Suchergebnisse - "Delbridge, L."

Molecular mechanisms of cardiac pathology in diabetes – Experimental insights von Varma, U., Koutsifeli, P., Benson, V.L., Mellor, K.M., Delbridge, L.M.D.

“… Diabetic cardiomyopathy is a distinct pathology independent of co-morbidities such as coronary artery disease and hypertension. Diminished glucose uptake due …”
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Myocardial deformation imaging by 2D speckle tracking echocardiography for assessment of diastolic dysfunction in murine cardiopathology von Daniels, L. J., Macindoe, C., Koutsifeli, P., Annandale, M., James, S. L., Watson, L. E., Coffey, S., Raaijmakers, A. J. A., Weeks, K. L., Bell, J. R., Janssens, J. V., Curl, C. L., Delbridge, L. M. D., Mellor, Kimberley M.

“… Diastolic dysfunction is increasingly identified as a key, early onset subclinical condition characterizing cardiopathologies of rising prevalence, including …”
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Ca2+‐dependent proteolysis of junctophilin‐1 and junctophilin‐2 in skeletal and cardiac muscle von Murphy, R. M., Dutka, T. L., Horvath, D., Bell, J. R., Delbridge, L. M., Lamb, G. D.

“… Key points If skeletal muscle fibres are subjected to excessive activation, or stretched whilst contracting, they subsequently display long‐term reductions in …”
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New insights into diabetes-induced cardiac pathology von Weeks, K.L., Bernardo, B.C., Bell, J.R., Delbridge, L.M.D., Mellor, K.M.

“… Individuals with diabetes have an elevated risk of heart disease, and there is a significant clinical need for evidence-based treatments. Heart disease in …”
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HFpEF etiology – Can focus on sex-specific mechanisms deliver insights for all? von Delbridge, L.M.D., Bell, J.R., Weeks, K.L., Raaijmakers, A.J.A., Mellor, K.M.

“… [Display omitted] •HFpEF is highly prevalent in women, with a gender distribution ratio of 2:1.•The aging female demographic confers an increased burden of …”
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Myocardial glycophagy — A specific glycogen handling response to metabolic stress is accentuated in the female heart von Reichelt, M.E., Mellor, K.M., Curl, C.L., Stapleton, D., Delbridge, L.M.D.

“… Cardiac metabolic stress is a hallmark of many cardiac pathologies, including diabetes. Cardiac glycogen mis-handling is a frequent manifestation of various …”
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Predictors of Bilateral Disease in Low-Risk Papillary Thyroid Cancer: Histopathologic Insights and Preoperative Ultrasonography von Rodriguez Schaap, P. M., Papachristos, A., Serrao-Brown, H., Aniss, A., van Dijkum, E. J. M. Nieveen, Gill, A. J., Delbridge, L., Engelsman, A. F., Sidhu, S., Sywak, M.

“… Background With the current shift toward de-escalation of surgical management in low-risk papillary thyroid cancer (PTC), understanding predictors and the …”
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ASO Visual Abstract: Predictors of Bilateral Disease in Low-Risk Papillary Thyroid Cancer—Histopathological Insights and Preoperative Ultrasonography: ASO Visual Abstract: Predictors of Bilateral Disease in Low-Risk Papillary Thyroid Cancer—Histopathological Insights and Preoperative Ultrasonography von Schaap, P. M. Rodriguez, Papachristos, A., Serrao-Brown, H., Aniss, A., van Dijkum, E. J. M. Nieveen, Gill, A. J., Delbridge, L., Engelsman, A. F., Sidhu, S., Sywak, M.

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Fructose Metabolism and Cardiac Metabolic Stress von Annandale, M., Daniels, L. J., Li, X., Neale, J. P. H., Chau, A. H. L., Ambalawanar, H. A., James, S. L., Koutsifeli, P., Delbridge, L. M. D., Mellor, K. M.

“… Cardiovascular disease is one of the leading causes of mortality in diabetes. High fructose consumption has been linked with the development of diabetes and …”
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HRPT2 mutations are associated with malignancy in sporadic parathyroid tumours von Howell, V M, Haven, C J, Kahnoski, K, Khoo, S K, Petillo, D, Chen, J, Fleuren, G J, Robinson, B G, Delbridge, L W, Philips, J, Nelson, A E, Krause, U, Hammje, K, Dralle, H, Hoang-Vu, C, Gimm, O, Marsh, D J, Morreau, H, Teh, B T

