Výsledky vyhľadávania - "D'Andrea, Alan"

Mechanisms of PARP inhibitor sensitivity and resistance Autor D’Andrea, Alan D.

“…BRCA1 and BRCA2 deficient tumor cells are sensitive to inhibitors of Poly ADP Ribose Polymerase (PARP1) through the mechanism of synthetic lethality. Several…”
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Repair Pathway Choices and Consequences at the Double-Strand Break Autor Ceccaldi, Raphael, Rondinelli, Beatrice, D’Andrea, Alan D.

“…DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity. Failure to repair a DSB has deleterious consequences, including genomic…”
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Targeting replication stress in cancer therapy Autor da Costa, Alexandre André B A, Chowdhury, Dipanjan, Shapiro, Geoffrey I, D'Andrea, Alan D, Konstantinopoulos, Panagiotis A

“…Replication stress is a major cause of genomic instability and a crucial vulnerability of cancer cells. This vulnerability can be therapeutically targeted by…”
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Chromatin remodeling at DNA double-strand breaks Autor Price, Brendan D, D'Andrea, Alan D

“…DNA double-strand breaks (DSBs) can arise from multiple sources, including exposure to ionizing radiation. The repair of DSBs involves both posttranslational…”
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The Fanconi anaemia pathway: new players and new functions Autor Ceccaldi, Raphael, Sarangi, Prabha, D'Andrea, Alan D.

“…Key Points The Fanconi anaemia pathway comprises 19 Fanconi anaemia proteins (FANCA to FANCT) and many associated proteins. Germline inactivation of any of the…”
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DNA Damage and Repair Biomarkers of Immunotherapy Response Autor Mouw, Kent W, Goldberg, Michael S, Konstantinopoulos, Panagiotis A, D'Andrea, Alan D

“…DNA-damaging agents are widely used in clinical oncology and exploit deficiencies in tumor DNA repair. Given the expanding role of immune checkpoint blockade…”
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Molecular pathogenesis and clinical management of Fanconi anemia Autor Kee, Younghoon, D’Andrea, Alan D.

“…Fanconi anemia (FA) is a rare genetic disorder associated with a high frequency of hematological abnormalities and congenital anomalies. Based on multilateral…”
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Exploiting the Microhomology-Mediated End-Joining Pathway in Cancer Therapy Autor Patterson-Fortin, Jeffrey, D'Andrea, Alan D

“…Repair of DNA double-strand breaks (DSB) is performed by two major pathways, homology-dependent repair and classical nonhomologous end-joining. Recent studies…”
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Biomarker-Guided Development of DNA Repair Inhibitors Autor Cleary, James M, Aguirre, Andrew J, Shapiro, Geoffrey I, D'Andrea, Alan D

“…Anti-cancer drugs targeting the DNA damage response (DDR) exploit genetic or functional defects in this pathway through synthetic lethal mechanisms. For…”
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Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets Autor Mengwasser, Kristen E, Adeyemi, Richard O, Leng, Yumei, Choi, Mei Yuk, Clairmont, Connor, D'Andrea, Alan D, Elledge, Stephen J

“…BRCA1 or BRCA2 inactivation drives breast and ovarian cancer but also creates vulnerability to poly(ADP-ribose) polymerase (PARP) inhibitors. To search for…”
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Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer Autor Konstantinopoulos, Panagiotis A, Ceccaldi, Raphael, Shapiro, Geoffrey I, D'Andrea, Alan D

“…Approximately 50% of epithelial ovarian cancers (EOC) exhibit defective DNA repair via homologous recombination (HR) due to genetic and epigenetic alterations…”
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Susceptibility Pathways in Fanconi's Anemia and Breast Cancer Autor D'Andrea, Alan D

“…Fanconi's anemia is a rare disorder that arises from defective repair of damaged DNA. Of the 13 Fanconi's anemia genes, 3 are breast-cancer–susceptibility…”
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Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway Autor Kim, Hyungjin, D'Andrea, Alan D

“…The maintenance of genome stability is critical for survival, and its failure is often associated with tumorigenesis. The Fanconi anemia (FA) pathway is…”
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The Fanconi Anemia Pathway in Cancer Autor Niraj, Joshi, Färkkilä, Anniina, D'Andrea, Alan D

“…Fanconi anemia (FA) is a complex genetic disorder characterized by bone marrow failure (BMF), congenital defects, inability to repair DNA interstrand…”
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Fanconi anemia pathway Autor Rodríguez, Alfredo, D'Andrea, Alan

“…Rodríguez and D'Andrea introduce the Fanconi anemia pathway and its role in DNA repair and other cellular functions…”
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FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair Autor Kais, Zeina, Rondinelli, Beatrice, Holmes, Amie, O’Leary, Colin, Kozono, David, D’Andrea, Alan D., Ceccaldi, Raphael

“…BRCA1/2 proteins function in homologous recombination (HR)-mediated DNA repair and cooperate with Fanconi anemia (FA) proteins to maintain genomic integrity…”
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TRIP13 regulates DNA repair pathway choice through REV7 conformational change Autor Clairmont, Connor S, Sarangi, Prabha, Ponnienselvan, Karthikeyan, Galli, Lucas D, Csete, Isabelle, Moreau, Lisa, Adelmant, Guillaume, Chowdhury, Dipanjan, Marto, Jarrod A, D'Andrea, Alan D

“…DNA double-strand breaks (DSBs) are repaired through homology-directed repair (HDR) or non-homologous end joining (NHEJ). BRCA1/2-deficient cancer cells cannot…”
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DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells Autor He, Yizhou Joseph, Meghani, Khyati, Caron, Marie-Christine, Yang, Chunyu, Ronato, Daryl A., Bian, Jie, Sharma, Anchal, Moore, Jessica, Niraj, Joshi, Detappe, Alexandre, Doench, John G., Legube, Gaelle, Root, David E., D’Andrea, Alan D., Drané, Pascal, De, Subhajyoti, Konstantinopoulos, Panagiotis A., Masson, Jean-Yves, Chowdhury, Dipanjan

“…Limited DNA end resection is the key to impaired homologous recombination in BRCA1 -mutant cancer cells. Here, using a loss-of-function CRISPR screen, we…”
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REV7 directs DNA repair pathway choice Autor Clairmont, Connor S., D’Andrea, Alan D.

“…REV7 is a small multifunctional protein that participates in multiple DNA repair pathways, most notably translesion DNA synthesis and double-strand break (DSB)…”
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EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation Autor Rondinelli, Beatrice, Gogola, Ewa, Yücel, Hatice, Duarte, Alexandra A., van de Ven, Marieke, van der Sluijs, Roxanne, Konstantinopoulos, Panagiotis A., Jonkers, Jos, Ceccaldi, Raphaël, Rottenberg, Sven, D’Andrea, Alan D.

“…Rondinelli et al. show that EZH2-mediated H3K27me3 at stalled replication forks recruits MUS81 nuclease to facilitate fork degradation. Loss of EZH2…”
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