Suchergebnisse - "Di Nicolantonio, Federica"

Precision oncology in metastatic colorectal cancer - from biology to medicine von Di Nicolantonio, Federica, Vitiello, Pietro Paolo, Marsoni, Silvia, Siena, Salvatore, Tabernero, Josep, Trusolino, Livio, Bernards, Rene, Bardelli, Alberto

“… Remarkable progress has been made in the development of biomarker-driven targeted therapies for patients with multiple cancer types, including melanoma, breast …”
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Adaptive mutability of colorectal cancers in response to targeted therapies von Russo, Mariangela, Crisafulli, Giovanni, Sogari, Alberto, Reilly, Nicole M, Arena, Sabrina, Lamba, Simona, Bartolini, Alice, Amodio, Vito, Magrì, Alessandro, Novara, Luca, Sarotto, Ivana, Nagel, Zachary D, Piett, Cortt G, Amatu, Alessio, Sartore-Bianchi, Andrea, Siena, Salvatore, Bertotti, Andrea, Trusolino, Livio, Corigliano, Mattia, Gherardi, Marco, Lagomarsino, Marco Cosentino, Di Nicolantonio, Federica, Bardelli, Alberto

“… The emergence of drug resistance limits the efficacy of targeted therapies in human tumors. The prevalent view is that resistance is a fait accompli: when …”
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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR von Prahallad, Anirudh, Sun, Chong, Huang, Sidong, Di Nicolantonio, Federica, Salazar, Ramon, Zecchin, Davide, Beijersbergen, Roderick L., Bardelli, Alberto, Bernards, René

“… Inhibition of activated BRAF has been ineffective in colon cancers with the mutation; here, this is shown to be due to the feedback activation of the epidermal …”
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Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients von Siravegna, Giulia, Mussolin, Benedetta, Buscarino, Michela, Corti, Giorgio, Cassingena, Andrea, Crisafulli, Giovanni, Ponzetti, Agostino, Cremolini, Chiara, Amatu, Alessio, Lauricella, Calogero, Lamba, Simona, Hobor, Sebastijan, Avallone, Antonio, Valtorta, Emanuele, Rospo, Giuseppe, Medico, Enzo, Motta, Valentina, Antoniotti, Carlotta, Tatangelo, Fabiana, Bellosillo, Beatriz, Veronese, Silvio, Budillon, Alfredo, Montagut, Clara, Racca, Patrizia, Marsoni, Silvia, Falcone, Alfredo, Corcoran, Ryan B, Di Nicolantonio, Federica, Loupakis, Fotios, Siena, Salvatore, Sartore-Bianchi, Andrea, Bardelli, Alberto

“… By monitoring ctDNA, the authors reveal the dynamic adaption of clonal populations in colorectal cancer patients treated with anti-EGFR therapy, suggesting …”
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European Groundshot—addressing Europe's cancer research challenges: a Lancet Oncology Commission von Lawler, Mark, Davies, Lynne, Oberst, Simon, Oliver, Kathy, Eggermont, Alexander, Schmutz, Anna, La Vecchia, Carlo, Allemani, Claudia, Lievens, Yolande, Naredi, Peter, Cufer, Tanja, Aggarwal, Ajay, Aapro, Matti, Apostolidis, Kathi, Baird, Anne-Marie, Cardoso, Fatima, Charalambous, Andreas, Coleman, Michel P, Costa, Alberto, Crul, Mirjam, Dégi, Csaba L, Di Nicolantonio, Federica, Erdem, Sema, Geanta, Marius, Geissler, Jan, Jassem, Jacek, Jagielska, Beata, Jonsson, Bengt, Kelly, Daniel, Kelm, Olaf, Kolarova, Teodora, Kutluk, Tezer, Lewison, Grant, Meunier, Françoise, Pelouchova, Jana, Philip, Thierry, Price, Richard, Rau, Beate, Rubio, Isabel T, Selby, Peter, Južnič Sotlar, Maja, Spurrier-Bernard, Gilliosa, van Hoeve, Jolanda C, Vrdoljak, Eduard, Westerhuis, Willien, Wojciechowska, Urszula, Sullivan, Richard

“… Cancer research is a crucial pillar for countries to deliver more affordable, higher quality, and more equitable cancer care. Patients treated in …”
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Mutational signatures of colorectal cancers according to distinct computational workflows von Battuello, Paolo, Corti, Giorgio, Bartolini, Alice, Lorenzato, Annalisa, Sogari, Alberto, Russo, Mariangela, Di Nicolantonio, Federica, Bardelli, Alberto, Crisafulli, Giovanni

