Výsledky vyhledávání - "Drug Monitoring - methods"

Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and Large Intestinal Contents in Healthy Subjects Shown by MRI Autor Murray, Kathryn, Wilkinson-Smith, Victoria, Hoad, Caroline, Costigan, Carolyn, Cox, Eleanor, Lam, Ching, Marciani, Luca, Gowland, Penny, Spiller, Robin C

“…The objective of this study was to investigate whether ingestion of fructose and fructans (such as inulin) can exacerbate irritable bowel syndrome (IBS)…”
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An international, multicentre survey of β-lactam antibiotic therapeutic drug monitoring practice in intensive care units Autor Wong, Gloria, Brinkman, Alexander, Benefield, Russell J, Carlier, Mieke, De Waele, Jan J, El Helali, Najoua, Frey, Otto, Harbarth, Stephan, Huttner, Angela, McWhinney, Brett, Misset, Benoit, Pea, Federico, Preisenberger, Judit, Roberts, Michael S, Robertson, Thomas A, Roehr, Anka, Sime, Fekade Bruck, Taccone, Fabio Silvio, Ungerer, Jacobus P J, Lipman, Jeffrey, Roberts, Jason A

“…Emerging evidence supports the use of therapeutic drug monitoring (TDM) of β-lactams for intensive care unit (ICU) patients to optimize drug exposure, although…”
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Pharmacokinetics, Safety, and Tolerability of Tezepelumab (AMG 157) in Healthy and Atopic Dermatitis Adult Subjects Autor Parnes, Jane R., Sullivan, John T., Chen, Li, Dias, Clapton

“…‐ascending doses in two randomized, double‐blind, placebo‐controlled phase I studies. Healthy and atopic dermatitis subjects were enrolled in the single…”
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Disposition and Metabolism of [ 14 C]Lemborexant in Healthy Human Subjects and Characterization of Its Circulating Metabolites Autor Ueno, Takashi, Ishida, Tomomi, Aluri, Jagadeesh, Suzuki, Michiyuki, Beuckmann, Carsten T, Kameyama, Takaaki, Asakura, Shoji, Kusano, Kazutomi

“… Here, disposition and metabolic profiles were investigated in healthy human subjects…”
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High feasibility of salivary therapeutic drug monitoring in linezolid, but lower feasibility in tedizolid: a single-dose study in healthy subjects and a monocentric prospective exploratory study in patients who received linezolid Autor Kawasuji, Hitoshi, Tsuji, Yasuhiro, Miyaki, Keiko, Aoyama, Takahiko, Kurosaki, Fumihiro, Ezaki, Masayoshi, Koshiyama, Yuki, Takegoshi, Yusuke, Kaneda, Makito, Murai, Yushi, Kimoto, Kou, Nagaoka, Kentaro, Yamamoto, Yoshihiro

“… We conducted a healthy subject study with 12 healthy participants. Linezolid and tedizolid were intravenously administered to 6 participants each…”
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The monitoring of vancomycin: a systematic review and meta-analyses of area under the concentration-time curve-guided dosing and trough-guided dosing Autor Tsutsuura, Moeko, Moriyama, Hiromu, Kojima, Nana, Mizukami, Yuki, Tashiro, Sho, Osa, Sumika, Enoki, Yuki, Taguchi, Kazuaki, Oda, Kazutaka, Fujii, Satoshi, Takahashi, Yoshiko, Hamada, Yukihiro, Kimura, Toshimi, Takesue, Yoshio, Matsumoto, Kazuaki

“…Background This systematic review and meta-analysis explored the relationship between vancomycin (VCM) monitoring strategies and VCM effectiveness and safety…”
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Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis Autor Kraus, V.B., Burnett, B., Coindreau, J., Cottrell, S., Eyre, D., Gendreau, M., Gardiner, J., Garnero, P., Hardin, J., Henrotin, Y., Heinegård, D., Ko, A., Lohmander, L.S., Matthews, G., Menetski, J., Moskowitz, R., Persiani, S., Poole, A.R., Rousseau, J.-C., Todman, M.

“…Osteoarthritis (OA) is a chronic and slowly progressive disease for which biomarkers may be able to provide a more rapid indication of therapeutic responses to…”
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Accuracy of the Eosinophilic Esophagitis Endoscopic Reference Score in Diagnosis and Determining Response to Treatment Autor Dellon, Evan S, Cotton, Cary C, Gebhart, Jessica H, Higgins, Leana L, Beitia, RoseMary, Woosley, John T, Shaheen, Nicholas J

“…); 144 subjects without EoE were included as control subjects. EREFS scores were compared between cases and control subjects…”
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Improved Long-term Outcomes of Patients With Inflammatory Bowel Disease Receiving Proactive Compared With Reactive Monitoring of Serum Concentrations of Infliximab Autor Papamichael, Konstantinos, Chachu, Karen A, Vajravelu, Ravy K, Vaughn, Byron P, Ni, Josephine, Osterman, Mark T, Cheifetz, Adam S

“…) receiving infliximab maintenance therapy. The subjects received proactive (n = 130) or reactive (n = 134) drug monitoring, based on measurements of first infliximab concentration and antibodies to infliximab, from September…”
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Vonoprazan, a novel potassium-competitive acid blocker, as a component of first-line and second-line triple therapy for Helicobacter pylori eradication: a phase III, randomised, double-blind study Autor Murakami, Kazunari, Sakurai, Yuuichi, Shiino, Madoka, Funao, Nobuo, Nishimura, Akira, Asaka, Masahiro

“… (with amoxicillin 750 mg and metronidazole 250 mg) as an open-label treatment.ResultsOf the 650 subjects randomly allocated to either first-line triple therapy, 641 subjects completed first-line therapy and 50…”
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Use of CTX-I and PINP as bone turnover markers: National Bone Health Alliance recommendations to standardize sample handling and patient preparation to reduce pre-analytical variability Autor Szulc, P., Naylor, K., Hoyle, N. R., Eastell, R., Leary, E. T.

