Suchergebnisse - "Derhovanessian, Evelyna"

Cytomegalovirus and human immunosenescence von Pawelec, Graham, Derhovanessian, Evelyna, Larbi, Anis, Strindhall, Jan, Wikby, Anders

“… ‘Immunosenescence’ is an imprecise term used to describe deleterious age‐associated changes to immune parameters observed in all mammals studied so far …”
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Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients von Weide, Benjamin, Pascolo, Steve, Scheel, Birgit, Derhovanessian, Evelyna, Pflugfelder, Annette, Eigentler, Thomas K, Pawelec, Graham, Hoerr, Ingmar, Rammensee, Hans-Georg, Garbe, Claus

“… In mice, injection of messenger RNA (mRNA) coding for tumor-associated antigens can induce antitumor immune responses and therefore offers a broadly applicable …”
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Immunity, ageing and cancer von Derhovanessian, Evelyna, Solana, Rafael, Larbi, Anis, Pawelec, Graham

“… Compromised immunity contributes to the decreased ability of the elderly to control infectious disease and to their generally poor response to vaccination. It …”
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Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people von Koch, Sven, Larbi, Anis, Derhovanessian, Evelyna, Özcelik, Dennis, Naumova, Elissaveta, Pawelec, Graham

“… Background T cell-mediated immunity in elderly people is compromised in ways reflected in the composition of the peripheral T cell pool. The advent of …”
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Functional T cells targeting NY-ESO-1 or Melan-A are predictive for survival of patients with distant melanoma metastasis von Weide, Benjamin, Zelba, Henning, Derhovanessian, Evelyna, Pflugfelder, Annette, Eigentler, Thomas K, Di Giacomo, Anna Maria, Maio, Michele, Aarntzen, Erik H J G, de Vries, I Jolanda M, Sucker, Antje, Schadendorf, Dirk, Büttner, Petra, Garbe, Claus, Pawelec, Graham

“… To analyze the prognostic relevance of circulating T cells responding to NY-ESO-1, Melan-A, MAGE-3, and survivin in patients with melanoma with distant …”
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Hallmark features of immunosenescence are absent in familial longevity von Derhovanessian, Evelyna, Maier, Andrea B, Beck, Robert, Jahn, Gerhard, Hähnel, Karin, Slagboom, P Eline, de Craen, Anton J M, Westendorp, Rudi G J, Pawelec, Graham

“… Seropositivity for CMV is one of the parameters of the "immune risk profile" associated with mortality in longitudinal studies of the very elderly and may …”
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Effect of Culture at Low Oxygen Tension on the Expression of Heat Shock Proteins in a Panel of Melanoma Cell Lines von Shipp, Christopher, Derhovanessian, Evelyna, Pawelec, Graham

“… Tumours are commonly hypoxic and this can be associated with aggressive tumour type, metastasis and resistance to therapy. Heat shock proteins (hsps) are …”
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Immunogenicity and safety of BNT162b2 mRNA vaccine in Chinese adults: A phase 2 randomised clinical trial von Hui, Ai-Min, Li, Jingxin, Zhu, Li, Tang, Rong, Ye, Huayue, Lin, Mei, Ge, Lei, Wang, Xiyuan, Peng, Fuzhong, Wu, Zhenggang, Guo, Xiling, Shi, Yunfeng, Pan, Hongxing, Zhu, Jiahong, Song, Zhizhou, Qiu, Jingjun, Wang, Wei, Zheng, Jianfei, Ozhelvaci, Orkun, Shpyro, Svetlana, Bushway, Meghan, Derhovanessian, Evelyna, Kühnle, Marie-Cristine, Luxemburger, Ulrich, Muik, Alexander, Shishkova, Yoana, Khondker, Zakaria, Hu, Simin, Lagkadinou, Eleni, Şahin, Uğur, Türeci, Özlem, Zhu, Fengcai

“… BNT162b2, an mRNA vaccine against COVID-19, is being utilised worldwide, but immunogenicity and safety data in Chinese individuals are limited. This phase 2, …”
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391 A first-in-human study of intratumoral SAR441000, an mRNA mixture encoding IL-12sc, interferon alpha2b, GM-CSF and IL-15sushi as monotherapy and in combination with cemiplimab in advanced solid tumors von Bechter, Oliver, Utikal, Jochen, Baurain, Jean-Francois, Massard, Christophe, Sahin, Ugur, Derhovanessian, Evelyna, Ozoux, Marie-Laure, Marpadga, Rahul, Imedio, Esteban-Rodrigo, Acquavella, Nicolas, Loquai, Carmen

“… BackgroundmRNA-based-drugs can be applied for cancer immunotherapy.1 SAR441000 is a novel saline-formulated mixture of four mRNAs encoding interleukin-12 …”
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Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study von Chen, Sijia, JM de Craen, Anton, Raz, Yotam, Derhovanessian, Evelyna, Vossen CTM, Ann, Westendorp GJ, Rudi, Pawelec, Graham, Maier, Andrea B

