Search Results - "Cyclooxygenase 1 genetics"

In situ click chemistry generation of cyclooxygenase-2 inhibitors by Bhardwaj, Atul, Kaur, Jatinder, Wuest, Melinda, Wuest, Frank

“…Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and overexpression of this enzyme is also associated with several cancers and…”
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Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice by Fritz, Michael, Klawonn, Anna M., Nilsson, Anna, Singh, Anand Kumar, Zajdel, Joanna, Björk Wilhelms, Daniel, Lazarus, Michael, Löfberg, Andreas, Jaarola, Maarit, Örtegren Kugelberg, Unn, Billiar, Timothy R., Hackam, David J., Sodhi, Chhinder P., Breyer, Matthew D., Jakobsson, Johan, Schwaninger, Markus, Schütz, Günther, Rodriguez Parkitna, Jan, Saper, Clifford B., Blomqvist, Anders, Engblom, David

“…Systemic inflammation causes malaise and general feelings of discomfort. This fundamental aspect of the sickness response reduces the quality of life for…”
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Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein by Richter-Dennerlein, Ricarda, Oeljeklaus, Silke, Lorenzi, Isotta, Ronsör, Christin, Bareth, Bettina, Schendzielorz, Alexander Benjamin, Wang, Cong, Warscheid, Bettina, Rehling, Peter, Dennerlein, Sven

“…Mitochondrial ribosomes translate membrane integral core subunits of the oxidative phosphorylation system encoded by mtDNA. These translation products…”
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Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis via COX-1 by Garshick, Michael S, Tawil, Michael, Barrett, Tessa J, Salud-Gnilo, Charissa M, Eppler, Michael, Lee, Angela, Scher, Jose U, Neimann, Andrea L, Jelic, Sanja, Mehta, Nehal N, Fisher, Edward A, Krueger, James G, Berger, Jeffrey S

“…Patients with psoriasis have impaired vascular health and increased cardiovascular disease (CVD). Platelets are key players in the pathogenesis of vascular…”
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Assessing the unified airway hypothesis in children via transcriptional profiling of the airway epithelium by Kicic, Anthony, de Jong, Emma, Ling, Kak-Ming, Nichol, Kristy, Anderson, Denise, Wark, Peter A.B., Knight, Darryl A., Bosco, Anthony, Stick, Stephen M., Kicic, Anthony, Stick, Stephen M., Knight, Darryl A., Kicic-Starcevich, Elizabeth, Garratt, Luke W., Padros-Goosen, Marc, Tan, Ee-Lyn, Sutanto, Erika N., Looi, Kevin, Hillas, Jessica, Iosifidis, Thomas, Shaw, Nicole C., Montgomery, Samuel T., Ling, Kak-Ming, Martinovich, Kelly M., Lannigan, Francis J., Bergesio, Ricardo, Lee, Bernard, Vijaya-Sekeran, Shyan, Swan, Paul, Heaney, Mairead, Forsyth, Ian, Schoep, Tobias, Larcombe, Alexander, Hunter, Monica, McGee, Kate, Millington, Nyssa, Poh, Matthew W.-P., Laucirica, Daniel R., Schofield, Craig, McLean, Samantha, Landwehr, Katherine, de Jong, Emma, Farrow, Nigel, Roscioli, Eugene, Parsons, David, Grainge, Christopher, Reid, Andrew T., Loo, Su-Ling, Veerati, Punnam C.

“…Emerging evidence suggests that disease vulnerability is expressed throughout the airways, the so-called unified airway hypothesis, but the evidence to support…”
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Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response by Rossaint, Jan, Kühne, Katharina, Skupski, Jennifer, Van Aken, Hugo, Looney, Mark R., Hidalgo, Andres, Zarbock, Alexander

“…The innate immune response to bacterial infections requires the interaction of neutrophils and platelets. Here, we show that a multistep reciprocal crosstalk…”
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MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation by Mick, David U, Dennerlein, Sven, Wiese, Heike, Reinhold, Robert, Pacheu-Grau, David, Lorenzi, Isotta, Sasarman, Florin, Weraarpachai, Woranontee, Shoubridge, Eric A, Warscheid, Bettina, Rehling, Peter

“…Mitochondrial respiratory-chain complexes assemble from subunits of dual genetic origin assisted by specialized assembly factors. Whereas core subunits are…”
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Modeling Enzyme Reaction and Mutation by Direct Machine Learning/Molecular Mechanics Simulations by Sha, Xinhu, Chen, Zhuo, Xie, Daiqian, Zhou, Yanzi

“…Accurately modeling enzyme reactions through direct machine learning/molecular mechanics simulations remains challenging in describing the electrostatic…”
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Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans by Easton, Alice, Gao, Shenghan, Lawton, Scott P, Bennuru, Sasisekhar, Khan, Asis, Dahlstrom, Eric, Oliveira, Rita G, Kepha, Stella, Porcella, Stephen F, Webster, Joanne, Anderson, Roy, Grigg, Michael E, Davis, Richard E, Wang, Jianbin, Nutman, Thomas B

“…Human ascariasis is a major neglected tropical disease caused by the nematode Ascaris lumbricoides . We report a 296 megabase (Mb) reference-quality genome…”
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Selective mitochondrial DNA degradation following double-strand breaks by Moretton, Amandine, Morel, Frédéric, Macao, Bertil, Lachaume, Philippe, Ishak, Layal, Lefebvre, Mathilde, Garreau-Balandier, Isabelle, Vernet, Patrick, Falkenberg, Maria, Farge, Géraldine