“…Summary The National Bone Health Alliance (NBHA) recommends standardized sample handling and patient preparation for C-terminal telopeptide of type I collagen…”
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Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial Autor Lou, Yan, Liu, Lin, Yao, Hangping, Hu, Xingjiang, Su, Junwei, Xu, Kaijin, Luo, Rui, Yang, Xi, He, Lingjuan, Lu, Xiaoyang, Zhao, Qingwei, Liang, Tingbo, Qiu, Yunqing

“…•An exploratory randomized, controlled trial of baloxavir marboxil and favipiravir in COVID-19 patients were conducted.•The free drug concentrations of…”
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Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban Autor Ansell, Jack E., Bakhru, Sasha H., Laulicht, Bryan E., Steiner, Solomon S., Grosso, Michael A., Brown, Karen, Dishy, Victor, Lanz, Hans J., Mercuri, Michele F., Noveck, Robert J., Costin, James C.

“…) alone and following a 60 mg dose of the FXa inhibitor edoxaban. Escalating, single IV doses of ciraparantag were administered alone and following a 60 mg oral dose of edoxaban in a double-blind, placebo-controlled fashion to healthy subjects…”
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Bedside Monitoring to Adjust Antiplatelet Therapy for Coronary Stenting Autor Collet, Jean-Philippe, Cuisset, Thomas, Rangé, Grégoire, Cayla, Guillaume, Elhadad, Simon, Pouillot, Christophe, Henry, Patrick, Motreff, Pascal, Carrié, Didier, Boueri, Ziad, Belle, Loic, Van Belle, Eric, Rousseau, Hélène, Aubry, Pierre, Monségu, Jacques, Sabouret, Pierre, O'Connor, Stephen A, Abtan, Jérémie, Kerneis, Mathieu, Saint-Etienne, Christophe, Barthélémy, Olivier, Beygui, Farzin, Silvain, Johanne, Vicaut, Eric, Montalescot, Gilles

“…In this trial, bedside platelet-function monitoring to adjust antiplatelet therapy after coronary stent implantation did not reduce the rate of subsequent…”
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Comparison of prasugrel and ticagrelor loading doses in ST-segment elevation myocardial infarction patients: RAPID (Rapid Activity of Platelet Inhibitor Drugs) primary PCI study Autor Parodi, Guido, Valenti, Renato, Bellandi, Benedetta, Migliorini, Angela, Marcucci, Rossella, Comito, Vincenzo, Carrabba, Nazario, Santini, Alberto, Gensini, Gian Franco, Abbate, Rosanna, Antoniucci, David

“…). However, the pharmacodynamic measurements after prasugrel and ticagrelor LD have been provided by assessing only healthy volunteers or subjects with stable coronary artery disease…”
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Accurate detection of outliers and subpopulations with Pmetrics, a nonparametric and parametric pharmacometric modeling and simulation package for R Autor Neely, Michael N, van Guilder, Michael G, Yamada, Walter M, Schumitzky, Alan, Jelliffe, Roger W

“…Nonparametric population modeling algorithms have a theoretical superiority over parametric methods to detect pharmacokinetic and pharmacodynamic subgroups and…”
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An Innovative Approach to Characterize Clinical ADME and Pharmacokinetics of the Inhaled Drug Nemiralisib Using an Intravenous Microtracer Combined with an Inhaled Dose and an Oral Radiolabel Dose in Healthy Male Subjects Autor Harrell, Andrew W, Wilson, Robert, Man, Yau Lun, Riddell, Kylie, Jarvis, Emily, Young, Graeme, Chambers, Robert, Crossman, Lee, Georgiou, Alex, Pereira, Adrian, Kenworthy, David, Beaumont, Claire, Marotti, Miriam, Wilkes, Denisa, Hessel, Edith M, Fahy, William A

“…An innovative open-label, crossover clinical study was used to investigate the excretion balance, pharmacokinetics, and metabolism of nemiralisib-an inhaled…”
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Impact of apixaban on routine and specific coagulation assays: a practical laboratory guide Autor Douxfils, Jonathan, Chatelain, Christian, Chatelain, Bernard, Dogné, Jean-Michel, Mullier, François

“…Apixaban does not require monitoring nor frequent dose adjustment. However, searching for the optimal dose for the individual patient may be useful in some…”
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Effects of repeated oral doses of ketoconazole on a sequential ascending single oral dose of fedratinib in healthy subjects Autor Ogasawara, Ken, Xu, Christine, Kanamaluru, Vanaja, Palmisano, Maria, Krishna, Gopal

“… The primary objective of this study was to evaluate the effects of 14-day repeated 200 mg twice daily (BID) oral doses of a strong CYP3A4 inhibitor, ketoconazole, on a sequential ascending single oral dose of fedratinib in healthy male subjects…”
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Risks of stroke and mortality associated with suboptimal anticoagulation in atrial fibrillation patients Autor Gallagher, A M, Setakis, E, Plumb, J M, Clemens, A, van Staa, T-P

“…Atrial fibrillation (AF) carries an increased risk of ischaemic stroke, and oral anticoagulation with warfarin can reduce this risk. The objective of this…”
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