Suchergebnisse - "Dobson, Stephanie M"

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells von Lechman, Eric R, Gentner, Bernhard, Ng, Stanley W K, Schoof, Erwin M, van Galen, Peter, Kennedy, James A, Nucera, Silvia, Ciceri, Fabio, Kaufmann, Kerstin B, Takayama, Naoya, Dobson, Stephanie M, Trotman-Grant, Aaron, Krivdova, Gabriela, Elzinga, Janneke, Mitchell, Amanda, Nilsson, Björn, Hermans, Karin G, Eppert, Kolja, Marke, Rene, Isserlin, Ruth, Voisin, Veronique, Bader, Gary D, Zandstra, Peter W, Golub, Todd R, Ebert, Benjamin L, Lu, Jun, Minden, Mark, Wang, Jean C Y, Naldini, Luigi, Dick, John E

“… To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we generated a prognostic LSC-associated miRNA signature derived from …”
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Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors von Wojtowicz, Edyta E, Lechman, Eric R, Hermans, Karin G, Schoof, Erwin M, Wienholds, Erno, Isserlin, Ruth, van Veelen, Peter A, Broekhuis, Mathilde J C, Janssen, George M C, Trotman-Grant, Aaron, Dobson, Stephanie M, Krivdova, Gabriela, Elzinga, Jantje, Kennedy, James, Gan, Olga I, Sinha, Ankit, Ignatchenko, Vladimir, Kislinger, Thomas, Dethmers-Ausema, Bertien, Weersing, Ellen, Alemdehy, Mir Farshid, de Looper, Hans W J, Bader, Gary D, Ritsema, Martha, Erkeland, Stefan J, Bystrykh, Leonid V, Dick, John E, de Haan, Gerald

“… Umbilical cord blood (CB) is a convenient and broadly used source of hematopoietic stem cells (HSCs) for allogeneic stem cell transplantation. However, …”
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CD200 expression marks leukemia stem cells in human AML von Ho, Jenny M., Dobson, Stephanie M., Voisin, Veronique, McLeod, Jessica, Kennedy, James A., Mitchell, Amanda, Jin, Liqing, Eppert, Kolja, Bader, Gary, Minden, Mark D., Dick, John E., Wang, Jean C.Y.

“… The leukemia stem cell (LSC) populations of acute myeloid leukemia (AML) exhibit phenotypic, genetic, and functional heterogeneity that contribute to therapy …”
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Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia von Kim, Jaeseung C., Chan-Seng-Yue, Michelle, Ge, Sabrina, Zeng, Andy G. X., Ng, Karen, Gan, Olga I., Garcia-Prat, Laura, Flores-Figueroa, Eugenia, Woo, Tristan, Zhang, Amy Xin Wei, Arruda, Andrea, Chithambaram, Shivapriya, Dobson, Stephanie M., Khoo, Amanda, Khan, Shahbaz, Ibrahimova, Narmin, George, Ann, Tierens, Anne, Hitzler, Johann, Kislinger, Thomas, Dick, John E., McPherson, John D., Minden, Mark D., Notta, Faiyaz

“… In BCR-ABL1 lymphoblastic leukemia, treatment heterogeneity to tyrosine kinase inhibitors (TKIs), especially in the absence of kinase domain mutations in …”
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Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia von Churchman, Michelle L, Low, Jonathan, Qu, Chunxu, Paietta, Elisabeth M, Kasper, Lawryn H, Chang, Yunchao, Payne-Turner, Debbie, Althoff, Mark J, Song, Guangchun, Chen, Shann-Ching, Ma, Jing, Rusch, Michael, McGoldrick, Dan, Edmonson, Michael, Gupta, Pankaj, Wang, Yong-Dong, Caufield, William, Freeman, Burgess, Li, Lie, Panetta, John C, Baker, Sharyn, Yang, Yung-Li, Roberts, Kathryn G, McCastlain, Kelly, Iacobucci, Ilaria, Peters, Jennifer L, Centonze, Victoria E, Notta, Faiyaz, Dobson, Stephanie M, Zandi, Sasan, Dick, John E, Janke, Laura, Peng, Junmin, Kodali, Kiran, Pagala, Vishwajeeth, Min, Jaeki, Mayasundari, Anand, Williams, Richard T, Willman, Cheryl L, Rowe, Jacob, Luger, Selina, Dickins, Ross A, Guy, R Kiplin, Chen, Taosheng, Mullighan, Charles G

“… Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of high-risk acute lymphoblastic leukemia (ALL), however the role of …”
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Relapse-Fated Latent Diagnosis Subclones in Acute B Lineage Leukemia Are Drug Tolerant and Possess Distinct Metabolic Programs von Dobson, Stephanie M, García-Prat, Laura, Vanner, Robert J, Wintersinger, Jeffrey, Waanders, Esmé, Gu, Zhaohui, McLeod, Jessica, Gan, Olga I, Grandal, Ildiko, Payne-Turner, Debbie, Edmonson, Michael N, Ma, Xiaotu, Fan, Yiping, Voisin, Veronique, Chan-Seng-Yue, Michelle, Xie, Stephanie Z, Hosseini, Mohsen, Abelson, Sagi, Gupta, Pankaj, Rusch, Michael, Shao, Ying, Olsen, Scott R, Neale, Geoffrey, Chan, Steven M, Bader, Gary, Easton, John, Guidos, Cynthia J, Danska, Jayne S, Zhang, Jinghui, Minden, Mark D, Morris, Quaid, Mullighan, Charles G, Dick, John E

“… Disease recurrence causes significant mortality in B-progenitor acute lymphoblastic leukemia (B-ALL). Genomic analysis of matched diagnosis and relapse samples …”
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Novel FGF9 variant contributes to multiple synostoses syndrome 3 von Dobson, Stephanie M., Kiss, Courtney, Borschneck, Daniel, Heath, Karen E., Gross, Adrian, Glucksman, Marc J., Guerin, Andrea

“… Multiple synostoses syndromes (SYNS) are autosomal dominant syndromes characterized by multiple joint fusions commonly involving the carpal‐tarsal, …”
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Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia von Iacobucci, Ilaria, Li, Yongjin, Roberts, Kathryn G, Dobson, Stephanie M, Kim, Jaeseung C, Payne-Turner, Debbie, Harvey, Richard C, Valentine, Marcus, McCastlain, Kelly, Easton, John, Yergeau, Donald, Janke, Laura J, Shao, Ying, Chen, I-Ming L, Rusch, Michael, Zandi, Sasan, Kornblau, Steven M, Konopleva, Marina, Jabbour, Elias, Paietta, Elisabeth M, Rowe, Jacob M, Pui, Ching-Hon, Gastier-Foster, Julie, Gu, Zhaohui, Reshmi, Shalini, Loh, Mignon L, Racevskis, Janis, Tallman, Martin S, Wiernik, Peter H, Litzow, Mark R, Willman, Cheryl L, McPherson, John D, Downing, James R, Zhang, Jinghui, Dick, John E, Hunger, Stephen P, Mullighan, Charles G

“… Chromosomal rearrangements are a hallmark of acute lymphoblastic leukemia (ALL) and are important ALL initiating events. We describe four different …”
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Reconstructing Complex Cancer Evolutionary Histories from Multiple Bulk DNA Samples Using Pairtree von Wintersinger, Jeff A, Dobson, Stephanie M, Kulman, Ethan, Stein, Lincoln D, Dick, John E, Morris, Quaid

