Výsledky vyhľadávania - "Drug Resistance"

Leading the Way: Multi‐Drug Resistance Protein (MDR1) and Clinical Pharmacology—Commentary on Kim et al Autor Giacomini, Kathleen M.

“… As gatekeepers of drug absorption, disposition and targeting, transporters in the intestine, liver, kidney and blood brain barrier have been the subject of many clinical pharmacology studies…”
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Prevalence and factors associated with HIV-1 drug resistance mutations in treatment-experienced patients in Nairobi, Kenya: A cross-sectional study Autor Scriven, Yvonne A., Mulinge, Martin M., Saleri, Norah, Luvai, Elizabeth A., Nyachieo, Atunga, Maina, Esther N., Mwau, Matilu

“…), with the majority of them unaware of their drug resistance status. In this study, we assessed the prevalence of drug resistance to nucleoside reverse transcriptase inhibitors (NRTIs…”
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NS3 protease polymorphisms and genetic barrier to drug resistance of distinct hepatitis C virus genotypes from worldwide treatment-naïve subjects Autor Vidal, L. L., Soares, M. A., Santos, A. F.

“… 099 HCV sequences from treatment‐naïve subjects retrieved at the Los Alamos HCV Sequence Database. The wild…”
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Persistence of transmitted drug resistance among subjects with primary human immunodeficiency virus infection Autor Little, Susan J, Frost, Simon D W, Wong, Joseph K, Smith, Davey M, Pond, Sergei L Kosakovsky, Ignacio, Caroline C, Parkin, Neil T, Petropoulos, Christos J, Richman, Douglas D

“…Following interruption of antiretroviral therapy among individuals with acquired drug resistance, preexisting drug-sensitive virus emerges relatively rapidly…”
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Prevalence and Clinical Significance of HIV Drug Resistance Mutations by Ultra-Deep Sequencing in Antiretroviral-Naïve Subjects in the CASTLE Study Autor Lataillade, Max, Chiarella, Jennifer, Yang, Rong, Schnittman, Steven, Wirtz, Victoria, Uy, Jonathan, Seekins, Daniel, Krystal, Mark, Mancini, Marco, McGrath, Donnie, Simen, Birgitte, Egholm, Michael, Kozal, Michael

“…-naïve subjects from 5 continents. Determine the baseline rate and clinical significance of TDR mutations using ultra-deep sequencing (UDS) in ARV…”
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Genomic Analysis of Global Mycobacterium abscessus Isolates Reveals Ongoing Evolution of Drug Resistance-Associated Genes Autor Yang, Tingting, Beach, Kylie E, Zhu, Chendi, Gan, Mingyu, Wang, Wenli, Zhou, Hongjuan, Peng, Lijun, Wang, Shanshan, Cai, Long, Li, Weimin, Davis, Jordan B, Cicchetti, Nico, Slechta, E Susan, Barker, Adam, Shakir, Salika M, Carey, Allison F, Liu, Qingyun

“…Mycobacterium abscessus (MAB) is intrinsically resistant to many antibiotics, but the evolution of acquired drug resistance is poorly understood…”
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Longitudinal assessment of virological failure and antiretroviral drug resistance among treatment-naïve subjects living with HIV Autor Mendes Marcon, Chaiana Esmeraldino, Schlindwein, Aline Daiane, Schuelter-Trevisol, Fabiana

“… However, some treatment-naive subjects living with HIV present resistance-associated mutations as a result of late diagnosis and/or mutant strain infections…”
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HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes Autor Mendoza, Yaxelis, Castillo Mewa, Juan, Martínez, Alexander A., Zaldívar, Yamitzel, Sosa, Néstor, Arteaga, Griselda, Armién, Blas, Bautista, Christian T., García-Morales, Claudia, Tapia-Trejo, Daniela, Ávila-Ríos, Santiago, Reyes-Terán, Gustavo, Bello, Gonzalo, Pascale, Juan M.

