Výsledky vyhledávání - "DNA, Neoplasm"

Liquid biopsies: genotyping circulating tumor DNA Autor Diaz, Jr, Luis A, Bardelli, Alberto

“…; tumor tissue is a single snapshot in time, is subject to selection bias resulting from tumor heterogeneity, and can be difficult to obtain…”
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Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes Autor Musumeci, Domenica, Amato, Jussara, Zizza, Pasquale, Platella, Chiara, Cosconati, Sandro, Cingolani, Chiara, Biroccio, Annamaria, Novellino, Ettore, Randazzo, Antonio, Giancola, Concetta, Pagano, Bruno, Montesarchio, Daniela

“…G-quadruplex (G4) structures are key elements in the regulation of cancer cell proliferation and their targeting is deemed to be a promising strategy in…”
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The feasibility of using mutation detection in ctDNA to assess tumor dynamics Autor Yi, Xin, Ma, Jianhui, Guan, Yanfang, Chen, Rongrong, Yang, Ling, Xia, Xuefeng

“… The advent of ultrasensitive and highly specific molecular assays has provided a comprehensive profile of the molecular characteristics and dynamics of circulating DNA in healthy subjects and cancer patients…”
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Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer Autor Yang, Sujuan, Che, Sara P. Y., Kurywchak, Paul, Tavormina, Jena L., Gansmo, Liv B., Correa de Sampaio, Pedro, Tachezy, Michael, Bockhorn, Maximilian, Gebauer, Florian, Haltom, Amanda R., Melo, Sonia A., LeBleu, Valerie S., Kalluri, Raghu

“…) and intraductal papillary mucinous neoplasm (IPMN), and in healthy human subjects. In 48 clinically…”
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EMICORON: A multi-targeting G4 ligand with a promising preclinical profile Autor Porru, Manuela, Zizza, Pasquale, Franceschin, Marco, Leonetti, Carlo, Biroccio, Annamaria

“…During the last decade, guanine G-rich sequences folding into G-quadruplex (G4) structures have received a lot of attention and their biological role is now a…”
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Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns Autor Schuh, Anna, Becq, Jennifer, Humphray, Sean, Alexa, Adrian, Burns, Adam, Clifford, Ruth, Feller, Stephan M, Grocock, Russell, Henderson, Shirley, Khrebtukova, Irina, Kingsbury, Zoya, Luo, Shujun, McBride, David, Murray, Lisa, Menju, Toshi, Timbs, Adele, Ross, Mark, Taylor, Jenny, Bentley, David

“… Similarly, in other malignancies leukemia cells accumulate mutations during growth, forming heterogeneous cell populations that are subject to Darwinian selection and may respond differentially to treatment…”
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The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer Autor Mattox, Austin K, Douville, Christopher, Wang, Yuxuan, Popoli, Maria, Ptak, Janine, Silliman, Natalie, Dobbyn, Lisa, Schaefer, Joy, Lu, Steve, Pearlman, Alexander H, Cohen, Joshua D, Tie, Jeanne, Gibbs, Peter, Lahouel, Kamel, Bettegowda, Chetan, Hruban, Ralph H, Tomasetti, Cristian, Jiang, Peiyong, Chan, K C Allen, Lo, Yuk Ming Dennis, Papadopoulos, Nickolas, Kinzler, Kenneth W, Vogelstein, Bert

“… Eighty-three of these individuals had cfDNA concentrations much greater than those generally observed in healthy subjects…”
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Phenanthroline-bis-oxazole ligands for binding and stabilization of G-quadruplexes Autor Medeiros-Silva, João, Guédin, Aurore, Salgado, Gilmar F., Mergny, Jean-Louis, Queiroz, João A., Cabrita, Eurico J., Cruz, Carla

“…G-quadruplexes (G4) are found at important genome regions such as telomere ends and oncogene promoters. One prominent strategy to explore the therapeutic…”
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Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures? Autor Amato, Jussara, Pagano, Alessia, Cosconati, Sandro, Amendola, Giorgio, Fotticchia, Iolanda, Iaccarino, Nunzia, Marinello, Jessica, De Magis, Alessio, Capranico, Giovanni, Novellino, Ettore, Pagano, Bruno, Randazzo, Antonio

“…Guanine-rich DNA motifs can form non-canonical structures known as G-quadruplexes, whose role in tumorigenic processes makes them attractive drug-target…”
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Diagnostic and prognostic role of cell‐free DNA testing for colorectal cancer patients Autor Bedin, Chiara, Enzo, Maria Vittoria, Del Bianco, Paola, Pucciarelli, Salvatore, Nitti, Donato, Agostini, Marco

“…) in comparison to healthy subjects (n = 56) and patients with adenomatous lesions (n = 22). Moreover, we studied the prognosis value focusing on histopathological staging and survival…”
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Telomere length in white blood cell DNA and lung cancer: a pooled analysis of three prospective cohorts Autor Seow, Wei Jie, Cawthon, Richard M, Purdue, Mark P, Hu, Wei, Gao, Yu-Tang, Huang, Wen-Yi, Weinstein, Stephanie J, Ji, Bu-Tian, Virtamo, Jarmo, Hosgood, 3rd, H Dean, Bassig, Bryan A, Shu, Xiao-Ou, Cai, Qiuyin, Xiang, Yong-Bing, Min, Shen, Chow, Wong-Ho, Berndt, Sonja I, Kim, Christopher, Lim, Unhee, Albanes, Demetrius, Caporaso, Neil E, Chanock, Stephen, Zheng, Wei, Rothman, Nathaniel, Lan, Qing

