Suchergebnisse - "Draper, Heather"

Evaluating pediatric antimicrobial dosing of β-lactam antibiotics for upper respiratory tract infections in emergency and primary care settings von Blower, Noah, Draper, Heather M, McAlpine, Tara, Dumkow, Lisa E

“… Pediatric prescribing is often weight and indication specific and has been associated with high rates of error. The aim of this study was to evaluate …”
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Pharmacokinetics, optimal dosing, and safety of linezolid in children with multidrug-resistant tuberculosis: Combined data from two prospective observational studies von Garcia-Prats, Anthony J., Schaaf, H. Simon, Draper, Heather R., Garcia-Cremades, Maria, Winckler, Jana, Wiesner, Lubbe, Hesseling, Anneke C., Savic, Rada M.

“… Linezolid is increasingly important for multidrug-resistant tuberculosis (MDR-TB) treatment. However, among children with MDR-TB, there are no linezolid …”
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A Systematic Review of the Prevalence and Associations of Limited Health Literacy in CKD von Taylor, Dominic M, Fraser, Simon D S, Bradley, J Andrew, Bradley, Clare, Draper, Heather, Metcalfe, Wendy, Oniscu, Gabriel C, Tomson, Charles R V, Ravanan, Rommel, Roderick, Paul J

“… The self-management and decision-making skills required to manage CKD successfully may be diminished in those with low health literacy. A 2012 review …”
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Tuberculosis Disease during Pregnancy and Treatment Outcomes in HIV-Infected and Uninfected Women at a Referral Hospital in Cape Town von Bekker, Adrie, Schaaf, Hendrik S., Draper, Heather R., Kriel, Magdalena, Hesseling, Anneke C.

“… Tuberculosis during pregnancy and treatment outcomes are poorly defined in high prevalence tuberculosis and HIV settings. A prospective cohort study of …”
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Factors associated with linkage to HIV care and TB treatment at community-based HIV testing services in Cape Town, South Africa von Meehan, Sue-Ann, Sloot, Rosa, Draper, Heather R., Naidoo, Pren, Burger, Ronelle, Beyers, Nulda

“… Diagnosing HIV and/or TB is not sufficient; linkage to care and treatment is conditional to reduce the burden of disease. This study aimed to determine factors …”
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Pharmacokinetics and safety of high-dose rifampicin in children with TB: the Opti-Rif trial von Garcia-Prats, Anthony J, Svensson, Elin M, Winckler, Jana, Draper, Heather R, Fairlie, Lee, van der Laan, Louvina E, Masenya, Masebole, Schaaf, H Simon, Wiesner, Lubbe, Norman, Jennifer, Aarnoutse, Rob E, Karlsson, Mats O, Denti, Paolo, Hesseling, Anneke C

“… Rifampicin doses of 40 mg/kg in adults are safe and well tolerated, may shorten anti-TB treatment and improve outcomes, but have not been evaluated in …”
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Impact of Opioid Administration in the Intensive Care Unit and Subsequent Use in Opioid-Naïve Patients von Krancevich, Niki M, Belfer, Julie J, Draper, Heather M, Schmidt, Kyle J

“… Opioids are a mainstay of therapy for patients in the intensive care unit (ICU) as part of the analgesia-first approach to sedation. Despite knowledge of acute …”
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Pharmacokinetics and Optimal Dosing of Levofloxacin in Children for Drug-Resistant Tuberculosis: An Individual Patient Data Meta-Analysis von White, Yasmine N, Solans, Belen P, Denti, Paolo, van der Laan, Louvina E, Schaaf, H Simon, Vonasek, Bryan, Malik, Amyn A, Draper, Heather R, Hussain, Hamidah, Hesseling, Anneke C, Garcia-Prats, Anthony J, Savic, Radojka M

“… Abstract Background Each year 25 000–32 000 children develop rifampicin- or multidrug-resistant tuberculosis (RR/MDR-TB), and many more require preventive …”
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SPIRIT-PRO Extension explanation and elaboration: guidelines for inclusion of patient-reported outcomes in protocols of clinical trials von Calvert, Melanie, King, Madeleine, Mercieca-Bebber, Rebecca, Aiyegbusi, Olalekan, Kyte, Derek, Slade, Anita, Chan, An-Wen, Basch, E, Bell, Jill, Bennett, Antonia, Bhatnagar, Vishal, Blazeby, Jane, Bottomley, Andrew, Brown, Julia, Brundage, Michael, Campbell, Lisa, Cappelleri, Joseph C, Draper, Heather, Dueck, Amylou C, Ells, Carolyn, Frank, Lori, Golub, Robert M, Griebsch, Ingolf, Haywood, Kirstie, Hunn, Amanda, King-Kallimanis, Bellinda, Martin, Laura, Mitchell, Sandra, Morel, Thomas, Nelson, Linda, Norquist, Josephine, O'Connor, Daniel, Palmer, Michael, Patrick, Donald, Price, Gary, Regnault, Antoine, Retzer, Ameeta, Revicki, Dennis, Scott, Jane, Stephens, Richard, Turner, Grace, Valakas, Antonia, Velikova, Galina, von Hildebrand, Maria, Walker, Anita, Wenzel, Lari

“… Patient-reported outcomes (PROs) are used in clinical trials to provide valuable evidence on the impact of disease and treatment on patients’ symptoms, …”
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Pharmacokinetics and safety of moxifloxacin in children with multidrug-resistant tuberculosis von Thee, Stephanie, Garcia-Prats, Anthony J, Draper, Heather R, McIlleron, Helen M, Wiesner, Lubbe, Castel, Sandra, Schaaf, H Simon, Hesseling, Anneke C

