Suchergebnisse - "Delgado, Justine L"

Topoisomerases as anticancer targets von Delgado, Justine L, Hsieh, Chao-Ming, Chan, Nei-Li, Hiasa, Hiroshi

“… Many cancer type-specific anticancer agents have been developed and significant advances have been made toward precision medicine in cancer treatment. However, …”
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Probing structural requirements for human topoisomerase I inhibition by a novel N1-Biphenyl fluoroquinolone von Delgado, Justine L., Lentz, Sarah R.C., Kulkarni, Chaitanya A., Chheda, Pratik R., Held, Hailey A., Hiasa, Hiroshi, Kerns, Robert J.

“… Fluoroquinolones substituted with N-1 biphenyl and napthyl groups were discovered to act as catalytically inhibitors of human topoisomerases I and II, and to …”
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Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity von Oppegard, Lisa M., Delgado, Justine L., Kulkarni, Chaitanya A., Towle, Tyrell R., Hart, Delaney E., Williams, Bridget P., Lentz, Sarah R. C., Norris, Beverly J., Flory, Craig M., Schumacher, Robert J., Murry, Daryl J., Kerns, Robert J., Hiasa, Hiroshi

“… Summary Fluoroquinolone-class agents selectively target the bacterial type IIA topoisomerases DNA gyrase and topoisomerase IV, with a few exceptions that …”
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