“… Background: Hyperparathyroidism is a common endocrinopathy characterised by the formation of parathyroid tumours. In this study, we determine the role of the …”
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Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues von Mellor, K M, Varma, U, Koutsifeli, P, Curl, C L, Janssens, J V, Daniels, L J, Bernasochi, G B, Raaijmakers, A J A, Annandale, M, Li, X, James, S L, Taylor, D J, Raedschelders, K, Weeks, K L, Mills, R J, Parton, R G, Hu, X, Bell, J R, O'Brien, T J, Katare, R, Porrello, E R, Hudson, J E, Xiao, R P, Van Eyk, J E, Gottlieb, R A, Delbridge, L M D

“… Diabetic heart disease is highly prevalent and is associated with the early development of impaired diastolic relaxation. The mechanisms of diabetic heart …”
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Involvement of human monogenic cardiomyopathy genes in experimental polygenic cardiac hypertrophy von Prestes, P R, Marques, F Z, Lopez-Campos, G, Lewandowski, P, Delbridge, L M D, Charchar, F J, Harrap, S B

“… Hypertrophic cardiomyopathy thickens heart muscles, reducing functionality and increasing risk of cardiac disease and morbidity. Genetic factors are involved, …”
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BRAF(V600E) Mutation is Associated with Decreased Disease-Free Survival in Papillary Thyroid Cancer von Fraser, S, Go, C, Aniss, A, Sidhu, S, Delbridge, L, Learoyd, D, Clifton-Bligh, R, Tacon, L, Tsang, V, Robinson, B, Gill, A J, Sywak, M

“… The BRAF (V600E) mutation is a recognised molecular marker in papillary thyroid cancer (PTC), reported incidence from 30 to 80 %. BRAF(V600E) aberrantly …”
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Regulation of angiotensinogen by angiotensin II in mouse primary astrocyte cultures von O’Callaghan, E. L., Bassi, J. K., Porrello, E. R., Delbridge, L. M. D., Thomas, W. G., Allen, A. M.

“… J. Neurochem. (2011) 119, 18–26. Astrocytes are the major source of angiotensinogen in the brain and play an important role in the brain renin‐angiotensin …”
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Medullary Thyroid Carcinoma: Survival Analysis and Evaluation of Mutation-Specific Immunohistochemistry in Detection of Sporadic Disease von Jayakody, S., Reagh, J., Bullock, M., Aniss, A., Clifton-Bligh, R., Learoyd, D., Robinson, B., Delbridge, L., Sidhu, S., Gill, A. J., Sywak, M.

“… Introduction Medullary thyroid cancer (MTC) is a rare tumour of neuroendocrine origin with a more aggressive profile than differentiated thyroid cancer …”
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Reoperative surgery for bilateral multinodular goitre in the era of total thyroidectomy von Vasica, G., O'Neill, C. J., Sidhu, S. B., Sywak, M. S., Reeve, T. S., Delbridge, L. W.

“… Background: Total thyroidectomy, rather than bilateral subtotal thyroidectomy, is now accepted as the preferred management for bilateral benign multinodular …”
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Utilization of a MAB for BRAF(V600E) detection in papillary thyroid carcinoma von Bullock, M, O'Neill, C, Chou, A, Clarkson, A, Dodds, T, Toon, C, Sywak, M, Sidhu, S B, Delbridge, L W, Robinson, B G, Learoyd, D L, Capper, D, von Deimling, A, Clifton-Bligh, R J, Gill, A J

“… Identification of BRAF(V600E) in thyroid neoplasia may be useful because it is specific for malignancy, connotes a worse prognosis, and is the target of novel …”
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Risk of needing completion thyroidectomy for low‐risk papillary thyroid cancers treated by lobectomy von DiMarco, A. N., Wong, M. S., Jayasekara, J., Cole‐Clark, D., Aniss, A., Glover, A. R., Delbridge, L. W., Sywak, M. S., Sidhu, S. B.

“… Background Low‐risk differentiated thyroid cancers may, according to the American Thyroid Association (ATA) 2015 guidelines, be managed initially with …”
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Management of follicular thyroid carcinoma should be individualised based on degree of capsular and vascular invasion von O’Neill, C.J., Vaughan, L., Learoyd, D.L., Sidhu, S.B., Delbridge, L.W., Sywak, M.S.

“… Follicular thyroid carcinoma (FTC) includes a spectrum of neoplasms with varying propensity for metastasis. The aim of this study is to describe outcomes for …”
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Long-term outcome after parathyroidectomy for lithium-induced hyperparathyroidism von Norlén, O., Sidhu, S., Sywak, M., Delbridge, L.

“… Background The accepted management of lithium‐associated hyperparathyroidism (LiHPT) is open four‐gland parathyroid exploration (OPTX). This approach has …”
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