“… Moxifloxacin is currently recommended at a dose of 7.5-10 mg/kg for children with multidrug-resistant (MDR) tuberculosis, but pharmacokinetic and long-term …”
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Pharmacokinetics and Safety of Clofazimine in Children With Rifampicin-Resistant Tuberculosis von Hughes, Jennifer A, Solans, Belén P, Garcia-Prats, Anthony J, Draper, Heather R, Schaaf, H Simon, Nielsen, James C, Nortier, Elri, Courtney, Ingrid, Palmer, Megan, van der Laan, Louvina, Savic, Radojka M, Hesseling, Anneke C

“… Abstract Background We described the pharmacokinetics and safety of clofazimine in children treated for multidrug/rifampicin-resistant tuberculosis …”
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Ethical challenges experienced by UK military medical personnel deployed to Sierra Leone (operation GRITROCK) during the 2014–2015 Ebola outbreak: a qualitative study von Draper, Heather, Jenkins, Simon

“… Background As part of its response to the 2014 Ebola outbreak in west Africa, the United Kingdom (UK) government established an Ebola treatment unit in Sierra …”
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Linezolid Pharmacokinetic-Anemia Modeling in Children With Rifampicin-Resistant Tuberculosis von Brooks, Jordan T, Solans, Belén P, Béranger, Agathe, Schaaf, H Simon, van der Laan, Louvina, Sharma, Sangeeta, Furin, Jennifer, Draper, Heather R, Hesseling, Anneke C, Garcia-Prats, Anthony J, Savic, Radojka M

“… Linezolid, a component of rifampicin-resistant/multidrug-resistant tuberculosis (RR/MDR-TB) treatment, is associated with treatment-limiting toxicities, …”
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QT Interval Prolongation with One or More QT-Prolonging Agents Used as Part of a Multidrug Regimen for Rifampicin-Resistant Tuberculosis Treatment: Findings from Two Pediatric Studies von Ali, Ali Mohamed, Radtke, Kendra K, Hesseling, Anneke C, Winckler, Jana, Schaaf, H Simon, Draper, Heather R, Solans, Belén P, van der Laan, Louvina, Hughes, Jennifer, Fourie, Barend, Nielsen, James, Garcia-Prats, Anthony J, Savic, Rada M

“… Rifampicin-resistant tuberculosis (RR-TB) involves treatment with many drugs that can prolong the QT interval; this risk may increase when multiple …”
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Inconsistencies in Quality of Life Data Collection in Clinical Trials: A Potential Source of Bias? Interviews with Research Nurses and Trialists von Kyte, Derek, Ives, Jonathan, Draper, Heather, Keeley, Thomas, Calvert, Melanie

“… Patient-reported outcomes (PROs), such as health-related quality of life (HRQL) are increasingly used to evaluate treatment effectiveness in clinical trials, …”
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Moxifloxacin Pharmacokinetics, Cardiac Safety, and Dosing for the Treatment of Rifampicin-Resistant Tuberculosis in Children von Radtke, Kendra K, Hesseling, Anneke C, Winckler, J L, Draper, Heather R, Solans, Belen P, Thee, Stephanie, Wiesner, Lubbe, van der Laan, Louvina E, Fourie, Barend, Nielsen, James, Schaaf, H Simon, Savic, Radojka M, Garcia-Prats, Anthony J

“… Moxifloxacin is a recommended drug for rifampin-resistant tuberculosis (RR-TB) treatment, but there is limited pediatric pharmacokinetic and safety data, …”
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Xpert MTB/RIF on Stool Is Useful for the Rapid Diagnosis of Tuberculosis in Young Children With Severe Pulmonary Disease von Walters, Elisabetta, van der Zalm, Marieke Magrieta, Palmer, Megan, Bosch, Corné, Demers, Anne-Marie, Draper, Heather, Goussard, Pierre, Schaaf, Hendrik Simon, Friedrich, Sven Olaf, Whitelaw, Andrew, Warren, Robin, Gie, Robert P, Hesseling, Anneke C

“… Tuberculosis (TB) continues to result in high morbidity and mortality in children from resource-limited settings. Diagnostic challenges, including …”
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Pharmacokinetics and cardiac safety of clofazimine in children with rifampicin-resistant tuberculosis von Ali, Ali Mohamed, P Solans, Belén, Hesseling, Anneke C, Winckler, Jana, Schaaf, H Simon, Draper, Heather R, van der Laan, Louvina, Hughes, Jennifer, Fourie, Barend, Nielsen, James, Wiesner, Lubbe, Garcia-Prats, Anthony J, Savic, Radojka M

“… Clofazimine is recommended for the treatment of rifampicin-resistant tuberculosis (RR-TB), but there is currently no verified dosing guideline for its use in …”
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Antibiotic stewardship in the emergency department setting: Focus on oral antibiotic selection for adults with skin and soft tissue infections von Draper, Heather M, Rybak, Michael J, LaPlante, Kerry L, Lodise, Thomas, Sakoulas, George, Burk, Muriel, Cunningham, Francesca E

“… Abstract Purpose An advisory panel of experts was convened by the ASHP Foundation as a part of its Medication-Use Evaluation Resources initiative to provide …”
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Pharmacokinetics and optimized dosing of dispersible and non-dispersible levofloxacin formulations in young children von van der Laan, Louvina E, Hesseling, Anneke C, Schaaf, H Simon, Palmer, Megan, Draper, Heather R, Wiesner, Lubbe, Denti, Paolo, Garcia-Prats, Anthony J

“… Abstract Background Levofloxacin is used for treatment and prevention of rifampicin-resistant (RR)-TB in children. Recent data showed higher exposures with 100 …”
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