Suchergebnisse - "Dear, James W."

Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review von Ranasinghe, Priyanga, Addison, Melisande L., Dear, James W., Webb, David J.

“… Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the expression of specific genes. RNA interference technology, using …”
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Zebrafish as model organisms for studying drug‐induced liver injury von Vliegenthart, A. D. Bastiaan, Tucker, Carl S., Del Pozo, Jorge, Dear, James W.

“… Drug‐induced liver injury (DILI) is a major challenge in clinical medicine and drug development. New models are needed for predicting which potential …”
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Identification and proteomic profiling of exosomes in human cerebrospinal fluid von Street, Jonathan M, Barran, Perdita E, Mackay, C Logan, Weidt, Stefan, Balmforth, Craig, Walsh, Tim S, Chalmers, Rod TA, Webb, David J, Dear, James W

“… Background Exosomes are released from multiple cell types, contain protein and RNA species, and have been exploited as a novel reservoir for disease biomarker …”
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Mechanistic biomarkers provide early and sensitive detection of acetaminophen‐induced acute liver injury at first presentation to hospital von Antoine, Daniel J., Dear, James W., Lewis, Philip Starkey, Platt, Vivien, Coyle, Judy, Masson, Moyra, Thanacoody, Ruben H., Gray, Alasdair J., Webb, David J., Moggs, Jonathan G., Bateman, D. Nicholas, Goldring, Christopher E., Park, B. Kevin

“… Acetaminophen overdose is a common reason for hospital admission and the most frequent cause of hepatotoxicity in the Western world. Early identification would …”
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Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes von Sabbisetti, Venkata S, Waikar, Sushrut S, Antoine, Daniel J, Smiles, Adam, Wang, Chang, Ravisankar, Abinaya, Ito, Kazumi, Sharma, Sahil, Ramadesikan, Swetha, Lee, Michelle, Briskin, Rebeccah, De Jager, Philip L, Ngo, Thanh Thu, Radlinski, Mark, Dear, James W, Park, Kevin B, Betensky, Rebecca, Krolewski, Andrzej S, Bonventre, Joseph V

“… Currently, no blood biomarker that specifically indicates injury to the proximal tubule of the kidney has been identified. Kidney injury molecule-1 (KIM-1) is …”
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Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment von Farrah, Tariq E., Pugh, Dan, Chapman, Fiona A., Godden, Emily, Balmforth, Craig, Oniscu, Gabriel C., Webb, David J., Dhillon, Baljean, Dear, James W., Bailey, Matthew A., Gallacher, Peter J., Dhaun, Neeraj

“… In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response, …”
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SLAMseq reveals potential transfer of RNA from liver to kidney in the mouse von Hunter, Robert W., Sun, Jialin, Palmer, Trecia, Czopek, Alicja, Nespoux, Josselin, Bailey, Matthew A., Dhaun, Neeraj, Buck, Amy H., Dear, James W.

“… Extracellular RNA (exRNA) mediates intercellular communication in lower animals; whether it serves a signalling function in mammals is uncertain. Reductionist …”
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Quantification of human urinary exosomes by nanoparticle tracking analysis von Oosthuyzen, Wilna, Sime, Nicole E. L., Ivy, Jessica R., Turtle, Emma J., Street, Jonathan M., Pound, John, Bath, Louise E., Webb, David J., Gregory, Christopher D., Bailey, Matthew A., Dear, James W.

“… Key points •  Exosomes are vesicles that are released from the kidney into the urine. They contain RNA and protein from the cell of origin and can track …”
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Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial von Bateman, D Nicholas, Dear, James W, Thanacoody, H K Ruben, Thomas, Simon H L, Eddleston, Michael, Sandilands, Euan A, Coyle, Judy, Cooper, Jamie G, Rodriguez, Aryelly, Butcher, Isabella, Lewis, Steff C, Vliegenthart, A D Bastiaan, Veiraiah, Aravindan, Webb, David J, Gray, Alasdair

“… Paracetamol poisoning is common worldwide. It is treated with intravenous acetylcysteine, but the standard regimen is complex and associated with frequent …”
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Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity von Bell, Catherine C., Chouhan, Bhavik, Andersson, Linda C., Andersson, Håkan, Dear, James W., Williams, Dominic P., Söderberg, Magnus

“… In addition to hepatocytes, the liver comprises a host of specialised non-parenchymal cells which are important to consider in the development of in vitro …”
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Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury von Widjaja, Anissa A, Dong, Jinrui, Adami, Eleonora, Viswanathan, Sivakumar, Ng, Benjamin, Pakkiri, Leroy S, Chothani, Sonia P, Singh, Brijesh K, Lim, Wei Wen, Zhou, Jin, Shekeran, Shamini G, Tan, Jessie, Lim, Sze Yun, Goh, Joyce, Wang, Mao, Holgate, Robert, Hearn, Arron, Felkin, Leanne E, Yen, Paul M, Dear, James W, Drum, Chester L, Schafer, Sebastian, Cook, Stuart A