“… Cancers are composed of genetically distinct subpopulations of malignant cells. DNA-sequencing data can be used to determine the somatic point mutations …”
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Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia von Waanders, Esmé, Gu, Zhaohui, Dobson, Stephanie M, Antić, Željko, Crawford, Jeremy Chase, Ma, Xiaotu, Edmonson, Michael N, Payne-Turner, Debbie, van de Vorst, Maartje, Jongmans, Marjolijn C J, McGuire, Irina, Zhou, Xin, Wang, Jian, Shi, Lei, Pounds, Stanley, Pei, Deqing, Cheng, Cheng, Song, Guangchun, Fan, Yiping, Shao, Ying, Rusch, Michael, McCastlain, Kelly, Yu, Jiangyan, van Boxtel, Ruben, Blokzijl, Francis, Iacobucci, Ilaria, Roberts, Kathryn G, Wen, Ji, Wu, Gang, Ma, Jing, Easton, John, Neale, Geoffrey, Olsen, Scott R, Nichols, Kim E, Pui, Ching-Hon, Zhang, Jinghui, Evans, William E, Relling, Mary V, Yang, Jun J, Thomas, Paul G, Dick, John E, Kuiper, Roland P, Mullighan, Charles G

“… Relapse of acute lymphoblastic leukemia (ALL) remains a leading cause of childhood death. Prior studies have shown clonal mutations at relapse often arise from …”
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miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells von Lechman, Eric R, Gentner, Bernhard, Ng, Stanley W K, Schoof, Erwin M, van Galen, Peter, Kennedy, James A, Nucera, Silvia, Ciceri, Fabio, Kaufmann, Kerstin B, Takayama, Naoya, Dobson, Stephanie M, Trotman-Grant, Aaron, Krivdova, Gabriela, Elzinga, Janneke, Mitchell, Amanda, Nilsson, Björn, Hermans, Karin G, Eppert, Kolja, Marke, Rene, Isserlin, Ruth, Voisin, Veronique, Bader, Gary D, Zandstra, Peter W, Golub, Todd R, Ebert, Benjamin L, Lu, Jun, Minden, Mark, Wang, Jean C Y, Naldini, Luigi, Dick, John E

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Distinct patterns of clonal evolution in patients with concurrent myelo- and lymphoproliferative neoplasms von Kennedy, James A, Medeiros, Jessie J F, Dobson, Stephanie M, Arruda, Andrea, Sukhai, Mahadeo A, Stockley, Tracy, Tierens, Anne, Minden, Mark D, Kamel-Reid, Suzanne, Dick, John E, Gupta, Vikas

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Multiomic Profiling of Central Nervous System Leukemia Identifies mRNA Translation as a Therapeutic Target von Vanner, Robert J, Dobson, Stephanie M, Gan, Olga I, McLeod, Jessica, Schoof, Erwin M, Grandal, Ildiko, Wintersinger, Jeff A, Garcia-Prat, Laura, Hosseini, Mohsen, Xie, Stephanie Z, Jin, Liqing, Mbong, Nathan, Voisin, Veronique, Chan-Seng-Yue, Michelle, Kennedy, James A, Waanders, Esmé, Morris, Quaid, Porse, Bo, Chan, Steven M, Guidos, Cynthia J, Danska, Jayne S, Minden, Mark D, Mullighan, Charles G, Dick, John E

“… Central nervous system (CNS) dissemination of B-precursor acute lymphoblastic leukemia (B-ALL) has poor prognosis and remains a therapeutic challenge. Here we …”
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Investigation of the Neumann triangle for dodecane liquid lenses on water von David, Robert, Dobson, Stephanie M., Tavassoli, Zahra, Cabezas, M. Guadalupe, Neumann, A. Wilhelm

“… Liquid lenses of dodecane resting on a water surface are imaged and analyzed computationally. The equilibrium condition for the three-phase line is a vector …”
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Reconstructing complex cancer evolutionary histories from multiple bulk DNA samples using Pairtree von Wintersinger, Jeff A, Dobson, Stephanie M, Stein, Lincoln D, Dick, John E, Morris, Quaid D

“… 1 Abstract Cancers are composed of genetically distinct subpopulations of malignant cells. By sequencing DNA from cancer tissue samples, we can characterize …”
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Deconvolution of Leukemic Evolution Through Initiation, Progression and Relapse von Dobson, Stephanie M

“… Significant advancements in the study of the genomic architecture of B-cell acute lymphoblastic leukemia (B-ALL) have been made, but our understanding of the …”
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