“… Abstract Tumor mutational signatures have gained prominence in cancer research, yet the lack of standardized methods hinders reproducibility and robustness …”
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Intrinsic Resistance to MEK Inhibition in KRAS Mutant Lung and Colon Cancer through Transcriptional Induction of ERBB3 von Sun, Chong, Hobor, Sebastijan, Bertotti, Andrea, Zecchin, Davide, Huang, Sidong, Galimi, Francesco, Cottino, Francesca, Prahallad, Anirudh, Grernrum, Wipawadee, Tzani, Anna, Schlicker, Andreas, Wessels, Lodewyk F.A., Smit, Egbert F., Thunnissen, Erik, Halonen, Pasi, Lieftink, Cor, Beijersbergen, Roderick L., Di Nicolantonio, Federica, Bardelli, Alberto, Trusolino, Livio, Bernards, Rene

“… There are no effective therapies for the ~30% of human malignancies with mutant RAS oncogenes. Using a kinome-centered synthetic lethality screen, we find that …”
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PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs von Prahallad, Anirudh, Heynen, Guus J.J.E., Germano, Giovanni, Willems, Stefan M., Evers, Bastiaan, Vecchione, Loredana, Gambino, Valentina, Lieftink, Cor, Beijersbergen, Roderick L., Di Nicolantonio, Federica, Bardelli, Alberto, Bernards, Rene

“… Most BRAF (V600E) mutant melanomas are sensitive to selective BRAF inhibitors, but BRAF mutant colon cancers are intrinsically resistant to these drugs because …”
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RAF Suppression Synergizes with MEK Inhibition in KRAS Mutant Cancer Cells von Lamba, Simona, Russo, Mariangela, Sun, Chong, Lazzari, Luca, Cancelliere, Carlotta, Grernrum, Wipawadee, Lieftink, Cor, Bernards, Rene, Di Nicolantonio, Federica, Bardelli, Alberto

“… KRAS is the most frequently mutated oncogene in human cancer, yet no therapies are available to treat KRAS mutant cancers. We used two independent reverse …”
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Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients von Carbone, Carmine, Piro, Geny, Simionato, Francesca, Ligorio, Francesca, Cremolini, Chiara, Loupakis, Fotios, Alì, Greta, Rossini, Daniele, Merz, Valeria, Santoro, Raffaela, Zecchetto, Camilla, Zanotto, Marco, Di Nicolantonio, Federica, Bardelli, Alberto, Fontanini, Gabriella, Tortora, Giampaolo, Melisi, Davide

“… The identification of predictive biomarkers for antiangiogenic therapies remains an unmeet need. We hypothesized that the transcription factor Homeobox B9 …”
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RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer von Khawaja, Hajrah, Campbell, Andrew, Roberts, Jamie Z., Javadi, Arman, O’Reilly, Paul, McArt, Darragh, Allen, Wendy L., Majkut, Joanna, Rehm, Markus, Bardelli, Alberto, Di Nicolantonio, Federica, Scott, Christopher J., Kennedy, Richard, Vitale, Nicolas, Harrison, Timothy, Sansom, Owen J., Longley, Daniel B., Evergren, Emma, Van Schaeybroeck, Sandra

“… RAS mutant (MT) metastatic colorectal cancer (mCRC) is resistant to MEK1/2 inhibition and remains a difficult-to-treat group. Therefore, there is an unmet need …”
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Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution von Misale, Sandra, Di Nicolantonio, Federica, Sartore-Bianchi, Andrea, Siena, Salvatore, Bardelli, Alberto

“… The EGFR-targeted antibodies cetuximab and panitumumab are used to treat metastatic colorectal cancers. Mutations in KRAS, NRAS, and BRAF and amplification of …”
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High-dose vitamin C enhances cancer immunotherapy von Magrì, Alessandro, Germano, Giovanni, Lorenzato, Annalisa, Lamba, Simona, Chilà, Rosaria, Montone, Monica, Amodio, Vito, Ceruti, Tommaso, Sassi, Francesco, Arena, Sabrina, Abrignani, Sergio, D'Incalci, Maurizio, Zucchetti, Massimo, Di Nicolantonio, Federica, Bardelli, Alberto

“… Vitamin C (VitC) is known to directly impair cancer cell growth in preclinical models, but there is little clinical evidence on its antitumoral efficacy. In …”
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Exploiting DNA repair defects in colorectal cancer von Reilly, Nicole M., Novara, Luca, Di Nicolantonio, Federica, Bardelli, Alberto