“… Acetaminophen ( -acetyl- -aminophenol; APAP) toxicity is a common cause of liver damage. In the mouse model of APAP-induced liver injury (AILI), interleukin 11 …”
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A point-of-care diagnostic for drug-induced liver injury using surface-enhanced Raman scattering lateral flow immunoassay von Sloan-Dennison, Sian, Scullion, Kathleen M., Clark, Benjamin, Fineran, Paul, Mair, Joanne, Laing, Stacey, Shand, Neil C., Rathmell, Cicely, Creasey, David, Bingemann, Dieter, Faircloth, Jonathan, Zieg, Mark, Varghese, Elizabeth, Weir, Christopher J., Dear, James W., Faulds, Karen, Graham, Duncan

“… Paracetamol overdose (POD) is common, with approximately 100,000 cases attending UK hospitals annually. Timely antidote administration is crucial for patients …”
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Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury von Rissin, David M., López-Longarela, Barbara, Pernagallo, Salvatore, Ilyine, Hugh, Vliegenthart, A. D. Bastiaan, Dear, James W., Díaz-Mochón, Juan J., Duffy, David C.

“… We have developed a single probe method for detecting microRNA from human serum using single molecule arrays, with sequence specificity down to a single base, …”
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Exosomal transmission of functional aquaporin 2 in kidney cortical collecting duct cells von Street, Jonathan M., Birkhoff, Willem, Menzies, Robert I., Webb, David J., Bailey, Matthew A., Dear, James W.

“… Non‐technical summary  Like most cells, those of the kidney release protein and RNA in structures called exosomes. It is possible that the contents of exosomes …”
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Candidate circulating microRNA biomarkers in dogs with chronic pancreatitis von Armstrong, Susan K., Hunter, Robert W., Oosthyuzen, Wilna, Parys, Maciej, Gow, Adam G., Schmitz, Silke Salavati, Dear, James W., Mellanby, Richard J.

“… Background Pancreatitis is an important cause of disease and death in dogs. Available circulating biomarkers are not sufficiently sensitive and specific for a …”
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miR-122 direct detection in human serum by time-gated fluorescence imaging von Garcia-Fernandez, Emilio, Gonzalez-Garcia, M Carmen, Pernagallo, Salvatore, Ruedas-Rama, Maria J, Fara, Mario A, López-Delgado, Francisco J, Dear, James W, Ilyine, Hugh, Ress, Cristina, Díaz-Mochón, Juan J, Orte, Angel

“… A simple method for direct detection of microRNAs (miRs) in human serum without the use of polymerase amplification is presented, achieving low miR-122 …”
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Glucocorticoids Induce Nondipping Blood Pressure by Activating the Thiazide-Sensitive Cotransporter von Ivy, Jessica R, Oosthuyzen, Wilna, Peltz, Theresa S, Howarth, Amelia R, Hunter, Robert W, Dhaun, Neeraj, Al-Dujaili, Emad A S, Webb, David J, Dear, James W, Flatman, Peter W, Bailey, Matthew A

“… Blood pressure (BP) normally dips during sleep, and nondipping increases cardiovascular risk. Hydrochlorothiazide restores the dipping BP profile in nondipping …”
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Recent advances in biomarkers and therapeutic interventions for hepatic drug safety - false dawn or new horizon? von Clarke, Joanna I., Dear, James W., Antoine, Daniel J.

“… Introduction: Drug-induced liver injury (DILI) represents a serious medical challenge and a potentially fatal adverse event. Currently, DILI is a diagnosis of …”
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Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells von Oosthuyzen, Wilna, Scullion, Kathleen M, Ivy, Jessica R, Morrison, Emma E, Hunter, Robert W, Starkey Lewis, Philip J, O'Duibhir, Eoghan, Street, Jonathan M, Caporali, Andrea, Gregory, Christopher D, Forbes, Stuart J, Webb, David J, Bailey, Matthew A, Dear, James W

“… Extracellular vesicles (ECVs) facilitate intercellular communication along the nephron, with the potential to change the function of the recipient cell …”
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Activated neutrophil fluorescent imaging technique for human lungs von Craven, Thomas H., Walton, Tashfeen, Akram, Ahsan R., Scholefield, Emma, McDonald, Neil, Marshall, Adam D.L., Humphries, Duncan C., Mills, Bethany, Campbell, Thane A., Bruce, Annya, Mair, Joanne, Dear, James W., Newby, David E., Hill, Adam T., Walsh, Timothy S., Haslett, Chris, Dhaliwal, Kevin

“… Neutrophil activation is an integral process to acute inflammation and is associated with adverse clinical sequelae. Identification of neutrophil activation in …”
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