“…Mitochondrial DNA (mtDNA) can undergo double-strand breaks (DSBs), caused by defective replication, or by various endogenous or exogenous sources, such as…”
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Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects by Simmons, Jon D, Lee, Yann-Leei, Mulekar, Sujata, Kuck, Jamie L, Brevard, Sidney B, Gonzalez, Richard P, Gillespie, Mark N, Richards, William O

“…Our objective was to execute a prospective cohort study to determine relationships between plasma mtDNA DAMP levels and the occurrence of systemic inflammatory…”
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Spatiotemporal characterization of cyclooxygenase pathway enzymes during vertebrate embryonic development by Leathers, Tess A., Ramarapu, Raneesh, Rogers, Crystal D.

“…Vertebrate development is regulated by several complex well-characterized morphogen signaling pathways, transcription factors, and structural proteins, but…”
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Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function by Chan, Melissa V., Hayman, Melissa A., Suthesh Sivapalaratnam, Marilena Crescente, Allan, Harriet E., Edin, Matthew L., Zeldin, Darryl C., Milne, Ginger L., Jonathan Stephens, Daniel Greene, Moghees Hanif, O'Donnell, Valerie B., Liang Dong, Malkowski, Michael G., Claire Lentaigne, Katherine Wedderburn, Matthew Stubbs, Kate Downes, Ouwehand, Willem H., Ernest Turro, NIHR BioResource, Hart, Daniel P., Kathleen Freson, Laffan, Michael A., Warner, Timothy D.

“…We have identified a rare missense variant on chromosome 9, position 125145990 (GRCh37), in exon 8 in PTGS1 (the gene encoding cyclo-oxygenase 1, COX-1, the…”
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Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Sacco, Angela, Bruno, Annalisa, Contursi, Annalisa, Dovizio, Melania, Tacconelli, Stefania, Ricciotti, Emanuela, Guillem-Llobat, Paloma, Salvatore, Tania, Di Francesco, Luigia, Fullone, Rosa, Ballerini, Patrizia, Arena, Vincenzo, Alberti, Sara, Liu, Guizhu, Gong, Yanjun, Sgambato, Alessandro, Patrono, Carlo, FitzGerald, Garret A, Yu, Ying, Patrignani, Paola

“…Inflammatory bowel disease (IBD) is associated with an increased risk for thromboembolism, platelet activation, and abnormalities in platelet number and size…”
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Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system by Segref, Alexandra, Kevei, Éva, Pokrzywa, Wojciech, Schmeisser, Kathrin, Mansfeld, Johannes, Livnat-Levanon, Nurit, Ensenauer, Regina, Glickman, Michael H, Ristow, Michael, Hoppe, Thorsten

“…Mitochondria maintain cellular homeostasis by coordinating ATP synthesis with metabolic activity, redox signaling, and apoptosis. Excessive levels of…”
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The COX1 mutation drives structural innovation despite silent tRNA variation in semiaquatic bugs by Zhao, Tianyou, Wu, Yunfei, Chen, Zhuo, Tian, Li, Duan, Yuange, Li, Hu, Cai, Wanzhi, Song, Fan

“…The semiaquatic bugs represent an aquatic clade within the Hemiptera. These insects inhabit a variety of microhabitats across both freshwater and marine…”
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Prenatal Fish Oil Supplementation, Maternal COX1 Genotype, and Childhood Atopic Dermatitis: A Secondary Analysis of a Randomized Clinical Trial by Chen, Liang, Brustad, Nicklas, Luo, Yang, Wang, Tingting, Ali, Mina, Ebrahimi, Parvaneh, Schoos, Ann-Marie M, Vahman, Nilo, Lovric, Mario, Rasmussen, Morten A, Kolmert, Johan, Wheelock, Craig E, Lasky-Su, Jessica A, Stokholm, Jakob, Bønnelykke, Klaus, Chawes, Bo

“…Eicosanoids have a pathophysiological role in atopic dermatitis (AD), but it is unknown whether this is affected by prenatal ω-3 long-chain polyunsaturated…”
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The 206 kbp mitochondrial genome of Phanerochaete carnosa reveals dynamics of introns, accumulation of repeat sequences and plasmid-derived genes by Wang, Xu, Song, Andong, Wang, Fengqin, Chen, Mingyue, Li, Xiao, Li, Qiang, Liu, Na

“…In this study, the mitogenome of Phanerochaete carnosa was sequenced and assembled by the next-generation sequencing. The P. carnosa mitogenome was composed of…”
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Platelet COX and LOX enzymes orchestrate amyloid-β secretion via RhoA signaling: Implications for neurodegenerative diseases by Trostchansky, A., Alarcón, M.

“…Arachidonic acid metabolism through cyclooxygenase (COX) and lipoxygenase (LOX) pathways is fundamental to inflammation, vascular homeostasis, and neuronal…”
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Effect of PEAR1, PTGS1 gene polymorphisms on the recurrence of aspirin-treated patients with ischemic stroke in the Han population of China: A 4-year follow-up study by Zhang, Linlin, Meng, Zhongru, Wang, Hongxia, Miao, Yang

“…Platelet endothelial aggregation receptor 1 (PEAR1) and prostaglandin endoperoxide synthase 1 (PTGS1) polymorphisms can affect laboratory aspirin resistance…”
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