Suchergebnisse - "Deriš, Helena"
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Extensive weight loss reduces glycan age by altering IgG N-glycosylation
ISSN: 0307-0565, 1476-5497, 1476-5497Veröffentlicht: England Nature Publishing Group 01.07.2021Veröffentlicht in International Journal of Obesity (01.07.2021)“… Obesity, a major global health problem, is associated with increased cardiometabolic morbidity and mortality. Protein glycosylation is a frequent …”
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Fast NMR-Based Assessment of Cancer-Associated Protein Glycosylations from Serum Samples
ISSN: 1520-6882, 1520-6882Veröffentlicht: United States 06.05.2025Veröffentlicht in Analytical chemistry (Washington) (06.05.2025)“… Nuclear magnetic resonance (NMR) spectra of blood serum and plasma show signals arising from metabolites, lipoproteins, and -acetyl methyl groups of -glycans …”
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Effects of low-calorie and different weight-maintenance diets on IgG glycome composition
ISSN: 1664-3224, 1664-3224Veröffentlicht: Frontiers Media S.A 21.09.2022Veröffentlicht in Frontiers in immunology (21.09.2022)“… Obesity-induced inflammation activates the adaptive immune system by altering immunoglobulin G (IgG) glycosylation in a way to produce more proinflammatory …”
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Susceptibility of Human Plasma N-glycome to Low-Calorie and Different Weight-Maintenance Diets
ISSN: 1422-0067, 1661-6596, 1422-0067Veröffentlicht: Switzerland MDPI AG 12.12.2022Veröffentlicht in International journal of molecular sciences (12.12.2022)“… Aberrant plasma protein glycosylation is associated with a wide range of diseases, including diabetes, cardiovascular, and immunological disorders. To …”
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Plasma protein N-glycome composition associates with postprandial lipaemic response
ISSN: 1741-7015, 1741-7015Veröffentlicht: London BioMed Central 03.07.2023Veröffentlicht in BMC medicine (03.07.2023)“… Background A dysregulated postprandial metabolic response is a risk factor for chronic diseases, including type 2 diabetes mellitus (T2DM). The plasma protein …”
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Physical Exercise Induces Significant Changes in Immunoglobulin G N-Glycan Composition in a Previously Inactive, Overweight Population
ISSN: 2218-273X, 2218-273XVeröffentlicht: Switzerland MDPI AG 27.04.2023Veröffentlicht in Biomolecules (Basel, Switzerland) (27.04.2023)“… Regular exercise improves health, modulating the immune system and impacting inflammatory status. Immunoglobulin G (IgG) N-glycosylation reflects changes in …”
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Anti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn’s Disease
ISSN: 2218-273X, 2218-273XVeröffentlicht: Switzerland MDPI AG 01.06.2023Veröffentlicht in Biomolecules (Basel, Switzerland) (01.06.2023)“… Crohn’s disease (CD) is a chronic inflammation of the digestive tract that significantly impairs patients’ quality of life and well-being. Anti-TNF biologicals …”
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Mediated spectroelectrochemical determination of holo-transferrin reduction potential using a flow cell with disposable screen-printed indium‑tin oxide electrode
ISSN: 1388-2481, 1873-1902Veröffentlicht: Elsevier B.V 01.11.2017Veröffentlicht in Electrochemistry communications (01.11.2017)“… A convenient spectroelectrochemical method for the determination of holo-transferrin reduction potential is described. All materials and accessories are …”
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Immunoglobulin G glycome composition in transition from premenopause to postmenopause
ISSN: 2589-0042, 2589-0042Veröffentlicht: United States Elsevier Inc 18.03.2022Veröffentlicht in iScience (18.03.2022)“… Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms …”
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Total serum N-glycans associate with response to immune checkpoint inhibition therapy and survival in patients with advanced melanoma
ISSN: 1471-2407, 1471-2407Veröffentlicht: London BioMed Central 18.02.2023Veröffentlicht in BMC cancer (18.02.2023)“… Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of melanoma and other cancers. However, no reliable biomarker of survival or …”
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Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels
ISSN: 2352-3964, 2352-3964Veröffentlicht: Netherlands Elsevier B.V 01.08.2023Veröffentlicht in EBioMedicine (01.08.2023)“… People with Down syndrome (DS) show clinical signs of accelerated ageing. Causative mechanisms remain unknown and hypotheses range from the (essentially …”
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A 2-year calorie restriction intervention may reduce glycomic biological age biomarkers – a pilot study
ISSN: 2731-6068, 2731-6068, 2056-3973Veröffentlicht: London Nature Publishing Group UK 01.08.2025Veröffentlicht in npj aging (01.08.2025)“… In this pilot study, a subset of CALERIE Phase 2 (No. NCT00427193, registered 25th Jan 2007) participants ( n = 26) were evaluated for the effects of 2 years …”
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High-Throughput Glycomic Methods
ISSN: 1520-6890, 1520-6890Veröffentlicht: United States 26.10.2022Veröffentlicht in Chemical reviews (26.10.2022)“… Glycomics aims to identify the structure and function of the glycome, the complete set of oligosaccharides (glycans), produced in a given cell or organism, as …”
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N-glycosylation of immunoglobulin G predicts incident hypertension
ISSN: 1473-5598, 1473-5598Veröffentlicht: Netherlands 01.12.2021Veröffentlicht in Journal of hypertension (01.12.2021)“… Glycosylation of immunoglobulin G (IgG) is an important regulator of the immune system and has been implicated in prevalent hypertension. The aim of this study …”
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Robustness and repeatability of GlycoWorks RapiFluor-MS IgG N-glycan profiling in a long-term high-throughput glycomic study
ISSN: 1460-2423, 1460-2423Veröffentlicht: England 20.09.2021Veröffentlicht in Glycobiology (Oxford) (20.09.2021)“… Protein glycosylation is the attachment of a carbohydrate moiety to a protein backbone affecting both structure and function of the protein. Abnormal …”
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Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levelsResearch in context
ISSN: 2352-3964, 2352-3964Veröffentlicht: Elsevier 01.08.2023Veröffentlicht in EBioMedicine (01.08.2023)“… Background: People with Down syndrome (DS) show clinical signs of accelerated ageing. Causative mechanisms remain unknown and hypotheses range from the …”
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A 2-year calorie restriction intervention reduces glycomic biological age biomarkers
Veröffentlicht: United States 05.12.2024Veröffentlicht in medRxiv : the preprint server for health sciences (05.12.2024)“… In a subset of participants from the CALERIE Phase 2 study we evaluated the effects of 2y of ~25% Calorie Restriction (CR) diet on IgG N-glycosylation …”
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