Suchergebnisse - "Detmar, Michael"

Inflammation and Lymphatic Function von Schwager, Simon, Detmar, Michael

“… The lymphatic vasculature plays a crucial role in regulating the inflammatory response by influencing drainage of extravasated fluid, inflammatory mediators, …”
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Beyond PROX1: transcriptional, epigenetic, and noncoding RNA regulation of lymphatic identity and function von Ducoli, Luca, Detmar, Michael

“… The lymphatic vascular system acts as the major transportation highway of tissue fluids, and its activation or impairment is associated with a wide range of …”
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Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice von Ma, Qiaoli, Ineichen, Benjamin V., Detmar, Michael, Proulx, Steven T.

“… Cerebrospinal fluid (CSF) has been commonly accepted to drain through arachnoid projections from the subarachnoid space to the dural venous sinuses. However, a …”
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Lymphatic vessels in cancer von Dieterich, Lothar C, Tacconi, Carlotta, Ducoli, Luca, Detmar, Michael

“… The lymphatic system, composed of initial and collecting lymphatic vessels as well as lymph nodes that are present in almost every tissue of the human body, …”
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Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes von Fujimoto, Noriki, He, Yuliang, D’Addio, Marco, Tacconi, Carlotta, Detmar, Michael, Dieterich, Lothar C.

“… Lymph nodes (LNs) are highly organized secondary lymphoid organs that mediate adaptive immune responses to antigens delivered via afferent lymphatic vessels …”
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The Cutaneous Vascular System in Chronic Skin Inflammation von Huggenberger, Reto, Detmar, Michael

“… The blood and lymphatic vasculature have an important role in skin homeostasis. Angiogenesis and lymphangiogenesis—the growth of new vessels from existing …”
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Lymphangiogenesis and cancer metastasis von Mumprecht, Viviane, Detmar, Michael

“… •  Anatomy and function of the lymphatic system •  Tumour‐induced lymphangiogenesis promotes metastasis •  Tumour‐induced lymph node lymphangiogenesis precedes …”
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An Important Role of the SDF-1/CXCR4 Axis in Chronic Skin Inflammation von Zgraggen, Silvana, Huggenberger, Reto, Kerl, Katrin, Detmar, Michael

“… Inflammatory angiogenesis and vascular remodeling play key roles in the chronic inflammatory skin disease psoriasis, but little is known about the molecular …”
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TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays von Gebäck, Tobias, Schulz, Martin Michael Peter, Koumoutsakos, Petros, Detmar, Michael

“… Cell migration plays a major role in development, physiology, and disease, and is frequently evaluated in vitro by the monolayer wound healing assay. The assay …”
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Stromal cells and epigenetics: emerging key players of chronic inflammatory skin diseases von Kim, Jihye, Detmar, Michael

“… Epigenetic alterations play a crucial role in developmental processes, tissue regeneration, and cellular differentiation. Epigenetic changes are dynamically …”
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Tumor lymphangiogenesis and melanoma metastasis von Rinderknecht, Matthias, Detmar, Michael

“… Malignant melanomas of the skin primarily metastasize to lymph nodes, and the detection of sentinel lymph node metastases serves as an important prognostic …”
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Open pathways for cerebrospinal fluid outflow at the cribriform plate along the olfactory nerves von Spera, Irene, Cousin, Nikola, Ries, Miriam, Kedracka, Anna, Castillo, Alina, Aleandri, Simone, Vladymyrov, Mykhailo, Mapunda, Josephine A., Engelhardt, Britta, Luciani, Paola, Detmar, Michael, Proulx, Steven T.

“… Routes along the olfactory nerves crossing the cribriform plate that extend to lymphatic vessels within the nasal cavity have been identified as a critical …”
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An important role of lymphatic vessel activation in limiting acute inflammation von Huggenberger, Reto, Siddiqui, Shoib S, Brander, Daniela, Ullmann, Stefan, Zimmermann, Kathrin, Antsiferova, Maria, Werner, Sabine, Alitalo, Kari, Detmar, Michael

“… In contrast to the established role of blood vessel remodeling in inflammation, the biologic function of the lymphatic vasculature in acute inflammation has …”
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Pathways targeting tumor lymphangiogenesis von Wissmann, Christoph, Detmar, Michael

“… Tumor metastasis to sentinel lymph nodes represents the first step of tumor dissemination in most human cancers and serves as a major prognostic indicator for …”
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Sostdc1 Secreted from Cutaneous Lymphatic Vessels Acts as a Paracrine Factor for Hair Follicle Growth von Yoon, Sun-Young, Detmar, Michael

“… In our previous study, we found that lymphatic vessels stimulate hair follicle growth through paracrine effects on dermal papilla cells. However, the paracrine …”
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Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation von Huggenberger, Reto, Ullmann, Stefan, Proulx, Steven T, Pytowski, Bronislaw, Alitalo, Kari, Detmar, Michael

“… The role of lymphangiogenesis in inflammation has remained unclear. To investigate the role of lymphatic versus blood vasculature in chronic skin inflammation, …”
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CD169+ lymph node macrophages have protective functions in mouse breast cancer metastasis von Tacconi, Carlotta, Commerford, Catharina D., Dieterich, Lothar C., Schwager, Simon, He, Yuliang, Ikenberg, Kristian, Friebel, Ekaterina, Becher, Burkhard, Tugues, Sònia, Detmar, Michael

“… Although the contribution of macrophages to metastasis is widely studied in primary tumors, the involvement of macrophages in tumor-draining lymph nodes (LNs) …”
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Activation of the VEGFC/VEGFR3 Pathway Induces Tumor Immune Escape in Colorectal Cancer von Tacconi, Carlotta, Ungaro, Federica, Correale, Carmen, Arena, Vincenzo, Massimino, Luca, Detmar, Michael, Spinelli, Antonino, Carvello, Michele, Mazzone, Massimiliano, Oliveira, Ana I, Rubbino, Federica, Garlatti, Valentina, Spanò, Salvatore, Lugli, Enrico, Colombo, Federico S, Malesci, Alberto, Peyrin-Biroulet, Laurent, Vetrano, Stefania, Danese, Silvio, D'Alessio, Silvia

“… Colorectal cancer is a major cause of cancer-related death in Western countries and is associated with increased numbers of lymphatic vessels (LV) and …”
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Lymphatic endothelium in health and disease von Jurisic, Giorgia, Detmar, Michael

“… The lymphatic vascular system has an important role in the maintenance of tissue fluid pressure homeostasis, in the mediation of the afferent immune response …”
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VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites von Hirakawa, Satoshi, Brown, Lawrence F, Kodama, Shohta, Paavonen, Karri, Alitalo, Kari, Detmar, Michael

“… The mechanisms by which tumors metastasize to sentinel and distant lymph nodes, and beyond, are poorly understood. We developed transgenic mice that …”
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