González Fernández, Martín, Duarte, Alexandra, Schmid, Jonas A., Decollogny, Morgane, Francica, Paola, Przetocka, Sara, Durant, Stephen T., Forment, Josep V., Klebic, Ismar, Siffert, Myriam, de Bruijn, Roebi, Kousholt, Arne N., Marti, Nicole A., Dettwiler, Martina, Sørensen, Claus S., Tille, Jean-Christophe, Undurraga, Manuela, Labidi-Galy, Intidhar, Lopes, Massimo, Sartori, Alessandro A., Jonkers, Jos, Rottenberg, Sven

“… Histone H2AX plays a key role in DNA damage signalling in the surrounding regions of DNA double-strand breaks (DSBs). In response to DNA damage, H2AX becomes …”
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Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality von Gogola, Ewa, Duarte, Alexandra A, de Ruiter, Julian R, Wiegant, Wouter W, Schmid, Jonas A, de Bruijn, Roebi, James, Dominic I, Llobet, Sergi Guerrero, Vis, Daniel J, Annunziato, Stefano, van den Broek, Bram, Barazas, Marco, Kersbergen, Ariena, van de Ven, Marieke, Tarsounas, Madalena, Ogilvie, Donald J, van Vugt, Marcel, Wessels, Lodewyk F A, Bartkova, Jirina, Gromova, Irina, Andújar-Sánchez, Miguel, Bartek, Jiri, Lopes, Massimo, van Attikum, Haico, Borst, Piet, Jonkers, Jos, Rottenberg, Sven

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A platinum complex that binds non-covalently to DNA and induces cell death via a different mechanism than cisplatin von Suntharalingam, Kogularamanan, Mendoza, Oscar, Duarte, Alexandra A, Mann, David J, Vilar, Ramon

“… Cisplatin and some of its derivatives have been shown to be very successful anticancer agents. Their main mode of action has been proposed to be via covalent …”
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Genetic Basis and Clonal Population Structure of Antibiotic Resistance in Campylobacter jejuni Isolated From Broiler Carcasses in Belgium von Elhadidy, Mohamed, Miller, William G., Arguello, Hector, Álvarez-Ordóñez, Avelino, Duarte, Alexandra, Dierick, Katelijne, Botteldoorn, Nadine

“… Human campylobacteriosis is the leading food-borne zoonosis in industrialized countries. This study characterized the clonal population structure, …”
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A facility-location model for biofuel plants: Applications in the Colombian context von Duarte, Alexandra E., Sarache, William A., Costa, Yasel J.

“… To reduce the logistical and operating costs for biofuel plants, it is important to make a strategic decision to select the proper site for a new facility. Due …”
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A Tri-copper(II) Complex Displaying DNA-Cleaving Properties and Antiproliferative Activity against Cancer Cells von Suntharalingam, Kogularamanan, Hunt, Douglas J., Duarte, Alexandra A., White, Andrew J. P., Mann, David J., Vilar, Ramon

“… A new disubstituted terpyridine ligand and the corresponding tri‐copper(II) complex have been prepared and characterised. The binding affinity and binding mode …”
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A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity von Sachs, Norman, de Ligt, Joep, Kopper, Oded, Gogola, Ewa, Bounova, Gergana, Weeber, Fleur, Balgobind, Anjali Vanita, Wind, Karin, Gracanin, Ana, Begthel, Harry, Korving, Jeroen, van Boxtel, Ruben, Duarte, Alexandra Alves, Lelieveld, Daphne, van Hoeck, Arne, Ernst, Robert Frans, Blokzijl, Francis, Nijman, Isaac Johannes, Hoogstraat, Marlous, van de Ven, Marieke, Egan, David Anthony, Zinzalla, Vittoria, Moll, Jurgen, Boj, Sylvia Fernandez, Voest, Emile Eugene, Wessels, Lodewyk, van Diest, Paul Joannes, Rottenberg, Sven, Vries, Robert Gerhardus Jacob, Cuppen, Edwin, Clevers, Hans

“… Breast cancer (BC) comprises multiple distinct subtypes that differ genetically, pathologically, and clinically. Here, we describe a robust protocol for …”
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Behavioral responses of three armadillo species (Mammalia: Xenarthra) to an environmental enrichment program in Villavicencio, Colombia von Cortés Duarte, Alexandra, Trujillo, Fernando, Superina, Mariella

“… Enrichment is a powerful tool to improve the welfare of animals under human care. Stress‐related health and behavioral problems, as well as reproductive …”
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Discriminative power of Campylobacter phenotypic and genotypic typing methods von Duarte, Alexandra, Seliwiorstow, Tomasz, Miller, William G., De Zutter, Lieven, Uyttendaele, Mieke, Dierick, Katelijne, Botteldoorn, Nadine

“… The aim of this study was to compare different typing methods, individually and combined, for use in the monitoring of Campylobacter in food. Campylobacter …”
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Advances in the Early Warning of Shellfish Toxification by Dinophysis acuminata von Duarte Silva, Alexandra, Rodrigues, Susana Margarida, Godinho, Lia

“… In Western Europe, the incidence of DST is likely the highest globally, posing a significant threat with prolonged bans on shellfish harvesting, mainly caused …”
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Evaluation of viral concentration methods from irrigation and processing water von De Keuckelaere, Ann, Baert, Leen, Duarte, Alexandra, Stals, Ambroos, Uyttendaele, Mieke

“… ► We compared four viral concentration methods for their recovery in water. ► MNV-1 and MS2 phages were used as surrogate viruses during this study. ► All …”
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Spatial differentiation of gene expression in Aspergillus niger colony grown for sugar beet pulp utilization von Benoit, Isabelle, Zhou, Miaomiao, Vivas Duarte, Alexandra, Downes, Damien J., Todd, Richard B., Kloezen, Wendy, Post, Harm, Heck, Albert J. R., Maarten Altelaar, A. F., de Vries, Ronald P.

“… Degradation of plant biomass to fermentable sugars is of critical importance for the use of plant materials for biofuels. Filamentous fungi are ubiquitous …”
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Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells von Chaudhuri, Arnab Ray, Callen, Elsa, Ding, Xia, Gogola, Ewa, Duarte, Alexandra A., Lee, Ji-Eun, Wong, Nancy, Lafarga, Vanessa, Calvo, Jennifer A., Panzarino, Nicholas J., John, Sam, Day, Amanda, Crespo, Anna Vidal, Shen, Binghui, Starnes, Linda M., de Ruiter, Julian R., Daniel, Jeremy A., Konstantinopoulos, Panagiotis A., Cortez, David, Cantor, Sharon B., Fernandez-Capetillo, Oscar, Ge, Kai, Jonkers, Jos, Rottenberg, Sven, Sharan, Shyam K., Nussenzweig, André

“… Nature 535, 382–387 (2016); doi: 10.1038/nature18325 It has come to our attention that in this Article, owing to an error during the production process, …”
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Heterologous expression of a Tpo1 homolog from Arabidopsis thaliana confers resistance to the herbicide 2,4-D and other chemical stresses in yeast von Cabrito, Tânia R, Teixeira, Miguel C, Duarte, Alexandra A, Duque, Paula, Sá-Correia, Isabel

“… The understanding of the molecular mechanisms underlying acquired herbicide resistance is crucial in dealing with the emergence of resistant weeds …”
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