“… Background Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, …”
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Inflammation, ageing and chronic disease von Pawelec, Graham, Goldeck, David, Derhovanessian, Evelyna

“… •Elderly people commonly show signs of low level systemic inflammation.•Causes include presence of senescent cells, chronic infections and obesity.•Systemic …”
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Immunosenescence and Cytomegalovirus: where do we stand after a decade? von Pawelec, Graham, Akbar, Arne, Beverley, Peter, Caruso, Calogero, Derhovanessian, Evelyna, Fülöp, Tamas, Griffiths, Paul, Grubeck-Loebenstein, Beatrix, Hamprecht, Klaus, Jahn, Gerhard, Kern, Florian, Koch, Sven D, Larbi, Anis, Maier, Andrea B, Macallan, Derek, Moss, Paul, Samson, Sandrine, Strindhall, Jan, Trannoy, Emanuelle, Wills, Mark

“… [...] an important question becomes whether the CMV-sensitive altered immune cell subset distributions in the elderly, particularly the decreased numbers and …”
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Role of CMV in immune senescence von Pawelec, Graham, Derhovanessian, Evelyna

“… “Immune senescence” is a descriptive term for the deleterious age-associated changes to immunity observed in all mammals studied so far. While all components …”
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Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer von Rojas, Luis A., Sethna, Zachary, Soares, Kevin C., Olcese, Cristina, Pang, Nan, Patterson, Erin, Lihm, Jayon, Ceglia, Nicholas, Guasp, Pablo, Chu, Alexander, Yu, Rebecca, Chandra, Adrienne Kaya, Waters, Theresa, Ruan, Jennifer, Amisaki, Masataka, Zebboudj, Abderezak, Odgerel, Zagaa, Payne, George, Derhovanessian, Evelyna, Müller, Felicitas, Rhee, Ina, Yadav, Mahesh, Dobrin, Anton, Sadelain, Michel, Łuksza, Marta, Cohen, Noah, Tang, Laura, Basturk, Olca, Gönen, Mithat, Katz, Seth, Do, Richard Kinh, Epstein, Andrew S., Momtaz, Parisa, Park, Wungki, Sugarman, Ryan, Varghese, Anna M., Won, Elizabeth, Desai, Avni, Wei, Alice C., D’Angelica, Michael I., Kingham, T. Peter, Mellman, Ira, Merghoub, Taha, Wolchok, Jedd D., Sahin, Ugur, Türeci, Özlem, Greenbaum, Benjamin D., Jarnagin, William R., Drebin, Jeffrey, O’Reilly, Eileen M., Balachandran, Vinod P.

“… Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients 1 , yet harbours mutation-derived T cell neoantigens that are suitable for vaccines 2 , 3 …”
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An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma von Sahin, Ugur, Oehm, Petra, Derhovanessian, Evelyna, Jabulowsky, Robert A., Vormehr, Mathias, Gold, Maike, Maurus, Daniel, Schwarck-Kokarakis, Doreen, Kuhn, Andreas N., Omokoko, Tana, Kranz, Lena M., Diken, Mustafa, Kreiter, Sebastian, Haas, Heinrich, Attig, Sebastian, Rae, Richard, Cuk, Katarina, Kemmer-Brück, Alexandra, Breitkreuz, Andrea, Tolliver, Claudia, Caspar, Janina, Quinkhardt, Juliane, Hebich, Lisa, Stein, Malte, Hohberger, Alexander, Vogler, Isabel, Liebig, Inga, Renken, Stephanie, Sikorski, Julian, Leierer, Melanie, Müller, Verena, Mitzel-Rink, Heidrun, Miederer, Matthias, Huber, Christoph, Grabbe, Stephan, Utikal, Jochen, Pinter, Andreas, Kaufmann, Roland, Hassel, Jessica C., Loquai, Carmen, Türeci, Özlem

“… Treating patients who have cancer with vaccines that stimulate a targeted immune response is conceptually appealing, but cancer vaccine trials have not been …”
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COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses von Sahin, Ugur, Muik, Alexander, Derhovanessian, Evelyna, Vogler, Isabel, Kranz, Lena M., Vormehr, Mathias, Baum, Alina, Pascal, Kristen, Quandt, Jasmin, Maurus, Daniel, Brachtendorf, Sebastian, Lörks, Verena, Sikorski, Julian, Hilker, Rolf, Becker, Dirk, Eller, Ann-Kathrin, Grützner, Jan, Boesler, Carsten, Rosenbaum, Corinna, Kühnle, Marie-Cristine, Luxemburger, Ulrich, Kemmer-Brück, Alexandra, Langer, David, Bexon, Martin, Bolte, Stefanie, Karikó, Katalin, Palanche, Tania, Fischer, Boris, Schultz, Armin, Shi, Pei-Yong, Fontes-Garfias, Camila, Perez, John L., Swanson, Kena A., Loschko, Jakob, Scully, Ingrid L., Cutler, Mark, Kalina, Warren, Kyratsous, Christos A., Cooper, David, Dormitzer, Philip R., Jansen, Kathrin U., Türeci, Özlem