“… In Panama, rollout of ART started in 1999 and national coverage has reached 62.8% since then. The objective of this study was to determine the level and patterns of acquired drug resistance mutations of clinical relevance (ADR-CRM…”
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Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas Autor Whitson, Ramon J, Lee, Alex, Urman, Nicole M, Mirza, Amar, Yao, Catherine Y, Brown, Alexander S, Li, Jiang R, Shankar, Gautam, Fry, Micah A, Atwood, Scott X, Lee, Eunice Y, Hollmig, S Tyler, Aasi, Sumaira Z, Sarin, Kavita Y, Scott, Matthew P, Epstein, Ervin H, Tang, Jean Y, Oro, Anthony E

“… These results advance understanding of the mechanisms underlying drug resistance and provide new actionable insights for clinical translation. Hedgehog pathway…”
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HIV Drug Resistance Mutations (DRMs) Detected by Deep Sequencing in Virologic Failure Subjects on Therapy from Hunan Province, China Autor Chen, Xi, Zou, Xiaobai, He, Jianmei, Zheng, Jun, Chiarella, Jennifer, Kozal, Michael J.

“…Determine HIV drug resistance mutations (DRMs) prevalence at low and high levels in ART-experienced patients experiencing virologic failure (VF…”
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Prevalence of acquired drug resistance mutations in antiretroviral- experiencing subjects from 2012 to 2017 in Hunan Province of central South China Autor Zou, Xiaobai, He, Jianmei, Zheng, Jun, Malmgren, Roberta, Li, Weisi, Wei, Xiuqing, Zhang, Guoqiang, Chen, Xi

“…Background There are few data on the prevalence of acquired drug resistance mutations (ADRs…”
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The Phenomenon of Antiretroviral Drug Resistance in the Context of Human Immunodeficiency Virus Treatment: Dynamic and Ever Evolving Subject Matter Autor Apetroaei, Miruna-Maria, Velescu, Bruno Ștefan, Nedea, Marina Ionela (Ilie), Dinu-Pîrvu, Cristina Elena, Drăgănescu, Doina, Fâcă, Anca Ionela, Udeanu, Denisa Ioana, Arsene, Andreea Letiția

“… The development of drug resistance can be attributed to various circumstances, including noncompliance with treatment regimens, insufficient dosage, interactions between drugs, viral mutations…”
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Brazilian network for HIV Drug Resistance Surveillance (HIV‐BresNet): a survey of treatment‐naive individuals Autor Arruda, Monica B, Boullosa, Lídia T, Cardoso, Cynthia C, Costa, Carolina M, Brites, Carlos, Lima, Shirlene TS, Kaminski, Helena T, Aleixo, Agdemir W, Esposito, Ana OP, Cavalcanti, Ana MS, Riedel, Maristela, Couto‐Fernandez, José C, Ferreira, Selma B, Oliveira, Ivi CM, Portal, Loreci E, Wolf, Hilda HC, Fernandes, Sandra B, M. C. Pardini, Maria I, Feiteiro, Manoel VC, Tolentino, Fernanda M, Diaz, Ricardo S, Lopes, Giselle ISL, Francisco, Roberta BL, Véras, Nazle MC, Pires, Ana F, Franchini, Miriam, Mesquita, Fábio, Tanuri, Amilcar, Melo Xavier Shimizu, Andrea, Jorge, Célia Regina Mayoral Pedroso, Mello, Leda Maria Simões, Freitas, Eider Gurgel, Tupinambás, Unaí, Barros Rosa Costa, Dijane Cristina, Silva, Sirleide Pereira, Graça Winhescki, Maria, Jesus, Carlos Silva, Santos Nascimento, Érica Ramos, Oliveira Prazim, Fatima Ercília, Rosa, Marilda Tereza Mar, Salvador, Karina, Alcântara Belettini, Senele Ana, Grotto, Rejane Maria Tommasini, Oliveira, Paulo Henrique, Gomes, Érica Valessa Ramos, Dias, Danilo Araujo, Galinskas, Juliana, Campos, Norberto Camilo, Neto, José Boullosa Alonso