“…We investigated the relationship between telomere length and lung cancer in a pooled analysis from three prospective cohort studies: the Prostate, Lung,…”
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Clinical utility of an epigenetic assay to detect occult prostate cancer in histopathologically negative biopsies: results of the MATLOC study Autor Stewart, Grant D, Van Neste, Leander, Delvenne, Philippe, Delrée, Paul, Delga, Agnès, McNeill, S Alan, O'Donnell, Marie, Clark, James, Van Criekinge, Wim, Bigley, Joseph, Harrison, David J

“… The MATLOC study blindly tested archived prostate biopsy needle core tissue samples of 498 subjects from the United Kingdom and Belgium with histopathologically negative prostate biopsies, followed by positive (cases) or negative (controls…”
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Glyco-genes change expression in cancer through aberrant methylation Autor Vojta, Aleksandar, Samaržija, Ivana, Bočkor, Luka, Zoldoš, Vlatka

“…Most eukaryotic proteins are modified by covalent addition of glycan molecules that considerably influence their function. Aberrant glycosylation is profoundly…”
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Integrating liquid biopsies into the management of cancer Autor Siravegna, Giulia, Marsoni, Silvia, Siena, Salvatore, Bardelli, Alberto

“…Key Points Patient selection is central to the success of targeted therapy; identification of tumour-specific molecular landscapes is pivotal to guiding…”
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Critical role of hnRNP A1 in activating KRAS transcription in pancreatic cancer cells: A molecular mechanism involving G4 DNA Autor Cogoi, Susanna, Rapozzi, Valentina, Cauci, Sabina, Xodo, Luigi E.

“…KRAS is one of the most mutated genes in human cancer. Its crucial role in the tumourigenesis of pancreatic ductal adenocarcinoma (PDAC) has been widely…”
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Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma Autor Cai, Jiabin, Chen, Lei, Zhang, Zhou, Zhang, Xinyu, Lu, Xingyu, Liu, Weiwei, Shi, Guoming, Ge, Yang, Gao, Pingting, Yang, Yuan, Ke, Aiwu, Xiao, Linlin, Dong, Ruizhao, Zhu, Yanjing, Yang, Xuan, Wang, Jiefei, Zhu, Tongyu, Yang, Deping, Huang, Xiaowu, Sui, Chengjun, Qiu, Shuangjian, Shen, Feng, Sun, Huichuan, Zhou, Weiping, Zhou, Jian, Nie, Ji, Zeng, Chang, Stroup, Emily Kunce, Zhang, Xu, Chiu, Brian C-H, Lau, Wan Yee, He, Chuan, Wang, Hongyang, Zhang, Wei, Fan, Jia

“… of HCC.DesignApplying the 5hmC-Seal technique, we obtained genome-wide 5-hydroxymethylcytosines (5hmC) in cfDNA samples from 2554 Chinese subjects…”
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Quantitative methylation-specific polymerase chain reaction gene patterns in urine sediment distinguish prostate cancer patients from control subjects Autor Hoque, Mohammad Obaidul, Topaloglu, Ozlem, Begum, Shahnaz, Henrique, Rui, Rosenbaum, Eli, Van Criekinge, Wim, Westra, William H, Sidransky, David

“…Aberrant promoter hypermethylation of several known or putative tumor suppressor genes occurs frequently during the pathogenesis of prostate cancers and is a…”
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Clinical utility of custom-designed NGS panel testing in pediatric tumors Autor Surrey, Lea F., MacFarland, Suzanne P., Chang, Fengqi, Cao, Kajia, Rathi, Komal S., Akgumus, Gozde T., Gallo, Daniel, Lin, Fumin, Gleason, Adam, Raman, Pichai, Aplenc, Richard, Bagatell, Rochelle, Minturn, Jane, Mosse, Yael, Santi, Mariarita, Tasian, Sarah K., Waanders, Angela J., Sarmady, Mahdi, Maris, John M., Hunger, Stephen P., Li, Marilyn M.

“… Methods Subjects were accrued retrospectively at a single pediatric quaternary-care hospital…”
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Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells Autor García-Olmo, Dolores C, Domínguez, Carolina, García-Arranz, Mariano, Anker, Phillipe, Stroun, Maurice, García-Verdugo, José M, García-Olmo, Damián

“… Cultures of NIH-3T3 cells and human adipose-derived stem cells (hASC) were supplemented with samples of plasma from patients with K-ras-mutated colorectal tumors or from healthy subjects using two different protocols…”
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Mutations in TSC1, TSC2, and MTOR Are Associated with Response to Rapalogs in Patients with Metastatic Renal Cell Carcinoma Autor Kwiatkowski, David J, Choueiri, Toni K, Fay, André P, Rini, Brian I, Thorner, Aaron R, de Velasco, Guillermo, Tyburczy, Magdalena E, Hamieh, Lana, Albiges, Laurence, Agarwal, Neeraj, Ho, Thai H, Song, Jiaxi, Pignon, Jean-Christophe, Barrios, Pablo M, Michaelson, M Dror, Van Allen, Eliezer, Krajewski, Katherine M, Porta, Camillo, Pal, Sumanta, Bellmunt, Joaquim, McDermott, David F, Heng, Daniel Y C, Gray, Kathryn P, Signoretti, Sabina

“… Tumor DNA from 79 subjects was successfully analyzed for mutations using targeted next-generation sequencing of 560 cancer genes…”
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