“… An effective vaccine is needed to halt the spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. Recently, we reported safety, …”
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Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy von Kranz, Lena M., Diken, Mustafa, Haas, Heinrich, Kreiter, Sebastian, Loquai, Carmen, Reuter, Kerstin C., Meng, Martin, Fritz, Daniel, Vascotto, Fulvia, Hefesha, Hossam, Grunwitz, Christian, Vormehr, Mathias, Hüsemann, Yves, Selmi, Abderraouf, Kuhn, Andreas N., Buck, Janina, Derhovanessian, Evelyna, Rae, Richard, Attig, Sebastian, Diekmann, Jan, Jabulowsky, Robert A., Heesch, Sandra, Hassel, Jessica, Langguth, Peter, Grabbe, Stephan, Huber, Christoph, Türeci, Özlem, Sahin, Ugur

“… The development of a nanoparticle RNA vaccine is reported that preferentially targets dendritic cells after systemic administration, and is shown to provide …”
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BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans von Sahin, Ugur, Muik, Alexander, Vogler, Isabel, Derhovanessian, Evelyna, Kranz, Lena M., Vormehr, Mathias, Quandt, Jasmin, Bidmon, Nicole, Ulges, Alexander, Baum, Alina, Pascal, Kristen E., Maurus, Daniel, Brachtendorf, Sebastian, Lörks, Verena, Sikorski, Julian, Koch, Peter, Hilker, Rolf, Becker, Dirk, Eller, Ann-Kathrin, Grützner, Jan, Tonigold, Manuel, Boesler, Carsten, Rosenbaum, Corinna, Heesen, Ludwig, Kühnle, Marie-Cristine, Poran, Asaf, Dong, Jesse Z., Luxemburger, Ulrich, Kemmer-Brück, Alexandra, Langer, David, Bexon, Martin, Bolte, Stefanie, Palanche, Tania, Schultz, Armin, Baumann, Sybille, Mahiny, Azita J., Boros, Gábor, Reinholz, Jonas, Szabó, Gábor T., Karikó, Katalin, Shi, Pei-Yong, Fontes-Garfias, Camila, Perez, John L., Cutler, Mark, Cooper, David, Kyratsous, Christos A., Dormitzer, Philip R., Jansen, Kathrin U., Türeci, Özlem

“… BNT162b2, a nucleoside-modified mRNA formulated in lipid nanoparticles that encodes the SARS-CoV-2 spike glycoprotein (S) stabilized in its prefusion …”
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Presence of circulating Her2-reactive CD8 + T-cells is associated with lower frequencies of myeloid-derived suppressor cells and regulatory T cells, and better survival in older breast cancer patients von Bailur, Jithendra Kini, Gueckel, Brigitte, Derhovanessian, Evelyna, Pawelec, Graham

“… Introduction Breast cancer is one of the most common cancers among women. Its incidence is increasing in many countries and a higher number of older women are …”
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Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer von Sahin, Ugur, Derhovanessian, Evelyna, Miller, Matthias, Kloke, Björn-Philipp, Simon, Petra, Löwer, Martin, Bukur, Valesca, Tadmor, Arbel D., Luxemburger, Ulrich, Schrörs, Barbara, Omokoko, Tana, Vormehr, Mathias, Albrecht, Christian, Paruzynski, Anna, Kuhn, Andreas N., Buck, Janina, Heesch, Sandra, Schreeb, Katharina H., Müller, Felicitas, Ortseifer, Inga, Vogler, Isabel, Godehardt, Eva, Attig, Sebastian, Rae, Richard, Breitkreuz, Andrea, Tolliver, Claudia, Suchan, Martin, Martic, Goran, Hohberger, Alexander, Sorn, Patrick, Diekmann, Jan, Ciesla, Janko, Waksmann, Olga, Brück, Alexandra-Kemmer, Witt, Meike, Zillgen, Martina, Rothermel, Andree, Kasemann, Barbara, Langer, David, Bolte, Stefanie, Diken, Mustafa, Kreiter, Sebastian, Nemecek, Romina, Gebhardt, Christoffer, Grabbe, Stephan, Höller, Christoph, Utikal, Jochen, Huber, Christoph, Loquai, Carmen, Türeci, Özlem

“… The authors report the first-in-human application of personalized neo-antigen RNA vaccines in patients with melanoma. Personalized cancer vaccine trials …”
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