“… Colorectal cancer (CRC) is the third leading cause of cancer‐related deaths worldwide. Therapies that take advantage of defects in DNA repair pathways have …”
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Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer von Siena, Salvatore, Sartore-Bianchi, Andrea, Di Nicolantonio, Federica, Balfour, Julia, Bardelli, Alberto

“… The monoclonal antibodies panitumumab and cetuximab that target the epidermal growth factor receptor (EGFR) have expanded the range of treatment options for …”
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A modified fluctuation-test framework characterizes the population dynamics and mutation rate of colorectal cancer persister cells von Russo, Mariangela, Pompei, Simone, Sogari, Alberto, Corigliano, Mattia, Crisafulli, Giovanni, Puliafito, Alberto, Lamba, Simona, Erriquez, Jessica, Bertotti, Andrea, Gherardi, Marco, Di Nicolantonio, Federica, Bardelli, Alberto, Cosentino Lagomarsino, Marco

“… Compelling evidence shows that cancer persister cells represent a major limit to the long-term efficacy of targeted therapies. However, the phenotype and …”
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A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin von Arena, Sabrina, Corti, Giorgio, Durinikova, Erika, Montone, Monica, Reilly, Nicole M, Russo, Mariangela, Lorenzato, Annalisa, Arcella, Pamela, Lazzari, Luca, Rospo, Giuseppe, Pagani, Massimiliano, Cancelliere, Carlotta, Negrino, Carola, Isella, Claudio, Bartolini, Alice, Cassingena, Andrea, Amatu, Alessio, Mauri, Gianluca, Sartore-Bianchi, Andrea, Mittica, Gloria, Medico, Enzo, Marsoni, Silvia, Linnebacher, Michael, Abrignani, Sergio, Siena, Salvatore, Di Nicolantonio, Federica, Bardelli, Alberto

“… Defects in the homologous recombination (HR) repair pathway are of clinical interest due to sensitivity of HR-deficient cells to PARP inhibitors. We were …”
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Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer von Misale, Sandra, Yaeger, Rona, Hobor, Sebastijan, Scala, Elisa, Janakiraman, Manickam, Liska, David, Valtorta, Emanuele, Schiavo, Roberta, Buscarino, Michela, Siravegna, Giulia, Bencardino, Katia, Cercek, Andrea, Chen, Chin-Tung, Veronese, Silvio, Zanon, Carlo, Sartore-Bianchi, Andrea, Gambacorta, Marcello, Gallicchio, Margherita, Vakiani, Efsevia, Boscaro, Valentina, Medico, Enzo, Weiser, Martin, Siena, Salvatore, Di Nicolantonio, Federica, Solit, David, Bardelli, Alberto

“… Molecular alterations in KRAS are associated with acquired resistance to anti-epidermal growth factor receptor (EGFR) treatment in colorectal cancer; resistant …”
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Cancer cell adaptation to chemotherapy von Di Nicolantonio, Federica, Mercer, Stuart J, Knight, Louise A, Gabriel, Francis G, Whitehouse, Pauline A, Sharma, Sanjay, Fernando, Augusta, Glaysher, Sharon, Di Palma, Silvana, Johnson, Penny, Somers, Shaw S, Toh, Simon, Higgins, Bernie, Lamont, Alan, Gulliford, Tim, Hurren, Jeremy, Yiangou, Constantinos, Cree, Ian A

“… Tumor resistance to chemotherapy may be present at the beginning of treatment, develop during treatment, or become apparent on re-treatment of the patient. The …”
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Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer von Barault, Ludovic, Amatu, Alessio, Siravegna, Giulia, Ponzetti, Agostino, Moran, Sebastian, Cassingena, Andrea, Mussolin, Benedetta, Falcomatà, Chiara, Binder, Alexandra M, Cristiano, Carmen, Oddo, Daniele, Guarrera, Simonetta, Cancelliere, Carlotta, Bustreo, Sara, Bencardino, Katia, Maden, Sean, Vanzati, Alice, Zavattari, Patrizia, Matullo, Giuseppe, Truini, Mauro, Grady, William M, Racca, Patrizia, Michels, Karin B, Siena, Salvatore, Esteller, Manel, Bardelli, Alberto, Sartore-Bianchi, Andrea, Di Nicolantonio, Federica

“… ObjectiveMutations in cell-free circulating DNA (cfDNA) have been studied for tracking disease relapse in colorectal cancer (CRC). This approach requires …”
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