Výsledky vyhledávání - "Double-Blind Method"

Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double‐Blind, Placebo‐Controlled, Crossover Study in Healthy Subjects Autor Becker, Anna M., Holze, Friederike, Grandinetti, Tanja, Klaiber, Aaron, Toedtli, Vanja E., Kolaczynska, Karolina E., Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Grünblatt, Edna, Liechti, Matthias E.

“…) in healthy subjects after pretreatment with escitalopram or placebo. The treatment order was random and counterbalanced…”
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Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects Autor Holze, Friederike, Ley, Laura, Müller, Felix, Becker, Anna M, Straumann, Isabelle, Vizeli, Patrick, Kuehne, Sebastian Silva, Roder, Marc A, Duthaler, Urs, Kolaczynska, Karolina E, Varghese, Nimmy, Eckert, Anne, Liechti, Matthias E

“… We used a double-blind, randomized, placebo-controlled, crossover design in 28 healthy subjects (14 women, 14 men…”
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Microbiota engraftment after faecal microbiota transplantation in obese subjects with type 2 diabetes: a 24-week, double-blind, randomised controlled trial Autor Ng, Siew C, Xu, Zhilu, Mak, Joyce Wing Yan, Yang, Keli, Liu, Qin, Zuo, Tao, Tang, Whitney, Lau, Louis, Lui, Rashid N, Wong, Sunny H, Tse, Yee Kit, Li, Amy Y L, Cheung, Kitty, Ching, Jessica Y L, Wong, Vincent W S, Kong, Alice P S, Ma, Ronald C W, Chow, Elaine Y K, Wong, Simon K H, Ho, Ivan Chak Hang, Chan, Paul K S, Chan, Francis K L

“…).DesignIn this double-blind, randomised, placebo-controlled trial, 61 obese subjects with T2DM were randomly assigned to three parallel groups…”
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A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects Autor Taylor, Lesley, Gidal, Barry, Blakey, Graham, Tayo, Bola, Morrison, Gilmour

“…] twice daily), and food effect (1500 mg CBD single dose [ n =  12]). All subjects completed all trial arms and were analyzed as planned…”
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Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate-to-severe plaque psoriasis up to 1 year: Results from the CLEAR study Autor Blauvelt, Andrew, Reich, Kristian, Tsai, Tsen-Fang, Tyring, Stephen, Vanaclocha, Francisco, Kingo, Külli, Ziv, Michael, Pinter, Andreas, Vender, Ronald, Hugot, Sophie, You, Ruquan, Milutinovic, Marina, Thaçi, Diamant

“…Secukinumab demonstrated superior efficacy to ustekinumab at week 4 and week 16 of the CLEAR study, with comparable safety, in subjects with moderate-to-severe plaque psoriasis…”
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Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects Autor Holze, Friederike, Vizeli, Patrick, Müller, Felix, Ley, Laura, Duerig, Raoul, Varghese, Nimmy, Eckert, Anne, Borgwardt, Stefan, Liechti, Matthias E

“…Lysergic acid diethylamide (LSD) is a classic psychedelic, 3,4-methylenedioxymethamphetamine (MDMA) is an empathogen, and D-amphetamine is a classic stimulant…”
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EPA and DHA differentially modulate monocyte inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study Autor So, Jisun, Wu, Dayong, Lichtenstein, Alice H., Tai, Albert K., Matthan, Nirupa R., Maddipati, Krishna Rao, Lamon-Fava, Stefania

“…The independent effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on chronic inflammation through their downstream lipid mediators,…”
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Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects Autor Schmid, Yasmin, Enzler, Florian, Gasser, Peter, Grouzmann, Eric, Preller, Katrin H., Vollenweider, Franz X., Brenneisen, Rudolf, Müller, Felix, Borgwardt, Stefan, Liechti, Matthias E.

“…) and placebo were administered to 16 healthy subjects (8 women, 8 men). Outcome measures included psychometric scales…”
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Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects Autor Kelly, John R., Allen, Andrew P., Temko, Andriy, Hutch, William, Kennedy, Paul J., Farid, Niloufar, Murphy, Eileen, Boylan, Geraldine, Bienenstock, John, Cryan, John F., Clarke, Gerard, Dinan, Timothy G.

“…•L. rhamnosus can reduce stress-related behaviour and corticosterone release in mice.•8week, randomized, placebo-controlled, cross-over trial in healthy males…”
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Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects Autor Nugent, Allison C, Ballard, Elizabeth D, Gould, Todd D, Park, Lawrence T, Moaddel, Ruin, Brutsche, Nancy E, Zarate, Jr, Carlos A

“…) as a proxy measure for homeostatic balance in 35 unmedicated subjects with major depressive disorder (MDD…”
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Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomized controlled trial Autor Thaçi, Diamant, Blauvelt, Andrew, Reich, Kristian, Tsai, Tsen-Fang, Vanaclocha, Francisco, Kingo, Külli, Ziv, Michael, Pinter, Andreas, Hugot, Sophie, You, Ruquan, Milutinovic, Marina

“…), 676 subjects were randomized 1:1 to subcutaneous injection of secukinumab 300 mg or ustekinumab per label…”
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Effects of once‐weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity Autor Blundell, John, Finlayson, Graham, Axelsen, Mads, Flint, Anne, Gibbons, Catherine, Kvist, Trine, Hjerpsted, Julie B.