“… In order to monitor the transmission of drug‐resistant strains and HIV subtype distribution in the country, this work aimed to estimate its prevalence and to characterize the nationwide pretreatment drug resistance in individuals recently…”
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HIV drug resistance in the era of contemporary antiretroviral therapy: A clinical perspective Autor Carr, Andrew, Mackie, Nicola E, Paredes, Roger, Ruxrungtham, Kiat

“…Contemporary antiretroviral therapy (ART) regimens have high barriers to the development of drug resistance…”
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The role of glutathione-S-transferase in anti-cancer drug resistance Autor Townsend, Danyelle M, Tew, Kenneth D

“…Glutathione- S -transferases (GSTs) are a family of Phase II detoxification enzymes that catalyse the conjugation of glutathione (GSH) to a wide variety of…”
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Cell population heterogeneity and evolution towards drug resistance in cancer: Biological and mathematical assessment, theoretical treatment optimisation Autor Chisholm, Rebecca H., Lorenzi, Tommaso, Clairambault, Jean

“…Drug-induced drug resistance in cancer has been attributed to diverse biological mechanisms at the individual cell or cell population scale, relying on stochastically or epigenetically varying…”
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Extensive drug resistance acquired during treatment of multidrug-resistant tuberculosis Autor Cegielski, J Peter, Dalton, Tracy, Yagui, Martin, Wattanaamornkiet, Wanpen, Volchenkov, Grigory V, Via, Laura E, Van Der Walt, Martie, Tupasi, Thelma, Smith, Sarah E, Odendaal, Ronel, Leimane, Vaira, Kvasnovsky, Charlotte, Kuznetsova, Tatiana, Kurbatova, Ekaterina, Kummik, Tiina, Kuksa, Liga, Kliiman, Kai, Kiryanova, Elena V, Kim, HeeJin, Kim, Chang-ki, Kazennyy, Boris Y, Jou, Ruwen, Huang, Wei-Lun, Ershova, Julia, Erokhin, Vladislav V, Diem, Lois, Contreras, Carmen, Cho, Sang Nae, Chernousova, Larisa N, Chen, Michael P, Caoili, Janice Campos, Bayona, Jaime, Akksilp, Somsak

“… In total, 832 subjects were enrolled. Of those without baseline…”
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Evaluation of a parasite-density based pooled targeted amplicon deep sequencing (TADS) method for molecular surveillance of Plasmodium falciparum drug resistance genes in Haiti Autor Louha, Swarnali, Herman, Camelia, Gupta, Mansi, Patel, Dhruviben, Kelley, Julia, OH, Je-Hoon M., Guru, Janani, Lemoine, Jean F., Chang, Michelle A., Venkatachalam, Udhayakumar, Rogier, Eric, Talundzic, Eldin

“…Sequencing large numbers of individual samples is often needed for countrywide antimalarial drug resistance surveillance…”
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A systematic review and meta-analysis of antimicrobial resistance knowledge, attitudes, and practices: Current evidence to build a strong national antimicrobial drug resistance narrative in Ethiopia Autor Woldegeorgis, Beshada Zerfu, Kerbo, Amene Abebe, Obsa, Mohammed Suleiman, Mokonnon, Taklu Marama

“…Antimicrobial resistance (AMR) is a silent pandemic that has claimed millions of lives, and resulted in long-term disabilities, limited treatment options, and…”
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The role of cytokines in ovarian cancer drug resistance Autor Wang, Lu, Zang, Yunxia, Dejenie, Rebeka, Bing, Junyuan, Dong, Shixia, Zhang, Yanfei, Zhu, Yi, Li, Jingjing

“… The knowledge of ovarian cancer drug resistance and the function of cytokines in the development of tumor resistance is currently the subject of numerous relevant studies…”
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