“… weeks of treatment with once‐weekly subcutaneous semaglutide, dose‐escalated to 1.0 mg, in 30 subjects with obesity…”
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The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes Autor Gaich, Gregory, Chien, Jenny Y, Fu, Haoda, Glass, Leonard C, Deeg, Mark A, Holland, William L, Kharitonenkov, Alexei, Bumol, Thomas, Schilske, Holger K, Moller, David E

“…Fibroblast growth factor 21 (FGF21) is a recently discovered metabolic regulator. Exogenous FGF21 produces beneficial metabolic effects in animal models;…”
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Long-lasting subjective effects of LSD in normal subjects Autor Schmid, Yasmin, Liechti, Matthias E.

“…Rationale Lysergic acid diethylamide (LSD) and other serotonergic hallucinogens can induce profound alterations of consciousness and mystical-type experiences,…”
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Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis Autor Hirani, Nikhil, MacKinnon, Alison C, Nicol, Lisa, Ford, Paul, Schambye, Hans, Pedersen, Anders, Nilsson, Ulf J, Leffler, Hakon, Sethi, Tariq, Tantawi, Susan, Gravelle, Lise, Slack, Robert J, Mills, Ross, Karmakar, Utsa, Humphries, Duncan, Zetterberg, Fredrik, Keeling, Lucy, Paul, Lyn, Molyneaux, Philip L, Li, Feng, Funston, Wendy, Forrest, Ian A, Simpson, A John, Gibbons, Michael A, Maher, Toby M

“… subjects and 24 patients with IPF. Six dose cohorts of six healthy subjects were evaluated (4:2 TD139:placebo ratio…”
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Daridorexant, a new dual orexin receptor antagonist, in elderly subjects with insomnia disorder Autor Zammit, Gary, Dauvilliers, Yves, Pain, Scott, Sebök Kinter, Dalma, Mansour, Yosef, Kunz, Dieter

“…To assess the dose-response of daridorexant, a new dual orexin receptor antagonist, on wake after sleep onset (WASO). Elderly (≥65 years) participants (n = 58)…”
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Efficacy of the Nav1.7 blocker PF-05089771 in a randomised, placebo-controlled, double-blind clinical study in subjects with painful diabetic peripheral neuropathy Autor McDonnell, Aoibhinn, Collins, Susie, Ali, Zahid, Iavarone, Laura, Surujbally, Raulin, Kirby, Simon, Butt, Richard P

“… Single-blind placebo was administered throughout run-in and run-out periods. Subjects were randomised to receive either PF-05089771 150 mg twice daily, pregabalin 150 mg twice daily, or placebo during the 4-week treatment period…”
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Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes Autor Lambers Heerspink, H. J., de Zeeuw, D., Wie, L., Leslie, B., List, J.

“…‐blind trial, 75 subjects with type 2 diabetes were assigned placebo, dapagliflozin 10…”
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The Effect of Increasing Dialysate Magnesium on Serum Calcification Propensity in Subjects with End Stage Kidney Disease: A Randomized, Controlled Clinical Trial Autor Bressendorff, Iain, Hansen, Ditte, Schou, Morten, Pasch, Andreas, Brandi, Lisbet

“… Increasing magnesium in serum increases T , but so far, no clinical trials have investigated whether increasing serum magnesium increases serum calcification propensity in subjects with ESKD…”
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Omalizumab facilitates rapid oral desensitization for peanut allergy Autor MacGinnitie, Andrew J., Rachid, Rima, Gragg, Hana, Little, Sara V., Lakin, Paul, Cianferoni, Antonella, Heimall, Jennifer, Makhija, Melanie, Robison, Rachel, Chinthrajah, R. Sharon, Lee, John, Lebovidge, Jennifer, Dominguez, Tina, Rooney, Courtney, Lewis, Megan Ott, Koss, Jennifer, Burke-Roberts, Elizabeth, Chin, Kimberly, Logvinenko, Tanya, Pongracic, Jacqueline A., Umetsu, Dale T., Spergel, Jonathan, Nadeau, Kari C., Schneider, Lynda C.

“… Thirty-seven subjects were randomized to omalizumab (n = 29) or placebo (n = 8). After 12 weeks of treatment, subjects underwent a rapid 1-day desensitization of up to…”
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